United States
Germany
Japan
United Kingdom
China
JIP1 (MAPK8IP1) (NM_005456) Human Untagged Clone
CAT＃: SC124125
MAPK8IP1 (untagged)-Human mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1)
CNY 5,216.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | IB1; JIP-1; JIP1; PRKM8IP |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC124125 sequence for NM_005456 edited (data generated by NextGen Sequencing)
ATGGCGGAGCGAGAAAGCGGCGGCCTGGGAGGGGGGGCCGCGTCCCCGCCCGCCGCCTCC CCGTTCCTGGGGCTGCACATCGCTTCGCCTCCCAATTTCAGGCTCACCCATGACATCAGC CTGGAGGAGTTTGAGGATGAAGACCTCTCGGAGATCACTGATGAGTGTGGCATCAGCTTA CAGTGCAAAGACACCCTGTCCTTACGGCCCCCGCGCGCCGGGCTGCTCTCTGCGGGCGGC GGCGGCGCGGGGAGCCGGTTGCAGGCCGAGATGCTGCAGATGGACCTGATCGACGCGACG GGGGACACTCCCGGGGCCGAGGACGACGAGGAGGACGACGACGAGGAGCGCGCGGCCCGG CGGCCGGGAGCGGGGCCGCCCAAGGCCGAGTCCGGCCAGGAGCCGGCGTCCCGCGGCCAG GGCCAGAGCCAAGGCCAGAGCCAGGGCCCGGGCAGCGGGGACACGTACCGGCCCAAGCGG CCCACCACGCTCAACCTCTTTCCGCAGGTGCCGCGGTCTCAGGACACACTGAATAATAAT TCTCTGGGCAAAAAGCACAGTTGGCAGGATCGGGTGTCTCGATCATCCTCACCCCTGAAG ACAGGGGAGCAGACACCACCGCATGAACACATCTGCCTGAGCGATGAGCTGCCCCCCCAG AGCGGCCCCGCCCCCACCACAGATCGAGGCACCTCCACCGACAGCCCTTGCCGCCGCAGC ACAGCCACCCAGATGGCACCTCCGGGTGGTCCCCCTGCTGCCCCGCCTGGGGGTCGGGGC CACTCGCATCGAGACCGAATCCACTACCAGGCCGATGTGCGACTAGAGGCCACTGAGGAG ATCTACCTGACCCCAGTGCAGAGGCCCCCAGACGCTGCAGAGCCCACCTCCGCCTTCCTG CCGCCCACTGAGAGCCGGATGTCAGTCAGCTCCGATCCAGACCCTGCCGCCTACCCCTCC ACGGCAGGGCGGCCGCACCCCTCCATCAGTGAAGAGGAAGAGGGCTTCGACTGCCTGTCG TCCCCAGAGCGGGCTGAGCCCCCAGGCGGAGGGTGGCGGGGGAGCCTGGGGGAGCCGCCG CCACCTCCACGGGCCTCTCTGAGCTCGGACACCAGCGCCCTGTCCTATGACTCTGTCAAG TACACGCTGGTGGTAGATGAGCATGCACAGCTGGAGCTGGTGAGCCTGCGGCCGTGCTTC GGAGACTACAGTGACGAGAGTGACTCTGCCACCGTCTATGACAACTGTGCCTCCGTCTCC TCGCCCTATGAGTCGGCCATCGGAGAGGAATATGAGGAGGCCCCGCGGCCCCAGCCCCCT GCCTGCCTCTCCGAGGACTCCACGCCTGATGAACCCGACGTCCATTTCTCCAAGAAATTC CTGAACGTCTTCATGAGTGGCCGCTCCCGCTCCTCCAGTGCTGAGTCCTTCGGGCTGTTC TCCTGCATCATCAACGGGGAGGAGCAGGAGCAGACCCACCGGGCCATATTCAGGTTTGTG CCTCGACACGAAGACGAACTTGAGCTGGAAGTGGATGACCCTCTGCTAGTGGAGCTCCAG GCTGAAGACTACTGGTACGAGGCCTACAACATGCGCACTGGTGCCCGGGGTGTCTTTCCT GCCTATTACGCCATCGAGGTCACCAAGGAGCCCGAGCACATGGCAGCCCTGGCCAAAAAC AGTGACTGGGTGGACCAGTTCCGGGTGAAGTTCCTGGGCTCAGTCCAGGTTCCCTATCAT AAGGGCAATGACGTCCTCTGTGCTGCTATGCAAAAGATTGCCACCACCCGCCGGCTCACC GTGCACTTTAACCCGCCCTCCAGCTGTGTCCTGGAGATCAGCGTGCGGGGTGTGAAGATA GGCGTCAAGGCCGATGACTCCCAGGAGGCCAAGGGGAATAAATGTAGCCACTTTTTCCAG TTAAAAAACATCTCTTTCTGCGGATATCATCCAAAGAACAACAAGTACTTTGGGTTCATC ACCAAGCACCCCGCCGACCACCGGTTTGCCTGCCACGTCTTTGTGTCTGAAGACTCCACC AAAGCCCTGGCAGAGTCCGTGGGGAGAGCATTCCAGCAGTTCTACAAGCAGTTTGTGGAG TACACCTGCCCCACAGAAGATATCTACCTGGAGTAG Clone variation with respect to NM_005456.3 1740 c=>t >OriGene 5' read for NM_005456 unedited
CGGTATTTGTNATACGACTCACTATAGGGCGGCCGCGTATTCGGCACGAGCTAGCCCGTA CTCCGCGGCGGCGGCTGCCCTCTCGCCGCGCCTCCGCCTCCTTCGCAGCCGCCGCCTCCT CCGCGCCGCGCTCCGCCCGGATGGCCAGGGCTGTGCCCGAGAATGGCGGAGCGAGAAAGC GGCGGCCTGGGAGGGGGGGCCGCGNCCCCGCCCGCCGCCTCCCCGTTCCTGGGGCTGCAC ATCGCTTGCCCTCCCAATTTCAGGGCTCACCCATGACATCAGCCTGGGAGAGTTTGAGGA TGAAGACCTCTCGAATATCAGTGATAACTGGGGCATTAATCTACGGTGCAGAGACTGCAC GATCTTTCGGCGGCACGTTGGCAGGTCTGTTTACTGTGGCTGCGGCGCACCTGGGGCACG TGGAAGACCGGTATGCGGAGAGGAGCCGGATTGGGAGGGGGGCGTGACGGAGAGGAGGAA GGAGCTTGTGGTGGACATGAAGAGTAGGACTAAGTGCGCAGAGAGAGGCGGCATGAGGGC GTAAGGCGTGGGGGAGGGGCCGAGGCGGATGTGTACTGGAGGTGGACGTGAGGAAACGGA GTCTTGAGAGGATTCCTGTGTGTAGCTGCGGTGGTGAGAGGGTGGCGTGTACGCAACCGC GAGCGCGGTCTGTCGGGCCTCGGTGGGCTGTTAGAAGATTCTCCCGTGGAGTCTGGTTTG TGCATGGCGTGCGGTTTAAGATTGCAGAGTGTGAGTATTGAGTAAATATATTTGTCACTT GTGTAGACGATGCGAGGTGGTATATTAGATCGTGCTAGCCGAGCTAGTGTAGCGTTTCGG GTTTGTATCGCTCTGCGAGCGTGTGAGTGTGGGGTCGACGTTGAGAGGGGGAGGTGTATT CTTGCTGACGGAAAGAGGAGCCCGTTATTGGGTACT >OriGene 3' read for NM_005456 unedited
CAGGGCCAGGAGAGGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGATCTGTTCAGGA AACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTGACA GGAAATGGCACTTTAATAGTTGGGGCCAGGGTGACAGGACCAAGATGGGGCTGGCCTGTG TCAGTCAGGAAGCCTCCCTCTTCTGCTGGGACAGGGCCTTGCGGCAGCTCCTCCTCCCCG CCTGAGGTCCTAGGCCTGCCACAGGCCAGCATGCCGGTGAGGTCAGTGGCAGGAGCCACC CAGAAGCCCCGCAGATGACGGAGCTGAGAACAGGGACTTCACCTCCACGTGTTGCCATTT CCTCACTGGAAAGTCCTTGGGAGGTGGCTGGGCTCAGCCTGAGCTCANGGCTCTTCGGTG GGGGTTGGGGCAGGGGCAGGGCGGGCACTTGCAAGTTGGCACCAGGCTTCATCAAGGCAG GACACGGGCTTCATCAAAGCAAGAGCCACAACGGCCCAACCCCTGCCAGGGGAGGTAAGG CCCCAGATTGGGCAAGGCCGTGTGCTCCTGGAACGGACATCCTTCTTTGGCCGGAGACCT GCTCCCCAAGCCCCTGGTCCCTCCAAATCCCCAGGCAGCCCAATCTGCCCTCCATAGATG AAATCTTATCCCCTATATTACCATAAACTGCATTTTGCCTCCCCCCATTGGCCCACCTTC CCTTAACCCTGGGCCAGGCGCCCCCCACTTT |
| Restriction Sites | Please inquire |
| ACCN | NM_005456 |
| Insert Size | 3300 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_005456.2, NP_005447.1 |
| RefSeq Size | 3079 bp |
| RefSeq ORF | 2136 bp |
| Locus ID | 9479 |
| UniProt ID | Q9UQF2 |
| Protein Families | Druggable Genome |
| Protein Pathways | MAPK signaling pathway |
| Gene Summary | This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
DCDC2 Mutations Cause a Renal-Hepatic Ciliopathy by Disrupting Wnt Signaling
,null,
American Journal of Human Genetics
,PubMed ID 25557784
[MAPK8IP1]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209734 | MAPK8IP1 (Myc-DDK-tagged)-Human mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1) |
CNY 5,208.00 |
|
| RC209734L1 | Lenti ORF clone of Human mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1), Myc-DDK-tagged |
CNY 7,608.00 |
|
| RC209734L2 | Lenti ORF clone of Human mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1), mGFP tagged |
CNY 5,890.00 |
|
| RC209734L3 | Lenti ORF clone of Human mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC209734L4 | Lenti ORF clone of Human mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1), mGFP tagged |
CNY 5,890.00 |
|
| RG209734 | MAPK8IP1 (tGFP-tagged) - Human mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1) |
CNY 4,370.00 |
