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PDE6 beta (PDE6B) (BC000249) Human Untagged Clone
CAT＃: SC123804
PDE6B (untagged)-Human phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant) (cDNA clone MGC:1689 IMAGE:3356353), complete cds
CNY 3,816.00
货期*
现货
规格
Product images
经常一起买 (4)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | congenital stationary night blindness 3, autosomal dominant; CSNB3; PDEB; phosphodiesterase 6B, cGMP-specific, rod, beta; rd1; RP40 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for BC000249 edited
TGCGTGCCTGGAGCAGCAGCGTCTCCAGGGACAGGCAGCCACCATGAGCCTCAGTGAGGA GCAGGCCCGGAGCTTTCTGGACCAGAACCCCGATTTTGCCCGCCAGTACTTTGGGAAGAA ACTGAGCCCTGAGAATGTGGCCGCGGCCTGCGAGGACGGGTGCCCGCCGGACTGCGACAG CCTCCGGGACCTCTGCCAGGTGGAGGAGAGCACGGCGCTGCTGGAGCTGGTGCAGGATAT GCAGGAGAGCATCAACATGGAGCGCGTGGTCTTCAAGGTCCTGCGGCGCCTCTGCACCCT CCTGCAGGCCGACCGCTGCAGCCTCTTCATGTACCGCCAGCGCAACGGCGTGGCCGAGCT GGCCACCAGGCTTTTCAGCGTGCAGCCGGACAGCGTCCTGGAGGACTGCCTGGTGCCCCC CGACTCCGAGATCGTCTTCCCACTGGACATCGGGGTCGTGGGCCACGTGGCTCAGACCAA AAAGATGGTGAACGTCGAGGACGTGGCCGAGTGCCCTCACTTCAGCTCATTTGCTGACGA GCTCACTGACTACAAGACAAAGAATATGCTGGCCACACCCATCATGAATGGCAAAGACGT CGTGGCGGTGATCATGGCAGTGAACAAGCTCAACGGCCCATTCTTCACCAGCGAAGACGA AGATGTGTTCTTGAAGTACCTGAATTTTGCCACGTTGTACCTGAAGATCTATCACCTGAG CTACCTCCACAACTGCGAGACGCGCCGCGGCCAGGTGCTGCTGTGGTCGGCCAACAAGGT GTTTGAGGAGCTGACGGACATCGAGAGGCAGTTCCACAAGGCCTTCTACACGGTGCGGGC CTACCTCAACTGCGAGCGGTACTCCGTGGGCCTCCTGGACATGACCAAGGAGAAGGAATT TTTTGACGTGTGGTCTGTGCTGATGGGAGAGTCCCAGCCGTACTCGGGCCCACGCACGCC TGATGGCCGGGAAATTGTCTTCTACAAAGTGATCGACTACATCCTCCACGGCAAGGAGGA GATCAAGGTCATTCCCACACCCTCAGCCGATCACTGGGCCCTGGCCAGCGGCCTTCCAAG CTACGTGGCAGAAAGCGGCTTTATTTGTAACATCATGAATGCTTCCGCTGACGAAATGTT CAAATTTCAGGAAGGGGCCCTGGACGACTCCGGGTGGCTCATCAAGAATGTGCTGTCCAT GCCCATCGTCAACAAGAAGGAGGAGATTGTGGGAGTCGCCACATTTTACAACAGGAAAGA CGGGAAGCCCTTTGACGAACAGGACGAGGTTCTCATGGAGTCCCTGACACAGTTCCTGGG CTGGTCAGTGATGAACACCGACACCTACGACAAGATGAACAAGCTGGAGAACCGCAAGGA CATCGCACAGGACATGGTCCTTTACCACGTGAAGTGCGACAGGGACGAGATCCAGCTCAT CCTGCCAACCAGAGCGCGCCTGGGGAAGGAGCCTGCTGACTGCGATGAGGACGAGCTGGG CGAAATCCTGAAGGAGGAGCTGCCAGGGCCCACCACATTTGACATCTACGAATTCCACTT CTCTGACCTGGAGTGCACCGAACTGGACCTGGTCAAATGTGGCATCCAGATGTACTACGA GCTGGGCGTGGTCCGAAAGTTCCAGATCCCCCAGGAGGTCCTGGTGCGGTTCCTGTTCTC CATCAGCAAAGGGTACCGGAGAATCACCTACCACAACTGGCGCCACGGCTTCAACGTGGC CCAGACGATGTTCACGCTGCTCATGACCGGCAAACTGAAGAGCTACTACACGGACCTGGA GGCCTTCGCCATGGTGACAGCCGGCCTGTGCCATGACATCGACCACCGCGGCACCAACAA CCTGTACCAGATGAAGTCCCAGAACCCCTTGGCTAAGCTCCACGGCTCCTCGATTTTGGA GCGGCACCACCTGGAGTTTGGGAAGTTCCTGCTCTCGGAGGAGACCCTGAACATCTACCA GAACCTGAACCGGCGGCAGCACGATCACGTGATCCACCTGATGGACATCGCCATCATCGC CACGGACCTGGCCCTGTACTTCAAGAAGAGAGCGATGTTTCAGAAGATCGTGGATGAGTC CAAGAACTACCAGGACAAGAAGAGCTGGGTGGAGTACCTGTCCCTGGAGACGACCCGGAA GGAGATCGTCATGGCCATGATGATGACAGCCTGCGACCTGTCTGCCATCACCAAGCCCTG GGAAGTCCAGAGCAAGGTCGCACTTCTCGTGGCTGCTGAGTTCTGGGAGCAAGGTGACTT GGAAAGGACAGTCTTGGATCAGCAGCCCATTCCTATGATGGACCGGAACAAGGCGGCCGA GCTCCCCAAGCTGCAAGTGGGCTTCATCGACTTCGTGTGCACATTCGTGTACAAGGAGTT CTCTCGTTTCCACGAAGAGATCCTGCCCATGTTCGACCGACTGCAGAACAATAGGAAAGA GTGGAAGGCGCTGGCTGATGAGTATGAGGCCAAAGTGAAGGCTCTGGAGGAGAAGGAGGA GGAGGAGAGGGTGGCAGCCAAGAAAGGCACAGAAATTTGCAATGGCGGCCCAGCACCCAA GTCTTCAACCTGCTGTATCCTGTGAGCACTGGTCCCATGGGGACCCTATGGCTCCCTCAA TCTTCACCCACTAGGATTTGGGTTCTGCCTGTGGCTATTTGCTACAAGAGGTTAGGAAGC CCAAGAAAATGACTGAAGATCATTCTGGATATTTTAATTTTTTTTTTTTTTTTTTTTTGA GATGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCCGTGGCACGATCTCAGCTCACTGCA ACCTCCACCTCCCAGGTTCAAGCGATTCTCGTGCCTCAGCCTCCTGAGTAGCTGGGACTA CAGGCGCCCACCACCACACATGGCTAATTTTTGTATTTTCAGTACAGATGGGGTTTCACC ATATTGGGCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCACCCGCCTCAGCTTCCTG AAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCTGTTTTTATAAACTGAAGCCA ACTGTGAATAAACTGTAGCCTACAAAAAAAAAAAAAAAAAAAAAAAAAA >OriGene 5' read for BC000249 unedited
AAAAACCGTTCANCATTTGTAATACGACTTACTATAGGCGGCACGCGAATTCGCACGAGG TGCGTGCCTGGAGCAGCAGCGTCTCCAGGGACAGGCAGCCACCATGAGCCTCAGTGAGGA GCAGGCCCGGAGCTTTCTGGACCAGAACCCCGATTTTGCCCGCCAGTACTTTGGGAAGAA ACTGAGCCCTGAGAATGTGGCCGCGGCCTGCGAGGACGGGTGCCCGCCGGACTGCGACAG CCTCCGGGACCTCTGCCAGGTGGAGGAGAGCACGGCGCTGCTGGAGCTGGTGCAGGATAT GCAGGAGAGCATCAACATGGAGCGCGTGGTCTTCAAGGTCCTGCGGCGCCTCTGCACCCT CCTGCAGGCCGACCGCTGCAGCCTCTTCATGTACCGCCAGCGCAACGGCGTGGCCGAGCT GGCCACCAGGCTTTTCAGCGTGCAGCCGGACAGCGTCCTGGAGGACTGCCTGGTGCCCCC CGACTCCGAGATCGTCTTCCCACTGGACATCGGGGTCGTGGGCCACGTGGCTCAGACCAA AAAGATGGTGAACGTCGAGGACGTGGCCGAGTGCCCTCACTTCAGCTCATTTGCTGACGA GCTCACTGACTACAAGACAAAGAATATGCTGGCCACACCCATCATGAATGGCAAAGACGT CGTGGCGGTGATCATGGCAGTGAACAAGCTCAACGGCCCATTCTTCACCAGCGAAGACGA AGATGTGTTCTTGAAGTACCTGAATTTTGCCACGTTGTACCTGAAGATCTATCACCTGAG CTACCTCCACAACTGCGAGACGCGCCGCGGCCCAGTGCTGCTGTGGTCGGCCAACAAGGT GTTTTGAGAGCTGACGGACATCGAGAGGCAGTT |
| Restriction Sites | Please inquire |
| ACCN | BC000249 |
| Insert Size | 3109 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC000249.1, AAH00249.1 |
| RefSeq Size | 3109 bp |
| Locus ID | 5158 |
| Protein Families | Druggable Genome |
| Gene Summary | Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
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