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TNFRSF1A (NM_001065) Human Untagged Clone
CAT＃: SC127913
TNFRSF1A (untagged)-Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A)
CNY 5,488.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC127913 sequence for NM_001065 edited (data generated by NextGen Sequencing)
ATGGGCCTCTCCACCGTGCCTGACCTGCTGCTGCCACTGGTGCTCCTGGAGCTGTTGGTG GGAATATACCCCTCAGGGGTTATTGGACTGGTCCCTCACCTAGGGGACAGGGAGAAGAGA GATAGTGTGTGTCCCCAAGGAAAATATATCCACCCTCAAAATAATTCGATTTGCTGTACC AAGTGCCACAAAGGAACCTACTTGTACAATGACTGTCCAGGCCCGGGGCAGGATACGGAC TGCAGGGAGTGTGAGAGCGGCTCCTTCACCGCTTCAGAAAACCACCTCAGACACTGCCTC AGCTGCTCCAAATGCCGAAAGGAAATGGGTCAGGTGGAGATCTCTTCTTGCACAGTGGAC CGGGACACCGTGTGTGGCTGCAGGAAGAACCAGTACCGGCATTATTGGAGTGAAAACCTT TTCCAGTGCTTCAATTGCAGCCTCTGCCTCAATGGGACCGTGCACCTCTCCTGCCAGGAG AAACAGAACACCGTGTGCACCTGCCATGCAGGTTTCTTTCTAAGAGAAAACGAGTGTGTC TCCTGTAGTAACTGTAAGAAAAGCCTGGAGTGCACGAAGTTGTGCCTACCCCAGATTGAG AATGTTAAGGGCACTGAGGACTCAGGCACCACAGTGCTGTTGCCCCTGGTCATTTTCTTT GGTCTTTGCCTTTTATCCCTCCTCTTCATTGGTTTAATGTATCGCTACCAACGGTGGAAG TCCAAGCTCTACTCCATTGTTTGTGGGAAATCGACACCTGAAAAAGAGGGGGAGCTTGAA GGAACTACTACTAAGCCCCTGGCCCCAAACCCAAGCTTCAGTCCCACTCCAGGCTTCACC CCCACCCTGGGCTTCAGTCCCGTGCCCAGTTCCACCTTCACCTCCAGCTCCACCTATACC CCCGGTGACTGTCCCAACTTTGCGGCTCCCCGCAGAGAGGTGGCACCACCCTATCAGGGG GCTGACCCCATCCTTGCGACAGCCCTCGCCTCCGACCCCATCCCCAACCCCCTTCAGAAG TGGGAGGACAGCGCCCACAAGCCACAGAGCCTAGACACTGATGACCCCGCGACGCTGTAC GCCGTGGTGGAGAACGTGCCCCCGTTGCGCTGGAAGGAATTCGTGCGGCGCCTAGGGCTG AGCGACCACGAGATCGATCGGCTGGAGCTGCAGAACGGGCGCTGCCTGCGCGAGGCGCAA TACAGCATGCTGGCGACCTGGAGGCGGCGCACGCCGCGGCGCGAGGCCACGCTGGAGCTG CTGGGACGCGTGCTCCGCGACATGGACCTGCTGGGCTGCCTGGAGGACATCGAGGAGGCG CTTTGCGGCCCCGCCGCCCTCCCGCCCGCGCCCAGTCTTCTCAGATGA Clone variation with respect to NM_001065.3 >OriGene 5' read for NM_001065 unedited
GTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCAGAATTCTCTGGACTG AGGCTCCAGTTCTGGCCTTTGGGGTTCAAGATCACTGGGACCAGGCCGTGATCTCTATGC CCGAGTCTCAACCCTCAACTGTCACCCCAAGGCACTTGGGACGTCCTGGACAGACCGAGT CCCGGGAAGCCCCAGCACTGCCGCTGCCACACTGCCCTGAGCCCAAATGGGGGAGTGAGA GGCCATAGCTGTCTGGCATGGGCCTCTCCACCGTGCCTGACCTGCTGCTGCCACTGGTGC TCCTGGAGCTGTTGGTGGGAATATACCCCTCAGGGGTTATTGGACTGGTCCCTCACCTAG GGGACAGGGAGAAGAGAGATAGTGTGTGTCCCCAAGGAAAATATATCCACCCTCAAAATA ATTCGATTTGCTGTACCAAGTGCCACAAAGGAACCTACTTGTACAATGACTGTCCAGGCC CGGGGCAGGATACGGACTGCAGGGAGTGTGAGAGCGGCTCCTTCACCGCTTCAGAAAACC ACCTCAGACACTGCCTCAGCTGCTCCAAATGCCGAAAGGAAATGGGTCAGGTGGAGATCT CTTCTTGCACAGTGGACCGGGACACCGTGTGTGGCTGCAGGAAGAACCAGTACCGGCATT ATTGGAGTGAAAACCTTTTCCAGTGCTTCAATTGCAGCCTCTGCCTCAATGGGACCGTGC ACCTCNTCCTGCCAGAGAAACAGAACACCGTGTGCACCTGCCATGCANNGTTCTTTCTAA GAGAAACGAGTGTGTCTCCTGTAGTACTGTAAGAAAAGCTGGAGTGCACGAAGTGTGCCT ACCCANATGAGAAATGTAGGGGCACTGAGACTAGCACACAGNNGCTGTGCCCCTGGCATT NTCTTGGNNCTTGCCTTTNATCCTCCTCTCATTGGNTAATGTATCGCTACACGGG >OriGene 3' read for NM_001065 unedited
CGGCACGCTTTTAGNATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGCTTT AACTTCAAAATTTTAGTGGATGTACAAAAGTCCACAGCTCCAGCTGAAGGCCCCATTGTT CCGTGCTCGCCCCTGCCTTAAGACAGTTCAGCTTGCTATGTGCTTGTCCAGGCAGAGGGC ACAGGAGTGCCAAGTTTCTATTAGTGTAACATGATTGATTTAAAAACAAAACAAAACAAA ACAAAAACAAAAAAAACTGCTTATGCACTGGGAAAAAGGCTCAGGGACGAACCAGGGGCC CCCGAGCAGCCTTGCTGGTGAGGACACCCAAAACGGGCATGAGGCATAGCGTCCCTCATC CTCGCAAACCACCCACTCAGGCTCTTGAGCCCACGGGGCACCTTTTTTCGCGCGCACAGG GCTGACTGTCGGCGGCGCGCAAGCAGCTGAAAAAAGCTATGTACATCGAGGGGTTAGCAC CAAGTAGGCGGCTGCTAGCTCCTGCTTGCCCCTGCAGGACCCCTCCTTTCCAGAAAAAAG TGGGGTTGGAAGGCGATCTCGCAGGACGGTCCTTATAGCTGCCCGCAAGGGCGCAGCCTC ATCTGAGAAAACTGGGCGCGGGCCGGAAGGCGGCCGGGCCCCAAAGCGCCTCCTCGATGT TCTCCAGGCAGCCCAACAAGTCCATGTCGCGGAGCACGCGTTCCAACAGCTTCAGCGTGG TCTCGCGCCGCCGCGTGCGCCGCCTNCAAGGCGCCAGAATGCTGTATTGCGCCTCGCGCA GCAGGGCCCGGTCTGAGCTCCAACCATCGATCTCGGGTTGCTCACCCTAGCGCCGACGAA TTCTTCACGCCAAGGGGCCGTTTCCCACGGGTAAGGTCGGGGCCATAATTCTAGCTTGGG GTTGGGGCGCTTCCTCCCTCTAAGGGTTGGATAGGTCGAAGCCAGCCTCCCAGTAGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001065 |
| Insert Size | 2050 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001065.2, NP_001056.1 |
| RefSeq Size | 2236 bp |
| RefSeq ORF | 1368 bp |
| Locus ID | 7132 |
| UniProt ID | P19438 |
| Domains | DEATH, TNFR |
| Protein Families | Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane |
| Protein Pathways | Adipocytokine signaling pathway, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Cytokine-cytokine receptor interaction, MAPK signaling pathway |
| Gene Summary | This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016] Transcript Variant: This variant (1) encodes the longest isoform (1). |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Tumor Suppressor Ras Association Domain Family 5 (RASSF5/NORE1) Mediates Death Receptor Ligand-induced Apoptosis
,Jikyoung Park, Soo Im Kang, Sun-Young Lee, Xian F. Zhang, Myoung Shin Kim, Lisa F. Beers, Dae-Sik Lim, Joseph Avruch, Ho-Shik Kim, and Sean Bong Lee,
J. Biol. Chem., Nov 2010; 285: 35029 - 35038
[TNFRSF1A]
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Stroma-dependent apoptosis in clonal hematopoietic precursors correlates with expression of PYCARD
,Andrew J Mhyre, A. Mario Marcondes, Emily Y Spaulding, and H Joachim Deeg,
Blood, Oct 2008; 10.1182/blood-2008-04-152686.
[TNFRSF1A]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC204008 | TNFRSF1A (Myc-DDK-tagged)-Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) |
CNY 3,656.00 |
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| RC204008L1 | Lenti ORF clone of Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A), Myc-DDK-tagged |
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|
| RC204008L2 | Lenti ORF clone of Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A), mGFP tagged |
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|
| RC204008L3 | Lenti ORF clone of Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A), Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC204008L4 | Lenti ORF clone of Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A), mGFP tagged |
CNY 6,056.00 |
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| RG204008 | TNFRSF1A (tGFP-tagged) - Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) |
CNY 5,256.00 |
|
| SC320382 | TNFRSF1A (untagged)-Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) |
CNY 5,488.00 |
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