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FURIN (NM_002569) Human Untagged Clone
CAT＃: SC118550
FURIN (untagged)-Human furin (paired basic amino acid cleaving enzyme) (FURIN)
CNY 8,736.00
| Cited in 5 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | FUR; PACE; PCSK3; SPC1 |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC118550 sequence for NM_002569 edited (data generated by NextGen Sequencing)
ATGGAGCTGAGGCCCTGGTTGCTATGGGTGGTAGCAGCAACAGGAACCTTGGTCCTGCTA GCAGCTGATGCTCAGGGCCAGAAGGTCTTCACCAACACGTGGGCTGTGCGCATCCCTGGA GGCCCAGCGGTGGCCAACAGTGTGGCACGGAAGCATGGGTTCCTCAACCTGGGCCAGATC TTCGGGGACTATTACCACTTCTGGCATCGAGGAGTGACGAAGCGGTCCCTGTCGCCTCAC CGCCCGCGGCACAGCCGGCTGCAGAGGGAGCCTCAATGGCTGGAACAGCAGGTGGCAAAG CGACGGACTAAACGGGACGTGTACCAGGAGCCCACAGACCCCAAGTTTCCTCAGCAGTGG TACCTGTCTGGTGTCACTCAGCGGGACCTGAATGTGAAGGCGGCCTGGGCGCAGGGCTAC ACAGGGCACGGCATTGTGGTCTCCATTCTGGACGATGGCATCGAGAAGAACCACCCGGAC TTGGCAGGCAATTATGATCCTGGGGCCAGTTTTGATGTCAATGACCAGGACCCTGACCCC CAGCCTCGGTACACACAGATGAATGACAACAGGCACGGCACACGGTGTGCGGGGGAAGTG GCTGCGGTGGCCAACAACGGTGTCTGTGGTGTAGGTGTGGCCTACAACGCCCGCATTGGA GGGGTGCGCATGCTGGATGGCGAGGTGACAGATGCAGTGGAGGCACGCTCGCTGGGCCTG AACCCCAACCACATCCACATCTACAGTGCCAGCTGGGGCCCCGAGGATGACGGCAAGACA GTGGATGGGCCAGCCCGCCTCGCCGAGGAGGCCTTCTTCCGTGGGGTTAGCCAGGGCCGA GGGGGGCTGGGCTCCATCTTTGTCTGGGCCTCGGGGAACGGGGGCCGGGAACATGACAGC TGCAACTGCGACGGCTACACCAACAGTATCTACACGCTGTCCATCAGCAGCGCCACGCAG TTTGGCAACGTGCCGTGGTACAGCGAGGCCTGCTCGTCCACACTGGCCACGACCTACAGC AGTGGCAACCAGAATGAGAAGCAGATCGTGACGACTGACTTGCGGCAGAAGTGCACGGAG TCTCACACGGGCACCTCAGCCTCTGCCCCCTTAGCAGCCGGCATCATTGCTCTCACCCTG GAGGCCAATAAGAACCTCACATGGCGGGACATGCAACACCTGGTGGTACAGACCTCGAAG CCAGCCCACCTCAATGCCAACGACTGGGCCACCAATGGTGTGGGCCGGAAAGTGAGCCAC TCATATGGCTACGGGCTTTTGGACGCAGGCGCCATGGTGGCCCTGGCCCAGAATTGGACC ACAGTGGCCCCCCAGCGGAAGTGCATCATCGACATCCTCACCGAGCCCAAAGACATCGGG AAACGGCTCGAGGTGCGGAAGACCGTGACCGCGTGCCTGGGCGAGCCCAACCACATCACT CGGCTGGAGCACGCTCAGGCGCGGCTCACCCTGTCCTATAATCGCCGTGGCGACCTGGCC ATCCACCTGGTCAGCCCCATGGGCACCCGCTCCACCCTGCTGGCAGCCAGGCCACATGAC TACTCCGCAGATGGGTTTAATGACTGGGCCTTCATGACAACTCATTCCTGGGATGAGGAT CCCTCTGGCGAGTGGGTCCTAGAGATTGAAAACACCAGCGAAGCCAACAACTATGGGACG CTGACCAAGTTCACCCTCGTACTCTATGGCACCGCCCCTGAGGGGCTGCCCGTACCTCCA GAAAGCAGTGGCTGCAAGACCCTCACGTCCAGTCAGGCCTGTGTGGTGTGCGAGGAAGGC TTCTCCCTGCACCAGAAGAGCTGTGTCCAGCACTGCCCTCCAGGCTTCGCCCCCCAAGTC CTCGATACGCACTATAGCACCGAGAATGACGTGGAGACCATCCGGGCCAGCGTCTGCGCC CCCTGCCACGCCTCATGTGCCACATGCCAGGGGCCGGCCCTGACAGACTGCCTCAGCTGC CCCAGCCACGCCTCCTTGGACCCTGTGGAGCAGACTTGCTCCCGGCAAAGCCAGAGCAGC CGAGAGTCCCCGCCACAGCAGCAGCCACCTCGGCTGCCCCCGGAGGTGGAGGCGGGGCAA CGGCTGCGGGCAGGGCTGCTGCCCTCACACCTGCCTGAGGTGGTGGCCGGCCTCAGCTGC GCCTTCATCGTGCTGGTCTTCGTCACTGTCTTCCTGGTCCTGCAGCTGCGCTCTGGCTTT AGTTTTCGGGGGGTGAAGGTGTACACCATGGACCGTGGCCTCATCTCCTACAAGGGGCTG CCCCCTGAAGCCTGGCAGGAGGAGTGCCCGTCTGACTCAGAAGAGGACGAGGGCCGGGGC GAGAGGACCGCCTTTATCAAAGACCAGAGCGCCCTCTGA Clone variation with respect to NM_002569.2 277 g=>-;278 t=>-;279 a=>-;280 c=>-;281 a=>-;282 g=>-;1851 g=>c >OriGene 5' read for NM_002569 unedited
CCCCGCCCCGTTGCCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGA GCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAAT TCGGCACGAGGCCAAGGAGACGGGCGCTCCAGGGTCCCAGCCACCTGTCCCCCCCATGGA GCTGAGGCCCTGGTTGCTATGGGTGGTAGCAGCAACAGGAACCTTGGTCCTGCTAGCAGC TGATGCTCAGGGCCAGAAGGTCTTCACCAACACGTGGGCTGTGCGCATCCCTGGAGGCCC AGCGGTGGCCAACAGTGTGGCACGGAAGCATGGGTTCCTCAACCTGGGCCAGATCTTCGG GGACTATTACCACTTCTGGCATCGAGGAGTGACGAAGCGGTCCCTGTCGCCTCACCGCCC GCGGCACAGCCGGCTGCAGAGGGAGCCTCAATGGCTGGAACAGCAGGTGGCAAAGCGACG GACTAAACGGGACGTGTACCAGGAGCCCACAGACCCCAAGTTTCCTCAGCAGTGGTACCT GTCTGGTGTCACTCAGCGGGACCTGAATGTGAAGGCGGCCTGGGCGCAGGGCTACACAGG GCACGGCATTGTGGTCTCCATTCTGGACGATGGCATCGAGAAGAACCACCCGGACTTGGC AGGCAATTATGATCCTGGGGCCAGTTTTGATGTCAATGACCAGGACCCTGACCCCCAGCC TCGGTACACACAGATGAATGACAACAGGCACGGCACACGGTGTGCGGNGGAAGTGGCTGC GGTGGCCAACAAACGTGTCTGTGGTGTANGGTGTGGCCCTACACGCCCGCATTGGAGGGG TGCGCATGCTGGATGGCGAGGTGACAGATGCAGTGGAGGCACGCTCGCTGGGCCTGAACC CCAACCCATNCCATCTACGTGCCAGCTGGNGCCCGAGGATGACGCAGACATNGATGGGCC ACCCGCTCGCGAGGAGCCTCTCCGTGG >OriGene 3' read for NM_002569 unedited
GGTTTGTTCAGCCCGATCATGGGTTTAAAAAAAACCCATTATCTCATGTCCATTAAATTT AACCAGCAATGCTGGGCCTGTTTAAATTACAAGAAAAAAATCACTGTGCACCAACCCAGT ATCTTACAAAACCAGCCGGGCTGGCCACGAGGGCAGGGGGATGGGAGAGGAGGGGGCACC CCTGGGCAGATGGCTGGGTACCTGGAATGGCTTGGGTAGAAAAGAAAAGGGGACTCCCAG ATGGGAGGGGACTGATTGTCCTAATGGGAGGGGTGCAAAAGGCACGTCAGATGAGGAGGT TTGAGGGGGGCATGACAGGTCAGTGCTTTCTCCACCAGGGCACAGTGTTGGGGGGGCTCA GTGCCACCACCTGCCCACCTCTGGCACTTGGAGAGCCAGTGACCTATGAACCCCCGGCAT GGCGAGCCCCACTTGAAACACAGATGTCAGCCTGCCCCTCCCACTGGGACCCCCTTTCCT TTGAGCCCGCCTGGCTGGCCCGCCCTCTTCAGGACTTGGGGGCTCAACTTATTCCTCAAT TCTTAAGCAACATTGCTGCAAGCCCCCACACCTTAAGGCCAGGGCCAACCAGGGAGGAGC CAGGCGGGACGGTGGTGGGTGAAAACGTGGGTTGGTCCAGCTGGCTCCCCCCATTTAGAA TACTAAAACCGAAATCATCCGGCACTCTACGGGGGAAGTATCCCCAGGGTGGAAAAATTT ATCGCTTAAAACGGGCCCCTTGGGTATCCTCAACCAGGGGGAAAAACCACATATTTGTGG TGGGGAAGGTCACAAAGAAGGCCGGGCGTGGGGCCATACGCGCGTCTTCCCAACACACCC CACCCTGGGGGCTTCGGAGTTGTGTGGAGGTCCCAATAAGCCTAGGCGAGCCCGGGCGCC TAAAAGAAACAGGGTCCATGTGGGCCCCTGTACCGAAGAGAAGGCGGGGTCTCAGAAGAA GGCGACGCGGTGGTTCAAGCAGACACCACCNACATAAGTGTTCACCCACCACAGTGTATG CTGTTAGTGGTTGTCGCCACACACGGGGTGGCCCCCACGGGCGATGGGGGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002569 |
| Insert Size | 2385 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002569.2, NP_002560.1 |
| RefSeq Size | 4180 bp |
| RefSeq ORF | 2385 bp |
| Locus ID | 5045 |
| UniProt ID | P09958 |
| Domains | Peptidase_S8, P_proprotein, FU |
| Protein Families | Druggable Genome, Protease, Transmembrane |
| Gene Summary | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. Like other members of this convertase family, the product of this gene specifically cleaves substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140, and may play a role in tumor progression. Unlike SARS-CoV and other coronaviruses, the spike protein of SARS-CoV-2 is thought to be uniquely cleaved by this protease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020] Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2, and 3 encode the same protein. |
Citations (5)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Structural and functional impact by SARS-CoV-2 Omicron spike mutations
,null,
Cell Reports
,PubMed ID 35452593
[FURIN]
|
|
A Highly Productive CHO Cell Line Secreting Human Blood Clotting Factor IX
,null,
Acta Naturae
,PubMed ID 29713519
[FURIN]
|
|
The eukaryotic signal sequence, YGRL, targets the chlamydial inclusion
,Kabeiseman, EM;Cichos, KH;,
Frontiers in Cellular and Infection Microbiology
[FURIN]
|
|
Characterization of Genotype-Specific Carboxyl-Terminal Cleavage Sites of Hepatitis B Virus e Antigen Precursor and Identification of Furin as the Candidate Enzyme
,Kiyoaki Ito, Kyun-Hwan Kim, Anna Suk-Fong Lok, and Shuping Tong,
. Virol., Apr 2009; 83: 3507 - 3517.
[furin]
|
|
Characterization of Genotype Specific Carboxyl Terminal Cleavage Sites of Hepatitis B Virus e Antigen Precursor and Identification of Furin as the Candidate Enzyme
,Kiyoaki Ito, Kyun-Hwan Kim, Anna Suk-Fong Lok, and Shuping Tong,
J. Virol., Feb 2009; 10.1128/JVI.02348-08.
[FURIN]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC204279 | FURIN (Myc-DDK-tagged)-Human furin (paired basic amino acid cleaving enzyme) (FURIN) |
CNY 5,816.00 |
|
| RC204279L1 | Lenti ORF clone of Human furin (paired basic amino acid cleaving enzyme) (FURIN), Myc-DDK-tagged |
CNY 8,216.00 |
|
| RC204279L2 | Lenti ORF clone of Human furin (paired basic amino acid cleaving enzyme) (FURIN), mGFP tagged |
CNY 5,890.00 |
|
| RC204279L3 | Lenti ORF clone of Human furin (paired basic amino acid cleaving enzyme) (FURIN), Myc-DDK-tagged |
CNY 8,216.00 |
|
| RC204279L4 | Lenti ORF clone of Human furin (paired basic amino acid cleaving enzyme) (FURIN), mGFP tagged |
CNY 8,216.00 |
|
| RG204279 | FURIN (tGFP-tagged) - Human furin (paired basic amino acid cleaving enzyme) (FURIN) |
CNY 7,416.00 |
