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CES2 (NM_003869) Human Untagged Clone
CAT＃: SC128182
CES2 (untagged)-Human carboxylesterase 2 (CES2), transcript variant 1
CNY 4,648.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CE-2; CES2A1; iCE; PCE-2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC128182 sequence for NM_003869 edited (data generated by NextGen Sequencing)
ATGACTGCTCAGTCCCGCTCTCCTACCACACCCACCTTTCCCGGCCCAAGCCAGCGCACC CCGCTGACTCCCTGCCCAGTCCAAACTCCAAGGCTGGGCAAGGCACTGATCCACTGCTGG ACAGACCCGGGGCAGCCTCTGGGTGAACAGCAGCGTGTCCGCCGGCAGCGAACCGAGACC AGCGAGCCGACCATGCGGCTGCACAGACTTCGTGCGCGGCTGAGCGCGGTGGCCTGTGGG CTTCTGCTGCTTCTTGTCCGGGGCCAGGGCCAGGACTCAGCCAGTCCCATCCGGACCACA CACACGGGGCAGGTGCTGGGGAGTCTTGTCCATGTGAAGGGCGCCAATGCCGGGGTCCAA ACCTTCCTGGGAATTCCATTTGCCAAGCCACCTCTAGGTCCGCTGCGATTTGCACCCCCT GAGCCCCCTGAATCTTGGAGTGGTGTGAGGGATGGAACCACCCATCCGGCCATGTGTCTA CAGGACCTCACCGCAGTGGAGTCAGAGTTTCTTAGCCAGTTCAACATGACCTTCCCTTCC GACTCCATGTCTGAGGACTGCCTGTACCTCAGCATCTACACGCCGGCCCATAGCCATGAA GGCTCTAACCTGCCGGTGATGGTGTGGATCCACGGTGGTGCGCTTGTTTTTGGCATGGCT TCCTTGTATGATGGTTCCATGCTGGCTGCCTTGGAGAACGTGGTGGTGGTCATCATCCAG TACCGCCTGGGTGTCCTGGGCTTCTTCAGCACTGGAGACAAGCACGCAACCGGCAACTGG GGCTACCTGGACCAAGTGGCTGCACTACGCTGGGTCCAGCAGAATATCGCCCACTTTGGA GGCAACCCTGACCGTGTCACCATTTTTGGCGAGTCTGCGGGTGGCACGAGTGTGTCTTCG CTTGTTGTGTCCCCCATATCCCAAGGACTCTTCCACGGAGCCATCATGGAGAGTGGCGTG GCCCTCCTGCCCGGCCTCATTGCCAGCTCAGCTGATGTCATCTCCACGGTGGTGGCCAAC CTGTCTGCCTGTGACCAAGTTGACTCTGAGGCCCTGGTGGGCTGCCTGCGGGGCAAGAGT AAAGAGGAGATTCTTGCAATTAACAAGCCTTTCAAGATGATCCCCGGAGTGGTGGATGGG GTCTTCCTGCCCAGGCACCCCCAGGAGCTGCTGGCCTCTGCCGACTTTCAGCCTGTCCCT AGCATTGTTGGTGTCAACAACAATGAATTCGGCTGGCTCATCCCCAAGGTCATGAGGATC TATGATACCCAGAAGGAAATGGACAGAGAGGCCTCCCAGGCTGCTCTGCAGAAAATGTTA ACGCTGCTGATGTTGCCTCCTACATTTGGTGACCTGCTGAGGGAGGAGTACATTGGGGAC AATGGGGATCCCCAGACCCTCCAAGCGCAGTTCCAGGAGATGATGGCGGACTCCATGTTT GTGATCCCTGCACTCCAAGTAGCACATTTTCAGTGTTCCCGGGCCCCTGTGTACTTCTAC GAGTTCCAGCATCAGCCCAGCTGGCTCAAGAACATCAGGCCACCGCACATGAAGGCAGAC CATGGTGATGAGCTTCCTTTTGTTTTCAGAAGTTTCTTTGGGGGCAACTACATTAAATTC ACTGAGGAAGAGGAGCAGCTAAGCAGGAAGATGATGAAGTACTGGGCCAACTTTGCGAGA AATGGGAACCCCAATGGCGAGGGTCTGCCACACTGGCCGCTGTTCGACCAGGAGGAGCAA TACCTGCAGCTGAACCTACAGCCTGCGGTGGGCCGGGCTCTGAAGGCCCACAGGCTCCAG TTCTGGAAGAAGGCGCTGCCCCAAAAGATCCAGGAGCTCGAGGAGCCTGAAGAGAGACAC ACAGAGCTGTAG Clone variation with respect to NM_003869.5 >OriGene 5' read for NM_003869 unedited
TTTAGGCTCCATTTGTATACCACTTACTATAGGCGGCCGCGNATTCANATCCACAAGTTT GTACAAAAAAGCAGCTTGTAAAACGACGGCCAGTAACTATAACGGTCCTAAGGTAGCGAG GCCTGGGTGGCGAATTCGGCACGAGGGTCGCGCGAGGGACACGCCGCGTTGTGGGTTCTC GGCCTGAGGTGCGAGAGAAGCGGTGACCGCGGCCCTGGCTGCTCGGACCCGGGAACATGA TGGTCGCTGGAGCAGAAGGCGCTGAGAAGGGACCACGGCGGCGCTGGGTCGTGCGAGCCA GTAGCGGGCTGAAACGTAGAGGCCAGAACCAGGTCTCAGGGGGCACTAAAGGCGGTCGGA GGTAATCCCCACACCGCTTCCTCCTGGAAGTCAGGCTGGCCGGGAGCTCCCGTATCCAGG ACGGTTGGTCGCCTCTGGCCTGGCAGGGATCCTAGTGTCTCGGGACCTCCCGGTGACGCG CCTGCCTCCCCTGCTGCACCATAGGCCCCGGGAGTACGGCGTCCCCCACAGCTTGAACCG GCGGGGGCTCGTGAAATGTTGTGCAGGGGGATAATTGACCATGGCCGTGGTCTTCGCGGG AGGTGAGGAAACTTGAAGCCACCCGTGAAAAGGGGGGCCCTCCTTTAGAAATGCCCGCGT CACCTGTCCCTTTCAAAAAATGGCCGTGCCTTGATAGGGAGGGGACCGCGGGAAACCTTT ACCCCCCTCTACTTTTAAAGAAAATTAGGGCCCCCTTAAGGGGTAACCCCGGGAAACTGG GTCCTCTGCAACAGAAGGGGGAATCTTCCCAATTTGAGGGGGGCCGAAACCTCCTTTCCT GCCTTTTGTAAGAGGGGTTCTCTTTCCCCCAATCAAATGCTTCTCCCACTTTCTCCCTTT CGGGGTGATTCCCTAACCCG |
| Restriction Sites | Please inquire |
| ACCN | NM_003869 |
| Insert Size | 3200 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003869.4, NP_003860.2 |
| RefSeq Size | 3957 bp |
| RefSeq ORF | 1872 bp |
| Locus ID | 8824 |
| UniProt ID | O00748 |
| Domains | COesterase |
| Protein Families | Druggable Genome |
| Protein Pathways | Drug metabolism - other enzymes |
| Gene Summary | This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010] Transcript Variant: This variant (1) encodes the longest isoform (1) and contains a longer 5' UTR than some of the other variants. This variant represent use of an alternate promote that is used in some tissues, and uses a downstream start codon. The upstream start codon is not well conserved. CCDS Note: The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Metabolism and Pharmacokinetics of the Anti-HCV Nucleotide Prodrug GS-6620
,Murakami, E;Wang, T;Babusis, D;Lepist, EI;Sauer, D;Park, Y;Vela, JE;Shih, R;Birkus, G;Stefanidis, D;Kim, CU;Cho, A;Ray, AS;,
Antimicrob. Agents Chemother., Jan 2014.
,PubMed ID 24419340
[CES2]
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Carboxylesterases 1 and 2 Hydrolyze Phospho-Nonsteroidal Anti-Inflammatory Drugs: Relevance to Their Pharmacological Activity
,Chi C. Wong, Ka-Wing Cheng, Gang Xie, Dingying Zhou, Cai-Hua Zhu, Panayiotis P. Constantinides, and Basil Rigas,
J. Pharmacol. Exp. Ther., Feb 2012; 340: 422 - 432.
[CES2]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC203009 | CES2 (Myc-DDK-tagged)-Human carboxylesterase 2 (CES2), transcript variant 1 |
CNY 4,640.00 |
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| RC203009L1 | Lenti ORF clone of Human carboxylesterase 2 (CES2), transcript variant 1, Myc-DDK-tagged |
CNY 7,040.00 |
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| RC203009L2 | Lenti ORF clone of Human carboxylesterase 2 (CES2), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC203009L3 | Lenti ORF clone of Human carboxylesterase 2 (CES2), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC203009L4 | Lenti ORF clone of Human carboxylesterase 2 (CES2), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG203009 | CES2 (tGFP-tagged) - Human carboxylesterase 2 (CES2), transcript variant 1 |
CNY 6,240.00 |
