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Hyaluronan synthase 2 (HAS2) (NM_005328) Human Untagged Clone
CAT＃: SC116826
HAS2 (untagged)-Human hyaluronan synthase 2 (HAS2)
CNY 6,176.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_005328 edited
ATGCATTGTGAGAGGTTTCTATGTATCCTGAGAATAATTGGAACCACACTCTTTGGAGTC TCTCTCCTCCTTGGAATCACAGCTGCTTATATTGTTGGCTACCAGTTTATCCAAACGGAT AATTACTATTTCTCTTTTGGACTGTATGGTGCCTTTTTGGCATCACACCTCATCATCCAA AGCCTGTTTGCCTTTTTGGAGCACCGAAAAATGAAAAAATCCCTAGAAACCCCCATAAAG TTGAACAAAACAGTTGCCCTTTGCATCGCTGCCTATCAAGAAGATCCAGACTACTTAAGG AAATGTTTGCAATCTGTGAAAAGGCTAACCTACCCTGGGATTAAAGTTGTCATGGTCATA GATGGGAACTCAGAAGATGACCTTTACATGATGGACATCTTCAGTGAAGTCATGGGCAGA GACAAATCAGCCACTTATATCTGGAAGAACAACTTCCACGAAAAGGGTCCCGGTGAGACA GATGAGTCACATAAAGAAAGCTCGCAACACGTAACGCAATTGGTCTTGTCCAACAAAAGT ATCTGCATCATGCAAAAATGGGGTGGAAAAAGAGAAGTCATGTACACAGCCTTCAGAGCA CTGGGACGAAGTGTGGATTATGTACAGGTTTGTGATTCAGACACTATGCTTGACCCAGCC TCATCTGTGGAGATGGTAAAAGTTTTAGAAGAAGATCCCATGGTTGGAGGTGTTGGGGGA GATGTCCAGATTTTAAACAAGTACGATTCCTGGATCTCATTCCTCAGCAGTGTAAGATAT TGGATGGCTTTTAATATAGAAAGGGCCTGTCAGTCTTATTTTGGGTGTGTTCAGTGCATT AGTGGACCTCTGGGAATGTACAGAAACTCCTTGTTGCATGAGTTTGTGGAAGATTGGTAC AATCAAGAATTTATGGGCAACCAATGTAGCTTTGGTGATGACAGGCATCTCACGAACCGG GTGCTGAGCCTGGGCTATGCAACAAAATACACAGCTCGATCTAAGTGCCTTACTGAAACA CCTATAGAATATCTCAGATGGCTAAACCAGCAGACCCGTTGGAGCAAGTCCTACTTCCGA GAATGGCTGTACAATGCAATGTGGTTTCACAAACATCACTTGTGGATGACCTACGAAGCG ATTATCACTGGATTCTTTCCTTTCTTTCTCATTGCCACAGTAATCCAGCTCTTCTACCGG GGTAAAATTTGGAACATTCTCCTCTTCTTGTTAACTGTCCAGCTAGTAGGTCTCATAAAA TCATCTTTTGCCAGCTGCCTTAGAGGAAATATCGTCATGGTCTTCATGTCTCTCTACTCA GTGTTATACATGTCGAGTTTACTTCCCGCCAAGATGTTTGCAATTGCAACAATAAACAAA GCTGGGTGGGGCACATCAGGAAGGAAAACCATTGTTGTTAATTTCATAGGACTCATTCCA GTATCAGTTTGGTTTACAATCCTCCTGGGTGGTGTGATTTTCACCATTTATAAGGAGTCT AAAAGGCCATTTTCAGAATCCAAACAGACAGTTCTAATTGTTGGAACGTTGCTCTATGCA TGCTATTGGGTCATGCTTTTGACGCTGTATGTAGTTCTCATCAATAAGTGTGGCAGGCGG AAGAAGGGACAACAATATGACATGGTGCTTGATGTATGA >OriGene 5' read for NM_005328 unedited
CCATTCCCCCGCCCCGCTGCGCATTGGGCGGTAGGCGTGTCCGGTGGGAGGTCTATATAA GCAGTTTTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCG CGAATTCGGCACGAGGAAGAGTTGAACCACCTAAGGCGGAGTTCAAACAAAGGCTGAAGC AGGAAGGTTTGCTGGGGGAAATCAGTGGGGTCCCCTGAGCAGCGTGAAGTCATCAGGCCA AGGTCGTCTCAAATTCATCTGATCTCTTATTACCTCAATTTTGGAAACTGCCCGCCACCG ACCCTCCGGGACCACACAGACAGGCTGAGGACGACTTTATGACCAAGAGCTGAACAAGAT GCATTGTGAGAGGTTTCTATGTATCCTGAGAATAATTGGAACCACACTCTTTGGAGTCTC TCTCCTCCTTGGAATCACAGCTGCTTATATTGTTGGCTACCAGTTTATCCAAACGGATAA TTACTATTTCTCTTTTGGACTGTATGGTGCCTTTTTGGCATCACACCTCATCATCCAAAG CCTGTTTGCCTTTTTGGAGCACCGAAAAATGAAAAAATCCCTAGAAACCCCCATAAAGTT GAACAAAACAGTTGCCCTTTGCATCGCTGCCTATCAAGAAGAGCCAGACTACTTAAGGAA ATGTTTGCAATCTGTGAAAAGGCTAACCTACCCTGNGATTAAAGTTGTCATGGTCATAGA TGGGAACTCAGCAGATGACCTTTACATGATGGACATCTTCAGTGAAGTCATGGGCAGAGA CTAATCAGCCACTTATATCTGGAAGACAACTTCCCGAAAAGGGTCCCTGTGAGACAGATG AGTCACATACAGCAAGCTCGCTACACGTAACGCTAATTGGTCTTGTCCTACACCAGTATC TGCATCATGCTAAAATGTNNGTGGGACAAGAGCAGTCT >OriGene 3' read for NM_005328 unedited
CCGGAAATACTATTACGCGGCCGCATTCTANGATCGAGTTTTTTTTTTTTTTTTTTCTTA TCAAAAATATTTTATTTACAAAAAATAATTATACTATACATCCTATACTGGAAATACATT GAATAATTGCTAAAATAAATACAGGCAATTAATTCAACTTTTTATAAGAATGAGAGAATT TGACATTTGAATGTTATCAAAGCTTAACTTAGAACATAATTAGTTAAAAAGGCAAACTCA AGTTTTCATCTCATTTATTGGCATGGTGTGTTTTGTTTTCCACAAGCTCTCCAATCAGTG AGAGTCTTGAGTCTCAGATGTACCTTTTTGTACTCTGAAGGTAGGATGTGCAGCTTTTTC TTAGGCAGGATAGATGTAACATAGATGACTGCCTAAAAAAGAGGCAGAAAGGCAGGAAGC CCATTTTTTTTTTAACACTTCTCCATGTGTCTCTGCCTCACCATAATGCTGTTTATTCAA TTATTCATATATTCCGATTGTGTTTTCAACACAGGTTTACACAGCACCAGCTACAAGGCA AGGTCAATCGTGTAAAAAATAAAACTGGATAATGGAGGCCTTGCAGTAACTAAATTAGCC AAGTTCAGAGTATGTGGTTCAACAATTTTTATATGTGCCCATCATTGATATACTTATTAA ACCTTGATGTCACTTCTACTGGGGAGACATTTTTATTCAGGTCCACAACAGGAAATAAGA AGTGATGATCTGTGTAATTCACAAAAACAAATTCCTCCTTTGTAAAGTAAAAGAGGAAAG AAACTTGGTGGAGTCTTCTTGCCCAATTTCAAATTATATGGTTTTAAAAATTATCCCACT TCACCCGGGTAGACCTTTTTACCTCCCTGGTAAAGGGAACG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_005328 |
| Insert Size | 1659 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_005328.1, NP_005319.1 |
| RefSeq Size | 3003 bp |
| RefSeq ORF | 1659 bp |
| Locus ID | 3037 |
| UniProt ID | Q92819 |
| Domains | Glycos_transf_2 |
| Protein Families | Druggable Genome, Transmembrane |
| Gene Summary | Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. [provided by RefSeq, Jul 2008] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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A novel mutation of hyaluronan synthase 2 gene in chinese children with ventricular septal defect
,Zhu, X;Deng, X;Huang, G;Wang, J;Yang, J;Chen, S;Ma, X;Wang, B;,
PLoS ONE, Feb 2014.
,PubMed ID 24558368
[HAS2]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC224227 | HAS2 (Myc-DDK-tagged)-Human hyaluronan synthase 2 (HAS2) |
CNY 6,168.00 |
|
| RC224227L1 | Lenti ORF clone of Human hyaluronan synthase 2 (HAS2), Myc-DDK-tagged |
CNY 8,568.00 |
|
| RC224227L2 | Lenti ORF clone of Human hyaluronan synthase 2 (HAS2), mGFP tagged |
CNY 5,890.00 |
|
| RC224227L3 | Lenti ORF clone of Human hyaluronan synthase 2 (HAS2), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC224227L4 | Lenti ORF clone of Human hyaluronan synthase 2 (HAS2), mGFP tagged |
CNY 5,890.00 |
|
| RG224227 | HAS2 (tGFP-tagged) - Human hyaluronan synthase 2 (HAS2) |
CNY 7,768.00 |
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