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TTF1 (NKX2-1) (NM_003317) Human Untagged Clone
CAT＃: SC118030
NKX2 (untagged)-Human NK2 homeobox 1 (NKX2-1), transcript variant 2
CNY 3,656.00
CNY 7,220.00
| Cited in 3 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BCH; BHC; NK-2; NKX2.1; NKX2A; NMTC1; T/EBP; TEBP; TITF1; TTF-1; TTF1 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC118030 sequence for NM_003317 edited (data generated by NextGen Sequencing)
ATGTCGATGAGTCCAAAGCACACGACTCCGTTCTCAGTGTCTGACATCTTGAGTCCCCTG GAGGAAAGCTACAAGAAAGTGGGCATGGAGGGCGGCGGCCTCGGGGCTCCGCTGGCGGCG TACAGGCAGGGCCAGGCGGCACCGCCAACAGCGGCCATGCAGCAGCACGCCGTGGGGCAC CACGGCGCCGTCACCGCCGCCTACCACATGACGGCGGCGGGGGTGCCCCAGCTCTCGCAC TCCGCCGTGGGGGGCTACTGCAACGGCAACCTGGGCAACATGAGCGAGCTGCCGCCGTAC CAGGACACCATGAGGAACAGCGCCTCTGGCCCCGGATGGTACGGCGCCAACCCAGACCCG CGCTTCCCCGCCATCTCCCGCTTCATGGGCCCGGCGAGCGGCATGAACATGAGCGGCATG GGCGGCCTGGGCTCGCTGGGGGACGTGAGCAAGAACATGGCCCCGCTGCCAAGCGCGCCG CGCAGGAAGCGCCGGGTGCTCTTCTCGCAGGCGCAGGTGTACGAGCTGGAGCGACGCTTC AAGCAACAGAAGTACCTGTCGGCGCCGGAGCGCGAGCACCTGGCCAGCATGATCCACCTG ACGCCCACGCAGGTCAAGATCTGGTTCCAGAACCACCGCTACAAAATGAAGCGCCAGGCC AAGGACAAGGCGGCGCAGCAGCAACTGCAGCAGGACAGCGGCGGCGGCGGGGGCGGCGGG GGCACCGGGTGCCCGCAGCAGCAACAGGCTCAGCAGCAGTCGCCGCGACGCGTGGCGGTG CCGGTCCTGGTGAAAGACGGCAAACCGTGCCAGGCGGGTGCCCCCGCGCCGGGCGCCGCC AGCCTACAAGGCCACGCGCAGCAGCAGGCGCAGCACCAGGCGCAGGCCGCGCAGGCGGCG GCAGCGGCCATCTCCGTGGGCAGCGGTGGCGCCGGCCTTGGCGCACACCCGGGCCACCAG CCAGGCAGCGCAGGCCAGTCTCCGGACCTGGCGCACCACGCCGCCAGCCCCGCGGCGCTG CAGGGCCAGGTATCCAGCCTGTCCCACCTGAACTCCTCGGGCTCGGACTACGGCACCATG TCCTGCTCCACCTTGCTATACGGTCGGACCTGGTGA Clone variation with respect to NM_003317.3 >OriGene 5' read for NM_003317 unedited
NGTCGCGATTAGTATACGACTCCTATAGGGCGGCCGCGAATTCGCACGAGGCTGACAGAC ACGTAGACCAACAGTGCGGCCCCAGGTTCGTCCCCAGACTCGCTCGCTCATTTGTTGGCG ACTGGGGCTCAGCGCAGCGAAGCCCGATGTGGTCCGGAGGCAGTGGGAAGGCGCGGGGCT GGGAGGCCGCGGCGGGAGGGAGGAGCAGCCCCGGCAGGCTCAGCCGCCGCCGAATCATGT CGATGAGTCCAAAGCACACGACTCCGTTCTCAGTGTCTGACATCTTGAGTCCCCTGGAGG AAAGCTACAAGAAAGTGGGCATGGAGGGCGGCGGCCTCGGGGCTCCGCTGGCGGCGTACA GGCAGGGCCAGGCGGCACCGCCAACAGCGGCCATGCAGCAGCACGCCGTGGGGCACCACG GCGCCGTCACCGCCGCCTACCACATGACGGCGGCGGGGGTGCCCCAGCTCTCGCACTCCG CCGTGGGGGGCTACTGCAACGGCAACCTGGGCAACATGAGCGAGCTGCCGCCGTACCAGG ACACCATGAGGAACAGCGCCTCTGGCCCCGGATGGTACGGCGCCAACCCAGACCCGCGCT TCCCCGCCATCTCCCGCTTCATGGGCCCGGCGAGCGGCATGAACATGAGCGGCATGGGCG GCCTGNGCTCGCTGGGGGACGTGAGCAAGAACATGGCCCCGCTGCCAAGCGCGCCGCGCA GGAAGCGCCGGGTGCTCTTCTCGCAGGCGCAGGTGTACGAGCTGGAGCGACGCTTCAAGC AACAGAAGTACCCTGTCGCGCCGGAGCGCGAGCACCTGGCCAGCATGATCCACCTGACGC CCACGCAGTCAGATCTGGTTCCAGAACCACCGCTACANATGAAGCGCCAGNNCAGGNACA NGGCNGCGCAGCAGCAACTGCAGCAGGACAGC >OriGene 3' read for NM_003317 unedited
GCGTTAAGGAGACTTTATTATTTTTTTAATTTATTAGNAGCTTCTTAGGGACTATATTTA AGCCAAATATCTACATAAGTTACAACAGAAAAAGATGACGCCGCAAATACCAAACTGCCA AATAATATACACAGATTTGTCAATGCCCATAAAAAATGTGAAGGGCTGGGGACTGGGAGT GGTTTTTCTTTTTACAACAAAATGTACAGATTACTAAAAACTAGGCATTTAGTCCAACTT TTGACAGCGTTTTACAGCTACAAGTTCACATTAAACAAACTATTTTCGCGGAGGGCGGTC GCCGCTGAGCCTAGGCGGCCAGAGGGTGCCGGGGAGGGGGCACTTCCTTTGTGTCAGTGA CAAGTGGGTTATGTTGAAGACTCTTTCCTCTCCCCAGCTCCCGTCCTCCCTTCAAAAAAA AAAAAAAAATCCTGGTATTTACAAGCGAGTCCTCTTTGCTGGCAGAGTGTGCCCAGAGTG AAGTTTGGTCTTTAGAGTCCAGAGCCATGTCAGCACAGAGCCCTCTCCAATCTGTGCCCC GCCCCTAGCGTGGAAAACCCATTTGAATCACCAAAAAAAGACACCCCAAAGCTGTTTTAT GCCCTTTTCTGCTTAAAGATTCCTTGAGATTGGATGCGCTTGGCTGCTCTTCATTTTCTT TTTTTTAAAAAAAAAAAACCCCCAAATTTTCAGGGGGGGAAAAAAACAAAGAAGTCCCAC CACTTAGGCCTTTGTGGTTTTTTTGTTCCTTGGGCCTAAAACCGGCCCGNTTCTAAAGAA AATTTAACGCGTTGGAACAACGGTGGATGGTGCTTCTTTGGCTGCCAGAAGGAACCGTGA AGCCAACCCTGGGCTTAGGCCGACCGGTGTCTTTTACCAATTCCAACCGTTTCAAGGTGT ACCGAATTGGGCCCCTTTCCACACCAG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003317 |
| Insert Size | 2300 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003317.3, NP_003308.1 |
| RefSeq Size | 2352 bp |
| RefSeq ORF | 1116 bp |
| Locus ID | 7080 |
| UniProt ID | P43699 |
| Domains | homeobox |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors |
| Gene Summary | This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014] Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1. |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Gamma-interferon-inducible, lysosome/endosome-localized thiolreductase, GILT, has anti-retroviral activity and its expression is counteracted by HIV-1
,Kubo, Y;Izumida, M;Yashima, Y;Yoshii-Kamiyama, H;Tanaka, Y;Yasui, K;Hayashi, H;Matsuyama, T;,
Oncotarget
,PubMed ID 27655726
[NKX2-1]
|
|
CCSP G38A polymorphism-environment interactions regulate CCSP levels differentially in COPD
,Knabe, L;Varilh, J;Bergougnoux, A;Gamez, AS;Bonini, J;Pommier, A;Petit, A;Molinari, N;Vachier, I;Taulan-Cadars, M;Bourdin, A;,
Am. J. Physiol. Lung Cell Mol. Physiol.
,PubMed ID 27496897
[NKX2-1]
|
|
Integrative Genomics Implicates EGFR as a Downstream Mediator in NKX2-1 Amplified Non-Small Cell Lung Cancer
,Clarke, N;Biscocho, J;Kwei, KA;Davidson, JM;Sridhar, S;Gong, X;Pollack, JR;,
PLoS ONE
,PubMed ID 26556242
[NKX2-1]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC217520 | NKX2 (Myc-DDK-tagged)-Human NK2 homeobox 1 (NKX2-1), transcript variant 2 |
CNY 3,656.00 |
|
| RC217520L1 | Lenti ORF clone of Human NK2 homeobox 1 (NKX2-1), transcript variant 2, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC217520L2 | Lenti ORF clone of Human NK2 homeobox 1 (NKX2-1), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RC217520L3 | Lenti ORF clone of Human NK2 homeobox 1 (NKX2-1), transcript variant 2, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC217520L4 | Lenti ORF clone of Human NK2 homeobox 1 (NKX2-1), transcript variant 2, mGFP tagged |
CNY 6,056.00 |
|
| RG217520 | NKX2 (tGFP-tagged) - Human NK2 homeobox 1 (NKX2-1), transcript variant 2 |
CNY 5,256.00 |
