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MAT1A (NM_000429) Human Untagged Clone
CAT＃: SC119881
MAT1A (untagged)-Human methionine adenosyltransferase I, alpha (MAT1A)
CNY 3,656.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | MAT; MATA1; SAMS; SAMS1 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC119881 sequence for NM_000429 edited (data generated by NextGen Sequencing)
ATGAATGGACCGGTGGATGGCTTGTGTGACCACTCTCTAAGTGAAGGAGTCTTCATGTTC ACATCGGAGTCTGTGGGAGAGGGACACCCGGATAAGATCTGTGACCAGATCAGTGATGCA GTGCTGGATGCCCATCTCAAGCAAGACCCCAATGCCAAGGTGGCCTGTGAGACAGTGTGC AAGACCGGCATGGTGCTGCTGTGTGGTGAGATCACCTCAATGGCCATGGTGGACTACCAG CGGGTGGTGAGGGACACCATCAAGCACATCGGCTACGATGACTCAGCCAAGGGCTTTGAC TTCAAGACTTGCAACGTGCTGGTGGCTTTGGAGCAGCAATCCCCAGATATTGCCCAGTGC GTCCATCTGGACAGAAATGAGGAGGATGTGGGGGCAGGAGATCAGGGTTTGATGTTCGGC TATGCCACCGACGAGACAGAGGAGTGCATGCCCCTCACCATCATCCTTGCTCACAAGCTC AACGCCCGGATGGCAGACCTCAGGCGCTCCGGCCTCCTCCCCTGGCTGCGGCCTGACTCT AAGACTCAGGTGACAGTTCAGTACATGCAGGACAATGGCGCAGTCATCCCTGTGCGCATC CACACCATCGTCATCTCTGTGCAGCACAACGAAGACATCACGCTGGAGGAGATGCGCAGG GCCCTGAAGGAGCAAGTCATCAGGGCCGTGGTGCCGGCCAAGTACCTGGACGAAGACACC GTCTACCACCTGCAGCCCAGTGGGCGGTTTGTCATCGGAGGTCCCCAGGGGGATGCGGGT GTCACTGGCCGTAAGATTATTGTGGACACCTATGGCGGCTGGGGGGCTCATGGTGGTGGG GCCTTCTCTGGGAAGGACTACACCAAGGTGGACCGCTCAGCCGCATATGCTGCCCGCTGG GTGGCCAAGTCTCTGGTGAAAGCAGGGCTCTGCCGGAGAGTGCTTGTCCAGGTTTCCTAT GCCATTGGTGTGGCCGAGCCGCTGTCCATTTCCATCTTCACCTACGGAACCTCTCAGAAG ACAGAGCGAGAGCTGCTGGATGTGGTGCATAAGAACTTCGACCTCCGGCCGGGCGTCATT GTCAGGGATTTGGACTTGAAGAAGCCCATCTACCAGAAGACAGCATGCTACGGCCATTTC GGAAGAAGCGAGTTCCCATGGGAGGTTCCCAGGAAGCTTGTATTTTAG Clone variation with respect to NM_000429.2 426 t=>c;870 a=>g;882 t=>c >OriGene 5' read for NM_000429 unedited
NGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGCGCTCAAAATGTTCACTGGAA AAAAGCGTGAGTGGAGAAGTGTGAGAAGATGAATGGACCGGTGGATGGCTTGTGTGACCA CTCTCTAAGTGAAGGAGTCTTCATGTTCACATCGGAGTCTGTGGGAGAGGGACACCCGGA TAAGATCTGTGACCAGATCAGTGATGCAGTGCTGGATGCCCATCTCAAGCAAGACCCCAA TGCCAAGGTGGCCTGTGAGACAGTGTGCAAGACCGGCATGGTGCTGCTGTGTGGTGAGAT CACCTCAATGGCCATGGTGGACTACCAGCGGGTGGTGAGGGACACCATCAAGCACATCGG CTACGATGACTCAGCCAAGGGCTTTGACTTCAAGACTTGCAACGTGCTGGTGGCTTTGGA GCAGCAATCCCCAGATATTGCCCAGTGCGTCCATCTGGACAGAAATGAGGAGGATGTGGG GGCAGGAGATCAGGGTTTGATGTTCGGCTATGCCACCGACGAGACAGAGGAGTGCATGCC CCTCACCATCATCCTTGCTCACAAGCTCAACGCCCGGATGGCAGACCTCANGCGCTTCGG CCTCCTNCCCTGGCTGCGGCCTGACTCTAAGACTCANGTGACAGTTCAGTACATGCAGGA CATGGGCGCAGTCATCCCTGTGCGCATNCACACATCGTCATCTCTGTGCAGCACAACGAA GACATCACGCTGGNAGAGATGCGCANGGCCCCTGAGGAGCAGTCATCGGGCCCGTGGNTG CCGNCCAGTACCTGNACGAAGACACCGTCTACCCCTGCAGCCAGTGGNGCGGTTNGTCAT CGGAGGTCCCAGGGGATGGCGGNTGTCACTGCCGTAGAATATTGTGGACACTATGGCGGC TGGGGCTATTGGGGGGGTGGGGCTCTNCTGGAAGGACTACACAAGTGGACCGTCACCGCT ATCTGCCCCTGGTGGCAGTCTTGNGN >OriGene 3' read for NM_000429 unedited
NAAGGTTTTTACTNTGNNACCGCGGCCGCATNCTANGATCGAGTTTTTTTTTTTTTTTTT TTTAGTTGCTCCTTGAGTTTTTATTCATTGTTTTAGCAGGAACTATTAACAAATAAAGGC TTTAGTTTCATACAAACAAACTGACAAAAAAGATCTTATTTCTCTAGAGGGTAGGGAAAG TATAAAATTCTGAATTTTCATGTCGAGTGTGAGCCAAGTTAGAGGAACTTGGCCACCTGC AAACCACTCCCTCCCTCCATGGGAAGGAATCTGAGGCTTCCTAGGTGACCAGGAGCCGGG CTTCTTTTGTTGCCTTAATTTCCTTTCACCTGAGAGAAAATGAAAGCCAGGGTCTTTGTG CTCCAGGCCAAGGCCCAGATGCTGGCTGCCTGCTCCCCAGATGAGACTTCCTGGGCTGCC TCTCCCAGCACCATGTACCCTAGAGAGAGGCCAAGTCCCCAGTGTTCCCCTGGGGCCCAT GGAGGCCCCTGCCTGAGCCTGTGGTCCTGGGAGCTGGGGAGAGGTANAGATGCTGCTGTC AGAAGTCCAGGCTAAGGACAAGTGGGGCANGTANGGCANGTGCTGCTGGCCATGGATGGA AAGGCANNGCAGTTTCCAGACCTTAGCANGCCAAGGACTGCTCANGCCCCTTGGGAGCAG ACCCGCTCCCAGACAGTACCTGGNCAAAGCAGAATCTNCTCATGACGTCTCAAAGCCTGT CCGACACCAGAAGGCAGCCCCGCCTATTTACATGAGGCCCATAGACCAGCCTNCCCTGAT CCCGAAAGGGCACTCACTTCCTTCAATGCCTCAGNCTGCAGGGGATACAGGGACCANNGA AAGAGAAAGACTGAGGCCTCTGTCTAGGGNGCTGCCTNTGTGCTGGAACAAGTGCTGCTC TGCTCCAGAGCCAGATAGACTGGACTGACT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000429 |
| Insert Size | 3520 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000429.2, NP_000420.1 |
| RefSeq Size | 3419 bp |
| RefSeq ORF | 1188 bp |
| Locus ID | 4143 |
| UniProt ID | Q00266 |
| Domains | S-AdoMet_synt |
| Protein Families | Druggable Genome |
| Protein Pathways | Cysteine and methionine metabolism, Metabolic pathways, Selenoamino acid metabolism |
| Gene Summary | This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008] |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice
,Martin, KA;Hum, NR;Sebastian, A;He, W;Siddiqui, S;Ghosh, PM;Pan, CX;de Vere White, R;Loots, GG;,
Int J Mol Sci
,PubMed ID 31600961
[MAT1A]
|
|
Human Liver Methionine Cycle: MAT1A and GNMT
,null,
Drug Metabolism and Disposition
,PubMed ID 22807109
[MAT1A]
|
|
Human Liver Methionine Cycle: MAT1A and GNMT Gene Resequencing, Functional Genomics, and Hepatic Genotype-Phenotype Correlation
,Yuan Ji, Kendra K. S. Nordgren, Yubo Chai, Scott J. Hebbring, Gregory D. Jenkins, Ryan P. Abo, Yi Peng, Linda L. Pelleymounter, Irene Moon, Bruce W. Eckloff, Xiaoshan Chai, Jianping Zhang, Brooke L. Fridley, Vivien C. Yee, Eric D. Wieben, and Richard M. Weinshilboum,
Drug Metab. Dispos., Oct 2012; 40: 1984 - 1992.
[MAT1A]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC203765 | MAT1A (Myc-DDK-tagged)-Human methionine adenosyltransferase I, alpha (MAT1A) |
CNY 3,656.00 |
|
| RC203765L3 | Lenti ORF clone of Human methionine adenosyltransferase I, alpha (MAT1A), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC203765L4 | Lenti ORF clone of Human methionine adenosyltransferase I, alpha (MAT1A), mGFP tagged |
CNY 5,890.00 |
|
| RG203765 | MAT1A (tGFP-tagged) - Human methionine adenosyltransferase I, alpha (MAT1A) |
CNY 5,256.00 |
