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HYPE (FICD) (NM_007076) Human Untagged Clone
CAT＃: SC125628
FICD (untagged)-Human FIC domain containing (FICD)
CNY 3,656.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HIP13; HYPE; UNQ3041 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_007076 edited
GCTGGGAGCGCGGGGAAGGCGGTTGGGGTTCTGACAGCTGCGCGCGATCCTGCTCTCTCT CAGCCGCCTGTGGACATGCGCAAAGGGCCCTCTCCTGAGTCCAGATGATGCTCATACCAA TGGCTTCAGTGATGGCGGTGACTGAACCGAAATGGGTCTCGGTCTGGAGCCGCTTCCTCT GGGTGACGCTGCTGAGCATGGTGCTGGGGTCCCTGCTGGCCCTGCTGCTGCCGCTGGGGG CTGTGGAGGAGCAGTGCTTGGCTGTGCTCAAAGGCCTCTACCTGCTCAGGAGCAAACCGG ACAGGGCGCAGCATGCCGCCACCAAGTGCACCAGCCCGTCCACGGAGCTCAGCATCACCT CCAGGGGCGCGACGCTGCTGGTGGCCAAGACCAAGGCCTCTCCAGCGGGTAAGTTGGAAG CCAGAGCTGCCCTGAACCAGGCCCTGGAGATGAAGCGCCAGGGCAAGCGGGAAAAAGCCC AAAAGCTCTTCATGCACGCCCTCAAGATGGACCCGGACTTCGTGGACGCGCTCACCGAGT TTGGCATCTTCTCGGAAGAAGACAAGGACATCATCCAGGCGGACTACTTGTACACCAGAG CATTGACCATCTCACCCTACCATGAGAAAGCACTGGTCAACCGCGATCGGACACTGCCTC TTGTGGAAGAGATCGACCAGAGGTATTTCAGCATCATCGACAGCAAAGTGAAGAAGGTCA TGTCCATCCCCAAGGGGAACTCAGCTCTGCGCAGGGTCATGGAGGAGACCTACTACCATC ACATCTACCACACAGTGGCCATCGAGGGCAACACCCTCACCCTCTCGGAAATCAGGCACA TCCTGGAGACCCGCTACGCCGTGCCCGGGAAGAGCCTGGAGGAGCAGAACGAGGTCATAG GCATGCATGCAGCCATGAAGTACATCAACACGACTCTGGTTTCGCGCATCGGCTCCGTCA CCATCAGCGACGTGCTGGAGATCCACAGGCGGGTGCTGGGCTACGTGGACCCCGTGGAAG CCGGCAGGTTTCGGACAACACAGGTCCTGGTCGGACACCACATCCCTCCCCATCCGCAGG ATGTGGAAAAGCAGATGCAGGAGTTTGTACAGTGGCTCAACTCCGAGGAAGCCATGAACC TGCACCCAGTGGAGTTTGCAGCCTTAGCCCATTATAAACTCGTTTACATCCACCCTTTCA TTGATGGCAACGGGAGGACCTCCCGTCTGCTCATGAACCTCATCCTCATGCAGGCGGGCT ACCCGCCCATCACCATCCGCAAGGAGCAGCGGTCCGACTACTACCACGTGTTGGAAGCTG CCAACGAGGGCGACGTGAGGCCTTTCATTCGCTTCATCGCCAAGTGTACTGAGACCACCC TGGACACCCTGCTTTTTGCCACAACTGAGTACTCGGTGGCACTGCCAGAAGCCCAACCCA ACCACTCTGGGTTCAAGGAGACGCTTCCTGTGAAGCCCTAACCCTAGAAATCCTCAGTGA CAAAGGCTGTCCTGAGGTAGGAAAAAAAAAAAAAAAAAA >OriGene 5' read for NM_007076 unedited
GGATAGGATTTGTATACGACTTACTATAGGCGGACCGCGAATCAAATCTGGTACCGGTCC GGAATTCCCGGGATATCGTCGACCCACGCGTCCGGCTGGGAGCGCGGGGAAGGCGGTTGG GGTTCTGACAGCTGCGCGCGATCCTGCTCTCTCTCAGCCGCCTGTGGACATGCGCAAAGG GCCCTCTCCTGAGTCCAGATGATGCTCATACCAATGGCTTCAGTGATGGCGGTGACTGAA CCGAAATGGGTCTCGGTCTGGAGCCGCTTCCTCTGGGTGACGCTGCTGAGCATGGTGCTG GGGTCCCTGCTGGCCCTGCTGCTGCCGCTGGGGGCTGTGGAGGAGCAGTGCTTGGCTGTG CTCAAAGGCCTCTACCTGCTCAGGAGCAAACCGGACAGGGCGCAGCATGCCGCCACCAAG TGCACCAGCCCGTCCACGGAGCTCAGCATCACCTCCAGGGGCGCGACGCTGCTGGTGGCC AAGACCAAGGCCTCTCCAGCGGGTAAGTTGGAAGCCAGAGCTGCCCTGAACCAGGCCCTG GAGATGAAGCGCCAGGGCAAGCGGGAAAAAGCCCAAAAGCTCTTCATGCACGCCCTCAAG ATGGACCCGGACTTCGTGGACGCGCTCACCGAGTTTGGCATCTTCTCGGGAAGAGAACAG GACATCATCCAGGCGGACTACTTGTACACCAGAGCATTGACCATCTCACCCTACCATGAG AAAGCACTGGTCAACCCGCGATCGGACACTGGCTCTTGTGGGAGAAATCGACCAGAGGTA TTTCAGCATCATCGACAGCAAAGTGAAGAAGGTCATGTTCATCCCCCAAGGGGAACTCAC CTCTTGCCCAGGGCATTGGAGGAAACCTACTACCATGACATGCTCCACAACGTGGGCCAT CGAGGGGCACACCCCTCCCCTCT |
| Restriction Sites | Please inquire |
| ACCN | NM_007076 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_007076.2, NP_009007.2 |
| RefSeq Size | 1651 bp |
| RefSeq ORF | 1377 bp |
| Locus ID | 11153 |
| UniProt ID | Q9BVA6 |
| Protein Families | Transmembrane |
| Gene Summary | Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:25601083). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (By similarity). In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity). Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (PubMed:19362538, PubMed:25601083).[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Entwicklung von MS-Transport-Assays für die humanen gamma-Aminobuttersäure-Transporter
,Schmitt, S;,
JBC Papers in Press
[FICD]
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Resources
Other Versions
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| RC201725 | FICD (Myc-DDK-tagged)-Human FIC domain containing (FICD) |
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| RC201725L3 | Lenti ORF clone of Human FIC domain containing (FICD), Myc-DDK-tagged |
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| RC201725L4 | Lenti ORF clone of Human FIC domain containing (FICD), mGFP tagged |
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| RG201725 | FICD (tGFP-tagged) - Human FIC domain containing (FICD) |
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