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Hyaluronan synthase 1 (HAS1) (NM_001523) Human Untagged Clone
CAT＃: SC119184
HAS1 (untagged)-Human hyaluronan synthase 1 (HAS1)
CNY 4,312.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HAS |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_001523, the custom clone sequence may differ by one or more nucleotides
ATGAGACAGCAGGACGCGCCCAAGCCCACTCCTGCAGCCTGCCGCTGCTCCGGCCTGGCCCGGAGGGTGC TGACCATCGCCTTCGCCCTGCTCATCCTGGGCCTCATGACCTGGGCCTACGCCGCCGGGGTGCCGCTGGC CTCCGATCGCTACGGCCTCCTGGCCTTCGGCCTCTACGGGGCCTTCCTTTCAGCGCACCTGGTGGCGCAG AGCCTCTTCGCGTACCTGGAGCACCGGCGGGTGGCGGCGGCGGCGCGGGGGCCGCTGGATGCAGCCACCG CGCGCAGTGTGGCGCTGACCATCTCCGCCTACCAGGAGGACCCCGCGTACCTGCGCCAGTGCCTGGCGTC CGCCCGCGCCCTGCTGTACCCGCGCGCGCGGCTGCGCGTCCTCATGGTGGTGGATGGCAACCGCGCCGAG GACCTCTACATGGTCGACATGTTCCGCGAGGTCTTCGCTGACGAGGACCCCGCCACGTACGTGTGGGACG GCAACTACCACCAGCCCTGGGAACCCGCGGCGGCGGGCGCGGTGGGCGCCGGAGCCTATCGGGAGGTGGA GGCGGAGGATCCTGGGCGGCTGGCAGTGGAGGCGCTGGTGAGGACTCGCAGGTGCGTGTGCGTGGCGCAG CGCTGGGGCGGCAAGCGCGAGGTCATGTACACAGCCTTCAAGGCGCTCGGAGATTCGGTGGACTACGTGC AGGTCTGTGACTCGGACACAAGGTTGGACCCCATGGCACTGCTGGAGCTCGTGCGGGTACTGGACGAGGA CCCCCGGGTAGGGGCTGTTGGTGGGGACGTGCGGATCCTTAACCCTCTGGACTCCTGGGTCAGCTTCCTA AGCAGCCTGCGATACTGGGTAGCCTTCAATGTGGAGCGGGCTTGTCAGAGCTACTTCCACTGTGTATCCT GCATCAGCGGTCCTCTAGGCCTATATAGGAATAACCTCTTGCAGCAGTTTCTTGAGGCCTGGTACAACCA GAAGTTCCTGGGTACCCACTGTACTTTTGGGGATGACCGGCACCTCACCAACCGCATGCTCAGCATGGGT TATGCTACCAAGTACACCTCCAGGTCCCGCTGCTACTCAGAGACGCCCTCGTCCTTCCTGCGGTGGCTGA GCCAGCAGACACGCTGGTCCAAGTCGTACTTCCGTGAGTGGCTGTACAACGCGCTCTGGTGGCACCGGCA CCATGCGTGGATGACCTACGAGGCGGTGGTCTCCGGCCTGTTCCCCTTCTTCGTGGCGGCCACTGTGCTG CGTCTGTTCTACGCGGGCCGCCCTTGGGCGCTGCTGTGGGTGCTGCTGTGCGTGCAGGGCGTGGCACTGG CCAAGGCGGCCTTCGCGGCCTGGCTGCGGGGCTGCCTGCGCATGGTGCTTCTGTCGCTCTACGCGCCCCT CTACATGTGTGGCCTCCTGCCTGCCAAGTTCCTGGCGCTAGTCACCATGAACCAGAGTGGCTGGGGCACC TCGGGCCGGCGGAAGCTGGCCGCTAACTACGTCCCTCTGCTGCCCCTGGCGCTCTGGGCGCTGCTGCTGC TTGGGGGCCTGGTCCGCAGCGTAGCACACGAGGCCAGGGCCGACTGGAGCGGCCCTTCCCGCGCAGCCGA GGCCTACCACTTGGCCGCGGGGGCCGGCGCCTACGTGGGCTACTGGGTGGCCATGTTGACGCTGTACTGG GTGGGCGTGCGGAGGCTTTGCCGGCGGCGGACCGGGGGCTACCGCGTCCAGGTGTGA >OriGene 5' read for NM_001523 unedited
NGGTTCACAATTTGTAAACGACTCATATAGGCGGCCGCGNATTCCCGGGATAGCAAGCCG GAGAGAAGAGAGAGCCCGGCCAGACCCACTGCGATGAGACAGGACGCGCCCAAGCCCACT CCTGCAGCCCGCCGCTGCTCCGGCCTGGCCCGGAGGGTGCTGACCATCGCCTTCGCCCTG CTCATCCTGGGCCTCATGACCTGGGCCTACGCCGCCGGGGTGCCGCTGGCCTCCGATCGC TACGGCCTCCTGGCCTTCGGCCTCTACGGGGCCTTCCTTTCAGCGCACCTGGTGGCGCAG AGCCTCTTCGCGTACCTGGAGCACCGGCGGGTGGCGGCGGCGGCGCGGGGGCCGCTGGAT GCAGCCACCGCGCGCAGTGTGGCGCTGACCATCTCCGCCTACCAGGAGGACCCCGCGTAC CTGCGCCAGTGCCTGGCGTCCGCCCGCGCCCTGCTGTACCCGCGCGCGCGGCTGCGCGTC CTCATGGTGGTGGATGGCAACCGCGCCGAGGACCTCTACATGGTCGACATGTTCCGCGAG GTCTTCGCTGACGAGGACCCCGCCACGTACGTGTGGGACGGCAACTACCACCAGCCCTGG GAACCCGCGGCGGCGGGCGCGGTGGGCGCCGGAGCCTATCGGGAGGTGGACGCGGAGGAT CCTGGGCGGCTGGCAGTGGAGGCGCTGGTGAGGACTCGTANGTGCGTGTGCGTGGCGCAN CGCTGGGGCGGCAAGCGCGAGGTCATGTACACAGCCTTCAAGGCGCTCGGAGATTCGATG GACTACGTGCAGGTCTGTGACTCGGACACAAGGTTGGACCCCATGGCACTGCTGNAGCTC GTGCGGGTACTGGNACGAGACCCCCGGNTAGGNNGCTGTTGTGGGGACGTGCGGATCCCT TACCCTCTGNACTCCC >OriGene 3' read for NM_001523 unedited
TTTTTTTTTTTTTTTTTGAAAATAAATAAAATTCTTTATTACATCCTGATCACACAGTAG AAATGGAGATTAAATAAGAACGAGGAGAAAGCAGGACCCTTTCCCTCCACTCCTCAGATC CCACACCCTGACCAATAAATACCCTCCCTGGAGACACCNAGNNNNNAAANNNAAGNNNNN NNNTTTNNNN |
| Restriction Sites | Please inquire |
| ACCN | NM_001523 |
| Insert Size | 1950 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001523.1, NP_001514.1 |
| RefSeq Size | 2088 bp |
| RefSeq ORF | 1737 bp |
| Locus ID | 3036 |
| UniProt ID | Q92839 |
| Protein Families | Druggable Genome, Transmembrane |
| Gene Summary | Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). |
Documents
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| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC207797 | HAS1 (Myc-DDK-tagged)-Human hyaluronan synthase 1 (HAS1) |
CNY 4,304.00 |
|
| RC207797L1 | Lenti ORF clone of Human hyaluronan synthase 1 (HAS1), Myc-DDK-tagged |
CNY 6,704.00 |
|
| RC207797L2 | Lenti ORF clone of Human hyaluronan synthase 1 (HAS1), mGFP tagged |
CNY 5,890.00 |
|
| RC207797L3 | Lenti ORF clone of Human hyaluronan synthase 1 (HAS1), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC207797L4 | Lenti ORF clone of Human hyaluronan synthase 1 (HAS1), mGFP tagged |
CNY 5,890.00 |
|
| RG207797 | HAS1 (tGFP-tagged) - Human hyaluronan synthase 1 (HAS1) |
CNY 5,904.00 |
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