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Haptoglobin (HP) (NM_005143) Human Untagged Clone
CAT＃: SC116954
HP (untagged)-Human haptoglobin (HP), transcript variant 1
CNY 3,656.00
CNY 7,220.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BP; HP2ALPHA2; HPA1S |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC116954 sequence for NM_005143 edited (data generated by NextGen Sequencing)
ATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGTGGAC TCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCA CATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACA GAAGGAGATGGAGTATACACCTTAAATGATAAGAAGCAGTGGATAAATAAGGCTGTTGGA GATAAACTTCCTGAATGTGAAGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGCACAT GGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCACAGAA GGAGATGGAGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGAT AAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAATCCGGCAAACCCAGTGCAG CGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTT TCCCACCATAATCTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACG GCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCGAAAGACATTGCCCCTACT TTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCT AACTACTCCCAGGTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAG AGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCAGAAGTAGGGCGTGTGGGTTAT GTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATG CTGCCTGTGGCTGACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAA AAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATACTGAATGAACACACCTTCTGT GCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCC GTTCACGACCTGGAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGC TGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCCATCCAGGACTGGGTTCAG AAGACCATAGCTGAGAACTAA Clone variation with respect to NM_005143.3 >OriGene 5' read for NM_005143 unedited
NGTTCAAATTTGTATACGACTCCTATAGGGCGGCCGCGAATCGGCACCAGCAAAACCAAC CAANATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGACAGCTTTTTGCAGT GGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGCCCGAAGCCCCCCGAGAT TGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCG CACAGAAGGAGATGGAGTATACACCTTAAATGATAAGAAGCAGTGGATAAATAAGGCTGT TGGAGATAAACTTCCTGAATGTGAAGCAGATGACGGCTGCCCGAAGCCCCCCGAGATTGC ACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAGAACTACTACAAACTGCGCAC AGAAGGAGATGGAGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGG AGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAATCCGGCAAACCCAGT GCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGAT GGTTTCCCACCATAATCTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGAC CACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCGAAAGACATTGCCCC TACTTTAACACTCTATGTGGNGAAAAAGCAGCTTGTAGAGATTGAGAAAGGNTGTTCTAC ACCCTAACTACTCCCCAGTAGATATTGGGGCTCATCAAACTCAACAGAAGGTGTCTGTTA TGAGAGAGTGATGCCCATCTGCCTACCCTTCAANATTATGCAGAGTAGGGCGTGTGGGGT TATGGTTNCTGGCTGGGGGCGAAAGCCAAT >OriGene 3' read for NM_005143 unedited
NNNNNNNTTTGACTTTGGACCCGCGGCCGCATNCNANGATCGAGTTTTTTTTTTTTTTTT TTTTTTTTGGGGCAAAAAAAACTCTTTATTGATTGACTCAGCAATGCAGGGCTGGCACCC ATCAGCTTCAAACCACATCTTATCGCATCCACTCCTGTCCACTCCCGTCCACTTTGCCCT CTTCCAGGCTGAAATCTTGCTTTCAGGCAAGGGCTTCCGGCCAGCCTTGCATTAGTTCTC AGCTATGGGCTTCTGAACCCAGTCCTGGATGGAAGTCACCTTCACATACACACCATACTC AGCCACAGCACAGCTCTTATCAAAGCTTAAGATCCCAGTCGCATACCAGGTGTCCTCCTC CAGGTCGTGAACGGCAAAGGCACTGCCCGCATCGCCATAGCAGGTGTCTTCTTGGTACTT AGACATGCCAGCACAGAAGGTGTGTTCATTCAGTATGGGCTGCACCCCTACAGGGCTCTT CGGTGTCTTCTTTTCGGGGACTGTGCTGCCTTCATAATGCCTTATGCATTGGTCTTGGTC AGCCACAGGCAGCATGACATACTTCAGATGGTCAGTAAATTTAAAATTGGCATTTCGCCC CCAGCCAGAAACATAACCCACACGCCCTACTTCTGCATAATCCTTTGAAGGTANGCAGAT GGGCATCACTCTCTCATTAACAGACACCTTCTGTTTGAGTTTGATGAGCCCAAATCTACC TGGNATAGTTAGGNTGTAGAACACCTTCTCATCTCTACAGCTGCTTTTTCCCCCATAGAG TGNTAAAGTAGGGGCATGTCTTTCGCTGNTGCATTTTCTGATGGGTCAGAAAGAGATTTA GCCGTGTCGCAGCCATGGTCATGATCACGTGCACCTGTGTGAGATATGGTGGAACCATCT AACTGCAGGGAGCTGCTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_005143 |
| Insert Size | 1450 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_005143.2, NP_005134.1 |
| RefSeq Size | 1433 bp |
| RefSeq ORF | 1221 bp |
| Locus ID | 3240 |
| UniProt ID | P00738 |
| Domains | CCP, Tryp_SPc |
| Protein Families | Druggable Genome, Protease, Secreted Protein, Transmembrane |
| Gene Summary | This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2
,Amit Tripathi, Karen M. Lammers, Simeon Goldblum, Terez Shea-Donohue, Sarah Netzel-Arnett, Marguerite S. Buzza, Toni M. Antalis, Stefanie N. Vogel, Aiping Zhao, Shiqi Yang, Marie-Claire Arrietta, Jon B. Meddings, and Alessio Fasano,
PNAS, Sep 2009; 106: 16799 - 16804
[HP]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC223612 | HP (Myc-DDK-tagged)-Human haptoglobin (HP), transcript variant 1 |
CNY 3,656.00 |
|
| RC223612L1 | Lenti ORF clone of Human haptoglobin (HP), transcript variant 1, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC223612L2 | Lenti ORF clone of Human haptoglobin (HP), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC223612L3 | Lenti ORF clone of Human haptoglobin (HP), transcript variant 1, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC223612L4 | Lenti ORF clone of Human haptoglobin (HP), transcript variant 1, mGFP tagged |
CNY 6,056.00 |
|
| RG223612 | HP (tGFP-tagged) - Human haptoglobin (HP), transcript variant 1 |
CNY 5,256.00 |
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