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Presenilin 2 (PSEN2) (NM_000447) Human Untagged Clone
CAT＃: SC119867
PSEN2 (untagged)-Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 1
CNY 3,656.00
CNY 7,220.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AD3L; AD4; CMD1V; PS2; STM2 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_000447 edited
CAGAGCAGGCATTTCCAGCAGTGAGGAGACAGCCAGAAGCAAGCTTTTGGAGCTGAAGGA ACCTGAGACAGAAGCTAGTCCCCCCTCTGAATTTTACTGATGAAGAAACTGAGGCCACAG AGCTAAAGTGACTTTTCCCAAGGTCGCCCAGCGAGGACGTGGGACTTCTCAGACGTCAGG AGAGTGATGTGAGGGAGCTGTGTGACCATAGAAAGTGACGTGTTAAAAACCAGCGCTGCC CTCTTTGAAAGCCAGGGAGCATCATTCATTTAGCCTGCTGAGAAGAAGAAACCAAGTGTC CGGGATTCAGACCTCTCTGCGGCCCCAAGTGTTCGTGGTGCTTCCAGAGGCAGGGCTATG CTCACATTCATGGCCTCTGACAGCGAGGAAGAAGTGTGTGATGAGCGGACGTCCCTAATG TCGGCCGAGAGCCCCACGCCGCGCTCCTGCCAGGAGGGCAGGCAGGGCCCAGAGGATGGA GAGAATACTGCCCAGTGGAGAAGCCAGGAGAACGAGGAGGACGGTGAGGAGGACCCTGAC CGCTATGTCTGTAGTGGGGTTCCCGGGCGGCCGCCAGGCCTGGAGGAAGAGCTGACCCTC AAATACGGAGCGAAGCATGTGATCATGCTGTTTGTGCCTGTCACTCTGTGCATGATCGTG GTGGTAGCCACCATCAAGTCTGTGCGCTTCTACACAGAGAAGAATGGACAGCTCATCTAC ACGCCATTCACTGAGGACACACCCTCGGTGGGCCAGCGCCTCCTCAACTCCGTGCTGAAC ACCCTCATCATGATCAGCGTCATCGTGGTTATGACCATCTTCTTGGTGGTGCTCTACAAG TACCGCTGCTACAAGTTCATCCATGGCTGGTTGATCATGTCTTCACTGATGCTGCTGTTC CTCTTCACCTATATCTACCTTGGGGAAGTGCTCAAGACCTACAATGTGGCCATGGACTAC CCCACCCTCTTGCTGACTGTCTGGAACTTCGGGGCAGTGGGCATGGTGTGCATCCACTGG AAGGGCCCTCTGGTGCTGCAGCAGGCCTACCTCATCATGATCAGTGCGCTCATGGCCCTA GTGTTCATCAAGTACCTCCCAGAGTGGTCCGCGTGGGTCATCCTGGGCGCCATCTCTGTG TATGATCTCGTGGCTGTGCTGTGTCCCAAAGGGCCTCTGAGAATGCTGGTAGAAACTGCC CAGGAGAGAAATGAGCCCATATTCCCTGCCCTGATATACTCATCTGCCATGGTGTGGACG GTTGGCATGGCGAAGCTGGACCCCTCCTCTCAGGGTGCCCTCCAGCTCCCCTACGACCCG GAGATGGAAGAAGACTCCTATGACAGTTTTGGGGAGCCTTCATACCCCGAAGTCTTTGAG CCTCCCTTGACTGGCTACCCAGGGGAGGAGCTGGAGGAAGAGGAGGAAAGGGGCGTGAAG CTTGGCCTCGGGGACTTCATCTTCTACAGTGTGCTGGTGGGCAAGGCGGCTGCCACGGGC AGCGGGGACTGGAATACCACGCTGGCCTGCTTCGTGGCCATCCTCATTGGCTTGTGTCTG ACCCTCCTGCTGCTTGCTGTGTTCAAGAAGGCGCTGCCCGCCCTCCCCATCTCCATCACG TTCGGGCTCATCTTTTACTTCTCCACGGACAACCTGGTGCGGCCGTTCATGGACACCCTG GCCTCCCATCAGCTCTACATCTGAGGGACATGGTGTGCCACAGGCTGCAAGCTGCAGGGA ATTTTCATTGGATGCAGTTGTATAGTTTTACACTCTAGTGCCATATATTTTTAAGACTTT TCTTTCCTTAAAAAATAAAGTACGTGTTTACTTGGTGAGGAGGAGGCAGAACCAGCTCTT TGGTGCCAGCTGTTTCATCACCAGACTTTGGCTCCCGCTTTGGGGAGCGCCTCGCTTCAC GGACAGGAAGCACAGCAGGTTTATCCAGATGAACTGAGAAGGTCAGATTAGGGTGGGGAG AAGAGCATCCGGCATGAGGGCTGAGATGCGCAAAGAGTGTGCTCGGGAGTGGCCCCTGGC ACCTGGGTGCTCTGGCTGGAGAGGAAAAGCCAGTTCCCTACGAGGAGTGTTCCCAATGCT TTGTCCATGATGTCCTTGTTATTTTATTGCCTTTAGAAACTGAGTCCTGTTCTTGTTACG GCAGTCACACTGCTGGGAAGTGGCTTAATAGTAATATCAATAAATAGATGAGTCCTGTTA GAATCTTGAAAAAAAAAAAAAAAAAAA >OriGene 5' read for NM_000447 unedited
NNNNGGGGGGNNNNNNNNCTCCCCNCNNNCGGTTCAAAATTGNATACGACTCATATAGGC GGCCGCGAAATTCGCACGAGGCAGAGCAGGCATTTCCAGCAGTGAGGAGACAGCCAGAAG CAAGCTTTTGGAGCTGAAGGAACCTGAGACAGAAGCTAGTCCCCCCTCTGAATTTTACTG ATGAAGAAACTGAGGCCACAGAGCTAAAGTGACTTTTCCCAAGGTCGCCCAGCGAGGACG TGGGACTTCTCAGACGTCAGGAGAGTGATGTGAGGGAGCTGTGTGACCATAGAAAGTGAC GTGTTAAAAACCAGCGCTGCCCTCTTTGAAAGCCAGGGAGCATCATTCATTTAGCCTGCT GAGAAGAAGAAACCAAGTGTCCGGGATTCAGACCTCTCTGCGGCCCCAAGTGTTCGTGGT GCTTCCAGAGGCAGGGCTATGCTCACATTCATGGCCTCTGACAGCGAGGAAGAAGTGTGT GATGAGCGGACGTCCCTAATGTCGGCCGAGAGCCCCACGCCGCGCTCCTGCCAGGAGGGC AGGCAGGGCCCAGAGGATGGAGAGAATACTGCCCAGTGGAGAAGCCAGGAGAACGAGGAG GACGGTGAGGAGGACCCTGACCGCTATGTCTGTAGTGGGGTTCCCGGGCGGNCGNCAGGC CTGGAGGAAGAGCTGACCCTCANATACNGAGCGAAGCATGTGATCATGCNTGTTGTGCCT GTCACTCTGTGCATGATCGTGGTGGTAGCCACCATCAAGTCTGTGCGCTTCTACACAGAG AAGAATGGACAGCTCATCTACACGCCATTCACTTGAGACACACCCCTCGTGGGGCAGCGC CTNCTCAACTNCGTGCTGAACACCCTCATCATGATCAGCGTCATCGTGGTTATGACCATC TTCTGGGTGTGCTCTACAGTACCGTGCTACAAGTCATCATGGCTGGNTGACATGTCTCAC TGAAGCTGCGGTCCTTT >OriGene 3' read for NM_000447 unedited
TCCCGGCCAGGAGAGGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGATCTGTTCAGG AAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTCAAGA TTCTAACAGGACTCATCTATTTATTGATATTACTATTAAGCCACTTCCCAGCAGTGTGAC TGCCGTAACAAGAACAGGACTCAGTTTCTAAAGGCAATAAAATAACAAGGACATCATGGA CAAAGCATTGGGAACACTCCTCGTAGGGAACTGGCTTTTCCTCTCCAGCCAGAGCACCCA GGTGCCAGGGGCCACTCCCGAGCACACTCTTTGCGCATCTCAGCCCTCATGCCGGATGCT CTTCTCCCCACCCTAATCTGACCTTCTCAGTTCATCTGGATAAACCTGCTGTGCTTCCTG TCCGTGAAGCGAGGCGCTCCCCAAAGCGGGAGCCAAAGTCTGGTGATGAAACAGCTGGCA CCAAAGAGCTGGTTCTGCCTCCTCCTCACCAAGTAAACACGTACTTTATTTTTTAAGGAA AGAAAAGTCTTAAAAATATATGGCACTAGAGTGTAAAACTATACAACTGCATCCAATGAA AATTCCCTGCAGCTTGCAGCCTGTGGCACACCATGTCCCTCANATGTAGAGCTGATGGGA GGCCAGGGTGTCCATGAACGGCCGCACCAGGTTGTCCGTGGAGAAGTAAAAGATGAGCCC GAACGTGATGGANATGGNGAGGGCGGGCAGCCN |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000447 |
| Insert Size | 2250 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The ORF of this clone has been fully sequenced and found to be a perfect match to NM_000447.2. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000447.1, NP_000438.1 |
| RefSeq Size | 2236 bp |
| RefSeq ORF | 1347 bp |
| Locus ID | 5664 |
| UniProt ID | P49810 |
| Domains | Presenilin, PSN |
| Protein Families | Druggable Genome, Protease, Transmembrane |
| Protein Pathways | Alzheimer's disease, Notch signaling pathway |
| Gene Summary | Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) encodes the longer isoform (1). |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC223613 | PSEN2 (Myc-DDK-tagged)-Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 1 |
CNY 4,024.00 |
|
| RC223613L3 | Lenti-ORF clone of PSEN2 (Myc-DDK-tagged)-Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 1 |
CNY 5,890.00 |
|
| RC223613L4 | Lenti-ORF clone of PSEN2 (mGFP-tagged)-Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 1 |
CNY 5,890.00 |
|
| RG223613 | PSEN2 (tGFP-tagged) - Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 1 |
CNY 5,624.00 |
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