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Sodium Potassium ATPase (ATP1A1) (NM_000701) Human Untagged Clone
CAT＃: SC119714
ATP1A1 (untagged)-Human ATPase, Na+/K+ transporting, alpha 1 polypeptide (ATP1A1), transcript variant 1
CNY 7,128.00
| Cited in 4 publications. |
Product images
CNY 5,381.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CMT2DD; HOMGSMR2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_000701, the custom clone sequence may differ by one or more nucleotides
ATGGGGAAGGGGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAAGGGCA AAAAGGGCAAAAAAGACAGGGACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAG CCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGCCGGGGATTAACATCTGCTCGTGCAGCTGAG ATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATCAAGTTTTGTC GGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCAT CCAAGCTGCTACAGAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTA ATCATAACTGGTTGCTTCTCCTACTATCAAGAAGCTAAAAGTTCAAAGATCATGGAATCCTTCAAAAACA TGGTCCCTCAGCAAGCCCTTGTGATTCGAAATGGTGAGAAAATGAGCATAAATGCGGAGGAAGTTGTGGT TGGGGATCTGGTGGAAGTAAAAGGAGGAGACCGAATTCCTGCTGACCTCAGAATCATATCTGCAAATGGC TGCAAGGTGGATAACTCCTCGCTCACTGGTGAATCAGAACCCCAGACTAGGTCTCCAGATTTCACAAATG AAAACCCCCTGGAGACGAGGAACATTGCCTTCTTTTCAACCAATTGTGTTGAAGGCACCGCACGTGGTAT TGTTGTCTACACTGGGGATCGCACTGTGATGGGAAGAATTGCCACACTTGCTTCTGGGCTGGAAGGAGGC CAGACCCCCATTGCTGCAGAAATTGAACATTTTATCCACATCATCACGGGTGTGGCTGTGTTCCTGGGTG TGTCTTTCTTCATCCTTTCTCTCATCCTTGAGTACACCTGGCTTGAGGCTGTCATCTTCCTCATCGGTAT CATCGTAGCCAATGTGCCGGAAGGTTTGCTGGCCACTGTCACGGTCTGTCTGACACTTACTGCCAAACGC ATGGCAAGGAAAAACTGCTTAGTGAAGAACTTAGAAGCTGTGGAGACCTTGGGGTCCACGTCCACCATCT GCTCTGATAAAACTGGAACTCTGACTCAGAACCGGATGACAGTGGCCCACATGTGGTTTGACAATCAAAT CCATGAAGCTGATACGACAGAGAATCAGAGTGGTGTCTCTTTTGACAAGACTTCAGCTACCTGGCTTGCT CTGTCCAGAATTGCAGGTCTTTGTAACAGGGCAGTGTTTCAGGCTAACCAGGAAAACCTACCTATTCTTA AGCGGGCAGTTGCAGGAGATGCCTCTGAGTCAGCACTCTTAAAGTGCATAGAGCTGTGCTGTGGTTCCGT GAAGGAGATGAGAGAAAGATACGCCAAAATCGTCGAGATACCCTTCAACTCCACCAACAAGTACCAGTTG TCTATTCATAAGAACCCCAACACATCGGAGCCCCAACACCTGTTGGTGATGAAGGGCGCCCCAGAAAGGA TCCTAGACCGTTGCAGCTCTATCCTCCTCCACGGCAAGGAGCAGCCCCTGGATGAGGAGCTGAAAGACGC CTTTCAGAACGCCTATTTGGAGCTGGGGGGCCTCGGAGAACGAGTCCTAGGTTTCTGCCACCTCTTTCTG CCAGATGAACAGTTTCCTGAAGGGTTCCAGTTTGACACTGACGATGTGAATTTCCCTATCGATAATCTGT GCTTTGTTGGGCTCATCTCCATGATTGACCCTCCACGGGCGGCCGTTCCTGATGCCGTGGGCAAATGTCG AAGTGCTGGAATTAAGGTCATCATGGTCACAGGAGACCATCCAATCACAGCTAAAGCTATTGCCAAAGGT GTGGGCATCATCTCAGAAGGCAATGAGACCGTGGAAGACATTGCTGCCCGCCTCAACATCCCAGTCAGCC AGGTGAACCCCAGGGATGCCAAGGCCTGCGTAGTACACGGCAGTGATCTAAAGGACATGACCTCCGAGCA GCTGGATGACATTTTGAAGTACCACACTGAGATAGTGTTTGCCAGGACCTCCCCTCAGCAGAAGCTCATC ATTGTGGAAGGCTGCCAAAGACAGGGTGCTATCGTGGCTGTGACTGGTGACGGTGTGAATGACTCTCCAG CTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGGATTGCTGGCTCAGATGTGTCCAAGCAAGCTGCTGA CATGATTCTTCTGGATGACAACTTTGCCTCAATTGTGACTGGAGTAGAGGAAGGTCGTCTGATCTTTGAT AACTTGAAGAAATCCATTGCTTATACCTTAACCAGTAACATTCCCGAGATCACCCCGTTCCTGATATTTA TTATTGCAAACATTCCACTACCACTGGGGACTGTCACCATCCTCTGCATTGACTTGGGCACTGACATGGT TCCTGCCATCTCCCTGGCTTATGAGCAGGCTGAGAGTGACATCATGAAGAGACAGCCCAGAAATCCCAAA ACAGACAAACTTGTGAATGAGCGGCTGATCAGCATGGCCTATGGGCAGATTGGAATGATCCAGGCCCTGG GAGGCTTCTTTACTTACTTTGTGATTCTGGCTGAGAACGGCTTCCTCCCAATTCACCTGTTGGGCCTCCG AGTGGACTGGGATGACCGCTGGATCAACGATGTGGAAGACAGCTACGGGCAGCAGTGGACCTATGAGCAG AGGAAAATCGTGGAGTTCACCTGCCACACAGCCTTCTTCGTCAGTATCGTGGTGGTGCAGTGGGCCGACT TGGTCATCTGTAAGACCAGGAGGAATTCGGTCTTCCAGCAGGGGATGAAGAACAAGATCTTGATATTTGG CCTCTTTGAAGAGACAGCCCTGGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGTGTTGCTCTTAGGATG TATCCCCTCAAACCTACCTGGTGGTTCTGTGCCTTCCCCTACTCTCTTCTCATCTTCGTATATGACGAAG TCAGAAAACTCATCATCAGGCGACGCCCTGGCGGCTGGGTGGAGAAGGAAACCTACTATTAG >OriGene 5' read for NM_000701 unedited
GCACATTTGTATACGACTCATATAGGGCGGCCGCGAATTCGCACGAGGGCTCCCTCCCTT GGCTCCCCTGGTCCCGCTCGCTCGGCCGGGAGCTGCTCTGTGCTTTTCTCTCTGATTCTC CAGCGACAGGACCCGGCGCCGGGCACTGAGCACCGCCACCATGGGGAAGGGGGTTGGACG TGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAAGGGCAAAAAGGGCAA AAAAGACAGGGACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAG CCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGCCGGGGATTAACATCTGCTCG TGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCC TGAATGGATCAAGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGG AGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCTACAGAAGAGGAACCTCAAAA CGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTAATCATAACTGGTTGCTTCTC CTACTATCAAGAAGCTAAAAGTTCAAAGATCATGGAATCCTTCAAAAACATGGTCCCTCA GCAAGCCCTTGTGATTCGAAATGGTGAGAAAATGAGCATAAATGCGGAGGAAGTTGTGGT TGGGGATCTGGTGGAAGTAAAAGGGAGGAGACCGATTCCTGCTGACCTCAGAATCATATC TGCANATGGCTGCAAGGTGGATAACTCCTCGCTCACTGGTGAATCAGAACCCCAGACTAN GTCTNNCAGATTCACAAATGANAACCCCCTGGAGACGAGAACATTGNCTTCTTTTCANCN ANTGTGTTGAAGGCACGNACGTGGTATGTTGT >OriGene 3' read for NM_000701 unedited
GAACGCGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTCCATTATAATAGCCAT CTTTATTTGTAAAAATCCAGATATAAAATGTATTCTTTCAGTCTTTCCGGGTGTTCCTTT TTTACAAAAACAAAAAGGCACATAAAAACCTTCCCCGCTGTCATTTCCACAGATGGATGG TTTTCAGGCAGCCCTCCCCCCTCCCCCCATAGAGCTACATGCTTCATTCCAGGACGTCTT GCTTCCCCACATGCTGCGGTGCTTTCCTACCAGGGTAGAGTTCCAAACTCCAAGACTGAA GTACACAAAGAGGGGGTGGGTGTCGGATGCAAAGTGTGTGGCCTGATGCTCCACGGCGTG CAGGACGGGGGGCTAATAGTAGGTTTCCTTCTCCACCCAGCCGCCAGGGCGTCGCCTGAT GATGAGTTTTCTGACTTCGTCATATACGAAGATGACAAGAGAGTAGGGGAAGGCACAGAA CCACCAGGTAGGTTTGAGGGGATACATCCTAAGAGCAACACCCATTCCAGGGCAGTAGGA AAGGAAAGCAGCCAGGGCTGTCTTTTTCAAAGAGGCCAAATATCAAGATCTTGTTCTTCA TCCCCTGCCTGAAAGACCGAATTCCTCCTGGTCTAACAGATGACCAAGTCGGCCCACTGC ACCACCACGATACTGACGAAGAAAGCTGTGTGGCAGGGGAACTCCAGATTTTCCTTTGTT ATAAGCCCCCTGCTGCCCGAACTTGTTTTCCAATCGTTATCCAGCGGCCATCCAGTCCCT CCGGAGCCCCACAGGGGAATGGGAAGAAACCGTTTTCAACCCCAAACACAAATAATTAAA AAATCCTCCCAGGCCTGGATCTATCTATTTCCCTTAGGCCTGCTGAACAACCC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000701 |
| Insert Size | 4040 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000701.6, NP_000692.2 |
| RefSeq Size | 3713 bp |
| RefSeq ORF | 3072 bp |
| Locus ID | 476 |
| UniProt ID | P05023 |
| Domains | E1-E2_ATPase, Cation_ATPase_N, Hydrolase, Cation_ATPase_C |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Cardiac muscle contraction |
| Gene Summary | The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] Transcript Variant: This variant (1) represents use of an alternate promoter and 5' exon, compared to variant 3. The resulting isoform (a) is the same length but has a distinct N-terminus, compared to isoform c. |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
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The glycoside oleandrin reduces glioma growth with direct and indirect effects on tumor cells
,Garofalo, S;Grimaldi, A;Chece, G;Porzia, A;Morrone, S;Mainiero, F;D'Alessandro, G;Esposito, V;Cortese, B;Di Angelantonio, S;Trettel, F;Limatola, C;,
J. Neurosci
,PubMed ID 28292827
[ATp1A1]
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Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension
,Elena A B Azizan, Hanne Poulsen, Petronel Tuluc, Junhua Zhou, Michael V Clausen, Andreas Lieb, Carmela Maniero, Sumedha Garg, Elena G Bochukova, Wanfeng Zhao, Lalarukh Haris Shaikh, Cheryl A Brighton, Ada E D Teo, Anthony P Davenport, Tanja Dekkers, Bas Tops, Benno Küsters, Jiri Ceral, Giles S H Yeo, Sudeshna Guha Neogi, Ian McFarlane, Nitzan Rosenfeld, Francesco Marass, James Hadfield, Wojciech Margas, Kanchan Chaggar, Miroslav Solar, Jaap Deinum, Annette C Dolphin, I Sadaf Farooqi, Joerg Striessnig, Poul Nissen & Morris J Brown – Show fewer authors,
Nature Genetics 45, 1055-1060 doi:10.1038/ng.2716
,PubMed ID 23913004
[ATP1A1]
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The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations
,J. Preben Morth, Hanne Poulsen, Mads S Toustrup-Jensen, Vivien Rodacker Schack, Jan Egebjerg, Jens Peter Andersen, Bente Vilsen, and Poul Nissen,
Phil Trans R Soc B, Jan 2009; 364: 217 - 227.
[ATP1A1]
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Reciprocal Modulation of Function between the D1 and D2 Dopamine Receptors and the Na+,K+-ATPase
,Lisa A. Hazelwood, R. Benjamin Free, David M. Cabrera, Mette Skinbjerg, and David R. Sibley,
J. Biol. Chem., Dec 2008; 283: 36441 - 36453.
[ATP1A1]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC201009 | ATP1A1 (Myc-DDK-tagged)-Human ATPase, Na+/K+ transporting, alpha 1 polypeptide (ATP1A1), transcript variant 1 |
CNY 7,128.00 |
|
| RC201009L1 | Lenti ORF clone of Human ATPase, Na+/K+ transporting, alpha 1 polypeptide (ATP1A1), transcript variant 1, Myc-DDK-tagged |
CNY 9,528.00 |
|
| RC201009L2 | Lenti ORF clone of Human ATPase, Na+/K+ transporting, alpha 1 polypeptide (ATP1A1), transcript variant 1, mGFP tagged |
CNY 10,640.00 |
|
| RC201009L3 | Lenti ORF clone of Human ATPase, Na+/K+ transporting, alpha 1 polypeptide (ATP1A1), transcript variant 1, Myc-DDK-tagged |
CNY 9,528.00 |
|
| RC201009L4 | Lenti ORF clone of Human ATPase, Na+/K+ transporting, alpha 1 polypeptide (ATP1A1), transcript variant 1, mGFP tagged |
CNY 9,528.00 |
|
| RG201009 | ATP1A1 (tGFP-tagged) - Human ATPase, Na+/K+ transporting, alpha 1 polypeptide (ATP1A1), transcript variant 1 |
CNY 8,728.00 |
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