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LGI1 (NM_005097) Human Untagged Clone
CAT＃: SC116925
LGI1 (untagged)-Human leucine-rich, glioma inactivated 1 (LGI1)
CNY 4,152.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ADLTE; ADPAEF; ADPEAF; EPITEMPIN; EPT; ETL1; IB1099 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC116925 sequence for NM_005097 edited (data generated by NextGen Sequencing)
ATGGAATCAGAAAGAAGCAAAAGGATGGGAAATGCCTGCATTCCCCTGAAAAGAATTGCT TATTTCCTATGTCTCTTATCTGCGCTTTTGCTGACTGAGGGGAAGAAACCAGCGAAGCCA AAATGCCCTGCCGTGTGTACTTGTACCAAAGATAATGCTTTATGTGAGAATGCCAGATCC ATTCCACGCACCGTTCCTCCTGATGTTATCTCATTATCCTTTGTGAGATCTGGTTTTACT GAAATCTCAGAAGGGAGTTTTTTATTCACGCCATCGCTGCAGCTCTTGTTATTCACATCG AACTCCTTTGATGTGATCAGTGATGATGCTTTTATTGGTCTTCCACATCTAGAGTATTTA TTCATAGAAAACAACAACATCAAGTCAATTTCAAGACATACTTTCCGGGGACTAAAGTCA TTAATTCACTTGAGCCTTGCAAACAACAATCTCCAGACACTCCCAAAAGATATTTTCAAA GGCCTGGATTCTTTAACAAATGTGGACCTGAGGGGTAATTCATTTAATTGTGACTGTAAA CTGAAATGGCTAGTGGAATGGCTTGGCCACACCAATGCAACTGTTGAAGACATCTACTGC GAAGGCCCCCCAGAATACAAGAAGCGCAAAATCAATAGTCTCTCCTCGAAGGATTTCGAT TGCATCATTACAGAATTTGCAAAGTCTCAAGACCTGCCTTATCAATCATTGTCCATAGAC ACTTTTTCTTATTTGAATGATGAGTATGTAGTCATCGCTCAGCCTTTTACTGGAAAATGC ATTTTCCTTGAATGGGACCATGTGGAAAAGACCTTCCGGAATTATGACAACATTACAGGC ACATCCACTGTAGTATGCAAGCCTATAGTCATTGAAACTCAGCTCTATGTTATTGTGGCC CAGCTGTTTGGTGGCTCTCACATCTATAAGCGAGACAGTTTTGCAAATAAATTCATAAAA ATCCAGGATATTGAAATTCTCAAAATCCGAAAACCCAATGACATTGAAACATTCAAGATT GAAAACAACTGGTACTTTGTTGTTGCTGACAGTTCAAAAGCTGGTTTTACTACCATTTAC AAATGGAACGGAAACGGATTCTACTCCCATCAATCCTTACACGCGTGGTACAGGGACACT GATGTGGAATATCTAGAAATAGTCAGAACACCTCAGACACTCAGAACGCCTCATTTAATT CTGTCTAGTAGTTCCCAGCGTCCTGTAATTTATCAGTGGAACAAAGCAACACAATTATTC ACTAACCAAACTGACATTCCTAACATGGAGGATGTGTACGCAGTGAAGCACTTCTCAGTG AAAGGGGACGTGTACATTTGCTTGACAAGATTCATTGGTGATTCCAAAGTCATGAAATGG GGAGGCTCCTCGTTCCAGGATATTCAGAGGATGCCATCGCGAGGATCCATGGTGTTCCAG CCTCTTCAAATAAATAATTACCAATATGCAATTCTTGGAAGTGATTACTCCTTTACTCAA GTGTATAACTGGGATGCAGAGAAAGCCAAATTTGTGAAATTTCAGGAATTAAATGTTCAG GCACCAAGATCATTCACACATGTGTCCATTAATAAGCGTAATTTTCTTTTTGCTTCCAGT TTTAAGGGAAATACACAGATTTACAAACATGTCATAGTTGACTTAAGCGCATGA Clone variation with respect to NM_005097.2 >OriGene 5' read for NM_005097 unedited
NGGTTCANGATATTTGTATACGACTCACTATAGNNGGCGGCCGCGCAATTCGGCACGAGG GAGCAGTGCATTGCTGGAGCGAGGAGAAGCTCACGAATCAGCTGCAGGTCTCTGTTTTGA AAAAGCAGAGATACAGAGGCAGAGGAAAAGGGTGGACTCCTATGTGACCTGTTCTTAGAG CAAGACAATCACCATCTGAATTCCAGAAGCCCTGTTCATGGTTGGGGATATTTTCTCGAC TGCATGGAATCAGAAAGAAGCAAAAGGATGGGAAATGCCTGCATTCCCCTGAAAAGAATT GCTTATTTCCTATGTCTCTTATCTGCGCTTTTGCTGACTGAGGGGAAGAAACCAGCGAAG CCAAAATGCCCTGCCGTGTGTACTTGTACCAAAGATAATGCTTTATGTGAGAATGCCAGA TCCATTCCACGCACCGTTCCTCCTGATGTTATCTCATTATCCTTTGTGAGATCTGGTTTT ACTGAAATCTCAGAAGGGAGTTTTTTATTCACGCCATCGCTGCAGCTCTTGTTATTCACA TCGAACTCCTTTGATGTGATCAGTGATGATGCTTTTATTGGTCTTCCACATCTAGAGTAT TTATTCATAGAAAACAACAACATCAAGTCAATTTCAAGACATACTTTCCGGGGACTAAAG TCATTAATTCACTTGAGCCTTGCAAACAACAATCTCCAGACACTCCCAAAAGAATTTTCA AAGGCCTGGATTCTTTAACANATGTGGACCTGAGGGGTAATTCATTTATTGTGACTGGTA ACTGAAATGGCTAGTGGAATGGCTTGGCCACACCAATGCACTGTTGAAGACATCTACTGC GAAGGCCCCCCAGATTACAGAGCGCAAATCATAGTCTCTCCTCGAAGATTTCGATTGCTC ATTC >OriGene 3' read for NM_005097 unedited
CCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGAAAAAAAATGTAAACAT TTTATTTGGCAGTTGTTTCTGTACACATGAATAAATAAATGGAAAAGTACATATTAATAT TTCTTTTTGGAGTAACAGATACCATTAAACGCTTATTTACACATCTTCACTGCAAAGAAC AGTTACACAATTAAATTTTGTCTTATAAAAGGTAACTTCCCACATCACTGGACTGGACAG TTAAAGGATGAATAACTGGTAAGGCTTGGTTTTAACAACCAAAAGTGTGGAAGGGGGTTT TTTTTTGCGGGGGGGAAAAAAAAAAAAAACCCCCTTTTTGTTGTTTTTCCCGGGGGGTTT TTGGGAAAAAAAAAATTTGTGGGGGGCGCCCACAAAAGAGGGGGGGGGGGCCCCCCCCCC CAAAAAAAAAAAAAAGGGGTGGGGGGGNGGNTTTTTTTTTTTTTTTTTCTTTAAAAAGGG GGGAGAAAAAAAAAAAANNCCTTTTTTTTTTTTTTCTCCCGCGGGGGGGGGGGGGGGTGT CTTCCCCCCCCCCCCCCCTCTCTTATAATACAAAAACNNNTTTGTTTGGTTTTTTTTTTT TCCCCCCCCGCCCCCGCGGGGGCGGGGGGGGGGGAGGGAGAAAAACACCCATCTCATTNN TTTCTTTTTTTTTTTTTTTTTTTAGGAAAATAAGGGGGNGGGGGGGNNGCCCCCCCCNCT CTCTCTTCNTTCTTTCCTCTCTCCTGTATCTCATACCCCTNCCCAACTCCCNCCATTANN NNTATATGTTGNGGGAATGCAAAAGGGACTGCCGGGNGCTTCCTGCCCTCCGTTCGTNCC TCCTCTCCTCCCATGCCCTTTTCACCGTAGTGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_005097 |
| Insert Size | 2240 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_005097.1, NP_005088.1 |
| RefSeq Size | 2254 bp |
| RefSeq ORF | 1674 bp |
| Locus ID | 9211 |
| UniProt ID | O95970 |
| Domains | LRRCT, LRR, LRR_TYP, EPTP |
| Protein Families | Druggable Genome, Secreted Protein |
| Gene Summary | This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
ADAM23 is a negative regulator of Kv1.1/Kv1.4 potassium currents
,Lancaster, E;Burnor, E;Zhang, J;Lancaster, E;,
Neurosci. Lett.
,PubMed ID 30965109
[LGI1]
|
|
LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory
,Petit-Pedrol, M;Sell, J;Planagumà, J;Mannara, F;Radosevic, M;Haselmann, H;Ceanga, M;Sabater, L;Spatola, M;Soto, D;Gasull, X;Dalmau, J;Geis, C;,
Brain
,PubMed ID 30346486
[LGI1]
|
|
Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series
,null,
Lancet neurology
,PubMed ID 20580615
[LGI1]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC205340 | LGI1 (Myc-DDK-tagged)-Human leucine-rich, glioma inactivated 1 (LGI1) |
CNY 4,152.00 |
|
| RC205340L1 | Lenti ORF clone of Human leucine-rich, glioma inactivated 1 (LGI1), Myc-DDK-tagged |
CNY 6,552.00 |
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| RC205340L2 | Lenti ORF clone of Human leucine-rich, glioma inactivated 1 (LGI1), mGFP tagged |
CNY 5,890.00 |
|
| RC205340L3 | Lenti ORF clone of Human leucine-rich, glioma inactivated 1 (LGI1), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC205340L4 | Lenti ORF clone of Human leucine-rich, glioma inactivated 1 (LGI1), mGFP tagged |
CNY 5,890.00 |
|
| RG205340 | LGI1 (tGFP-tagged) - Human leucine-rich, glioma inactivated 1 (LGI1) |
CNY 5,752.00 |
