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CHM (NM_000390) Human Untagged Clone
CAT＃: SC119948
CHM (untagged)-Human choroideremia (Rab escort protein 1) (CHM), transcript variant 1
CNY 4,872.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | DXS540; GGTA; HSD-32; REP-1; TCD |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC119948 sequence for NM_000390 edited (data generated by NextGen Sequencing)
ATGGCGGATACTCTCCCTTCGGAGTTTGATGTGATCGTAATAGGGACGGGTTTGCCTGAA TCCATCATTGCAGCTGCATGTTCAAGAAGTGGCCGGAGAGTTCTGCATGTTGATTCAAGA AGCTACTATGGAGGAAACTGGGCCAGTTTTAGCTTTTCAGGACTATTGTCCTGGCTAAAG GAATACCAGGAAAACAGTGACATTGTAAGTGACAGTCCAGTGTGGCAAGACCAGATCCTT GAAAATGAAGAAGCCATTGCTCTTAGCAGGAAGGACAAAACTATTCAACATGTGGAAGTA TTTTGTTATGCCAGTCAGGATTTGCATGAAGATGTCGAAGAAGCTGGTGCACTGCAGAAA AATCATGCTCTTGTGACATCTGCAAACTCCACAGAAGCTGCAGATTCTGCCTTCCTGCCT ACGGAGGATGAGTCATTAAGCACTATGAGCTGTGAAATGCTCACAGAACAAACTCCAAGC AGCGATCCAGAGAATGCGCTAGAAGTAAATGGTGCTGAAGTGACAGGGGAAAAAGAAAAC CATTGTGATGATAAAACTTGTGTGCCATCAACTTCAGCAGAAGACATGAGTGAAAATGTG CCTATAGCAGAAGATACCACAGAGCAACCAAAGAAAAACAGAATTACTTACTCACAAATT ATTAAAGAAGGCAGGAGATTTAATATTGATTTAGTATCAAAGCTGCTGTATTCTCGAGGA TTACTAATTGATCTTCTAATCAAATCTAATGTTAGTCGATATGCAGAGTTTAAAAATATT ACCAGGATTCTTGCATTTCGAGAAGGACGAGTGGAACAGGTTCCGTGTTCCAGAGCAGAT GTCTTTAATAGCAAACAACTTACTATGGTAGAAAAGCGAATGCTAATGAAATTTCTTACA TTTTGTATGGAATATGAGAAATATCCTGATGAATATAAAGGATATGAAGAGATCACATTT TATGAATATTTAAAGACTCAAAAATTAACCCCCAACCTCCAATATATTGTCATGCATTCA ATTGCAATGACATCAGAGACAGCCAGCAGCACCATAGATGGTCTCAAAGCTACCAAAAAC TTTCTTCACTGTCTTGGGCGGTATGGCAACACTCCATTTTTGTTTCCTTTATATGGCCAA GGAGAACTCCCCCAGTGTTTCTGCAGGATGTGTGCTGTGTTTGGTGGAATTTATTGTCTT CGCCATTCAGTACAGTGCCTTGTAGTGGACAAAGAATCCAGAAAATGTAAAGCAATTATA GATCAGTTTGGTCAGAGAATAATCTCTGAGCATTTCCTCGTGGAGGACAGTTACTTTCCT GAGAACATGTGCTCACGTGTGCAATACAGGCAGATCTCCAGGGCAGTGCTGATTACAGAT AGATCTGTCCTAAAAACAGATTCAGATCAACAGATTTCCATTTTGACAGTGCCAGCAGAG GAACCAGGAACTTTTGCTGTTCGGGTCATTGAGTTATGTTCTTCAACGATGACATGCATG AAAGGCACCTATTTGGTTCATTTGACTTGCACATCTTCTAAAACAGCAAGAGAAGATTTA GAATCAGTTGTGCAGAAATTGTTTGTTCCATATACTGAAATGGAGATAGAAAATGAACAA GTAGAAAAGCCAAGAATTCTGTGGGCTCTTTACTTCAATATGAGAGATTCGTCAGACATC AGCAGGAGCTGTTATAATGATTTACCATCCAACGTTTATGTCTGCTCTGGCCCAGATTGT GGTTTAGGAAATGATAATGCAGTCAAACAGGCTGAAACACTTTTCCAGGAAATCTGCCCC AATGAAGATTTCTGTCCCCCTCCACCAAATCCTGAAGACATTATCCTTGATGGAGACAGT TTACAGCCAGAGGCTTCAGAATCCAGTGCCATACCAGAGGCTAACTCGGAGACTTTCAAG GAAAGCACAAACCTTGGAAACCTAGAGGAGTCCTCTGAATAA Clone variation with respect to NM_000390.2 >OriGene 5' read for NM_000390 unedited
TACTAATTTGTNAATACGCACTCTCTATAGGGNNCGGCCGCGCAATTCGGCACGAGGTCA AGATGGCGGATACTCTCCCTTCGGAGTTTGATGTGATCGTAATAGGGACGGGTTTGCCTG AATCCATCATTGCAGCTGCATGTTCAAGAAGTGGCCGGAGAGTTCTGCATGTTGATTCAA GAAGCTACTATGGAGGAAACTGGGCCAGTTTTAGCTTTTCAGGACTATTGTCCTGGCTAA AGGAATACCAGGAAAACAGTGACATTGTAAGTGACAGTCCAGTGTGGCAAGACCAGATCC TTGAAAATGAAGAAGCCATTGCTCTTAGCAGGAAGGACAAAACTATTCAACATGTGGAAG TATTTTGTTATGCCAGTCAGGATTTGCATGAAGATGTCGAAGAAGCTGGTGCACTGCAGA AAAATCATGCTCTTGTGACATCTGCAAACTCCACAGAAGCTGCAGATTCTGCCTTCCTGC CTACGGAGGATGAGTCATTAAGCACTATGAGCTGTGAAATGCTCACAGAACAAACTCCAA GCAGCGATCCAGAGAATGCGCTAGAAGTAAATGGTGCTGAAGTGACAGGGGAAAAAGATA ACCATTGTGATGATAAAACTTGTGTGCCATCAACTTCAGCAGAAGACATGAGTGAAAATG TGCCTATAGCAGAAGATACCACAGAGCACCCAAAGAAAACCAGAATTACTTACTCACAAA ATATTAAAGAAGGCAGGAGATTTAATATTGATTTGTATCAAAGCTGCTGTATTCTCGAAG ATTACCTAATGATCTTCTAATCAAACCTATGGTAGTCGATATGCAGAGTTTAAAACTATA CCAAGATCTTTGCATTTCGAAAAGAACGATTGAACAAGTTCCGCGTTCCAGAGCAGATGC TTTTATAGCAACCACTTACTATGCAGGAAACCGAAGCTAATGAAATTT >OriGene 3' read for NM_000390 unedited
GTCCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGTGAGACAGAGTCTTG CTCTGTCACCCACGCTGGAGTGCAGTGGCAAAATCTTGGCTCACTGCAACCTCCGCCTCC CTGGTTCAAGTGAGTCTGCTACCTCATCTTCAAAGTAGCTGGGATTACAGGTGCCCACCA TAACACCCAGCTAAAATTTTGTATTTTTAGTAGAGACAGGGTTTCGCCATGTTGGCCAGG CTGGTCTCGAACTCCTGACCTCAAGTGATCTACCCACCTCAGCTTCCCAAAGTGCTGGGA TTACAGGCAGCCCTAACGTTTTTATGTAGTGTATATTAGGGCTTACCAACTGTCATACAC AATTTGGAGTCCTTGGTGGTTGCAGGTTTACCTACCAGAAAAGGAATAAAACAATTTATA GAGTGTTTTCCTTAGTAATATTTCAAAACCACAATTCTACTTGTTACTATTTTTACTGGT CTGTAAGACTATAAAATACTACTTTAAAAAAGAAATTTTCATTTAAAAAGCTTAATGCAA TAAAAACACTGTGATCTATTTTGTTTGGAAGTTGACTGACAGCAAGCAATTATTTCCTGC GTGAGACTTTTGAGATTCATCAAGTCAATGGGAAAATTCTAAAACAATTTTCTTCTGGCA AACCGATTCTAAACATGGCATTGCATTGTCTTCATAACCATTCTCATATAGTAAGCATAG TAATACTATTTCCACTTTATATATGGAGAAACGTANGCTCAGAAGTTAAACAATTTACCA CATATCATCAGTACGACAGCCAGAATTAAATTAAGTCTGTAGACAATTAGCCTATACTCT TAGTACTTGACAGACAGAATATTCAAAACCCATGAGCCTATCACACCCTTCCTTNCATTC TTTCATTCCTCATTATTGACCTTTNCCAGTATGGAATAAATTAAC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000390 |
| Insert Size | 3590 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000390.1, NP_000381.1 |
| RefSeq Size | 2115 bp |
| RefSeq ORF | 1962 bp |
| Locus ID | 1121 |
| UniProt ID | P24386 |
| Domains | GDI |
| Protein Families | Druggable Genome |
| Gene Summary | This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016] Transcript Variant: This variant (1) represents the predominant transcript and encodes the longest isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC213610 | CHM (Myc-DDK-tagged)-Human choroideremia (Rab escort protein 1) (CHM), transcript variant 1 |
CNY 5,352.00 |
|
| RC213610L3 | Lenti-ORF clone of CHM (Myc-DDK-tagged)-Human choroideremia (Rab escort protein 1) (CHM), transcript variant 1 |
CNY 6,460.00 |
|
| RC213610L4 | Lenti-ORF clone of CHM (mGFP-tagged)-Human choroideremia (Rab escort protein 1) (CHM), transcript variant 1 |
CNY 6,460.00 |
|
| RG213610 | CHM (tGFP-tagged) - Human choroideremia (Rab escort protein 1) (CHM), transcript variant 1 |
CNY 6,952.00 |
