United States
Germany
Japan
United Kingdom
China
PMS2 (NM_000535) Human Untagged Clone
CAT＃: SC119825
PMS2 (untagged)-Human PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2), transcript variant 1
CNY 6,320.00
CNY 7,220.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HNPCC4; MLH4; MMRCS4; PMS2CL; PMSL2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_000535, the custom clone sequence may differ by one or more nucleotides
ATGGAGCGAGCTGAGAGCTCGAGTACAGAACCTGCTAAGGCCATCAAACCTATTGATCGGAAGTCAGTCC ATCAGATTTGCTCTGGGCAGGTGGTACTGAGTCTAAGCACTGCGGTAAAGGAGTTAGTAGAAAACAGTCT GGATGCTGGTGCCACTAATATTGATCTAAAGCTTAAGGACTATGGAGTGGATCTTATTGAAGTTTCAGAC AATGGATGTGGGGTAGAAGAAGAAAACTTCGAAGGCTTAACTCTGAAACATCACACATCTAAGATTCAAG AGTTTGCCGACCTAACTCAGGTTGAAACTTTTGGCTTTCGGGGGGAAGCTCTGAGCTCACTTTGTGCACT GAGCGATGTCACCATTTCTACCTGCCACGCATCGGCGAAGGTTGGAACTCGACTGATGTTTGATCACAAT GGGAAAATTATCCAGAAAACCCCCTACCCCCGCCCCAGAGGGACCACAGTCAGCGTGCAGCAGTTATTTT CCACACTACCTGTGCGCCATAAGGAATTTCAAAGGAATATTAAGAAGGAGTATGCCAAAATGGTCCAGGT CTTACATGCATACTGTATCATTTCAGCAGGCATCCGTGTAAGTTGCACCAATCAGCTTGGACAAGGAAAA CGACAGCCTGTGGTATGCACAGGTGGAAGCCCCAGCATAAAGGAAAATATCGGCTCTGTGTTTGGGCAGA AGCAGTTGCAAAGCCTCATTCCTTTTGTTCAGCTGCCCCCTAGTGACTCCGTGTGTGAAGAGTACGGTTT GAGCTGTTCCGATGCTCTGCATAATCTTTTTTACATCTCAGGTTTCATTTCACAATGCACGCATGGAGTT GGAAGGAGTTCAACAGACAGACAGTTTTTCTTTATCAACCGGCGGCCTTGTGACCCAGCAAAGGTCTGCA GACTCGTGAATGAGGTCTACCACATGTATAATCGACACCAGTATCCATTTGTTGTTCTTAACATTTCTGT TGATTCAGAATGCGTTGATATCAATGTTACTCCAGATAAAAGGCAAATTTTGCTACAAGAGGAAAAGCTT TTGTTGGCAGTTTTAAAGACCTCTTTGATAGGAATGTTTGATAGTGATGTCAACAAGCTAAATGTCAGTC AGCAGCCACTGCTGGATGTTGAAGGTAACTTAATAAAAATGCATGCAGCGGATTTGGAAAAGCCCATGGT AGAAAAGCAGGATCAATCCCCTTCATTAAGGACTGGAGAAGAAAAAAAAGACGTGTCCATTTCCAGACTG CGAGAGGCCTTTTCTCTTCGTCACACAACAGAGAACAAGCCTCACAGCCCAAAGACTCCAGAACCAAGAA GGAGCCCTCTAGGACAGAAAAGGGGTATGCTGTCTTCTAGCACTTCAGGTGCCATCTCTGACAAAGGCGT CCTGAGACCTCAGAAAGAGGCAGTGAGTTCCAGTCACGGACCCAGTGACCCTACGGACAGAGCGGAGGTG GAGAAGGACTCGGGGCACGGCAGCACTTCCGTGGATTCTGAGGGGTTCAGCATCCCAGACACGGGCAGTC ACTGCAGCAGCGAGTATGCGGCCAGCTCCCCAGGGGACAGGGGCTCGCAGGAACATGTGGACTCTCAGGA GAAAGCGCCTGAAACTGACGACTCTTTTTCAGATGTGGACTGCCATTCAAACCAGGAAGATACCGGATGT AAATTTCGAGTTTTGCCTCAGCCAACTAATCTCGCAACCCCAAACACAAAGCGTTTTAAAAAAGAAGAAA TTCTTTCCAGTTCTGACATTTGTCAAAAGTTAGTAAATACTCAGGACATGTCAGCCTCTCAGGTTGATGT AGCTGTGAAAATTAATAAGAAAGTTGTGCCCCTGGACTTTTCTATGAGTTCTTTAGCTAAACGAATAAAG CAGTTACATCATGAAGCACAGCAAAGTGAAGGGGAACAGAATTACAGGAAGTTTAGGGCAAAGATTTGTC CTGGAGAAAATCAAGCAGCCGAAGATGAACTAAGAAAAGAGATAAGTAAAACGATGTTTGCAGAAATGGA AATCATTGGTCAGTTTAACCTGGGATTTATAATAACCAAACTGAATGAGGATATCTTCATAGTGGACCAG CATGCCACGGACGAGAAGTATAACTTCGAGATGCTGCAGCAGCACACCGTGCTCCAGGGGCAGAGGCTCA TAGCACCTCAGACTCTCAACTTAACTGCTGTTAATGAAGCTGTTCTGATAGAAAATCTGGAAATATTTAG AAAGAATGGCTTTGATTTTGTTATCGATGAAAATGCTCCAGTCACTGAAAGGGCTAAACTGATTTCCTTG CCAACTAGTAAAAACTGGACCTTCGGACCCCAGGACGTCGATGAACTGATCTTCATGCTGAGCGACAGCC CTGGGGTCATGTGCCGGCCTTCCCGAGTCAAGCAGATGTTTGCCTCCAGAGCCTGCCGGAAGTCGGTGAT GATTGGGACTGCTCTTAACACAAGCGAGATGAAGAAACTGATCACCCACATGGGGGAGATGGACCACCCC TGGAACTGTCCCCATGGAAGGCCAACCATGAGACACATCGCCAACCTGGGTGTCATTTCTCAGAACTGA >OriGene 5' read for NM_000535 unedited
AGAATTTGTATACGACTCATATAGGCGGCCGCGNATTCGGCACGAGGCTGGAGGGAACTT TCCCAGTCCCCGAGGCGGATCGGGTGTTGCATCCATGGAGCGAGCTGAGAGCTCGAGTAC AGAACCTGCTAAGGCCATCAAACCTATTGATCGGAAGTCAGTCCATCAGATTTGCTCTGG GCAGGTGGTACTGAGTCTAAGCACTGCGGTAAAGGAGTTAGTAGAAAACAGTCTGGATGC TGGTGCCACTAATATTGATCTAAAGCTTAAGGACTATGGAGTGGATCTTATTGAAGTTTC AGACAATGGATGTGGGGTAGAAGAAGAAAACTTCGAAGGCTTAACTCTGAAACATCACAC ATCTAAGATTCAAGAGTTTGCTGACCTAACTCAGGTTGAAACTTTTGGCTTTCGGGGGGA AGCTCTGAGCTCACTTTGTGCACTGAGCGATGTCACCATTTCTACCTGCCACGCATCGGC GAAGGTTGGAACTCGACTGATGTTTGATCACAATGGGAAAATTATCCAGAAAACCCCCTA CCCCCGCCCCAGAGGGACCACAGTCAGCGTGCAGCAGTTATTTTCCACACTACCTGTGCG CCATAAGGAATTTCAAAGGAATATTAAGAAGGAGTATGCCAAAATGGTCCAGGTCTTACA TGCATACTGTATCATTTCAGCAGGCATCCGTGTAAGTTGCACCAATCAGCTTGGACAAGG AAAACGACAGCCTGTGGTATGCACAGGTGGAAGCCCCAGCATAAAGGAAAATATCGGCTC TGTGTTTGGGCAGAAGCAGTTGCAAAGCCTCATTCCTTTTGTTCAGCTGCCCCCTAGTGA CTNCGTGTGTGAAGAGTACGGTTTGAGCTGTTCNGATGCTCTGCATAATCTTTTTACATC TCAGGNTTCATTTCACATGCACGCTGGANNTGGGGGNAGTTCACAGACAGACC >OriGene 3' read for NM_000535 unedited
GCCCGAATCTAGAATCGAGTTTTTTTTTTTTTTTTTTGTTTTGGTTTTTGAAACACAGTC TTGCTCTATCTCACCCAGGCTGGAGCGCAGTGGCGCAATCTCGGTTCACTGCAACCTCCG TCTCCCGGGCCCAAGCGATTCTCCCGCCTCAGCCTCCTGGGTAGCGGGGATCACAGGCAT GCGCCAGCACACCTGGCTAATTTTGTATTTTTAGTAAAGGCAGGGTTTCTCCATGTTGGT CAAGCTGGTCTCGAACTTCTGATCTCAGGTGATCCGCCGGCCTCGGCCTCCCAAAGTGCT GCGATCACAGGCATGAGCCACCATGCCCAGCCCAAGTGTTCTTATTTTTATAAAATGTGT TCTTGCCTGGACACACACACACGAGCGCATGCAAACATAGAGAAAAAAAATTTGCAAGCA ATGCTCCATCTGGTTTGAAAAGGGTCTCAAGATCACTTTTAAATGGGTGTGATGTGTATT TTTTTTAAGTAGCAGGTTCATTTCAAAACAAAAAAGGTTAGTGAAGACTCTGTCTTTCAA AACATAAAAATCTGCGATAAAACCAATTATTCCATACAGTGACTACGGTCAGTTCTGAGA AATGACACCCAAGTTGGCGATGTGTCTCATGTTTGGCCTTCCATGGGGACAGTTCCAGAG GTGGTCCATTTCCCCCATGTGGGAGATCAGTTTCTTCATTTCGCTTGTGGTTAAAAGCAG TCCCAATCATTACCGACTTCCGGCAGGGCTCTGTGAGGCAAACATCTGCTTTGACTCTCG GAAAGGCCGGAACAAGAACCCCAAGGCCTGGCGCCCAACCTTGATTATCATTTAATTCAA CGCACTGGGTGCCCGAAGTGCCAATTTCTACATTATTGGCAAGAAAAACATTTATACCCT ATACAAGACTAGAGCACTTCTTTCCGCTAACATAAATAAAGCCACTCCTTTCTTAAATAT TCCCACTATTTTTTTAACAACCCTCCAANATAACCAGGTAGTCGAGAGACTCGAGTGCCT ACAC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000535 |
| Insert Size | 3090 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_000535.3, NP_000526.1 |
| RefSeq Size | 2851 bp |
| RefSeq ORF | 2589 bp |
| Locus ID | 5395 |
| UniProt ID | P54278 |
| Domains | DNA_mis_repair, HATPase_c |
| Protein Families | Druggable Genome |
| Protein Pathways | Mismatch repair |
| Gene Summary | The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016] Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC210880 | PMS2 (Myc-DDK-tagged)-Human PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2), transcript variant 1 |
CNY 9,472.00 |
|
| RC210880L1 | Lenti ORF clone of Human PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2), transcript variant 1, Myc-DDK-tagged |
CNY 11,872.00 |
|
| RC210880L2 | Lenti ORF clone of Human PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2), transcript variant 1, mGFP tagged |
CNY 9,030.00 |
|
| RC210880L3 | Lenti ORF clone of Human PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2), transcript variant 1, Myc-DDK-tagged |
CNY 11,872.00 |
|
| RC210880L4 | Lenti ORF clone of Human PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2), transcript variant 1, mGFP tagged |
CNY 9,030.00 |
|
| RG210880 | PMS2 (tGFP-tagged) - Human PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2), transcript variant 1 |
CNY 7,890.00 |
