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SUV39H2 (NM_024670) Human Untagged Clone
CAT＃: SC125719
SUV39H2 (untagged)-Human suppressor of variegation 3-9 homolog 2 (Drosophila) (SUV39H2), transcript variant 3
CNY 3,656.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | KMT1B |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_024670 edited
CGGGGCCGAGGCGCGAGGAGGTGAGGCTGGAGCGCGGCCCCCTCGCCTTCCCTGTTCCCA GGCAAGCTCCCAAGGCCCGGGCGGCGGGGCCGTCCCGCGGGCCAGCCAGATGGCGACGTG GCGGTTCCCCGCCCGCCGCGACCCCAACTCCGGGACGCACGCTGCGGACGCCTATCCTCC CCCAGGCCGCTGACCCGCCTCCCTGCCCGGCCGGCTCCCGCCGCGGAGGATATGGAATAT TATCTTGTAAAATGGAAAGGATGGCCAGATTCTACAAATACTTGGGAACCTTTGCAAAAT CTGAAGTGCCCGTTACTGCTTCAGCAATTCTCTAATGACAAGCATAATTATTTATCTCAG GTAAAGAAAGGCAAAGCAATAACTCCAAAAGACAATAACAAAACTTTGAAACCTGCCATT GCTGAGTACATTGTGAAGAAGGCTAAACAAAGGATAGCTCTGCAGAGATGGCAAGATGAA CTCAACAGAAGAAAGAATCATAAAGGAATGATATTTGTTGAAAATACTGTTGATTTAGAG GGCCCACCTTCAGACTTCTATTACATTAACGAATACAAACCAGCTCCTGGAATCAGCTTA GTCAATGAAGCTACCTTTGGTTGTTCATGCACAGATTGCTTCTTTCAAAAATGTTGTCCT GCTGAAGCTGGAGTTCTTTTGGCTTATAATAAAAACCAACAAATTAAAATCCCACCTGGT ACTCCCATCTATGAATGCAACTCAAGGTGTCAGTGTGGTCCTGATTGTCCCAATAGGATT GTACAAAAAGGCACACAGTATTCGCTTTGCATCTTTCGAACTAGCAATGGACGTGGCTGG GGTGTAAAGACCCTTGTGAAGATTAAAAGAATGAGTTTTGTCATGGAATATGTTGGAGAG GTAATCACAAGTGAAGAAGCTGAAAGACGAGGACAGTTCTATGACAACAAGGGAATCACG TATCTCTTTGATCTGGACTATGAGTCTGATGAATTCACAGTGGATGCGGCTCGATACGGC AATGTGTCTCATTTTGTGAATCACAGCTGTGACCCAAATCTTCAGGTGTTCAATGTTTTC ATTGATAACCTCGATACTCGTCTTCCCCGAATAGCATTGTTTTCCACAAGAACCATAAAT GCTGGAGAAGAGCTGACTTTTGATTATCAAATGAAAGGTTCTGGAGATATATCTTCAGAT TCTATTGACCACAGCCCAGCCAAAAAGAGGGTCAGAACAGTATGTAAATGTGGAGCTGTG ACTTGCAGAGGTTACCTCAACTGAACTTTTTCAGGAAATAGAGCTGATGATTATAATATT TTTTTCCTAATGTTAACATTTTTAAAAATACATATTTGGGACTCTTATTATCAAGGTTCT ACCTATGTTAATTTACAATTCATGTTTCAAGACATTTGCCAAATGTATTACCGATGCCTC TGAAAAGGGGGTCACTGGGTCTCATAGACTGATATGAAGTCGACATATTTATAGTGCTTA GAGACCAAACTAATGGAAGGCAGACTATTTACAGCTTAGTATATGTGTACTTAAGTCTAT GTGAACAGAGAAATGCCTCCCGTAGTGTTTGAAAGCGTTAAGCTGATAATGTAATTAACA ACTGCTGAGAGATCAAAGATTCAACTTGCCATACACCTCAAATTCGGAGAAACAGTTAAT TTGGGCAAATCTACAGTTCTGTTTTTGCTACTCTATTGTCATTCCTGTTTAATACTCACT GTACTTGTATTTGAGACAAATAGGTGATACTGAATTTTATACTGTTTTCTACTTTTCCAT TAAAACATTGGCACCTCAATGATAAAGAAATTTAAGGTATAAAATTAAATGTAAAAATTA ATTTCAGCTTCATTTCGTATTTCGAAGCAATCTAGACTGTTGTGATGAGTGTATGTCTGA ACCTGTAATTCTTAAAAGACTTCTTAATCTTCTAGAAGAAAAATCTCCGAAGAGCTCTCT CTAGAAGTCCAAAATGGCTAGCCATTATGCTTCTTTGAAAGGACATGATAATGGGACCAG GATGGTTTTTTGGAGTACCAAGCAAGGGGAATGGAGCACTTTAAGGGCGCCTGTTAGTAA CATGAATTGGAAATCTGTGTCGAGTACCTCTGATCTAAACGGTAAAACAAGCTGCCTGGA GAGCAGCTGTACCTAACAATACTGTAATGTACATTAACATTACAGCCTCTCAATTTCAGG CAGGTGTAACAGTTCCTTTCCACCAGATTTAATATTTTTATACTTCCTGCAGGTTCTTCT TAAAAAGTAATCTATATTTTTGAACTGATACTTGTTTTATACATAAATTTTTTTTAGATG TGATAAAGCTAAACTTGGCCAAAGTGTGTGCCTGAATTATTAGACCTTTTTATTAGTCAA CCTACGAAGACTAAAATAGAATATATTAGTTTTCAAGGGAGTGGGAGGCTTCCAACATAG TATTGAATCTCAGGAAAAACTATTCTTTCATGTCTGATTCTGAGATTTCTAATTGTGTTG TGAAAATGATAAATGCAGCAAATCTAGCTTTCAGTATTCCTAATTTTTACCTAAGCTCAT TGCTCCAGGCTTTGATTACCTAAAATAAGCTTGGATAAAATTGAACCAACTTCAAGAATG CAGCACTTCTTAATCTTTAGCTCTTTCTTGGGAGAAGCTAGACTTTATTCATTATATTGC TATGACAACTTCACTCTTTCATAATATATAGGATAAATTGTTTACATGATTGGACCCTCA GATTCTGTTAACCAAAATTGCAGAATGGGGGGCCAGGCCTGTGTGGTGGCTCACACCTGT GATCCCAGCACTTTGGGAGGCTGAGGTAGGAGGATCACGTGAGGTCGGGAGTTCAAGACC AGCCTGGCCATCATGGTGAAACCCTGTCTCTACTGAAAATACAAAAATTAGCCGGGCGTG GTGGCACACGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAATT CAGGAGGCGGAGGTTGCAGTGAGCCAAGATCATACCACTGCACTGCAGCCTGAGTGACAC AGTAAGACTGTCTCCAAAAAAAAAAAAAAAAAA >OriGene 5' read for NM_024670 unedited
NNCCGTTCAGATTTTGTAATACGACTCACTATAGGGNCGGACCGCGNAATTCGGCACGAG GCGGGGCCGAGGCGCGAGGAGGTGAGGCTGGAGCGCGGCCCCCTCGCCTTCCCTGTTCCC AGGCAAGCTCCCAAGGCCCGGGCGGCGGGGCCGTCCCGCGGGCCAGCCAGATGGCGACGT GGCGGTTCCCCGCCCGCCGCGACCCCAACTCCGGGACGCACGCTGCGGACGCCTATCCTC CCCCAGGCCGCTGACCCGCCTCCCTGCCCGGCCGGCTCCCGCCGCGGAGGATATGGAATA TTATCTTGTAAAATGGAAAGGATGGCCAGATTCTACAAATACTTGGGAACCTTTGCAAAA TCTGAAGTGCCCGTTACTGCTTCAGCAATTCTCTAATGACAAGCATAATTATTTATCTCA GGTAAAGAAAGGCAAAGCAATAACTCCAAAAGACAATAACAAAACTTTGAAACCTGCCAT TGCTGAGTACATTGTGAAGAAGGCTAAACAAAGGATAGCTCTGCAGAGATGGCAAGATGA ACTCAACAGAAGAAAGAATCATAAAGGAATGATATTTGTTGAAAATACTGTTGATTTAGA GGGCCCACCTTCAGACTTCTATTACATTAACGAATACAAACCAGCTCCTGGAATCAGCTT AGTCAATGAAGCTACCTTTGGTTGTTCATGCACAGATTGCTTCTTTCAAAAATGTTGTCC TGCTGAAGCTGGAGTTCTTTTGGCTTATAATAAAAACCAANCAATTAAAATCCCACCTGG TACTCCCATCTATGAATGCAACTCAAGGTGTCAGTGTGGTCCTGATTGTCCCATAGGATT GTACAAAAGGCACACAGTATTCGCTTTGCATCTTTCGAACTAGCAATGGACGTGGCTGGG GTGTAAAGACCCCG |
| Restriction Sites | Please inquire |
| ACCN | NM_024670 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_024670.3, NP_078946.1 |
| RefSeq Size | 3093 bp |
| RefSeq ORF | 1053 bp |
| Locus ID | 79723 |
| UniProt ID | Q9H5I1 |
| Protein Families | Druggable Genome |
| Protein Pathways | Lysine degradation |
| Gene Summary | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and is missing the subsequent exon compared to variant 1. This results in translation initiation from an in-frame, downstream AUG, and a shorter isoform (2) compared to isoform 1. Variants 2 and 3 encode the same isoform. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC203032 | SUV39H2 (Myc-DDK-tagged)-Human suppressor of variegation 3-9 homolog 2 (Drosophila) (SUV39H2), transcript variant 3 |
CNY 3,656.00 |
|
| RC203032L1 | Lenti ORF clone of Human suppressor of variegation 3-9 homolog 2 (Drosophila) (SUV39H2), transcript variant 3, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC203032L2 | Lenti ORF clone of Human suppressor of variegation 3-9 homolog 2 (Drosophila) (SUV39H2), transcript variant 3, mGFP tagged |
CNY 5,890.00 |
|
| RC203032L3 | Lenti ORF clone of Human suppressor of variegation 3-9 homolog 2 (Drosophila) (SUV39H2), transcript variant 3, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC203032L4 | Lenti ORF clone of Human suppressor of variegation 3-9 homolog 2 (Drosophila) (SUV39H2), transcript variant 3, mGFP tagged |
CNY 6,056.00 |
|
| RG203032 | SUV39H2 (tGFP-tagged) - Human suppressor of variegation 3-9 homolog 2 (Drosophila) (SUV39H2), transcript variant 3 |
CNY 5,256.00 |
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