CLDN19 (BC030524) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	claudin 19; OTTHUMP00000008733
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC030524 edited CTGGCCATGACCAAAGCCCCTGCTGGCACCCTGGCCCAGCTCTGAGTCCTGGGACCCTCG GTCCTCTCTCCTGGGCCATGGCCAACTCAGGCCTCCAGCTCCTGGGCTACTTCTTGGCCC TGGGTGGCTGGGTGGGCATCATTGCTAGCACAGCCCTGCCACAGTGGAAGCAGTCTTCCT ACGCAGGCGACGCCATCATCACTGCCGTGGGCCTCTATGAAGGGCTCTGGATGTCCTGCG CCTCCCAGAGCACTGGGCAAGTGCAGTGCAAGCTCTACGACTCGCTGCTCGCCCTGGACG GTCACATCCAATCAGCGCGGGCCCTGATGGTGGTGGCCGTGCTCCTGGGCTTCGTGGCCA TGGTCCTCAGCGTAGTTGGCATGAAGTGTACGCGGGTGGGAGACAGCAACCCCATTGCCA AGGGCCGTGTTGCCATCGCCGGGGGAGCCCTCTTCATCCTGGCAGGCCTCTGCACTTTGA CTGCTGTCTCGTGGTATGCCACCCTGGTGACCCAGGAGTTCTTCAACCCAAGCACACCTG TCAATGCCAGGTATGAATTTGGCCCAGCCCTGTTCGTGGGCTGGGCCTCAGCTGGCCTGG CCGTGCTGGGCGGCTCCTTCCTCTGCTGCACATGCCCGGAGCCAGAGAGACCCAACAGCA GCCCACAGCCCTATCGGCCTGGACCCTCTGCTGCTGCCCGAGAGTACGTCTGAGCTCTGC CTGCCCTGGCCAGCCCCCCACCCAGTGGCCCCCTTGCCCAGCATCCAGCCAGCCTCGCAG CACCCTGGGCAGGGCCACTGGGGCATAGGATGGGCATAGGTGCTCTGAGCAGCTTGTCCT CAACACAAGCACCCACCCTGCAATCTGAGACCCAGATCCTCAGAGAGACACCAGAGGCAG GACCCAGCCCCCAGGCATACACACAGATGCAGGTCCAGGCACGGTCTTGTCTGCACAGCC TGGTGGGCACCAGCATGCATCCCTGGAGACAGGCCCTCAGGCACCAGCCCGGCTGTTTAC TCACTGAAGAGCTGCGTGGGTGTCTGCTACGTGCTGGGCCCTAGAGATAGAGCAGTGGCC AAGACGTACCTTAGTACCCAGGTCCTTGGGGTGAGCAGAAACCTTCACCCTCCCCAGTCC CATGGGCTCCTCACAGCAACCCCACAAGGGCAGTGCCGGGATGCTGAACGTTCACACAAG GACAGGGAGGGTCTGAGTTTAGGTCTCAGGTTCTTCCAGTGCGCCCAGGGCTGGGGGCCA CCTACACAGATGGTGAGGTCGGACCATGGCGCCCCTGCCCCCGGGAATGGGCCCCAGGCA GGGCTGCTGTGAGGGCCAAGGTCTGGCCACGCTGGCCAGTACCCATGTCCGGGCCTGAAT GCACAGCCCCTGCCCCCGACCCCACAGCTCACTCCACTAACCAGCTCTCTCTCTTTTGAC TTTCAGACCAGTTGTTAAATTGCCCGCCTCCGCCAAGGGCCCCCTGGGTGTGTAATGTCC AGTCCCCAGCCAGGCTCTGTCCCCTGCCATACCTAGACTGTGTGTTTCATATTTTTTTGG AAAGAGAAGTGAACATCCAGCCCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC030524 unedited NTTTCAGTTCAAAATTTGTATACGACTCACTATAGGCGGCCGCGAATCCCGGGATCTGGC CATGACCAAAGCCCCTGCTGGCACCCTGGCCCAGCTCTGAGTCCTGGGACCCTCGGTCCT CTCTCCTGGGCCATGGCCAACTCAGGCCTCCAGCTCCTGGGCTACTTCTTGGCCCTGGGT GGCTGGGTGGGCATCATTGCTAGCACAGCCCTGCCACAGTGGAAGCAGTCTTCCTACGCA GGCGACGCCATCATCACTGCCGTGGGCCTCTATGAAGGGCTCTGGATGTCCTGCGCCTCC CAGAGCACTGGGCAAGTGCAGTGCAAGCTCTACGACTCGCTGCTCGCCCTGGACGGTCAC ATCCAATCAGCGCGGGCCCTGATGGTGGTGGCCGTGCTCCTGGGCTTCGTGGCCATGGTC CTCAGCGTAGTTGGCATGAAGTGTACGCGGGTGGGAGACAGCAACCCCATTGCCAAGGGC CGTGTTGCCATCGCCGGGGGAGCCCTCTTCATCCTGGCAGGCCTCTGCACTTTGACTGCT GTCTCGTGGTATGCCACCCTGGTGACCCAGGAGTTCTTCAACCCAAGCACACCTGTCAAT GCCAGGATGAAATTTTGGCCCAGCCCTGTTCGTGGGCTGGGCCTCAGCTGGCCTGGCCGT GCTGGGCGGCTCCTTCCTCTGCTGCACATGCCCGGAGCCAGAGAGACCCAACAGCAGCCC ACAGCCCTATCGGCCTGGACCCTCTGCTGCTGCCCGAGAGTACGTCTGAGCTCTGCCTGC CCTGGCCAGCCCCCCACCCAGTGGCCCCCTTGCCCAGCATCCAGCCAGCCTCGCAGCACC CTGGGCAGGGCCACTGGNGCATTAGATGGGCATAGGTGCTCTGAGCAGCTTGTCCA
Restriction Sites	Please inquire
ACCN	BC030524
Insert Size	1616 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	BC030524.1, AAH30524.1
RefSeq Size	1616 bp
RefSeq ORF	633 bp
Locus ID	149461
Protein Families	Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction
Gene Summary	The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]

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