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cIAP2 (BIRC3) (NM_001165) Human Untagged Clone
CAT＃: SC119402
BIRC3 (untagged)-Human baculoviral IAP repeat containing 3 (BIRC3), transcript variant 1
CNY 6,752.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1; IAP-1; MALT2; MIHC; RNF49 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC119402 sequence for NM_001165 edited (data generated by NextGen Sequencing)
ATGAACATAGTAGAAAACAGCATATTCTTATCAAATTTGATGAAAAGCGCCAACACGTTT GAACTGAAATACGACTTGTCATGTGAACTGTACCGAATGTCTACGTATTCCACTTTTCCT GCTGGGGTTCCTGTCTCAGAAAGGAGTCTTGCTCGTGCTGGTTTCTATTACACTGGTGTG AATGACAAGGTCAAATGCTTCTGTTGTGGCCTGATGCTGGATAACTGGAAAAGAGGAGAC AGTCCTACTGAAAAGCATAAAAAGTTGTATCCTAGCTGCAGATTCGTTCAGAGTCTAAAT TCCGTTAACAACTTGGAAGCTACCTCTCAGCCTACTTTTCCTTCTTCAGTAACAAATTCC ACACACTCATTACTTCCGGGTACAGAAAACAGTGGATATTTCCGTGGCTCTTATTCAAAC TCTCCATCAAATCCTGTAAACTCCAGAGCAAATCAAGATTTTTCTGCCTTGATGAGAAGT TCCTACCACTGTGCAATGAATAACGAAAATGCCAGATTACTTACTTTTCAGACATGGCCA TTGACTTTTCTGTCGCCAACAGATCTGGCAAAAGCAGGCTTTTACTACATAGGACCTGGA GACAGAGTGGCTTGCTTTGCCTGTGGTGGAAAATTGAGCAATTGGGAACCGAAGGATAAT GCTATGTCAGAACACCTGAGACATTTTCCCAAATGCCCATTTATAGAAAATCAGCTTCAA GACACTTCAAGATACACAGTTTCTAATCTGAGCATGCAGACACATGCAGCCCGCTTTAAA ACATTCTTTAACTGGCCCTCTAGTGTTCTAGTTAATCCTGAGCAGCTTGCAAGTGCGGGT TTTTATTATGTGGGTAACAGTGATGATGTCAAATGCTTTTGCTGTGATGGTGGACTCAGG TGTTGGGAATCTGGAGATGATCCATGGGTTCAACATGCCAAGTGGTTTCCAAGGTGTGAG TACTTGATAAGAATTAAAGGACAGGAGTTCATCCGTCAAGTTCAAGCCAGTTACCCTCAT CTACTTGAACAGCTGCTATCCACATCAGACAGCCCAGGAGATGAAAATGCAGAGTCATCA ATTATCCATTTTGAACCTGGAGAAGACCATTCAGAAGATGCAATCATGATGAATACTCCT GTGATTAATGCTGCCGTGGAAATGGGCTTTAGTAGAAGCCTGGTAAAACAGACAGTTCAG AGAAAAATCCTAGCAACTGGAGAGAATTATAGACTAGTCAATGATCTTGTGTTAGACTTA CTCAATGCAGAAGATGAAATAAGGGAAGAGGAGAGAGAAAGAGCAACTGAGGAAAAAGAA TCAAATGATTTATTATTAATCCGGAAGAATAGAATGGCACTTTTTCAACATTTGACTTGT GTAATTCCAATCCTGGATAGTCTACTAACTGCCGGAATTATTAATGAACAAGAACATGAT GTTATTAAACAGAAGACACAGACGTCTTTACAAGCAAGAGAACTGATTGATACGATTTTA GTAAAAGGAAATATTGCAGCCACTGTATTCAGAAACTCTCTGCAAGAAGCTGAAGCTGTG TTATATGAGCATTTATTTGTGCAACAGGACATAAAATATATTCCCACAGAAGATGTTTCA GATCTACCAGTGGAAGAACAATTGCGGAGACTACAAGAAGAAAGAACATGTAAAGTGTGT ATGGACAAAGAAGTGTCCATAGTGTTTATTCCTTGTGGTCATCTAGTAGTATGCAAAGAT TGTGCTCCTTCTTTAAGAAAGTGTCCTATTTGTAGGAGTACAATCAAGGGTACAGTTCGT ACATTTCTTTCATGA Clone variation with respect to NM_001165.4 >OriGene 5' read for NM_001165 unedited
GCGTTCAAATTTTGTAATACGACTCACTATAGGGCGGCCGACGAATTCGCACGAGGAAAG ATATACAAAGGTGCAATTGTGTATTTCTTCCTTAAAAGTATCAGTATAGGATTTAGAATC TCCATGTTGAAACTCTAAATGCATAGAAATAAAAATAATAAAAAATTTTTCATTTTGGCT TTTCAGCCTAGTATTAAAACTGATAAAAGCAAAGCCATGCACAAAACTACCTCCCTAGAG AAAGGCTAGTCCCTTTTCTTCCCCATTCATTTCATTATGAACATAGTAGAAAACAGCATA TTCTTATCAAATTTGATGAAAAGCGCCAACACGTTTGAACTGAAATACGACTTGTCATGT GAACTGTACCGAATGTCTACGTATTCCACTTTTCCTGCTGGGGTTCCTGTCTCATAAAGG AGTCTTGCTCGTGCTGGTTTCTATTACACTGGTGTGAATGACAAGGTCAAATGCTTCTGT TGTGGCCTGATGCTGGATAACTGGAAAAGAGGAGACAGTCCTACTGAAAAGCATAAAAAG TTGTATCCTAGCTGCAGATTCGTTCAGAGTCTAAATTCCGTTAACAACTTGGAAGCTACC TCTCAGCCTACTTTTCCTTCTTCAGTAACAAATTCCACACACTCATTACTTCCGGGTACA GAAAACAGTGGATANTTTCCGTNGGCTCTTATTCAAACTCTCCATCAAATCCTGTAAACT CCAGAGCANATCAAGATTTTTCTGCCTTGATGAGAAGTTCCTACCACTGGTGCATGAATA ACGAANATGCCAGATTACTTACTTTTCAGAATGGCCATTGACTTTTCTGTCGCCAACAGA TCTGGGCAAAGCANGCTTTTACTACATANGACCTGGANACAGAGTGGCTTGCTTTGCCTG TGNTGGAAAAATGAGCATTNGGAACCGAAGATT >OriGene 3' read for NM_001165 unedited
GGGGGCGCGNNNNNGNNNTTTTCNNNNNNNNNNTTTTGTTTAGNACCNCGGNCCCGCATN TAANNGATCGGTTTTTTTTTTTTTTTTTTAAAATAATTTTTGTTGCTTTATTAAATTTTT TCTCACAGAATTCTTTATAAAAACACCATGGTCCCTAAAATGTCATTCAACATATATGCA CACCTTCGATGTATAGGACACTGATCAAAAAAGACAGAGAAATGTGTCCCTGGTGTTTTG TTTTTGTTCTGTTTGTTTTTAAAGGCAGGGTCTCAGTATGCTGCCCAGGATGGATTCAAA CTCCTGGGCTCAAGTAATTCTCTTGCCTCAGCCTGGGACTACAGGCACATACCACCACAC CTGGCTTCATGTTCCCGGTATTAGTACAATGCCAAAATATTTAAAATTCTTAAAGGTTAA CTCAAATATCTTAAGTTTTACTTCACTTACAATTTCAATAATGCTGAAATTTTGATTGAA TATTGTGTTTGTAGTGCTACCTCTTTTTCGTTCATAAGAACAAAAGCCTATCATTCTCTT AGTTTCTAAAAAATATATGTTCATATGGTTTAGATACATATATAAATATGTTACACANAA CAATGTTTTTTGAGTTGTAAATAAATAAAAATTTTAAGGAAACCAAATAGGATAAAAGTT AAAGNTATAATACATTTAATAAATTAATTCTAAAGNTTAGATGATGNTTTGGTTCTTCCT CATGAAAGAAATGTACGAACTGTACCCCTTGGATGGACTCCTACAAATAGACAACTTTCT AAANGAANGAGCCCAATCTTTGCCTACTACTAGATGACCCCAGGAATAAAACCCTTTGGA CACTCCTTTGNCCATACCACTTTACAATGTCTTTCTCCTGAAGCCTCCGCAATTGTTCTT CCACTGTAAGAACTGAAACATCTTCTGGGGGAATTAATTTATGCCCTGTTGCCCAAAAAA TGCCAATTACCAAGTTTAACTTTCTTGAAAAAGGTTTGAAACAAGGGCTGAAATTTCCTT TACTAAAACGAAAATCATTTCTTGCTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001165 |
| Insert Size | 2620 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001165.3, NP_001156.1 |
| RefSeq Size | 5243 bp |
| RefSeq ORF | 1815 bp |
| Locus ID | 330 |
| UniProt ID | Q13489 |
| Domains | CARD, BIR, RING |
| Protein Families | Druggable Genome |
| Protein Pathways | Apoptosis, Focal adhesion, NOD-like receptor signaling pathway, Pathways in cancer, Small cell lung cancer, Ubiquitin mediated proteolysis |
| Gene Summary | This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011] Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival
,Calandria, JM;Asatryan, A;Balaszczuk, V;Knott, EJ;Jun, BK;Mukherjee, PK;Belayev, L;Bazan, NG;,
Cell Death Differ.
,PubMed ID 25633199
[BIRC3]
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