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OLFM2 (NM_058164) Human Untagged Clone
CAT＃: SC120238
OLFM2 (untagged)-Human olfactomedin 2 (OLFM2)
CNY 3,656.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | NOE2; NOELIN2; NOELIN2_V1; OlfC |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC120238 sequence for NM_058164 edited (data generated by NextGen Sequencing)
ATGTGGCCGCTCACGGTCCCGCCGCCGCTGCTGCTGCTGCTGTGCTCAGGCCTGGCCGGA CAGACTCTCTTCCAGAACCCAGAAGAGGGCTGGCAGCTGTACACCTCAGCCCAGGCCCCT GACGGGAAATGCATCTGCACGGCCGTGATCCCAGCGCAGAGTACCTGCTCTCGAGATGGC AGGAGTCGGGAGCTGCGGCAACTGATGGAGAAGGTCCAGAACGTCTCCCAGTCCATGGAG GTCCTTGAGTTGCGGACGTATCGCGACCTCCAGTATGTACGCGGCATGGAGACCCTCATG CGGAGCCTGGATGCGCGGCTCCGGGCAGCTGATGGGTCCCTCTCGGCCAAGAGCTTCCAG GAGCTGAAGGACAGGATGACGGAACTGTTGCCCCTGAGCTCGGTCCTGGAGCAGTACAAG GCAGACACGCGGACCATTGTACGCTTGCGGGAGGAGGTGAGGAATCTCTCCGGCAGTCTG GCGGCCATTCAGGAGGAGATGGGTGCCTACGGGTATGAGGACCTGCAGCAACGGGTGATG GCCCTGGAGGCCCGGCTCCACGCCTGCGCCCAGAAGCTGGGCTGTGGGAAGCTGACCGGG GTCAGTAACCCCATCACCGTTCGGGCCATGGGGTCCCGCTTCGGCTCCTGGATGACTGAC ACGATGGCCCCCAGTGCGGATAGCCGGGTCTGGTACATGGATGGCTATTACAAAGGCCGC CGGGTCCTGGAGTTCCGTACCCTGGGAGACTTCATCAAAGGCCAGAACTTTATCCAGCAC CTGCTGCCCCAGCCGTGGGCGGGCACGGGCCACGTGGTGTACAACGGCTCCCTGTTCTAT AACAAGTACCAGAGCAACGTGGTGGTCAAATACCACTTCCGCTCGCGCTCTGTGCTGGTG CAGAGGAGCCTCCCGGGCGCCGGTTACAACAACACCTTCCCCTACTCCTGGGGCGGCTTC TCCGACATGGACTTCATGGTGGACGAGAGCGGGCTCTGGGCTGTGTACACCACCAACCAG AACGCGGGCAACATCGTGGTCAGCCGGCTGGACCCGCACACCCTCGAGGTCATGCGGTCC TGGGACACCGGCTACCCCAAGCGCAGCGCTGGCGAGGCCTTCATGATCTGCGGTGTGCTC TACGTGACCAACTCCCACCTGGCTGGGGCCAAGGTCTACTTCGCCTATTTTACCAACACG TCCAGTTACGAGTACACGGACGTGCCCTTCCACAACCAGTATTCCCACATCTCGATGCTG GATTACAACCCCCGGGAGCGCGCCCTCTATACCTGGAACAACGGCCACCAGGTGCTCTAC AATGTCACCCTGTTTCACGTCATCAGCACCTCTGGGGACCCCTGA Clone variation with respect to NM_058164.2 >OriGene 5' read for NM_058164 unedited
GNCCCATTCCGCACGAGGGGCTAGGGGTTCGTCATGTGGCCGCTCACGGTCCCGCCGCCG CTGCTGCTGCTGCTGTGCTCAGGCCTGGCCGGACAGACTCTCTTCCAGAACCCAGAAGAG GGCTGGCAGCTGTACACCTCAGCCCAGGCCCCTGACGGGAAATGCATCTGCACTGTCCGT ANCCCAGCGCAGAGTACCTGCTCTCGAGATGGCAGGAGTCGGGAGCTGCGGCAACTGATG GAGAAGGTCCAGAACGTCTCCCAGTCCATGGAGGTCCTTGAGTTGCGGACGTATCGCGAC CTCCAGTATGTACGCGGCATGGAGACCCTCATGCGGAGCCTGGATGCGCGGCTCCGGGCA GCTGATGGGTCCCTCTCGGCCAAGAGCTTCCAGGAGCTGAAGGACAGGATGACGGAACTG TTGCCCCTGAGCTCGGTCCTGGAGCAGTACAAGGCAGACACGCGGACCATTGTACGCTTG CGGGAGGAGGTGAGGAATCTCTCCGGCAGTCTGGCGGCCATTCAGGAGGAGATGGGTGCC TACGGGTATGAGGACCTGCAGCAACGGGTGATGGCCCTGGAGGCCCGGCTCCACGCCTGC GCCCAGAAGCTGGGCTGTGGGAAGCTGACCGGGGTCAGTAACCCCATCACCGTTCGGGCC ATGGGGTCCCGCTTCGGCTCCTGGATGACTGACACGATGGCCCCCAGTGCGGATAGCCGG GTCTGGTACATGGATGGCTATTACAAAGGCCGCCGGGTCCTGGAGTTCCGTACCCTGGGA GACTTCATTANAAGCCAGAACTTTATCCAGCACCTGCTGCCCCAACCCGTGGGCGGGCAC CGGCCCACGTGGGGNCCAACGGCTCCCTGTTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_058164 |
| Insert Size | 1960 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_058164.1, NP_477512.1 |
| RefSeq Size | 1902 bp |
| RefSeq ORF | 1365 bp |
| Locus ID | 93145 |
| UniProt ID | O95897 |
| Domains | OLF |
| Protein Families | Druggable Genome, Secreted Protein |
| Gene Summary | Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) uses an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC203786 | OLFM2 (Myc-DDK-tagged)-Human olfactomedin 2 (OLFM2) |
CNY 3,656.00 |
|
| RC203786L1 | Lenti ORF clone of Human olfactomedin 2 (OLFM2), Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC203786L2 | Lenti ORF clone of Human olfactomedin 2 (OLFM2), mGFP tagged |
CNY 5,890.00 |
|
| RC203786L3 | Lenti ORF clone of Human olfactomedin 2 (OLFM2), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC203786L4 | Lenti ORF clone of Human olfactomedin 2 (OLFM2), mGFP tagged |
CNY 5,890.00 |
|
| RG203786 | OLFM2 (tGFP-tagged) - Human olfactomedin 2 (OLFM2) |
CNY 5,256.00 |
|
| SC322272 | OLFM2 (untagged)-Human olfactomedin 2 (OLFM2) |
CNY 3,656.00 |
