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NR0B2 (NM_021969) Human Untagged Clone
CAT＃: SC122920
NR0B2 (untagged)-Human nuclear receptor subfamily 0, group B, member 2 (NR0B2)
CNY 2,400.00
CNY 2,950.00
| Cited in 3 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | SHP; SHP1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_021969 edited
CTGGAAGTGAGAGCAGATCCCTAACCATGAGCACCAGCCAACCAGGGGCCTGCCCATGCC AGGGAGCTGCAAGCCGCCCCGCCATTCTCTACGCACTTCTGAGCTCCAGCCTCAAGGCTG TCCCCCGACCCCGTAGCCGCTGCCTATGTAGGCAGCACCGGCCCGTCCAGCTATGTGCAC CTCATCGCACCTGCCGGGAGGCCTTGGATGTTCTGGCCAAGACAGTGGCCTTCCTCAGGA ACCTGCCATCCTTCTGGCAGCTGCCTCCCCAGGACCAGCGGCGGCTGCTGCAGGGTTGCT GGGGCCCCCTCTTCCTGCTTGGGTTGGCCCAAGATGCTGTGACCTTTGAGGTGGCTGAGG CCCCGGTGCCCAGCATACTCAAGAAGATTCTGCTGGAGGAGCCCAGCAGCAGTGGAGGCA GTGGCCAACTGCCAGACAGACCCCAGCCCTCCCTGGCTGCGGTGCAGTGGCTTCAATGCT GTCTGGAGTCCTTCTGGAGCCTGGAGCTTAGCCCCAAGGAATATGCCTGCCTGAAAGGGA CCATCCTCTTCAACCCCGATGTGCCAGGCCTCCAAGCCGCCTCCCACATTGGGCACCTGC AGCAGGAGGCTCACTGGGTGCTGTGTGAAGTCCTGGAACCCTGGTGCCCAGCAGCCCAAG GCCGCCTGACCCGTGTCCTCCTCACGGCCTCCACCCTCAAGTCCATTCCGACCAGCCTGC TTGGGGACCTCTTCTTTCGCCCTATCATTGGAGATGTTGACATCGCTGGCCTTCTTGGGG ACATGCTTTTGCTCAGGTGACCTGTTCCAGCCCAGGCAGAGATCAGGTGGGCAGAGGCTG GCAGTGCTGATTCAGCCTGGCCATCCCCAGAGGTGACCCAATGCTCCTGGAGGGGGCAAG CCTGTATAGACAGCACTTGGCTCCTTAGGAACAGCTCTTCACTCAGCCACACCCCACATT GGACTTCCTTGGTTTGGACACAGTGTTCCAGCTGCCTGGGAGGCTTTTGGTGGTCCCCAC AGCCTCTGGGCCAAGACTCCTGTCCCTTCTTGGGATGAGAATGAAAGCTTAGGCTGCTTA TTGGACCAGAAGTCCTATCGACTTTATACAGAACTGAATTAAGTTATTGATTTTTGTAAT AAAAGGTATGAAACACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA >OriGene 5' read for NM_021969 unedited
CCCCCCAGTCGGGATTTGTAAACNATTATATAGGCGGCCGCGCAATCCCGGGATCTGGAA GTGAGAGCAGATCCCTAACCATGAGCACCAGCCAACCAGGGGCCTGCCCATGCCAGGGAG CTGCAAGCCGCCCCGCCATTCTCTACGCACTTCTGAGCTCCAGCCTCAAGGCTGTCCCCC GACCCCGTAGCCGCTGCCTATGTAGGCAGCACCGGCCCGTCCAGCTATGTGCACCTCATC GCACCTGCCGGGAGGCCTTGGATGTTCTGGCCAAGACAGTGGCCTTCCTCAGGAACCTGC CATCCTTCTGGCAGCTGCCTCCCCAGGACCAGCGGCGGCTGCTGCAGGGTTGCTGGGGCC CCCTCTTCCTGCTTGGGTTGGCCCAAGATGCTGTGACCTTTGAGGTGGCTGAGGCCCCGG TGCCCAGCATACTCAAGAAGATTCTGCTGGAGGAGCCCAGCAGCAGTGGAGGCAGTGGCC AACTGCCAGACAGACCCCAGCCCTCCCTGGCTGCGGTGCAGTGGCTTCAATGCTGTCTGG AGTCCTTCTGGAGCCTGGAGCTTAGCCCCAAGGAATATGCCTGCCTGAAAGGGACCATCC TCTTCAACCCCGATGTGCCAGGCCTCCAAGCCGCCTCCCACATTGGGCACCTGCAGCAGG AGGCTCACTGGGTGCTGTGTGAAGTCCTGGAACCCTGGTGCCCAGCAGCCCAAGGCCGCC TGACCCGTGTCCTCCTCACGGCCTCCACCCTCAAGTCCATTCCGACCAGCCTGCTTGGGG ACCTCTTCTTTCGCCCTATCATTGGAGATGTTGACATCGCTGGCCTTCTTGGGGACATGC TTTTGCTCANGTGACCTGTNTCAGCCCAGCAGANATCAGGTGGGCAG |
| Restriction Sites | Please inquire |
| ACCN | NM_021969 |
| Insert Size | 1200 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_021969.1, NP_068804.1 |
| RefSeq Size | 1168 bp |
| RefSeq ORF | 774 bp |
| Locus ID | 8431 |
| UniProt ID | Q15466 |
| Protein Families | Druggable Genome, Transcription Factors |
| Gene Summary | The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008] |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Inhibition of β-catenin dependent WNT signalling upregulates the transcriptional repressor NR0B1 and downregulates markers of an A9 phenotype in human embryonic stem cell-derived dopaminergic neurons: Implications for Parkinson’s disease
,null,
PLoS ONE
,PubMed ID 34941945
[NR0B2]
|
|
The Orphan Nuclear Receptor DAX-1 Functions as a Potent Corepressor of the Constitutive Androstane Receptor (NR1I3)
,Elizabeth M. Laurenzana, Tao Chen, Malavika Kannuswamy, Brian E. Sell, Stephen C. Strom, Yong Li, and Curtis J. Omiecinski,
Mol. Pharmacol., Nov 2012; 82: 918 - 928.
[NR0B2]
|
|
Dosage-Sensitive Sex Reversal Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1 (DAX1) (NR0B1) and Small Heterodimer Partner (SHP) (NR0B2) Form Homodimers Individually, as Well as DAX1-SHP Heterodimers
,Anita K. Iyer, Yao-Hua Zhang, and Edward R. B. McCabe,
Mol. Endocrinol. 2006 Oct;20(10):2326-42.
[NR0B2]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC206422 | NR0B2 (Myc-DDK-tagged)-Human nuclear receptor subfamily 0, group B, member 2 (NR0B2) |
CNY 2,400.00 |
|
| RC206422L1 | Lenti ORF clone of Human nuclear receptor subfamily 0, group B, member 2 (NR0B2), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC206422L2 | Lenti ORF clone of Human nuclear receptor subfamily 0, group B, member 2 (NR0B2), mGFP tagged |
CNY 5,890.00 |
|
| RC206422L3 | Lenti ORF clone of Human nuclear receptor subfamily 0, group B, member 2 (NR0B2), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC206422L4 | Lenti ORF clone of Human nuclear receptor subfamily 0, group B, member 2 (NR0B2), mGFP tagged |
CNY 4,800.00 |
|
| RG206422 | NR0B2 (tGFP-tagged) - Human nuclear receptor subfamily 0, group B, member 2 (NR0B2) |
CNY 4,000.00 |
