CDC2L1 (CDK11B) (NM_033490) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	CDC2L1; CDK11; CDK11-p46; CDK11-p58; CDK11-p110; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA; PK58
Vector	pCMV6-XL6
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for NM_033490 edited GCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCATTTAGGTGACACTATAGAATACAA GCTACTTGTTCTTTTTGCAGCGGCCGCGAATTCGGCACGAGGAGAAGGAGCGCGAGCGGC GGGCAGAGGAGCGGCGCAAGGAGCGGGAGGCCCGCAGGGAAGTGTCTGCACATCACCGAA CGATGAGAGAGGACTACAGCGACAAAGTGAAAGCCAGCCACTGGAGTCGCAGCCCGCCTC GGCCGCCGCGGGAGCGGTTCGAGTTGGGAGACGGCCGGAAGCCAGTAAAAGAAGAGAAAA TGGAAGAAAGGGACCTGCTGTCCGACTTACAGGACATCAGCGACAGCGAGAGGAAGACCA GCTCGGCCGAGTCCTCGTCAGCGGAATCAGGCTCAGGTTCTGAGGAAGAAGAGGAGGAGG AGGAAGAGGAGGAGGAGGAAGGGAGCACCAGTGAAGAATCAGAGGAGGAGGAGGAGGAAG AGGAAGAGGAGGAGGAGGAGACCGGCAGCAACTCTGAGGAGGCATCAGAGCAGTCTGCCG AAGAAGTAAGTGAGGAAGAAATGAGTGAAGATGAAGAACGAGAAAATGAAAACCACCTCT TGGTTGTTCCAGAGTCACGGTTCGACCGAGATTCCGGGGAGAGTGAAGAAGCAGAGGAAG AAGTGGGTGAGGGAACGCCGCAGAGCAGCGCCCTGACAGAGGGCGACTATGTGCCCGACT CCCCTGCCCTGTCGCCCATCGAGCTCAAGCAGGAGCTGCCCAAGTACCTGCCGGCCCTGC AGGGCTGCCGGAGCGTCGAGGAGTTCCAGTGCCTGAACAGGATCGAGGAGGGCACCTATG GAGTGGTCTACAGAGCAAAAGACAAGAAAACAGATGAAATTGTGGCTCTAAAGCGGCTGA AGATGGAGAAGGAGAAGGAGGGCTTCCCGATCACGTCGCTGAGGGAGATCAACACCATCC TCAAGGCCCAGCATCCCAACATCGTCACCGTTAGAGAGATTGTGGTGGGCAGCAACATGG ACAAGATCTACATCGTGATGAACTATGTGGAGCACGACCTCAAGAGCCTGATGGAGACCA TGAAACAGCCCTTCCTGCCAGGGGAGGTGAAGACCCTGATGATCCAGCTGCTGCGTGGGG TGAAACACCTGCACGACAACTGGATCCTGCACCGTGACCTCAAGACGTCCAACCTGCTGC TGAGCCACGCCGGCATCCTCAAGGTGGGTGACTTCGGGCTGGCGCGGGAGTACGGATCCC CTCTGAAGGCCTACACCCCGGTCGTGGTGACCCTGTGGTACCGCGCCCCAGAGCTGCTGC TTGGTGCCAAGGAATACTCCACGGCCGTGGACATGTGGTCAGTGGGTTGCATCTTCGGGG AGCTGCTGACTCAGAAGCCTCTGTTCCCCGGGAAGTCAGAAATCGATCAGATCAACAAGG TGTTCAAGGATCTGGGGACCCCTAGTGAGAAAATCTGGCCCGGCTACAGCGAGCTCCCAG CAGTCAAGAAGATGACCTTCAGCGAGCACCCCTACAACAACCTCCGCAAGCGCTTCGGGG CTCTGCTCTCAGACCAGGGCTTCGACCTCATGAACAAGTTCCTGACCTACTTCCCCGGGA GGAGGATCAGCGCTGAGGACGGCCTCAAGCATGAGTATTTCCGCGAGACCCCCCTCCCCA TCGACCCCTCCATGTTCCCCACGTGGCCCGCCAAGAGCGAGCAGCAGCGTGTGAAGCGGG GCACCAGCCCGAGGCCCCCTGAGGGAGGCCTGGGCTACAGCCAGCTGGGTGACGACGACC TGAAGGAGACGGGCTTCCACCTTACCACCACGAACCAGGGGGCCTCTGCCGCGGGCCCCG GCTTCAGCCTCAAGTTCTGAAGGTCAGAGTGGACCCCGTCATGGGGAGAACTCAGCCGGG ACCACAGGCGTGGCTACTGCGGCTGGAGCTGCGATGAGACTCGGAACTCCTCGTCTTACT TTGTGCTCCATGTTTTGTTTTTGTATTTTGGTTTGTAAATTTGTAGAATTAAATCATTTT CCTTGTTGTGGAGGAAAGAGCTGTGTTTTCTCCGTGACTTGCCCAGGGCGGAGAGGGTGG GCATCTTCGGGTGCCCACGTGGGGCAGCACAAACCTCCACACACCCTCTCCCACTCTCGA CACGCACGGGGCTGGCTGGGCCGTGATTTGGAAAGGAACTGGTGGGAGCCGGGTGGATTG TTTAATCTTCGGAGCTGGAGACCTGTTTCTGTGTTGGGATGAGCGATGCCCTCTTGCCCC AACCCACTCGTCCAGACCAGCCCTGTCCACACAGGCCCCCGGCCCCCAACCCCCAGCCCC AGCTGTGCCAGCAGACTCGACAGGTTTTTATACAAGGTTGTTGAGTTTTAAAATGTATTA AAATATTCTTCGAGAAAAAAAAAAAAAAAAAACTCGACTCTAGATTGCGGCCGCGGTCAT AGCTGTTTCCTGAACAGATCCCGGGTGGCATCCCTGTGACCCCTCCCCAGTGCCT 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for NM_033490 unedited GAGGGGNGGGAGGAAANANNNNNNNNTNTNNNNNNNATTTCTTACACCCGCCCGTTGNCG CAAAGGGCGGTAGGCGTGTACGGTGGGNAGTCTATATAAGCAGAGCTCATTTAGGTGACA CTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAATTCGGCACGAGGAGAAG GAGCGCGAGCGGCGGGCAGAGGAGCGGCGCAAGGAGCGGGAGGCCCGCAGGGAAGTGTCT GCACATCACCGAACGATGAGAGAGGACTACAGCGACAAAGTGAAAGCCAGCCACTGGAGT CGCAGCCCGCCTCGGCCGCCGCGGGAGCGGTTCGAGTTGGGAGACGGCCGGAAGCCAGTA AAAGAAGAGAAAATGGAAGAAAGGGACCTGCTGTCCGACTTACAGGACATCAGCGACAGC GAGAGGAAGACCAGCTCGGCCGAGTCCTCGTCAGCGGAATCAGGCTCAGGTTCTGAGGAA GAAGAGGAGGAGGAGGAAGAGGAGGANGNNGAANGNNNNNCANNGAANAANAAAGGAGGA GGAGGAGGAANAGGAANANAAAAAAAAAAAAGAAGAAAGGGGGAAAGAGAAAAAAAAAGA AGAAAAAANAAGGAAGAAGAGGAGCCGAGAGAAAAAGAGAAGAAAAAAAAGAAAAAGAAA AAAAAAAAAAGAAGAANAAAGAAAGAANAAAGAAAAAAAGAAAAGGCCGAGAAGGAAGGA AGAAAAAGAAAAAANAGAGGAGGGAAAGGACCAACCANNAGCANAAAAAGACGAGACCCC ACCCCCCCCNCGCCCCCCGCAGCACCCCCACCCACCACGCCACCCACCCCCAAACAGACA CCGCCACCCCCCGCCGCGCCACCCCCCAGACCGGCCCGAGAACACCCACACACGCCAACC CCCCAGCCCCCCCCCCCCCGCCCGCCGCCCCCCCCACACCCCGGCCCCCGCGCCACACGC AGACCCCCCCCCCCACCG 3' Read Nucleotide Sequence (showhide) >OriGene 3' read for NM_033490 unedited CATCCGATGTACGCGGCCGCNCTCNANGATCGAGTTTTTTTTTTTTTTTTTTCTCGAAGA ATATTTTAATACATTTTAAAACTCAACAACCTTGTATAAAAACCTGTCGAGTCTGCTGGC ACAGCTGGGGCTGGGGGTTGGGGGCCGGGGGCCTGTGTGGACAGGGCTGGTCTGGACGAG TGGGTTGGGGCAAGAGGGCATCGCTCATCCCAACACAGAAACAGGTCTCCAGCTCCGAAG ATTAAACAATCCACCCGGCTCCCACCAGTTCCTTTCCAAATCACGGCCCAGCCAGCCCCG TGCGTGTCGAGAGTGGGAGAGGGTGTGTGGAGGTTTGTGCTGCCCCACGTGGGCACCCGA AGATGCCCACCCTCTCCGCCCTGGGCAAGTCACGGAGAAAACACAGCTCTTTCCTCCACA ACAAGGAAAATGATTTAATTCTACAAATTTACAAACCAAAATACAAAAACAAAACATGGA GCACAAAGTAAGACGAGGAGTTCCGAGTCTCATCGCAGCTCCAGCCGCAGTAGCCACGCC TGTGGTCCCGGCTGAGTTCTCCCCATGACGGGGTCCACTCTGACCTTCAGAACTTGAGGC TGAAGCCGGGGCCCGCGGCAGATGCCCCCTGGTTCGTGGTGGTAAGGTGGAAGCCCGTCT CCTTCAAGTCGTCGTCACCCAGCTGGCTGTAGCCCAGGCCTCCCTCAGGGAGCCTCGGGC TGGTGCCCCGCTTACACGCTGCTGCTCGCTCTTGGCGGGCACGTGGGGAACATGGAGGGG TCNATGGGGAGGGGGGGCTCGCGGAAATACTCATGCTGAGGGCGTCCTCAACGCTGATCC TCTCCCGGGGAATTAGTTAAGGACTTGTCATGAGGTCAAAACCTGTTTGAAACC
Restriction Sites	NotI-NotI
ACCN	NM_033490
Insert Size	2500 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_033490.1, NP_277025.1
RefSeq Size	2349 bp
RefSeq ORF	1698 bp
Locus ID	984
UniProt ID	P21127
Domains	pkinase, TyrKc, S_TKc
Protein Families	Druggable Genome, Transcription Factors
Gene Summary	This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] Transcript Variant: This variant (6) differs in its 5' UTR, uses a downstream start codon, and uses an alternate splice site in its 5' coding region, compared to variant 1. The encoded isoform (6) is shorter, compared to isoform 1.

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