HDAC6 (BC011498) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	FLJ16239; HD6; histone deacetylase 6; JM21; KIAA0901; OTTHUMP00000032398
Vector	pCMV6-XL4
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene ORF within SC127689 sequence for BC011498 edited (data generated by NextGen Sequencing) ATGACCTCAACCGGCCAGGATTCCACCACAACCAGGCAGCGAAGAAGTAGGCAGAACCCC CAGTCGCCCCCTCAGGACTCCAGTGTCACTTCGAAGCGAAATATTAAAAAGGGAGCCGTT CCCCGCTCTATCCCCAATCTAGCGGAGGTAAAGAAGAAAGGCAAAATGAAGAAGCTCGGC CAAGCAATGGAAGAAGACCTAATCGTGGGACTGCAAGGGATGGATCTGAACCTTGAGGCT GAAGCACTGGCTGGCACTGGCTTGGTGTTGGATGAGCAGTTAAATGAATTCCATTGCCTC TGGGATGACAGCTTCCCGGAAGGCCCTGAGCGGCTCCATGCCATCAAGGAGCAACTGATC CAGGAGGGCCTCCTAGATCGCTGCGTGTCCTTTCAGGCCCGGTTTGCTGAAAAGGAAGAG CTGATGTTGGTTCACAGGTGA Clone variation with respect to BC011498.1 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC011498 unedited GCCGCGAAATTCGCACGAGGGCGGGGCTGGTTGAAACGCTAGGGGCGGGATCTGGCGGAG TGGAAGAACCGCGGCAGGGGCCAAGCCTCCTCAACTATGACCTCAACCGGCCAGGATTCC ACCACAACCAGGCAGCGAAGAAGTAGGCAGAACCCCCAGTCGCCCCCTCAGGACTCCAGT GTCACTTCGAAGCGAAATATTAAAAAGGGAGCCGTTCCCCGCTCTATCCCCAATCTAGCG GAGGTAAAGAAGAAAGGCAAAATGAAGAAGCTCGGCCAAGCAATGGAAGAAGACCTAATC GTGGGACTGCAAGGGATGGATCTGAACCTTGAGGCTGAAGCACTGGCTGGCACTGGCTTG GTGTTGGATGAGCAGTTAAATGAATTCCATTGCCTCTGGGATGACAGCTTCCCGGAAGGC CCTGAGCGGCTCCATGCCATCAAGGAGCAACTGATCCAGGAGGGCCTCCTAGATCGCTGC GTGTCCTTTCAGGCCCGGTTTGCTGAAAAGGAAGAGCTGATGTTGGTTCACAGGTGAAGG CTTGGGAGCCTTGTAGGGATGGGGAGGAGCCTGCCCTGGACAAACCAGGGCAAGCTAAAC GCTTTGGGAAGCAATGTCATGGTCTCTGCAGCCAGCCTTGGGCAAGTCGCTGAGCCTTTC TGAATCTGTGTCATCGCCTGTAACAAGGGGACCAGTANACATAAGTTCCTCAGGAGAGTC TGATGTGTGTCAAGTGCTTAAACAGGGCCTGATTATAATCAGCCCATGATGAGCCATTAC TGGTATCATGGACCGAATGTGTGAAATAAAGGTGGATGTGTGAACAGAGGATCGGGTTT
Restriction Sites	NotI-NotI
ACCN	BC011498
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	BC011498.1, AAH11498.1
RefSeq Size	1859 bp
RefSeq ORF	441 bp
Locus ID	10013
Protein Families	Druggable Genome, Transcription Factors
Gene Summary	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]

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