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RUNX2 (NM_004348) Human Untagged Clone
CAT＃: SC123971
RUNX2 (untagged)-Human runt-related transcription factor 2 (RUNX2), transcript variant 3
CNY 3,784.00
CNY 8,080.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 3,600.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AML3; CBFA1; CCD; CCD1; OSF-2; OSF2; PEA2aA; PEBP2A1; PEBP2A2; PEBP2aA; PEBP2aA1 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC123971 sequence for NM_004348 edited (data generated by NextGen Sequencing)
ATGCGTATTCCCGTAGATCCGAGCACCAGCCGGCGCTTCAGCCCCCCCTCCAGCAGCCTG CAGCCCGGCAAAATGAGCGACGTGAGCCCGGTGGTGGCTGCGCAACAGCAGCAGCAACAG CAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGGAGGCGGCG GCGGCGGCTGCGGCGGCGGCGGCGGCTGCGGCGGCGGCAGCTGCAGTGCCCCGGTTGCGG CCGCCCCACGACAACCGCACCATGGTGGAGATCATCGCCGACCACCCGGCCGAACTCGTC CGCACCGACAGCCCCAACTTCCTGTGCTCGGTGCTGCCCTCGCACTGGCGCTGCAACAAG ACCCTGCCCGTGGCCTTCAAGGTGGTAGCCCTCGGAGAGGTACCAGATGGGACTGTGGTT ACTGTCATGGCGGGTAACGATGAAAATTATTCTGCTGAGCTCCGGAATGCCTCTGCTGTT ATGAAAAACCAAGTAGCAAGGTTCAACGATCTGAGATTTGTGGGCCGGAGTGGACGAGGC AAGAGTTTCACCTTGACCATAACCGTCTTCACAAATCCTCCCCAAGTAGCTACCTATCAC AGAGCAATTAAAGTTACAGTAGATGGACCTCGGGAACCCAGAAGGCACAGACAGAAGCTT GATGACTCTAAACCTAGTTTGTTCTCTGACCGCCTCAGTGATTTAGGGCGCATTCCTCAT CCCAGTATGAGAGTAGGTGTCCCGCCTCAGAACCCACGGCCCTCCCTGAACTCTGCACCA AGTCCTTTTAATCCACAAGGACAGAGTCAGATTACAGACCCCAGGCAGGCACAGTCTTCC CCGCCGTGGTCCTATGACCAGTCTTACCCCTCCTACCTGAGCCAGATGACGTCCCCGTCC ATCCACTCTACCACCCCGCTGTCTTCCACACGGGGCACTGGGCTTCCTGCCATCACCGAT GTGCCTAGGCGCATTTCAGATGATGACACTGCCACCTCTGACTTCTGCCTCTGGCCTTCC ACTCTCAGTAAGAAGAGCCAGGCAGGTGCTTCAGAACTGGGCCCTTTTTCAGACCCCAGG CAGTTCCCAAGCATTTCATCCCTCACTGAGAGCCGCTTCTCCAACCCACGAATGCACTAT CCAGCCACCTTTACTTACACCCCGCCAGTCACCTCAGGCATGTCCCTCGGTATGTCCGCC ACCACTCACTACCACACCTACCTGCCACCACCCTACCCCGGCTCTTCCCAAAGCCAGAGT GGACCCTTCCAGACCAGCAGCACTCCATATCTCTACTATGGCACTTCGTCAGGATCCTAT CAGTTTCCCATGGTGCCGGGGGGAGACCGGTCTCCTTCCAGAATGCTTCCGCCATGCACC ACCACCTCGAATGGCAGCACGCTATTAAATCCAAATTTGCCTAACCAGAATGATGGTGTT GACGCTGATGGAAGCCACAGCAGTTCCCCAACTGTTTTGAATTCTAGTGGCAGAATGGAT GAATCTGTTTGGCGACCATATTGA Clone variation with respect to NM_004348.3 >OriGene 5' read for NM_004348 unedited
ACTGCAGTGCACTTNCGAGAGNATATGGCGAACGCGAACTGGGGGCCAGGTCTCGCCTTC ACCCCCCCAATTTCCTCCTTGCCCTTTATTTCCACCCTCCTCCCCCTCCCCCGGCGGGTT CGCTAACTTGTGGCTGTGGGTGATGCGTATTCCCGTAGATCCGAGCACCAGCCGGCGCTT CAGCCCCCCCTCCAGCAGCCTGCAGCCCGGCAAAATGAGCGACGTGAGCCCGGTGGTGGC TGCGCAACAGCAGCAGCAACAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAACAGCA GCAGCAGCAGCAGGAGGCGGCGGCGGCGGCTGCGGCGGCGGCGGCGGCTGCGGCGGCGGC AGCTGCAGTGCCCCGGTTGCGGCCGCCCCACGACAACCGCACCATGGTGGAGATCATCGC CGACCACCCGGCCGAACTCGTCCGCACCGACAGCCCCAACTTCCTGTGCTCGGTGCTGCC CTCGCACTGGCGCTGCAACAAGACCCTGCCCGTGGCCTTCAAGGTGGTAGCCCTCGGAGA GGTACCAGATGGGACTGTGGTTACTGTCATGGCGGGTAACGATGAAAATTATTCTGCTGA GCTCCGGAATGCCTCTGCTGTTATGAAAAACCAAGTAGCAAGGTTCAACGATCTGAGATT TGTGGGCCGGAGTGGACGAGGCAAGAGTTTCACCTTGACCATAACCGTCTTCACAATCCT CCCCAGTAGCTACCTAT >OriGene 3' read for NM_004348 unedited
GTATTCTTTGTACCCGCCTGACAGTTACCACAGTCCCATCTGGTAGCTCTCCGAGGGCTA CCACCTTGAAGGCCACGGGCAGGGTTTTGTTGCAGCGCCAGTGCGAGGGCAGCACCGAGC ACAGGAAGTTGGGGCTGTCGGTGCGGACGAGTTCGGCCGGGTGGTCGGCGATGATCTCCA CCATGGTGCGGTTGTCGTGGGGCGGCCGCAACCGGGGCACTGCAGCTGCCGCCGCCGCAG CCGCCGCCGCCGCCGCAGCCGCCGCCGCCGCCTCCTGCTGCTGCTGCTGCTGTTGCTGCT GCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGCTGCTGCTGTTGCGCAGCCACCACCGGGC TCACGTCGCTCATTTTGCCGGGCTGCAGGCTGCTGGAGGGGGGGCTGAAGCGCCGGCTGG TGCTCGGATCTACGGGAATACGCATCACAACAGCCACAAGTTAGCGAAGTGGCCGGGGGA GGGGGAGGAGGGTGGAAATGAGGGGCAAGGAGGAAATTGGGGGGGTGAANGCNANNACNN GNTGCNGAANGNNNGANNNGCCCNAGAGTGAATCGAGATTACAAGAATTTTGGACAGGAT TTACTAAATGCGACGCTTCGCTTATAGAACAAGTAGCCTACAACACCATGTCTCGACTGG CATATCGGTGACCATTTTTCACGTCCTCTACCGCGGGCCCTGGTGTATTAATCTGAACGA GACTGTGTTATGGGAGAGAGGACGACCTCGCCTTGACGTTGTCGAAGACGCGCCGCAGAT GCCAATATGAGGTCACTGATGTTGGAATCGTCGAGTAATTGGGACGATTGCAGACAGCT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004348 |
| Insert Size | 5000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004348.3, NP_004339.3 |
| RefSeq Size | 5720 bp |
| RefSeq ORF | 1524 bp |
| Locus ID | 860 |
| Domains | Runt |
| Protein Families | Druggable Genome, Transcription Factors |
| Gene Summary | This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016] Transcript Variant: This variant (3) is transcribed from an alternate promoter (P2) and contains a different segment for the 5' UTR and 5' coding region than variant 1. It encodes a protein (isoform c) with a shorter and distinct N-terminus when it is compared to isoform a. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Deregulation of RUNX2 by miR-320a deficiency impairs steroidogenesis in cumulus granulosa cells from polycystic ovary syndrome (PCOS) patients
,Zhang, CL;Wang, H;Yan, CY;Gao, XF;Ling, XJ;,
Biochem. Biophys. Res. Commun
,PubMed ID 27965096
[RUNX2]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC213097 | RUNX2 (Myc-DDK-tagged)-Human runt-related transcription factor 2 (RUNX2), transcript variant 3 |
CNY 3,776.00 |
|
| RC213097L1 | Lenti ORF clone of Human runt-related transcription factor 2 (RUNX2), transcript variant 3, Myc-DDK-tagged |
CNY 6,176.00 |
|
| RC213097L2 | Lenti ORF clone of Human runt-related transcription factor 2 (RUNX2), transcript variant 3, mGFP tagged |
CNY 6,940.00 |
|
| RC213097L3 | Lenti ORF clone of Human runt-related transcription factor 2 (RUNX2), transcript variant 3, Myc-DDK-tagged |
CNY 6,176.00 |
|
| RC213097L4 | Lenti ORF clone of Human runt-related transcription factor 2 (RUNX2), transcript variant 3, mGFP tagged |
CNY 6,940.00 |
|
| RG213097 | RUNX2 (tGFP-tagged) - Human runt-related transcription factor 2 (RUNX2), transcript variant 3 |
CNY 5,376.00 |
