United States
Germany
Japan
United Kingdom
China
HDAC5 (NM_005474) Human Untagged Clone
CAT＃: SC124229
HDAC5 (untagged)-Human histone deacetylase 5 (HDAC5), transcript variant 1
CNY 11,728.00
| Cited in 2 publications. |
Product images
热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HD5; NY-CO-9 |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_005474 edited
GACAGGGGCGCCTTCCCTACAGGGATGCCGTTCTGAGTGCCTGACTGCCTCGCCCCGAAG GATGGCCTCGGATGGGCATTAGAGGCACGGCGGCCCCGGGCTCCCGTCCCGTCCGTCTGT CTGTTATCGTCTGTCTCTCTTGACATCACCGCAGCTCCACCCCCTCCCGTCCCAGCCCCC AACGCCAGCTTCCTGCAGGCCCAGAGCCGGCATGAACTCTCCCAACGAGTCGGATGGGAT GTCAGGTCGGGAACCATCCTTGGAAATCCTGCCGCGGACTTCTCTGCACAGCATCCCTGT GACAGTGGAGGTGAAGCCGGTGCTGCCAAGAGCCATGCCCAGTTCCATGGGGGGTGGGGG TGGAGGCAGCCCCAGCCCTGTGGAGCTACGGGGGGCTCTGGTGGGCTCTGTGGACCCCAC ACTGCGGGAGCAGCAACTGCAGCAGGAGCTCCTGGCGCTCAAGCAGCAGCAGCAGCTGCA GAAGCAGCTCCTGTTCGCTGAGTTCCAGAAACAGCATGACCACCTGACAAGGCAGCATGA GGTCCAGCTGCAGAAGCACCTCAAGCAGCAGCAGGAGATGCTGGCAGCCAAGCAGCAGCA GGAGATGCTGGCAGCCAAGCGGCAGCAGGAGCTGGAGCAGCAGCGGCAGCGGGAGCAGCA GCGGCAGGAAGAGCTGGAGAAGCAGCGGCTGGAGCAGCAGCTGCTCATCCTGCGGAACAA GGAGAAGAGCAAAGAGAGTGCCATTGCCAGCACTGAGGTAAAGCTGAGGCTCCAGGAATT CCTCTTGTCGAAGTCAAAGGAGCCCACACCAGGCGGCCTCAACCATTCCCTCCCACAGCA CCCCAAATGCTGGGGAGCCCACCATGCTTCTTTGGACCAGAGTTCCCCTCCCCAGAGCGG CCCCCCTGGGACGCCTCCCTCCTACAAACTGCCTTTGCCTGGGCCCTACGACAGTCGAGA CGACTTCCCCCTCCGCAAAACAGCCTCTGAACCCAACTTGAAAGTGCGTTCAAGGCTAAA ACAGAAGGTGGCTGAGCGGAGAAGCAGTCCCCTCCTGCGTCGCAAGGATGGGACTGTTAT TAGCACCTTTAAGAAGAGAGCTGTTGAGATCACAGGTGCCGGGCCTGGGGCGTCGTCCGT GTGTAACAGCGCACCCGGCTCCGGCCCCAGCTCTCCCAACAGCTCCCACAGCACCATCGC TGAGAATGGCTTTACTGGCTCAGTCCCCAACATCCCCACTGAGATGCTCCCTCAGCACCG AGCCCTCCCTCTGGACAGCTCCCCCAACCAGTTCAGCCTCTACACGTCTCCTTCTCTGCC CAACATCTCCCTAGGGCTGCAGGCCACGGTCACTGTCACCAACTCACACCTCACTGCCTC CCCGAAGCTGTCGACACAGCAGGAGGCCGAGAGGCAGGCCCTCCAGTCCCTGCGGCAGGG TGGCACGCTGACCGGCAAGTTCATGAGCACATCCTCTATTCCTGGCTGCCTGCTGGGCGT GGCACTGGAGGGCGACGGGAGCCCCCACGGGCATGCCTCCCTGCTGCAGCATGTGCTGTT GCTGGAGCAGGCCCGGCAGCAGAGCACCCTCATTGCTGTGCCACTCCACGGGCAGTCCCC ACTAGTGACGGGTGAACGTGTGGCCACCAGCATGCGGACGGTAGGCAAGCTCCCGCGGCA TCGGCCCCTGAGCCGCACTCAGTCCTCACCGCTGCCGCAGAGTCCCCAGGCCCTGCAGCA GCTGGTCATGCAACAACAGCACCAGCAGTTCCTGGAGAAGCAGAAGCAGCAGCAGCTACA GCTGGGCAAGATCCTCACCAAGACAGGGGAGCTGCCCAGGCAGCCCACCACCCACCCTGA GGAGACAGAGGAGGAGCTGACGGAGCAGCAGGAGGTCTTGCTGGGGGAGGGAGCCCTGAC CATGCCCCGGGAGGGCTCCACAGAGAGTGAGAGCACACAGGAAGACCTGGAGGAGGAGGA CGAGGAAGAGGATGGGGAGGAGGAGGAGGATTGCATCCAGGTTAAGGACGAGGAGGGCGA GAGTGGTGCTGAGGAGGGGCCCGACTTGGAGGAGCCTGGTGCTGGATACAAAAAACTGTT CTCAGATGCCCAGCCGCTGCAGCCTTTGCAGGTGTACCAGGCGCCCCTCAGCCTGGCCAC TGTGCCCCACCAGGCCCTGGGCCGTACCCAGTCCTCCCCTGCTGCCCCTGGGGGCATGAA GAGCCCCCCAGACCAGCCCGTCAAGCACCTCTTCACCACAGGTGTGGTCTACGACACGTT CATGCTAAAGCACCAGTGCATGTGCGGGAACACACACGTGCACCCTGAGCATGCTGGCCG GATCCAGAGCATCTGGTCCCGGCTGCAGGAGACAGGCCTGCTTAGCAAGTGCGAGCGGAT CCGAGGTCGCAAAGCCACGCTAGATGAGATCCAGACAGTGCACTCTGAATACCACACCCT GCTCTATGGGACCAGTCCCCTCAACCGGCAGAAGCTAGACAGCAAGAAGTTGCTCGGCCC CATCAGCCAGAAGATGTATGCTGTGCTGCCTTGTGGGGGCATCGGGGTGGACAGTGACAC CGTGTGGAATGAGATGCACTCCTCCAGTGCTGTGCGCATGGCAGTGGGCTGCCTGCTGGA GCTGGCCTTCAAGGTGGCTGCAGGAGAGCTCAAGAATGGATTTGCCATCATCCGGCCCCC AGGACACCACGCCGAGGAATCCACAGCCATGGGATTCTGCTTCTTCAACTCTGTAGCCAT CACCGCAAAACTCCTACAGCAGAAGTTGAACGTGGGCAAGGTCCTCATCGTGGACTGGGA CATTCACCATGGCAATGGCACCCAGCAGGCGTTCTACAATGACCCCTCTGTGCTCTACAT CTCTCTGCATCGCTATGACAACGGGAACTTCTTTCCAGGCTCTGGGGCTCCTGAAGAGGT TGGTGGAGGACCAGGCGTGGGGTACAATGTGAACGTGGCATGGACAGGAGGTGTGGACCC CCCCATTGGAGACGTGGAGTACCTTACAGCCTTCAGGACAGTGGTGATGCCCATTGCCCA CGAGTTCTCACCTGATGTGGTCCTAGTCTCCGCCGGGTTTGATGCTGTTGAAGGACATCT GTCTCCTCTGGGTGGCTACTCTGTCACCGCCAGATGTTTTGGCCACTTGACCAGGCAGCT GATGACCCTGGCAGGGGGCCGGGTGGTGCTGGCCCTGGAGGGAGGCCATGACTTGACCGC CATCTGTGATGCCTCTGAGGCTTGTGTCTCGGCTCTGCTCAGTGTAGAGCTGCAGCCCTT GGATGAGGCAGTCTTGCAGCAAAAGCCCAACATCAACGCAGTGGCCACGCTAGAGAAAGT CATCGAGATCCAGAGCAAACACTGGAGCTGTGTGCAGAAGTTCGCCGCTGGTCTGGGCCG GTCCCTGCGAGAGGCCCAAGCAGGTGAGACCGAGGAGGCCGAGACTGTGAGCGCCATGGC CTTGCTGTCGGTGGGGGCCGAGCAGGCCCAGGCTGCGGCAGCCCGGGAACACAGCCCCAG GCCGGCAGAGGAGCCCATGGAGCAGGAGCCTGCCCTGTGACGCCCCGGCCCCCATCCCTC TGGGCTTCACCATTGTGATTTTGTTTATTTTTTCTATTAAAAACAAAAAGTCACACATTC AAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_005474 |
| Insert Size | 3700 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | The ORF of this clone has been fully sequenced and found to be a perfect match to NM_005474.4. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_005474.4, NP_005465.2 |
| RefSeq Size | 5324 bp |
| RefSeq ORF | 3369 bp |
| Locus ID | 10014 |
| UniProt ID | Q9UQL6 |
| Domains | Hist_deacetyl |
| Protein Families | Druggable Genome, Transcription Factors |
| Gene Summary | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) uses an alternate in-frame splice site compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is 1 aa shorter compared to isoform 3. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
AMPK-HDAC5 Pathway Facilitates Nuclear Accumulation of HIF-1a and Functional Activation of HIF-1 by Deacetylating Hsp70 in the Cytosol
,Chen, S;Yin, C;Lao, T;Liang, D;He, D;Wang, C;Sang, N;,
Cell Cycle
,PubMed ID 26061431
[HDAC5]
|
|
Substance P Induces CCN1 Expression via Histone Deacetylase Activity in Human Colonic Epithelial Cells
,null,
The American Journal of Pathology
,PubMed ID 21945803
[HDAC5]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC212863 | HDAC5 (Myc-DDK-tagged)-Human histone deacetylase 5 (HDAC5), transcript variant 1 |
CNY 11,720.00 |
|
| RC212863L1 | Lenti-ORF clone of HDAC5 (Myc-DDK-tagged)-Human histone deacetylase 5 (HDAC5), transcript variant 1 |
CNY 14,120.00 |
|
| RC212863L2 | Lenti-ORF clone of HDAC5 (mGFP-tagged)-Human histone deacetylase 5 (HDAC5), transcript variant 1 |
CNY 14,120.00 |
|
| RC212863L3 | Lenti-ORF clone of HDAC5 (Myc-DDK-tagged)-Human histone deacetylase 5 (HDAC5), transcript variant 1 |
CNY 14,120.00 |
|
| RC212863L4 | Lenti-ORF clone of HDAC5 (mGFP-tagged)-Human histone deacetylase 5 (HDAC5), transcript variant 1 |
CNY 14,120.00 |
|
| RG212863 | HDAC5 (tGFP-tagged) - Human histone deacetylase 5 (HDAC5), transcript variant 1 |
CNY 13,320.00 |
