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PD1 (PDCD1) (NM_005018) Human Untagged Clone
CAT＃: SC117011
PD-1 / PDCD1 (untagged)-Human programmed cell death 1 (PD-1 / PDCD1)
CNY 3,600.00
| Cited in 3 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_005018 edited
GAATTCGGCACGAGGTGGAGAAGGCGGCACTCTGGTGGGGCTGCTCCAGGCATGCAGATC CCACAGGCGCCCTGGCCAGTCGTCTGGGCGGTGCTACAACTGGGCTGGCGGCCAGGATGG TTCTTAGACTCCCCAGACAGGCCCTGGAACCCCCCCACCTTCTCCCCAGCCCTGCTCGTG GTGACCGAAGGGGACAACGCCACCTTCACCTGCAGCTTCTCCAACACATCGGAGAGCTTC GTGCTAAACTGGTACCGCATGAGCCCCAGCAACCAGACGGACAAGCTGGCCGCCTTCCCC GAGGACCGCAGCCAGCCCGGCCAGGACTGCCGCTTCCGTGTCACACAACTGCCCAACGGG CGTGACTTCCACATGAGCGTGGTCAGGGCCCGGCGCAATGACAGCGGCACCTACCTCTGT GGGGCCATCTCCCTGGCCCCCAAGGCGCAGATCAAAGAGAGCCTGCGGGCAGAGCTCAGG GTGACAGAGAGAAGGGCAGAAGTGCCCACAGCCCACCCCAGCCCCTCACCCAGGCCAGCC GGCCAGTTCCAAACCCTGGTGGTTGGTGTCGTGGGCGGCCTGCTGGGCAGCCTGGTGCTG CTAGTCTGGGTCCTGGCCGTCATCTGCTCCCGGGCCGCACGAGGGACAATAGGAGCCAGG CGCACCGGCCAGCCCCTGAAGGAGGACCCCTCAGCCGTGCCTGTGTTCTCTGTGGACTAT GGGGAGCTGGATTTCCAGTGGCGAGAGAAGACCCCGGAGCCCCCCGTGCCCTGTGTCCCT GAGCAGACGGAGTATGCCACCATTGTCTTTCCTAGCGGAATGGGCACCTCATCCCCCGCC CGCAGGGGCTCAGCCGACGGCCCTCGGAGTGCCCAGCCACTGAGGCCTGAGGATGGACAC TGCTCTTGGCCCCTCTGACCGGCTTCCTTGGCCACCAGTGTTCTGCAGACCCTCCACCAT GAGCCCGGGTCAGCGCATTTCCTCAGGAGAAGCAGGCAGGGTGCAGGCCATTGCAGGCCG TCCAGGGGCTGAGCTGCCTGGGGGCGACCGGGGCTCCAGCCTGCACCTGCACCAGGCACA GCCCCACCACAGGACTCATGTCTCAATGCCCACAGTGAGCCCAGGCAGCAGGTGTCACCG TCCCCTACAGGGAGGGCCAGATGCAGTCACTGCTTCAGGTCCTGCCAGCACAGAGCTGCC TGCGTCCAGCTCCCTGAATCTCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCCTGCGGCC CGGGGCTGAAGGCGCCGTGGCCCTGCCTGACGCCCCGGAGCCTCCTGCCTGAACTTGGGG GCTGGTTGGAGATGGCCTTGGAGCAGCCAAGGTGCCCCTGGCAGTGGCATCCCGAAACGC CCTGGACGCAGGGCCCAAGACTGGGCACAGGAGTGGGAGGTACATGGGGCTGGGGACTCC CCAGGAGTTATCTGCTCCCTGCAGGCCTAGAGAAGTTTCAGGGAAGGTCAGAAGAGCTCC TGGCTGTGGTGGGCAGGGCAGGAAACCCCTCCACCTTTACACATGCCCAGGCAGCACCTC AGGCCCTTTGTGGGGCAGGGAAGCTGAGGCAGTAAGCGGGCAGGCAGAGCTGGAGGCCTT TCAGGCCCAGCCAGCACTCTGGCCTCCTGCCGCCGCATTCCACCCCAGCCCCTCACACCA CTCGGGAGAGGGACATCCTACGGTCCCAAGGTCAGGAGGGCAGGGCTGGGGTTGACTCAG GCCCCTCCCAGCTGTGGCCACCTGGGTGTTGGGAGGGCAGAAGTGCAGGCACCTAGGGCC CCCCATGTGCCCACCCTGGGAGCTCTCCTTGGAACCCATTCCTGAAATTATTTAAAGGGG TTGGCCGGGCTCCCACCAGGGCCTGGGTGGGAAGGTACAGGCGTTCCCCCGGGGCCTAGT ACCCCCGCCGTGGCCTATCCACTCCTCACATCCACACACTGCACCCCCACTCCTGGGGCA GGGCCACCAGCATCCAGGCGGCCAGCAGGCACCTGAGTGGCTGGGACAAGGGATCCCCCT TCCCTGTGGTTCTATTATATTATAATTATAATTAAATATGAGAGCATGCCAAAAAAAAAA AAAAAAAACTCGAC >OriGene 5' read for NM_005018 unedited
GCATTTTGTAATACGAACTCACTATAGGGCGGCCGCGAATTCGCACGAGGTGGAGAAGGC GGCACTCTGGTGGGGCTGCTCCAGGCATGCAGATCCCACAGGCGCCCTGGCCAGTCGTCT GGGCGGTGCTACAACTGGGCTGGCGGCCAGGATGGTTCTTAGACTCCCCAGACAGGCCCT GGAACCCCCCCACCTTCTCCCCAGCCCTGCTCGTGGTGACCGAAGGGGACAACGCCACCT TCACCTGCAGCTTCTCCAACACATCGGAGAGCTTCGTGCTAAACTGGTACCGCATGAGCC CCAGCAACCAGACGGACAAGCTGGCCGCCTTCCCCGAGGACCGCAGCCAGCCCGGCCAGG ACTGCCGCTTCCGTGTCACACAACTGCCCAACGGGCGTGACTTCCACATGAGCGTGGTCA GGGCCCGGCGCAATGACAGCGGCACCTACCTCTGTGGGGCCATCTCCCTGGCCCCCAAGG CGCAGATCAAAGAGAGCCTGCGGGCAGAGCTCAGGGTGACAGAGAGAAGGGCAGAAGTGC CCACAGCCCACCCCAGCCCCTCACCCAGGCCAGCCGGCCAGTTCCAAACCCTGGTGGTTG GTGTCGTGGGCGGCCTGCTGGGCAGCCTGGTGCTGCTAGTCTGGGTCCTGGCCGTCATCT GCTCCCGGGCCGCACGAGGGACAATAGGAGCCAGGCGCACCGGCCAGCNCCCTGAAGAGG ACCCCTCAGCCGTGCCTGTGTTCTCTGTGGACTATGGGGAGCTGGATTTCCAGTGGCGAG AGAAGACCCCGGACCCCCCGTGCCCTGTGTCCCTGAGCAGACGGAGTATGCCACCATTGT CTTTCCTAGCGGAATGGGCACCTCATNCNCCGCCCGCAGGGGCTCAGCCGACGGCCCTCG GAGTGCCCAGCCCTGAGGCCTGAGATGGACCTGCTCTTGCCCTCTGACGGCTNCTGGCCC CAGGT >OriGene 3' read for NM_005018 unedited
CGCGGCCGCAATTTAGNATCGAGTTTTTTTTTTTTTTTTTTGGCATGCTCTCATATTTAA TTATAATTATAATATAATAGAACCACAGGGAAGGGGGATCCCTTGTCCCAGCCACTCAGG TGCCTGCTGGCCGCCTGGATGCTGGTGGCCCTGCCCCAGGAGTGGGGGTGCAGTGTGTGG ATGTGAGGAGTGGATAGGCCACGGCGGGGGTACTAGGCCCCGGGGGAACGCCTGTACCTT CCCACCCAGGCCCTGGTGGGAGCCCGGCCAACCCCTTTAAATAATTTCAGGAATGGGTTC CAAGGAGAGCTCCCAGGGTGGGCACATGGGGGGCCCTAGGTGCCTGCACTTCTGCCCTCC CAACACCCAGGTGGCCACAGCTGGGAGGGGCCTGAGTCAACCCCAGCCCTGCCCTCCTGA CCTTGGGACCGTAGGATGTCCCTCTCCCGAGTGGTGTGAGGGGCTGGGGTGGAATGCGGC GGCAGGAGGCCAGAGTGCTGGCTGGGCCTGAAAGGCCTCCAGCTCTGCCTGCCCGCTTAC TGCCTCAGCTTTCCTGCCCCACAAAGGGCCTGAGGTGCTGCCTGGGCATGTGTAAAGGTG GAGGGGTTTCCTGCCCTGCCCACCACAGCCAGGAGCTCTTCTGACCTTTCCTGAAACTTC TCTAGGCCTGCAGGGAGCAGATAACTTCTGGGGAGTCCCCAGCCCCATTGTCCTTCCAAT TCTGTGCCCAGTCTTGGGCCCTGCGCCCAGGGCGTTTTGGGATGCCCCTGCCCGGGGCCC CTTTGCTGGTCCAAGCCATTTCCAACCAACCCCAAGTTCAGCAGGAAGTTCCGGGCGTAA GGAAGGGCCCGCGCCTTTAACCCCGGCCCCATGCACTACTACATCATATCATCAGTTCCG AGTATATGGAGCTGGCCCCAGCACTTTTTGTCTGCAGGACTCGAAACAT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_005018 |
| Insert Size | 867 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_005018.1, NP_005009.1 |
| RefSeq Size | 2106 bp |
| RefSeq ORF | 867 bp |
| Locus ID | 5133 |
| UniProt ID | Q15116 |
| Domains | ig, IGv, IG |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs), T cell receptor signaling pathway |
| Gene Summary | Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020] |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NFκB pathway
,null,
Science Advances
,PubMed ID 34739319
[PDCD1]
|
|
Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells
,Franchini, DM;Lanvin, O;Tosolini, M;Patras de Campaigno, E;Cammas, A;Péricart, S;Scarlata, CM;Lebras, M;Rossi, C;Ligat, L;Pont, F;Arimondo, PB;Laurent, C;Ayyoub, M;Despas, F;Lapeyre-Mestre, M;Millevoi, S;Fournié, JJ;,
Cell Rep
,PubMed ID 30605689
[PDCD1]
|
|
PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1
,Chen, G;Kim, YH;Li, H;Luo, H;Liu, DL;Zhang, ZJ;Lay, M;Chang, W;Zhang, YQ;Ji, RR;,
Nat. Neurosci.
,PubMed ID 28530662
[PDCD1]
|
Documents
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Resources
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