C2 (BC029781) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	C3/C5 convertase; CO2; complement C2; complement component 2; complement component C2; DKFZp779M0311; OTTHUMP00000029277; OTTHUMP00000062690
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC029781 edited CTTTTCCCTCCCGCGGCTCTCTACCTCTCGCCGCCCCTAGGGAGGACACCATGGGCCCAC TGATGGTTCTTTTTTGCCTGCTGTTCCTGTACCCAGGTCTGGCAGACTCGGCTCCCTCCT GCCCTCAGAACGTGAATATCTCGGGTGGCACCTTCACCCTCAGCCATGGCTGGGCTCCTG GGAGCCTTCTCACCTACTCCTGCCCCCAGGGCCTGTACCCATCCCCAGCATCACGGCTGT GCAAGAGCAGCGGACAGTGGCAGACCCCAGGAGCCACCCGGTCTCTGTCTAAGGCGGTCT GCAAACCTGTGCGCTGTCCAGCCCCTGTCTCCTTTGAGAATGGCATTTATACCCCACGGC TGGGGTCCTATCCCGTGGGTGGCAATGTGAGCTTCGAGTGTGAGGATGGCTTCATATTGC GGGGCTCGCCTGTGCGTCAGTGTCGCCCCAACGGCATGTGGGATGGAGAAACAGCTGTGT GTGATAATGGGGCTGGCCACTGCCCCAACCCAGGCATTTCACTGGGCGCAGTGCGGACAG GCTTCCGCTTTGGTCATGGGGACAAGGTCCGCTATCGCTGCTCCTCGAATCTTGTGCTCA CGGGGTCTTCGGAGCGGGAGTGCCAGGGCAACGGGGTCTGGAGTGGAACGGAGCCCATCT GCCGCCAACCCTACTCTTATGACTTCCCTGAGGACGTGGCCCCTGCCCTGGGCACTTCCT TCTCCCACATGCTTGGGGCCACCAATCCCACCCAGAAGACAAAGGAAAGCCTGGGCCGTA AAATCCAAATCCAGCGCTCTGGTCATCTGAACCTCTACCTGCTCCTGGACTGTTCGCAGA GTGTGTCGGAAAATGACTTTCTCATCTTCAAGGAGAGCGCCTCCCTCATGGTGGACAGGG TCAGGAATCAGGAGTCTGCCTGCAGCAGAGGCCTTCCTGTGCTCACTATCTCTCTCTGTC TCCTTCCCCTCCTCAGAACCCCACTCACAGCCCACCTCCTCCAAGAAGTCTTCTCAGATT ATACTCATGCCATGTAGGAATCATGAATTCAATTTATACAATCATAATTTTTATTCCACA AGCACTGTTGGGACACTGTGCTGGGGCTGGGCGACAGCAAAGATGGAAAGGCTGAGGTCT TACTTTCCAGGAATTCATCATCTAGAACAGTGGTCTCCACAGAAAGGTAGTGAGATAACC CACAGGAGTGAAGCAGAAAAATACTGGTGCCCCTGTGGAATAATTTAAATCAGATTAATA ATTTAATATTTAATAATTTCCTTTTAAAACTTCAACATTTTGTGCAGGCTTTAAAATGTG TGTGATAGACTGGGCATGGTGGCTAGTGCCTGTAATCCCAACACTTTGGGAGGCCGAGGC AGGTGGATCACTTGAGGTCAGGAGTTTGAGACCACCCTGACCAACATGATGAAACCCTGT CTATACTAAAAATACAAAATTAGCCACATGTGATGGCGCACGCCTGTAACCCAGCTACTT GGGAGGATGAGGCAGGAGAATCGCTTGGATCCGGGAGGTGGAGGTTGCAGTGGGCTGAGA TCACGCCATTGCACTCCAGCCTGGGCAACTAGAGCAAAACTCTGTCTCAAAAAAAATAAA TAAAATAAAATAAAATAAAATAAAATATGTGTGATAGAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC029781 unedited NCCGTTAAATTTGTATACGACTCATATAGGCGGCCGCGNAATTCAAATCTGGTACCGGTC CGGAATTCCCGGGATCTTTTCCCTCCCGCGGCTCTCTACCTCTCGCCGCCCCTAGGGAGG ACACCATGGGCCCACTGATGGTTCTTTTTTGCCTGCTGTTCCTGTACCCAGGTCTGGCAG ACTCGGCTCCCTCCTGCCCTCAGAACGTGAATATCTCGGGTGGCACCTTCACCCTCAGCC ATGGCTGGGCTCCTGGGAGCCTTCTCACCTACTCCTGCCCCCAGGGCCTGTACCCATCCC CAGCATCACGGCTGTGCAAGAGCAGCGGACAGTGGCAGACCCCAGGAGCCACCCGGTCTC TGTCTAAGGCGGTCTGCAAACCTGTGCGCTGTCCAGCCCCTGTCTCCTTTGAGAATGGCA TTTATACCCCACGGCTGGGGTCCTATCCCGTGGGTGGCAATGTGAGCTTCGAGTGTGAGG ATGGCTTCATATTGCGGGGCTCGCCTGTGCGTCAGTGTCGCCCCAACGGCATGTGGGATG GAGAAACAGCTGTGTGTGATAATGGGGCTGGCCACTGCCCCAACCCAGGCATTTCACTGG GCGCAGTGCGGACAGGCTTCCGCTTTGGTCATGGGGACAAGGTCCGCTATCGCTGCTCCT CGAATCTTGTGCTCACGGNGTCTTCGGAGCGGGAGTGCCAGGGCAACGGGGTCTGGAGTG GAACGGAGCCCATCTGCCGCCAACCCTACTCTTATGACTTCCCTGAGGACGTGGCCNCTG CCCTGNGCACTTCCTTCTCCACATGCTTGNNGCCACCAATCCCACCCAGAAAACAAAGAA AGCCTGGGCCGTAAAATCAAATCCAGCGCTCTGGTCATCTGAACCTCTACCTGCTCCTGG ACCTGTCGCANAGTGTGTCGGAC
Restriction Sites	Please inquire
ACCN	BC029781
Insert Size	2000 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	BC029781.1, AAH29781.1
RefSeq Size	1691 bp
Locus ID	717
Protein Families	Druggable Genome, Protease, Secreted Protein
Protein Pathways	Complement and coagulation cascades, Systemic lupus erythematosus
Gene Summary	Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]

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