United States
Germany
Japan
United Kingdom
China
Fas Ligand (FASLG) (NM_000639) Human Untagged Clone
CAT＃: SC119739
FASLG (untagged)-Human Fas ligand (TNF superfamily, member 6) (FASLG)
CNY 3,600.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ALPS1B; APT1LG1; APTL; CD95-L; CD95L; CD178; FASL; TNFSF6; TNLG1A |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC119739 sequence for NM_000639 edited (data generated by NextGen Sequencing)
ATGCAGCAGCCCTTCAATTACCCATATCCCCAGATCTACTGGGTGGACAGCAGTGCCAGC TCTCCCTGGGCCCCTCCAGGCACAGTTCTTCCCTGTCCAACCTCTGTGCCCAGAAGGCCT GGTCAAAGGAGGCCACCACCACCACCGCCACCGCCACCACTACCACCTCCGCCGCCGCCG CCACCACTGCCTCCACTACCGCTGCCACCCCTGAAGAAGAGAGGGAACCACAGCACAGGC CTGTGTCTCCTTGTGATGTTTTTCATGGTTCTGGTTGCCTTGGTAGGATTGGGCCTGGGG ATGTTTCAGCTCTTCCACCTACAGAAGGAGCTGGCAGAACTCCGAGAGTCTACCAGCCAG ATGCACACAGCATCATCTTTGGAGAAGCAAATAGGCCACCCCAGTCCACCCCCTGAAAAA AAGGAGCTGAGGAAAGTGGCCCATTTAACAGGCAAGTCCAACTCAAGGTCCATGCCTCTG GAATGGGAAGACACCTATGGAATTGTCCTGCTTTCTGGAGTGAAGTATAAGAAGGGTGGC CTTGTGATCAATGAAACTGGGCTGTACTTTGTATATTCCAAAGTATACTTCCGGGGTCAA TCTTGCAACAACCTGCCCCTGAGCCACAAGGTCTACATGAGGAACTCTAAGTATCCCCAG GATCTGGTGATGATGGAGGGGAAGATGATGAGCTACTGCACTACTGGGCAGATGTGGGCC CGCAGCAGCTACCTGGGGGCAGTGTTCAATCTTACCAGTGCTGATCATTTATATGTCAAC GTATCTGAGCTCTCTCTGGTCAATTTTGAGGAATCTCAGACGTTTTTCGGCTTATATAAG CTCTAA Clone variation with respect to NM_000639.1 >OriGene 5' read for NM_000639 unedited
TAAGTCATATTTGTATACGACTCATATAGGCGGCCGACGAATTCGCACCAGGTCCTTGAC ACCTCAGCCTCTAAGGACTGAGAAGAAGTAAAACCGTTTGCTGGGGCTGGCCTGACTCAC CAGCTGCCATGCAGCAGCCCTTCAATTACCCATATCCCCAGATCTACTGGGTGGACAGCA GTGCCAGCTCTCCCTGGGCCCCTCCAGGCACAGTTCTTCCCTGTCCAACCTCTGTGCCCA GAAGGCCTGGTCAAAGGAGGCCACCACCACCACCGCCACCGCCACCACTACCACCTCCGC CGCCGCCGCCACCACTGCCTCCACTACCGCTGCCACCCCTGAAGAAGAGAGGGAACCACA GCACAGGCCTGTGTCTCCTTGTGATGTTTTTCATGGTTCTGGTTGCCTTGGTAGGATTGG GCCTGGGGATGTTTCAGCTCTTCCACCTACAGAAGGAGCTGGCAGAACTCCGAGAGTCTA CCAGCCAGATGCACACAGCATCATCTTTGGAGAAGCAAATAGGCCACCCCAGTCCACCCC CTGAAAAAAAGGAGCTGAGGAAAGTGGCCCATTTAACAGGCAAGTCCAACTCAAGGTCCA TGCCTCTGGAATGGGAAGACACCTATGGAATTGTCCTGCTTTCTGGAGTGAAGTATAAGA AGGGTGGCCTTGTGATCAATGAAACTGGGCTGTACTTTGTATATTCCAAAGTATACTTCC GGAGTCAATCTTGCAACAACCTGCCCCTGAGCCACAAGGTCTACATGATGAAACTCTAGT ANTCCCAGGATCTGGTGATGATGGAGGGGGAAGATGATGAGCTACTGCACTACTGGGCAG ATGTGGGCCCGCAGCAGCTACCTGGGGGCAGTGGTCAATCTTACCCAGTGCTGATCATTA TATGT >OriGene 3' read for NM_000639 unedited
NAAANTTTAGCTTTGGACCCGCGGCCGCATNCTAGNGATCGGTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTTTTTTTTTTAATTGGGACCCAAACATAAACTTTTTATTAC AGGTTTTCATTTCACAAAAAGGCCCATCTCCCTAAATTTTTATTATTTTATAGGAAAACA TCTTTAGTAGCTGACAATCAAGGATTTTTAAGCCCTTTTAAAGTTGATTGTCAGGAACCA TTCAAAATTTTGACCAAAGGCAACCCATATTTTCCTAATATGGCCTTCACAATATCTACA TTCTTTTTTTAGTCATACACACACACACCCACACACCCCCACACCCCCCCTTACAATGGG ACTGGAAATACCCATGCTGGGTTAGGAATGAAATGAGTCCCCAAAACATTTCTTTTGCTT ATCTGGAAGTTCCACCGAGGGCTCAGGATTTGCTTTTAAAAGGGAAAATGCTGCCAGGGG GGCATTGGCCTTTTTCACCCTTTTTAGCTTATTATGCAAGCCTCTAGTCTTCCTTTTCCA TCCCTTAAATCCTCAGGGCACAACCATGTTTCTGAAAAACAGCCCCCCTTGAGGTAGCAA GGCCCACCTTGAGAGGGGAGTTAAAAGGGGTCCTTTTCAATCTGCCTAAATACTCTCAGG CCCTAAGATGAGGTGAAAAACACCTGGGANCGGGTTTTTAATGCTTCCCCCCTCTTAACA GGGGAGCCCAAGAGTTCTATGGTCCTCCGCACATATCCCCCCCTTTGGGGGGGCGTCATA ACCCTTAGGGGGAAGTTGGAGGGAGCTCCAAAACATTTGAACCCCCGTGGGGTCCAAAGG GGCCACTTGGGTTCTAGGTTTTTTTACCCTGGCCCCAAAAGGCGTTGAAAAAAACCCTTC CCTGGAAACACAATTTCTGGGGGCTGGTAAACAAAAATTTATAGGGAAGAATC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000639 |
| Insert Size | 1790 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000639.1, NP_000630.1 |
| RefSeq Size | 1909 bp |
| RefSeq ORF | 846 bp |
| Locus ID | 356 |
| UniProt ID | P48023 |
| Domains | TNF |
| Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
| Protein Pathways | Allograft rejection, Apoptosis, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Pathways in cancer, Type I diabetes mellitus |
| Gene Summary | This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Foxo3a Regulates Apoptosis by Negatively Targeting miR-21
,Kun Wang and Pei-Feng Li,
J. Biol. Chem., May 2010; 285: 16958 - 16966
[FASLG]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC204894 | FASLG (Myc-DDK-tagged)-Human Fas ligand (TNF superfamily, member 6) (FASLG) |
CNY 3,600.00 |
|
| RC204894L1 | Lenti ORF clone of Human Fas ligand (TNF superfamily, member 6) (FASLG), Myc-DDK-tagged |
CNY 6,000.00 |
|
| RC204894L2 | Lenti ORF clone of Human Fas ligand (TNF superfamily, member 6) (FASLG), mGFP tagged |
CNY 5,890.00 |
|
| RC204894L3 | Lenti ORF clone of Human Fas ligand (TNF superfamily, member 6) (FASLG), Myc-DDK-tagged |
CNY 6,000.00 |
|
| RC204894L4 | Lenti ORF clone of Human Fas ligand (TNF superfamily, member 6) (FASLG), mGFP tagged |
CNY 6,000.00 |
|
| RG204894 | FASLG (tGFP-tagged) - Human Fas ligand (TNF superfamily, member 6) (FASLG) |
CNY 5,200.00 |
|
| SC320927 | FASLG (untagged)-Human Fas ligand (TNF superfamily, member 6) (FASLG) |
CNY 3,600.00 |
其它Fas Ligand产品
