PTPN18 (BC031076) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	BDP1; PTP-HSCF
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for BC031076, the custom clone sequence may differ by one or more nucleotides CTCTCCCGCGGCGTCCACACTCGCCGCGCGCGCGGCGGCCGGGCTGGACCTTGCTGGCCAGCGGCGCCAT GAGCCGCAGCCTGGACTCGGCGCGGAGCTTCCTGGAGCGGCTGGAAGCGCGGGGCGGCCGGGAGGGGGCA GTCCTCGCCGGCGAGTTCAGCGTGAGTGGCACACGGGGTCCGCGAGCGGCGCGCCCCGGCCCTGGCCCTG CGTACGCCTGTCCTCCGCGCACGGCGGGCTCTGCCTTTCTGTCTCGGTGTCCCCGGTGTCTCCCCGCCTC GGGGGGTCTCTCCGTGTTTCTCTCCCCAGCACTTCTCTGTCGCTCTTGCTGTCTCCGTCTTCACTCTCTG CCCCCCGGCCCCGGAGCGCGACGTCCACGGCCAGGCCGGGACGGACCGTGCACACCCTCGTTCCCGGTGT CCTCGTCGCGCTCCCGGAACAACCTGGCTGCGGGCGGGACAGGTGGGGCGGGCGCCGCAGGGGAGGGCGG GCGGCCCTGCTGCGCTGGACAGCCCCGGCCCCGCCGCTTCTGGCGACCTGACTGTCCCCTGTGACCACAG GAAGGAAGGGGCTGCAGCAGGGCGAAGAGGAACACGGAGGCTGTGGCGTGGTGAGGGTGTGAACGCCGGG CTCGAATCCGCGTCCGGGCCCGAATCCGCTTCCCGTCCCGAATCCGCGTCCCGGCCATCCGCGTGTGGTC CAGGCGGTCTACCTGGCCCCTCTGACCTCGGCTTCTCCCTTGGTGAAATGGGGACATGAATGACCAAACT GGTCTAAGGATTAAATGATGTGGGTGAAAAGCACTTAGTACATATTGGGCGCACACTTCGTAGGGGCGTT CGTCACTGCCTATAAAGATTCTAAACGTGGGCCAGGTGCGGTGGCTCACACCTGTAATCCCAGCACTTTG GGAGGCCGAGGTGGGAGGATCGCTTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAACACAGCGAAACCCC GTCTCTACTAAAAATACAAAAATCAACTGGGCATGGGCGCATGCCTGTAATCCCAGCTACTAGGGAGCAG AGACAGGGGACTCGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATGGTTCCACTGCACAGCTG AGATGGTGCCACTGCACTCCAGCCTGGGCCACAGAGTGAGATCCCATCTCAAACAAAACAAAACCAAACA AAAAATCTAAACGTTACAATACAGGTAGTGCAAGCCCAGCATTAGGAAGGCTCACGCAGAATGCTAGGCA CTGTACATTACAGTTGATGACGTGTTTAAAGTGTAATCGCTTATGTACCAGACATAGAAACATACCATAC AAACGCATAAACTGATATATGGTGACATGTATCAAGTTTAGAAATATGACAAATATATAAAAGTATTATA AATGACCGTTTATACAATAAACATTGCATAACTGCATAAAACAATACAACAAATGAATATAACAAAGATT ATAATTTATAAAATGACCAAAGTTATTTGATAAATTCATAAGTAGATATAAAATATGTAACAGATGGCCG GGCACGGTGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAG ATCCACACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAACACACAAAAAATTAGCTGGGCGTG GTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGTGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGG AGCTTGCAGTGAGCCGAGATCGCGCCACTGCAGTCCAGCCTGGGCAACAGAGCGAGACTACATCTCAAAA AAAAAAAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC031076 unedited ATTTTGTAATACGACTTACTATAGGGCGGCCGCGAATTCGGCACGAGGCCGCGGCGCCAT GAGCCGCAGCCTGGACTCGGCGCGGAGCTTCCTGGAGCGGCTGGAAGCGCGGGGCGGCCG GGAGGGGGCAGTCCTCGCCGGCGAGTTCAGCGTGAGTGGCACACGGGGTCCGCGAGCGGC GCGCCCCGGCCCTGGCCCTGCGTACGCCTGTCCTCCGCGCACGGCGGGCTCTGCCTTTCT GTCTCGGTGTCCCCGGTGTCTCCCCGCCTCGGGGGGTCTCTCCGTGTTTCTCTCCCCAGC ACTTCTCTGTCGCTCTTGCTGTCTCCGTCTTCACTCTCTGCCCCCCGGCCCCGGAGCGCG ACGTCCACGGCCAGGCCGGGACGGACCGTGCACACCCTCGTTCCCGGTGTCCTCGTCGCG CTCCCGGAACAACCTGGCTGCGGGCGGGACAGGTGGGGCGGGCGCCGCAGGGGAGGGCGG GCGGCCCTGCTGCGCTGGACAGCCCCGGCCCCGCCGCTTCTGGCGACCTGACTGTCCCCT GTGACCACAGGAAGGAAGGGGCTGCAGCAGGGCGAAGAGGAACACGGAGGCTGTGGCGTG GTGAGGGTGTGAACGCCGGGCTCGAATCCGCGTCCGGGCCCGAATCCGCTTCCCGTCCCG AATCCGCGTCCCGGCCATCCGCGTGTGGTCCAGGCGGTCTACCTGGCCCCTCTGACCTCG GCTTCTCCCTTGGNNTGAATGGGGACATGAATGACCNAACTGGTCTAANGATTAATGATG TGGGGTGAAAGCACTTTAGTACATATGGGCGCCACTTCGTAGGGGCGTTCGTCACTGCTA TAAGATCTAANCGTGGCCAGNGGGCGGGGCTCACACTGTATCCACACTTTTGGAAGGCCA GGTGGGAAGATCGCTGAC 3' Read Nucleotide Sequence (showhide) >OriGene 3' read for BC031076 unedited CCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTGAAATGGAGTCTCGCTCTG TTGCCCAGGCTGGACTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGT TCACGCCATTCTCCTGCCTCAGCCACCCGAGTAGCTGGGACTACAGGCGCCCGCCACCAC GCCCAGCTAATTTTTTGTGTGTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGG TGTGGATCTCCTGACCTCGTGATCCGCCCGCCTCGACCTCCCAAAGTGCTGGGATTATAG GCGTGAGCCACCGTGCCCGGCCATCTGTTACATATTTTATATCTACTTATGAATTTATCA AATAACTTTGGTCATTTTATAAATTATAATCTTTGTTATATTCATTTGTTGTATTGTTTT ATGCAGTTATGCAATGTTTATTGTATAAACGGCCATTTATAATACTTTTATATATTTGTC ATATTTCTAAACTTGATACATGTCACCATATATCAGTTTATGCGTTTGTATGGTATGTTT CTATGTCTGGTACATAAGCGATTACACTTTAAACACGTCATCAACTGTAATGTACAGTGC CTAGCATTCTGCGTGAGCCTTCCTAATGCTGGGCTTGCACTACCTGTATTGTAACGTTTA GATTTTTTTGTTTGGGTTTGTTTTGTTTGAGATGGGATCTCACTCTGTGGCCCACGCTGG AGTGCAATGGCACCATCTCAGCTGTGCAGTGGGACCATCTCAGCTTACTGCAACCTCTTG CTTCCAGTTCAAGCGAGATCCCTGTCTCTGCTCCCTAGTAGCTGGGATTACAGGCATGCG CCCATGCCCAGTTGATTTTTGTAATTTAGGAAAAACAGGGTTTCCTTGGTTGCCAAGCTG TCTTGAACTCTGACTAAAGGAACCTTCCACCTGGCCTCCCAAGGTTGGATTACAGGGGAA CCCACGCCCTGCCCCCTTTATAATCTTTAGGCAAGACCACCCCCTACAAAGGGG
Restriction Sites	NotI-NotI
ACCN	BC031076
Insert Size	1790 bp
OTI Disclaimer	The sequence of an 'OriGene Unique Variant' differs significantly from the associated reference. It represents a novel splice variant from the same gene locus of the reference. Although such variants are true transcripts and present opportunity for discoveries, they are not yet curated by NCBI and should not be used if the exact reference accession sequence is required.
OTI Annotation	This TrueClone was found to represent an alternative form of the specific reference to which it is associated. Its Open Reading Frame (ORF) may represent a novel form or alternative splice variant. By virtue of it being a true transcript (cDNA clone not PCR product), it provides a biologically relevant copy of its mRNA template. For more details, please evaluate the sequence information provided on this website or contact our customer care specialists.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC031076.1
RefSeq Size	1831 bp
RefSeq ORF	1831 bp
Locus ID	26469
Protein Families	Druggable Genome, Phosphatase
Gene Summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

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