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HMG1 (HMGB1) (NM_002128) Human Untagged Clone
CAT＃: SC118802
HMGB1 (untagged)-Human high mobility group box 1 (HMGB1)
CNY 3,600.00
| Cited in 1 publication. |
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热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HMG-1; HMG1; HMG3; SBP-1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_002128, the custom clone sequence may differ by one or more nucleotides
ATGGGCAAAGGAGATCCTAAGAAGCCGAGAGGCAAAATGTCATCATATGCATTTTTTGTGCAAACTTGTC GGGAGGAGCATAAGAAGAAGCACCCAGATGCTTCAGTCAACTTCTCAGAGTTTTCTAAGAAGTGCTCAGA GAGGTGGAAGACCATGTCTGCTAAAGAGAAAGGAAAATTTGAAGATATGGCAAAAGCGGACAAGGCCCGT TATGAAAGAGAAATGAAAACCTATATCCCTCCCAAAGGGGAGACAAAAAAGAAGTTCAAGGATCCCAATG CACCCAAGAGGCCTCCTTCGGCCTTCTTCCTCTTCTGCTCTGAGTATCGCCCAAAAATCAAAGGAGAACA TCCTGGCCTGTCCATTGGTGATGTTGCGAAGAAACTGGGAGAGATGTGGAATAACACTGCTGCAGATGAC AAGCAGCCTTATGAAAAGAAGGCTGCGAAGCTGAAGGAAAAATACGAAAAGGATATTGCTGCATATCGAG CTAAAGGAAAGCCTGATGCAGCAAAAAAGGGAGTTGTCAAGGCTGAAAAAAGCAAGAAAAAGAAGGAAGA GGAGGAAGATGAGGAAGATGAAGAGGATGAGGAGGAGGAGGAAGATGAAGAAGATGAAGATGAAGAAGAA GATGATGATGATGAATAA >OriGene 5' read for NM_002128 unedited
ACTCACTATAGGCGGCCGCGAATTCGCACGAGGAGAGTGAGGAGGCTGCGTCTGGCTCCC GCTCTCACAGCCATTGCAGTACATTGAGCTCCATAGAGACAGCGCCGGGGCAAGTGAGAG CCGGACGGGCACTGGGCGACTCTGTGCCTCGCTGAGGAAAAATAACTAAACATGGGCAAA GGAGATCCTAAGAAGCCGAGAGGCAAAATGTCATCATATGCATTTTTTGTGCAAACTTGT CGGGAGGAGCATAAGAAGAAGCACCCAGATGCTTCAGTCAACTTCTCAGAGTTTTCTAAG AAGTGCTCAGAGAGGTGGAAGACCATGTCTGCTAAAGAGAAAGGAAAATTTGAAGATATG GCAAAAGCGGACAAGGCCCGTTATGAAAGAGAAATGAAAACCTATATCCCTCCCAAAGGG GAGACAAAAAAGAAGTTCAAGGATCCCAATGCACCCAAGAGGCCTCCTTCGGCCTTCTTC CTCTTCTGCTCTGAGTATCGCCCAAAAATAAAGGAGAACATCCTGGCCTGTCCATTGGTG ATGTTGCGAAGAAACTGGGAGAGATGTGGAATAACACTGCTGCAGATGACAAGCAGCCTT ATGAAAAGAAGGCTGCGAAGCTGAAGGAANAATACAAAAGGATATTGCTGCATATCGAGC TAAAGAAAGCCTGATGCAGCAAANAGGGGAGTGTCAAGGGCTGAAAAAGNCAGAAAAGAA GGAAGAAGANGAAGATGANGAANATGAANAGGATGANNGAGAGNANGAAGATGAANAANA TGAAGATGAAGAAAAGATGATGATGATGAAATAAGNTGGTTCTAAGCGCAGTTTTTTTTT TCTTGGCTATAAGCATTTTACCCCCCCTGTACACAACTNACTTCTTTTAAGAAAAAATTG AATGNANGGCTGGGTAANAATTGTTTTAAACTGNACAGGCCTTTTTTTGGATAGGTAACA CCTACCCAAGTGGGTTAAAAAACCTGGCCCGGGGGGATTTCAAAGCACCTACCTGCTGAC GGNGGGGGGA >OriGene 3' read for NM_002128 unedited
NNNTTAGCTCTGNNACCGCGGCCGCATTCTAGGATCGAGNTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTTTTAACTAAAAAAAAAAATGGATTTACTTAAAAGCATTCA AAATGGCAACAAAACAGCTGCAACTTTTTTTTTTTTGCAATTACAGAGGGGTATTCAGTT AACAAAACAACAATTATTTCGTATAAGCTGCATCAAAGACAACTGAAGATGAAAAAACTA CCATCCCCATATATAACTAATTTGGGCTGGGCCCCAACAAAAACCTGCTTTAAATTTCCA TGCCAATTTACAACCCCCATACTGTACCAGGCAAGGTTAGGGGCTATTGAAAATACCACC AGGACAGGGCTATCTAAAGACACATTCGGGAGGGGGTTAACTATACAAAAAAAGACACTG GACAGTTTAAAAACAAATTTTACACAGCCTTACATTTAAATTTTTTTCTTTAAAAGGAGT GAGTTGGGCACAGGGGGGTTAAATGCTTTATAGACAAAAAAAAAAAAACTGCGCTAGAAC CAACTTATTCATCATCATCATCTTCTTCTTAATCTTCATATTCTTAATCTTCCTCCTCCT CCCCATCCCCTTTATCTTCCTCATCTTCCTCCTCTTCCTTTCTTTTCTTGCTTTTTNCAG CCTTGACAACTCCCTTTTTTGCTGGATAAGGCCTTTCCTTTAACCCGAAAAGCCGAAATA ACCCTTTTGGAATTTTTCCTTTAGCTTCCCAACCTCTTTTTTATAAGGCGGCTTGCATTC GGCAGAGGGTTTTTCCCAATCTTCCCCGGTTTTTCCCACCACCACAAGGGCCAGCCCAGG AGGTCCCTTTTGTTTTTGGGCCAACCCCAAAACCAAAGAGAAAAAGCGCCCAAGAAGCCC TCTGGGGGC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002128 |
| Insert Size | 1320 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002128.3, NP_002119.1 |
| RefSeq Size | 3428 bp |
| RefSeq ORF | 648 bp |
| Locus ID | 3146 |
| UniProt ID | P09429 |
| Domains | HMG |
| Protein Families | Druggable Genome, Stem cell - Pluripotency, Transcription Factors |
| Protein Pathways | Base excision repair |
| Gene Summary | This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015] Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes
,Albert R. Davalos, Misako Kawahara, Gautam K. Malhotra, Nicholas Schaum, Jiahao Huang, Urvi Ved, Christian M. Beausejour, Jean-Philippe Coppe, Francis Rodier, and Judith Campisi,
J. Cell Biol., May 2013; 201: 613 - 629.
,PubMed ID 23649808
[HMGB1]
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Other Versions
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| RC205918L2 | Lenti ORF clone of Human high mobility group box 1 (HMGB1), mGFP tagged |
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| RC205918L3 | Lenti ORF clone of Human high mobility group box 1 (HMGB1), Myc-DDK-tagged |
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| RC205918L4 | Lenti ORF clone of Human high mobility group box 1 (HMGB1), mGFP tagged |
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| RG205918 | HMGB1 (tGFP-tagged) - Human high mobility group box 1 (HMGB1) |
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| SC324540 | HMGB1 (untagged)-Human high mobility group box 1 (HMGB1) |
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