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Cyclin D1 (CCND1) (NM_053056) Human Untagged Clone
CAT＃: SC119035
CCND1 (untagged)-Human cyclin D1 (CCND1)
CNY 3,600.00
| Cited in 2 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BCL1; D11S287E; PRAD1; U21B31 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC119035 sequence for NM_053056 edited (data generated by NextGen Sequencing)
ATGGAACACCAGCTCCTGTGCTGCGAAGTGGAAACCATCCGCCGCGCGTACCCCGATGCC AACCTCCTCAACGACCGGGTGCTGCGGGCCATGCTGAAGGCGGAGGAGACCTGCGCGCCC TCGGTGTCCTACTTCAAATGTGTGCAGAAGGAGGTCCTGCCGTCCATGCGGAAGATCGTC GCCACCTGGATGCTGGAGGTCTGCGAGGAACAGAAGTGCGAGGAGGAGGTCTTCCCGCTG GCCATGAACTACCTGGACCGCTTCCTGTCGCTGGAGCCCGTGAAAAAGAGCCGCCTGCAG CTGCTGGGGGCCACTTGCATGTTCGTGGCCTCTAAGATGAAGGAGACCATCCCCCTGACG GCCGAGAAGCTGTGCATCTACACCGACAACTCCATCCGGCCCGAGGAGCTGCTGCAAATG GAGCTGCTCCTGGTGAACAAGCTCAAGTGGAACCTGGCCGCAATGACCCCGCACGATTTC ATTGAACACTTCCTCTCCAAAATGCCAGAGGCGGAGGAGAACAAACAGATCATCCGCAAA CACGCGCAGACCTTCGTTGCCCTCTGTGCCACAGATGTGAAGTTCATTTCCAATCCGCCC TCCATGGTGGCAGCGGGGAGCGTGGTGGCCGCAGTGCAAGGCCTGAACCTGAGGAGCCCC AACAACTTCCTGTCCTACTACCGCCTCACACGCTTCCTCTCCAGAGTGATCAAGTGTGAC CCAGACTGCCTCCGGGCCTGCCAGGAGCAGATCGAAGCCCTGCTGGAGTCAAGCCTGCGC CAGGCCCAGCAGAACATGGACCCCAAGGCCGCCGAGGAGGAGGAAGAGGAGGAGGAGGAG GTGGACCTGGCTTGCACACCCACCGACGTGCGGGACGTGGACATCTGA Clone variation with respect to NM_053056.2 723 g=>a >OriGene 5' read for NM_053056 unedited
GTTCACATTTTGTATACGACTCACTATAGGCGGCCGCGAATCGGCACGAGGCGCAGTAGC AGCGAGCAGCAGAGTCCGCACGCTCCGGCGAGGGGCAGAAGAGCGCGAGGGAGCGCGGGG CAGCAGAAGCGAGAGCCGAGCGCGGACCCAGCCAGGACCCACAGCCCTCCCCAGCTGCCC AGGAAGAGCCCCAGCCATGGAACACCAGCTCCTGTGCTGCGAAGTGGAAACCATCCGCCG CGCGTACCCCGATGCCAACCTCCTCAACGACCGGGTGCTGCGGGCCATGCTGAAGGCGGA GGAGACCTGCGCGCCCTCGGTGTCCTACTTCAAATGTGTGCAGAAGGAGGTCCTGCCGTC CATGCGGAAGATCGTCGCCACCTGGATGCTGGAGGTCTGCGAGGAACAGAAGTGCGAGGA GGAGGTCTTCCCGCTGGCCATGAACTACCTGGACCGCTTCCTGTCGCTGGAGCCCGTGAA AAAGAGCCGCCTGCAGCTGCTGGGGGCCACTTGCATGTTCGTGGCCTCTAAGATGAAGGA GACCATCCCCCTGACGGCCGAGAAGCTGTGCATCTACACCGACAACTCCATCCGGCCCGA GGAGCTGCTGCAAATGGAGCTGCTCCTGGTGAACAAGCTCAAGTGGAACCTGCCCGCAAT GACCCCGCACGATTTCATTGAACACTTCCTCTCCAAAAGCCAGAAGCGGAGGAGAACANA CAGATCATCCGCAAACACGCGCAGACCCTTCGTGCCCTCTGTGCACAGATGTGAAGTTCA TTTCCATCCGCCCTCCATGTTGCANCGGCGAGCGTGGTGGCCGCACTGCAAGCCTGAACT TGAGAAGCCCAACAACTTCCTGTCTACTACGGCCTAAAACGTTTCTCTCCAGAGTGATCA AGGGGGACCCAAACTGCCTTC >OriGene 3' read for NM_053056 unedited
CCGCGGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTACATAGCCAAGATGTG CAAATTGTCTATTTTGTCACTAAGTTTTTTAAAGGAAGGGGCAGGGGATAAGAATTCATC GGAACCGAACTTAGGTTGAGTACCCTAATTTTCCTTGCACCCATGCCTGTCCAATCAGAT GACTCTGGGAAACGCCAAACAGGCTGAATCAATGTCTTTGTGTGGTTTTTTTCTTCCAGA TTGTTTTTTTCTCACCTATAAAAGGATCTATCTTTAAAAATAAACTGTATTAAATCTGTA ACATCAAAGGCAGAAGGTTTGTGTGTGTGTGTGTGTGTGTGTGTGTATCTGTGTGTTTAA ATCAAGGGGAGATTGCATTTATAAATCATACTGGCCTTATGAACATCCTCTGCAATAAAT ATACTTTTTAGCCTTAACTATAAATTATATATTTTAGTGTTTAAAAACCTTCCGGTGTGA AACATCTAAGATAACCCTTAAAAACCACCTGTTCTCTAGGTAAACCTCTGAGGTCCCTAC TTTCAAACACCAGTTGGCACCAAAGGATTCCTAAACTTCAACTTCTTTAAAGAAAAGGAA AGGAACTTATCATCCTGGCAATGTGAGAATGCAAACCTTTTTCTTCTTGACTGGCACGCA GCCTCCCAAACACCCCACCTTCACTGCCACACAGTGGCCCACACTTGCCTCAAAGTCTGC TTGCAAACCAGACATGGATATTCCAAACCTTTCCATTAAAAACTGCCCTCCTTGCACACC AACAAAAACAGCGTTATTTCCTCCACCTATTGTACTGAAATGCCTTGAAATGGAATGGTT TTATATTTGAACAAGAACCACAACCAGTTCCTGTGGGTTAACCCTGACACTAACCTGCTG CAGGGCCCTTGGTATAAAACCAACTTTTTTAAAGGTGTCTTCANAATTGGAAAGTTAAAA ATAT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_053056 |
| Insert Size | 888 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_053056.1, NP_444284.1 |
| RefSeq Size | 4306 bp |
| RefSeq ORF | 888 bp |
| Locus ID | 595 |
| UniProt ID | P24385 |
| Domains | cyclin_C, CYCLIN, cyclin |
| Protein Families | Druggable Genome, Stem cell - Pluripotency, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - Wnt Signaling pathway |
| Protein Pathways | Acute myeloid leukemia, Bladder cancer, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, Focal adhesion, Glioma, Jak-STAT signaling pathway, Melanoma, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer, Thyroid cancer, Viral myocarditis, Wnt signaling pathway |
| Gene Summary | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Regulation and function of Cav3.1 T-type calcium channels in IGF-I-stimulated pulmonary artery smooth muscle cells
,Florentina Pluteanu and Leanne L. Cribbs,
Am J Physiol Cell Physiol, Mar 2011; 300: C517 - C525
[CCND1]
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Down-Regulation of the Oncogene Cyclin D1 Increases Migratory Capacity in Breast Cancer and Is Linked to Unfavorable Prognostic Features
,Sophie Lehn, Nicholas P. Tobin, Pontus Berglund, Kristina Nilsson, Andrew H. Sims, Karin Jirström, Pirkko Härkönen, Rebecca Lamb, and Göran Landberg,
Am. J. Pathol., Dec 2010; 177: 2886 - 2897
[CCND1]
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Resources
Other Versions
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| RC204957L3 | Lenti ORF clone of Human cyclin D1 (CCND1), Myc-DDK-tagged |
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| RG204957 | CCND1 (tGFP-tagged) - Human cyclin D1 (CCND1) |
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