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LXR alpha (NR1H3) (NM_005693) Human Untagged Clone
CAT＃: SC116564
NR1H3 (untagged)-Human nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 1
CNY 5,488.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | LXR-a; LXRA; RLD-1 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_005693 edited
ATGTCCTTGTGGCTGGGGGCCCCTGTGCCTGACATTCCTCCTGACTCTGCGGTGGAGCTG TGGAAGCCAGGCGCACAGGATGCAAGCAGCCAGGCCCAGGGAGGCAGCAGCTGCATCCTC AGAGAGGAAGCCAGGATGCCCCACTCTGCTGGGGGTACTGCAGGGGTGGGGCTGGAGGCT GCAGAGCCCACAGCCCTGCTCACCAGGGCAGAGCCCCCTTCAGAACCCACAGAGATCCGT CCACAAAAGCGGAAAAAGGGGCCAGCCCCCAAAATGCTGGGGAACGAGCTATGCAGCGTG TGTGGGGACAAGGCCTCGGGCTTCCACTACAATGTTCTGAGCTGCGAGGGCTGCAAGGGA TTCTTCCGCCGCAGCGTCATCAAGGGAGCGCACTACATCTGCCACAGTGGCGGCCACTGC CCCATGGACACCTACATGCGTCGCAAGTGCCAGGAGTGTCGGCTTCGCAAATGCCGTCAG GCTGGCATGCGGGAGGAGTGTGTCCTGTCAGAAGAACAGATCCGCCTGAAGAAACTGAAG CGGCAAGAGGAGGAACAGGCTCATGCCACATCCTTGCCCCCCAGGGCTTCCTCACCCCCC CAAATCCTGCCCCAGCTCAGCCCGGAACAACTGGGCATGATCGAGAAGCTCGTCGCTGCC CAGCAACAGTGTAACCGGCGCTCCTTTTCTGACCGGCTTCGAGTCACGCCTTGGCCCATG GCACCAGATCCCCATAGCCGGGAGGCCCGTCAGCAGCGCTTTGCCCACTTCACTGAGCTG GCCATCGTCTCTGTGCAGGAGATAGTTGACTTTGCTAAACAGCTACCCGGCTTCCTGCAG CTCAGCCGGGAGGACCAGATTGCCCTGCTGAAGACCTCTGCGATCGAGGTGATGCTTCTG GAGACATCTCGGAGGTACAACCCTGGGAGTGAGAGTATCACCTTCCTCAAGGATTTCAGT TATAACCGGGAAGACTTTGCCAAAGCAGGGCTGCAAGTGGAATTCATCAACCCCATCTTC GAGTTCTCCAGGGCCATGAATGAGCTGCAACTCAATGATGCCGAGTTTGCCTTGCTCATT GCTATCAGCATCTTCTCTGCAGACCGGCCCAACGTGCAGGACCAGCTCCAGGTAGAGAGG CTGCAGCACACATATGTGGAAGCCCTGCATGCCTACGTCTCCATCCACCATCCCCATGAC CGACTGATGTTCCCACGGATGCTAATGAAACTGGTGAGCCTCCGGACCCTGAGCAGCGTC CACTCAGAGCAAGTGTTTGCACTGCGTCTGCAGGACAAAAAGCTCCCACCGCTGCTCTCT GAGATCTGGGATGTGCACGAATGA >OriGene 5' read for NM_005693 unedited
GGGGGNNNCNNTTTTTTNNNNNNNNGGTTCAGAATTGNATACGACTCCTATAGGCGGCCG CGNAATTCGCACCAGGTCCTGCTTGTGCTCAGCTCCAGCTCACTGGCTGGCCACCGAGAC TTCTGGACAGGAAACTGCACCATCCTCTTCTCCCAGCAAGGGGGCTCCAGAGACTGCCCA CCCAGGAAGTCTGGTGGCCTGGGGATTTGGACAGTGCCTTGGTAATGACCAGGGCTCCAG GAAGAGATGTCCTTGTGGCTGGGGGCCCCTGTGCCTGACATTCCTCCTGACTCTGCGGTG GAGCTGTGGAAGCCAGGCGCACAGGATGCAAGCAGCCAGGCCCAGGGAAGGCAGCAGCTG CATCCTCAGAGAGGAAGCCAGGATGCCCCACTCTGCTGGGGGTACTGCAGGGGTGGGGCT GGAGGCTGCAGAGCCCACAGCCCTGCTCACCAGGGCAGAGCCCCCTTCAGAACCCACAGA GATCCGTCCACAAAAGCGGAAAAAGGGGCCAGCCCCCANAATGCTGNGGAACGAGCTATG CAGCGTGTGTGGGGACAAGGCCTNCGGCTTCCACTACAATGTTCTGAGCTGCGAGGGCTG CAGGGGATTCTTCCGCCGCAGCGTCATCAAGGGAGCGCACTACATCTGCCACAGTGGCGG CCACTNGCCCATGGACACCTACATGCGTCGCAAGTGCCAGGAGTGTCCGCTTCGCAAATG CCGTCAGGCTGGCATGCCGGAGGAGTGTGTCCTGTCAGAAGAACAGATCCGCCTGAAGAA AACTGAGCCGCCAGAAGGAGGAACAGGCTCATGCCACATNCCTTTGCCCNNCCAGGCTTT TCTCACCCCNCCCAAANCCTGCCCCCAGCTCAGCCCGNAACAACTGGGCATGAATCGAGA AGCTCGTCCCTGCCCACCAACAGTGGTAACCGGNCGCTCCTTTTCTTGACCGGCTTCNGA TCCACGCCTGGGCCCATGGCACCAGATCCCATAACCGGNNAGCCCGTTACAAGCGCTTTG CCCCACTTACTGAGCTGGGCATCGGCTCTGGGCAGGAGGAAATTGAC >OriGene 3' read for NM_005693 unedited
CGGAGAGGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGATCTGTTCAGGAAACAGCT ATGATTTCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTGGTTTTTTTTTAACCCTTTGAC TCTCTTTTAATGCCACGGGAGGATCTCCTTGCCCAGCTCCCAGGAATGTTTGCCCTTCTC AGTCTGTTCCACTTCTAGGAGGCAGCCACCAGGCCTCAGCCATCCGGCCAAGAAAACAGA AAATATGGGGACAGAACAGTCATTCGTGCACATCCCAGATCTCAGAGAGCAGCGGTGGGA GCTTTTTGTCCTGCAGACGCAGTGCAAACACTTGCTCTGAGTGGACGCTGCTCAGGGTCC GGAGGCTCACCAGTTTCATTAGCATCCGTGGGAACATCAGTCGGTCATGGGGATGGTGGA TGGAGACGTAGGCATGCAGGGCTTCCACATATGTGTGCTGCAGCCTCTCTACCTGGAGCT GGTCCTGCACGTTGGGCCGGTCTGCAGAGAAGATGCTGATAGCAATGAGCAAGGCAAACT CGGCATCATTGAGTTGCAGCTCATTCATGGCCCTGGAGAACTCGAAGATGGGGTTGATGA ATTCCACTTGCAGCCCTGCTTTGGCAAAGTCTTCCNCGTTATAACTGANATCCTTGAGGA AGGTGATACTCTCACTCCCAGGGTTGTACCTCCGAGATGTCTCCAGAAGCATCACCTCGA TCGCAGAGGTCTTCAGCAGGGCAATCTGGTCCTNCCCGCTGAGCTGCAAGAAGCCGGGTA GCTGTTTAACAAATC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_005693 |
| Insert Size | 1700 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_005693.1, NP_005684.1 |
| RefSeq Size | 1528 bp |
| RefSeq ORF | 1344 bp |
| Locus ID | 10062 |
| UniProt ID | Q13133 |
| Domains | HOLI, zf-C4 |
| Protein Families | Druggable Genome, Nuclear Hormone Receptor, Transcription Factors |
| Protein Pathways | PPAR signaling pathway |
| Gene Summary | The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC223767 | NR1H3 (Myc-DDK-tagged)-Human nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 1 |
CNY 3,656.00 |
|
| RC223767L1 | Lenti ORF clone of Human nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 1, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC223767L2 | Lenti ORF clone of Human nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC223767L3 | Lenti ORF clone of Human nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 1, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC223767L4 | Lenti ORF clone of Human nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 1, mGFP tagged |
CNY 6,056.00 |
|
| RG223767 | NR1H3 (tGFP-tagged) - Human nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 1 |
CNY 5,256.00 |
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