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Caspase 9 (CASP9) (NM_001229) Human Untagged Clone
CAT＃: SC119362
CASP9 (untagged)-Human caspase 9, apoptosis-related cysteine peptidase (CASP9), transcript variant alpha
CNY 3,656.00
| Cited in 5 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_001229 edited
GAATTCGGCACGAGGCCGAGGCCCGGAAGCGGACTGAGGCGGCCTGGAGTCTTAGTTGGC TACTCGCCATGGACGAAGCGGATCGGCGGCTCCTGCGGCGGTGCCGGCTGCGGCTGGTGG AAGAGCTGCAGGTGGACCAGCTCTGGGACGTCCTGCTGAGCCGCGAGCTGTTCAGGCCCC ATATGATCGAGGACATCCAGCGGGCAGGCTCTGGATCTCGGCGGGATCAGGCCAGGCAGC TGATCATAGATCTGGAGACTCGAGGGAGTCAGGCTCTTCCTTTGTTCATCTCCTGCTTAG AGGACACAGGCCAGGACATGCTGGCTTCGTTTCTGCGAACTAACAGGCAAGCAGCAAAGT TGTCGAAGCCAACCCTAGAAAACCTTACCCCAGTGGTGCTCAGACCAGAGATTCGCAAAC CAGAGGTTCTCAGACCGGAAACACCCAGACCAGTGGACATTGGTTCTGGAGGATTCGGTG ATGTCGGTGCTCTTGAGAGTTTGAGGGGAAATGCAGATTTGGCTTACATCCTGAGCATGG AGCCCTGTGGCCACTGCCTCATTATCAACAATGTGAACTTCTGCCGTGAGTCCGGGCTCC GCACCCGCACTGGCTCCAACATCGACTGTGAGAAGTTGCGGCGTCGCTTCTCCTCGCTGC ATTTCATGGTGGAGGTGAAGGGCGACCTGACTGCCAAGAAAATGGTGCTGGCTTTGCTGG AGCTGGCGCGGCAGGACCACGGTGCTCTGGACTGCTGCGTGGTGGTCATTCTCTCTCACG GCTGTCAGGCCAGCCACCTGCAGTTCCCAGGGGCTGTCTACGGCACAGATGGATGCCCTG TGTCGGTCGAGAAGATTGTGAACATCTTCAATGGGACCAGCTGCCCCAGCCTGGGAGGGA AGCCCAAGCTCTTTTTCATCCAGGCCTGTGGTGGGGAGCAGAAAGACCATGGGTTTGAGG TGGCCTCCACTTCCCCTGAAGACGAGTCCCCTGGCAGTAACCCCGAGCCAGATGCCACCC CGTTCCAGGAAGGTTTGAGGACCTTCGACCAGCTGGACGCCATATCTAGTTTGCCCACAC CCAGTGACATCTTTGTGTCCTACTCTACTTTCCCAGGTTTTGTTTCCTGGAGGGACCCCA AGAGTGGCTCCTGGTACGTTGAGACCCTGGACGACATCTTTGAGCAGTGGGCTCACTCTG AAGACCTGCAGTCCCTCCTGCTTAGGGTCGCTAATGCTGTTTCGGTGAAAGGGATTTATA AACAGATGCCTGGTTGCTTTAATTTCCTCCGGAAAAAACTTTTCTTTAAAACATCATAAG GCCAGGGCCCCTCACCCTGCCTTATCTTGCACCCCAAAGCTTTCCTGCCCCAGGCCTGAA AGAGGCTGAGGCCTGGACTTTCCTGCAACTCAAGGACTTTGCAGCCGGCACAGGGTCTGC TCTTTCTCTGCCAGTGACAGACAGGCTCTTAGCAGCTTCCAGATTGACGACAAGTGCTGA ACAGTGGAGGAAGAGGGACAGATGAATGCCGTGGATTGCACGTGGCCTCTTGAGCAGTGG CTGGTCCAGGGCTAGTGACTTGTGTCCCATGATCCCTGTGTTGTCTCTAGAGCAGGGATT AACCTCTGCACTACTGACATGTGGGGCCAGGTCACCCTTTGCTGTGAGGCTGTCCTGTAC ATTGTGGGATGTTCAGCACTGTCCCTTGCCTCAATGCCAGTAACGCGTCTTCCTGAGTGG TGCCAAACAAAAAGGTTCTCAGGTGTTGCCAAATATGTCCTGGGGTATAAAACTTTCCTC GCCTGACAACCACTGGTCTGTAGGGATTTTTGGCTACACACAAACCAGTATCGCTCATAG ATCAGCAAACCGGGGCCTACTAGAGTCTGAACAGCTGTAATCTATGAATTCTAAGTGAAA TTTTAAAAATTGTTAATTTTTCCTATATTGCATTAATTTTAAAAAATAAATCTGAGGCAA ATATGGACTCTCTTTTGCCTATTTCTTCCCTCATTTTGCTCCAACTCTTTCTTCTTCCTT ACAAAAGAGACTTTTGCTTTTTTCGAAACATTTCCCCATGTTTTTCTGGGGTCTCGCTAT GTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGTGACCCTCCCAAGTAGCTCTTACTA CAGGCGTGCACCATTGCACCCAGCCCCATTTATTCATGTCTTATTTCACTTGATCCTTAT CCCATCCCAGGAAGGCAACAAGGGTGAGAACCCTGTGCTCAGGGAGGTTAGGTCTCTTGT CCAAGGGAAAACGATTATCCAGAGAAGAGACCTGGCCAGAACCTGGGTCCCCTGAGTCCT AGCCATGCTTCCCATGTGCCTTACTTGCTGAAGCACCCCCGGACTGCAGTGTGAACGTGC TGTGCAATAGTGACACGCTGGGCTTCCCCACAXXXXXXXXXXXXXXXXXXXAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_001229 unedited
CAGATTTTGTATACACTCACTATAGGCGGCCGCGATTCGGCACGAGGCCGAGGCCCGGAA GCGGACTGAGGCGGCCTGGAGTCTTATTTGGCTACTCGCCATGGACGAAGCGGATCGGCG GCTCCTGCGGCGGTGCCGGCTGCGGCTGGTGGAATATCTGCAGGTGGACCAGCTCTGGGA CGTCCTGCTGAGCCGCGAGCTGTTCATGCCCCATATGATCGAGGACATCCAGCGGGCAGG CTCTGGATCTCGGCGGGATCAGGCCAGGCAGCTGATCATAGATCTGGAGACTCGAGGGAG TCAGGCTCTTCCTTTGTTCATCTCCTGCTTATAGGACACAGGCCAGGACATGCTGGCTTC GTTTCTGCGAACTAACAGGCAAGCAGCAAAGTTGTCGAAGCCAACCCTATAAAACCTTAC CCCAGTGGTGCTCAGACCAGAGATTCGCAAACCAGAGGTTCTCAGACCGGAAACACCCAT ACCAGTGGACATTGGTTCTGGAGGATTCGGTGATGTCGGTGCTCTTGAGAGTTTGAGGGG AAATGCAGATTTGGCTTACATCCTGAGCATGGAGCCCTGTGGCCACTGCCTCATTATCAT ACATGTGAACTTCTGCCGTGAGTCCGGGCTCCGCACCCGCACTGGCTCCAACATCGACTG TGAGAAGTTGCGGCGTCGCTCCTCCTCGCTGCATTTCATGGTGGAGGTGAATGGCGACCT GACTGCCAAGATATGGTGCTGGCTTTGCTGGAGCTGGGCGCGCANGACCACGGTGCTCTG GACTGCTGCGTGGTGGTCATTCTCTCTCACGCTGTCAGGCCNCCACCTGCAGTTCCAGGG GCTGTCTACGCACATNATGGATGCCTGTGTCGGCCGAAAAATGTGAACATTTTCATGGGA CAGCTGCCCCACCCTGGGAGGAACCCAACCTTTTTATCAAGCCGGGGGGGGACACAAAAC CTGGTTGGGGGGCCCCCCTTCCTGAAAG >OriGene 3' read for NM_001229 unedited
TTATAATGANAAACCACCTAACATCCAGGGCCCTAATAACCAGGAAATAGTCATGCGCAA TGGCTCAAGCCTGTAACCCCTGCACTTTGGGAGGCTAAGGCAGGCTGATCGCCTGAGTCC AGGAGTTCAAGACCAGCCTGAGTAACATGGCATAACTCTGTCTCTACTAAAAATACAAAA ATTAACTGGTATATGTGGTGCACACCTGTAGTCCAAGCTACTCAGGTGGCTGAGGTGGAA GGATCTCTTGAGCCCAGGAGGTCGAGACTGCAATAAGCCAAGATTGCGTCATTGCACTCC AGCCTGGGCGACAGAGTGAGACCCCATCTCCAAAAAAAAAGGCCCAAAAAACAAGATATA GGCTGGCATAAGGACAGCTTAAAAGACCTCAGGGTGGAGCCTTGTGGGGAAGCCCAGCGT GTCACTATTGCACAGCACGTTCACACTGCAGTCCGGGGGTGCTTCAGCAAGTAAGGCACA TGGGAAGCATGGCTAGGACTCAAGGGACCCAAGTTTCTGCCAGGTCTCCTCTCTGGATAA TCGTTTTCCCTTGGACAAGAAACTAAACCTCCTGAACACAGGGTTCTAACCCCTGGTGCC TTCCTGGGATGGGATAAAGATCAAGTTGAATTAAGACTTGAATTAATGGGGGCTGGGTGC AATGTTGCCCCCCCGGTTGTAAGAACTACCTGGGAAGGGCCACTTGAGCCCCAGGAATTT TGAACCAGCCCGGGGCAACCTTTCGGGGACCCCCAGAAAAACCGGGGGGAAAAGGTTTCC AAAATAAGCAAAAATCTCCTTTTGGTAAGGAAAAAAAAAAGAGTTTTGGGCCCAAAGTGG GGGGAAAAAAAAGGCCAAAAAGAAAGTCCCATTTTGCCCCAAAATTTTTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001229 |
| Insert Size | 3000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001229.2, NP_001220.2 |
| RefSeq Size | 2034 bp |
| RefSeq ORF | 1251 bp |
| Locus ID | 842 |
| UniProt ID | P55211 |
| Domains | Peptidase_C14, CARD, CASc |
| Protein Families | Druggable Genome, Protease, Stem cell - Pluripotency |
| Protein Pathways | Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Endometrial cancer, Huntington's disease, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Parkinson's disease, Pathways in cancer, Prostate cancer, Small cell lung cancer, VEGF signaling pathway, Viral myocarditis |
| Gene Summary | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] Transcript Variant: This variant (alpha) encodes the longest isoform (alpha). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (5)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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ASTX660, a novel non-peptidomimetic antagonist of cIAP1/2 and XIAP, potently induces TNF-α dependent apoptosis in cancer cell lines and inhibits tumor growth
,Ward, GA;Lewis, EJ;Ahn, JS;Johnson, CN;Lyons, JF;Martins, V;Munck, JM;Rich, SJ;Smyth, T;Thompson, NT;Williams, PA;Wilsher, NE;Wallis, NG;Chessari, G;,
Mol. Cancer Ther.
,PubMed ID 29695633
[CASP9]
|
|
Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).
,null,
Journal of medicinal chemistry
,PubMed ID 28492317
[CASP9]
|
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Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP
,Chessari, G;Buck, IM;Day, JE;Day, PJ;Iqbal, A;Johnson, CN;Lewis, EJ;Martins, V;Miller, DL;Reader, M;Rees, DC;Rich, SJ;Tamanini, E;Vitorino, M;Ward, GA;Williams, PA;Williams, G;Wilsher, NE;Woolford, AJ;,
J. Med. Chem.
,PubMed ID 26218264
[CASP9]
|
|
cIAP1 Cooperatively Inhibits Procaspase-3 Activation by the Caspase-9 Apoptosome *
,null,
The Journal of Biological Chemistry
,PubMed ID 20667824
[CASP9]
|
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cIAP1 Cooperatively Inhibits Procaspase-3 Activation by the Caspase-9 Apoptosome
,Stephen P. Burke, Lucinda Smith, and Jeffrey B. Smith,
J. Biol. Chem., Sep 2010; 285: 30061 - 30068
[CASP9]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC200635 | CASP9 (Myc-DDK-tagged)-Human caspase 9, apoptosis-related cysteine peptidase (CASP9), transcript variant alpha |
CNY 3,656.00 |
|
| RC200635L1 | Lenti ORF clone of Human caspase 9, apoptosis-related cysteine peptidase (CASP9), transcript variant alpha, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC200635L2 | Lenti ORF clone of Human caspase 9, apoptosis-related cysteine peptidase (CASP9), transcript variant alpha, mGFP tagged |
CNY 5,890.00 |
|
| RC200635L3 | Lenti ORF clone of Human caspase 9, apoptosis-related cysteine peptidase (CASP9), transcript variant alpha, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC200635L4 | Lenti ORF clone of Human caspase 9, apoptosis-related cysteine peptidase (CASP9), transcript variant alpha, mGFP tagged |
CNY 6,056.00 |
|
| RG200635 | CASP9 (tGFP-tagged) - Human caspase 9, apoptosis-related cysteine peptidase (CASP9), transcript variant alpha |
CNY 5,256.00 |
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