NADPH oxidase 4 (NOX4) (BC040105) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	kidney superoxide-producing NADPH oxidase; KOX; KOX-1; NADPH oxidase 4; renal NAD(P)H-oxidase; RENOX
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC040105 edited CCGCTGCCCCGGCCGCCGCCCGCTCCTTCTCGGTCCGGCGGGCACAGAGCGCAGCGCGGC GGGGCCGGCGGCATGGCTGTGTCCTGGAGGAGCTGGCTCGCCAACGAAGGGGTTAAACAC CTCTGCCTGTTCATCTGGCTCTCCATGAATGTCCTGCTTTTCTGGAAAACCTTCTTGCTG TATAACCAAGGGCCAGAGTATCACTACCTCCACCAGATGTTGGGGCTAGGATTGTGTCTA AGCAGAGCCTCAGCATCTGTTCTTAACCTCAACTGCAGCCTTATCCTTTTACCCATGTGC CGAACACTCTTGGCTTACCTCCGAGGATCACAGAAGGTTCCAAGCAGGAGAACCAGGAGA TTGTTGGATAAAAGCAGAACATTCCATATTACCTGTGGTGTTACTATCTGTATTTTCTCA GGCGTGCATGTGGCTGCCCATCTGGTGAATGCCCTCAACTTCTCAGTGAATTACAGTGAA GACTTTGTTGAACTGAATGCAGCAAGATACCGAGATGAGGATCCTAGAAAACTTCTCTTC ACAACTGTTCCTGGCCTGACAGGGGTCTGCATGGTGGTGGTGCTATTCCTCATGATCACA GCCTCTACATATGCAATAAGAGTTTCTAACTATGATATCTTCTGGTATACTCATAACCTC TTCTTTGTCTTCTACATGCTGCTGACGTTGCATGTTTCAGGAGGGCTGCTGAAGTATCAA ACTAATTTAGATACCCACCCTCCCGGCTGCATCAGTCTTAACCGAACCAGCTCTCAGAAT ATTTCCTTACCAGAGTATTTCTCAGAACATTTTCATGAACCTTTCCCTGAAGGATTTTCA AAACCGGCAGAGTTTACCCAGCACAAATTTGTGAAGATTTGTATGGAAGAGCCCAGATTC CAAGCTAATTTTCCACAGACTTGGCTTTGGATTTCTGGACCTTTGTGCCTGTACTGTGCC GAAAGACTTTACAGGTATATCCGGAGCAATAAGCCAGTCACCATCATTTCGGTCATAAGT CATCCCTCAGATGTCATGGAAATCCGAATGGTCAAAGAAAATTTTAAAGCAAGACCTGGT CAGTATATTACTCTACATTGTCCCAGTGTATCTGCATTAGAAAATCATCCATTTACCCTC ACAATGTGTCCAACTGAAACCAAAGCAACATTTGGGGTTCATCTTAAAATAGTAGGAGAC TGGACAGAACGATTTCGAGATTTACTACTGCCTCCATCTAGTCAAGACTCCGAAATTCTG CCCTTCATTCAATCTAGAAATTATCCCAAGCTGTATATTGATGGTCCTTTTGGAAGTCCA TTTGAGGAATCACTGAACTATGAGGTCAGCCTCTGCGTGGCTGGAGGCATTGGAGTAACT CCATTTGCATCAATACTCAACACCCTGTTGGATGACTGGAAACCATACAAGCTTAGAAGA CTATACTTTATTTGGGTATGCAGAGATATCCAGTCCTTCCGTTGGTTTGCAGATTTACTC TGTATGTTGCATAACAAGTTTTGGCAAGAGAACAGACCTGACTATGTCAACATCCAGCTG TACCTCAGTCAAACAGATGGGATACAGAAGATAATTGGAGAAAAATATCATGCACTGAAT TCAAGACTGTTTATAGGACGTCCTCGGTGGAAACTTTTGTTTGATGAAATAGCAAAATAT AACAGAGGAAAAACAGTTGGTGTTTTCTGTTGTGGACCCAATTCACTATCCAAGACTCTT CATAAACTGAGTAACCAGAACAACTCATATGGGACAAGATTTGAATACAATAAAGAGTCT TTCAGCTGAAAACTTTTGCCATGAAGCAGGACTCTAAAGAAGGAATGAGTGCAATTTCTA AGACTTTGAAACTCAGCGGAATCAATCAGCTGTGTTATGCCAAAGAATAGTAAGGTTTTC TTATTTATGATTATTTAAAATGGAAATGTGAGAATGTGGCAAGATGACCGTCACATTACA TGTTTAATCTGGAAACCAAAGAGACCCTGAAGAATATTTGATGTGATGATTCACTTTTCA GTTCTCAAATTAAAAGAAAACTGTTAGATGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC040105 unedited NNNNNGCGTTCANATTTTGTAATACGACTCACTATAGGGNNCGGCCGCGNAATTCAGTTN CTNNGGTACCGGTCCGGNAATTCCCGGGATCCGCTGCCCCGGCCGCCGCCCGCTCCTTCT CGGTCCGGCGGGCACAGAGCGCAGCGCGGCGGGGCCGGCGGCATGGCTGTGTCCTGGAGG AGCTGGCTCGCCAACGAAGGGGTTAAACACCTCTGCCTGTTCATCTGGCTCTCCATGAAT GTCCTGCTTTTCTGGAAAACCTTCTTGCTGTATAACCAAGGGCCAGAGTATCACTACCTC CACCAGATGTTGGGGCTAGGATTGTGTCTAAGCAGAGCCTCAGCATCTGTTCTTAACCTC AACTGCAGCCTTATCCTTTTACCCATGTGCCGAACACTCTTGGCTTACCTCCGAGGATCA CAGAAGGTTCCAAGCAGGAGAACCAGGAGATTGTTGGATAAAAGCAGAACATTCCATATT ACCTGTGGTGTTACTATCTGTATTTTCTCAGGCGTGCATGTGGCTGCCCATCTGGTGAAT GCCCTCAACTTCTCAGTGAATTACAGTGAAGACTTTGTTGAACTGAATGCAGCAAGATAC CGAGATGAGGATCCTAGAAAACTTCTCTTCACAACTGTTCCTGGCCTGACAGGGGTCTGC ATGGTGGTGGTGCTATTCCTCATGATCACAGCCTCTACATATGCAATAAGAGTTTCTAAC TATGAATATCTTCTGGTATACTCATAACCCTCTCTTTGTCTTCTACATGCTGCTGACGTT GCATGTTTCAGGAGGGCTGCTGAAGTATCAACTAATTAGATCCCACCCTTCCGGCTGCAT TAATCTTAACCGACCCGCTTTAA
Restriction Sites	NotI-NotI
ACCN	BC040105
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC040105.1, AAH40105.1
RefSeq Size	2108 bp
RefSeq ORF	1734 bp
Locus ID	50507
Protein Families	Druggable Genome, Transmembrane
Gene Summary	This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

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