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SMAD1 (NM_005900) Human Untagged Clone
CAT＃: SC116433
SMAD1 (untagged)-Human SMAD family member 1 (SMAD1), transcript variant 1
CNY 3,656.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_005900 edited
GAATTCGGCACGAGGGGCGGGCGGGCGGAGAAAGGAGAGGCCGAGCGGCTCAACCCGGGC CGAGGCTCGGGGAGCGGAGAGTGGCGCAGCGCCCGGCCGTCCGGACCCGGGCCGCGAGAC CCCGCTCGCCCGGCCACTCGTGCTCCCGCACGGACGGGCGCGCCGCCAACCCGGTGCTGA CTGGGTTACTTTTTTAAACACTAGGAATGGTAATTTCTACTCTTCTGGACTTCAAACTAA GAAGTTAAAGAGACTTCTCTGTAAATAAACAAATCTCTTCTGCTGTCCTTTTGCATTTGG AGACAGCTTTATTTCACCATATCCAAGGAGTATAACTAGTGCTGTCATTATGAATGTGAC AAGTTTATTTTCCTTTACAAGTCCAGCTGTGAAGAGACTTCTTGGGTGGAAACAGGGCGA TGAAGAAGAAAAATGGGCAGAGAAAGCTGTTGATGCTTTGGTGAAAAAACTGAAGAAAAA GAAAGGTGCCATGGAGGAACTGGAAAAGGCCTTGAGCTGCCCAGGGCAACCGAGTAACTG TGTCACCATTCCCCGCTCTCTGGATGGCAGGCTGCAAGTCTCCCACCGGAAGGGACTGCC TCATGTCATTTACTGCCGTGTGTGGCGCTGGCCCGATCTTCAGAGCCACCATGAACTAAA ACCACTGGAATGCTGTGAGTTTCCTTTTGGTTCCAAGCAGAAGGAGGTCTGCATCAATCC CTACCACTATAAGAGAGTAGAAAGCCCTGTACTTCCTCCTGTGCTGGTTCCAAGACACAG CGAATATAATCCTCAGCACAGCCTCTTAGCTCAGTTCCGTAACTTAGGACAAAATGAGCC TCACATGCCACTCAACGCCACTTTTCCAGATTCTTTCCAGCAACCCAACAGCCACCCGTT TCCTCACTCTCCCAATAGCAGTTACCCAAACTCTCCTGGGAGCAGCAGCAGCACCTACCC TCACTCTCCCACCAGCTCAGACCCAGGAAGCCCTTTCCAGATGCCAGCTGATACGCCCCC ACCTGCTTACCTGCCTCCTGAAGACCCCATGACCCAGGATGGCTCTCAGCCGATGGACAC AAACATGATGGCGCCTCCCCTGCCCTCAGAAATCAACAGAGGAGATGTTCAGGCGGTTGC TTATGAGGAACCAAAACACTGGTGCTCTATTGTCTACTATGAGCTCAACAATCGTGTGGG TGAAGCGTTCCATGCCTCCTCCACAAGTGTGTTGGTGGATGGTTTCACTGATCCTTCCAA CAATAAGAACCGTTTCTGCCTTGGGCTGCTCTCCAATGTTAACCGGAATTCCACTATTGA AAACACCAGGCGGCATATTGGAAAAGGAGTTCATCTTTATTATGTTGGAGGGGAGGTGTA TGCCGAATGCCTTAGTGACAGTAGCATCTTTGTGCAAAGTCGGAACTGCAACTACCATCA TGGATTTCATCCTACTACTGTTTGCAAGATCCCTAGTGGGTGTAGTCTGAAAATTTTTAA CAACCAAGAATTTGCTCAGTTATTGGCACAGTCTGTGAACCATGGATTTGAGACAGTCTA TGAGCTTACAAAAATGTGTACTATACGTATGAGCTTTGTGAAGGGCTGGGGAGCAGAATA CCACCGCCAGGATGTTACTAGCACCCCCTGCTGGATTGAGATACATCTGCACGGCCCCCT CCAGTGGCTGGATAAAGTTCTTACTCAAATGGGTTCACCTCATAATCCTATTTCATCTGT ATCTTAAATGGCCCCAGGCATCTGCCTCTGGAAAACTATTGAGCCTTGCATGTACTTGAA GGATGGATGAGTCAGATACGATTGAGAACTGACAAAGGAGCCTTGATAATACTTGACCTC TGTGACCAACTGTTGGATTCAGAAATTTAAACAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_005900 unedited
GTGTTCGAATATTTGTATACGACTCACTATAGGGCGGCCGCGNAATCGGCACGAGGGGCG GGCGGGCGGAGAAAGGAGAGGCCGAGCGGCTCAACCCGGGCCGAGGCTCGGGGAGCGGAG AGTGGCGCAGCGCCCGGCCGTCCGGACCCGGGCCGCGAGACCCCGCTCGCCCGGCCACTC GTGCTCCCGCACGGACGGGCGCGCCGCCAACCCGGTGCTGACTGGGTTACTTTTTTAAAC ACTAGGAATGGTAATTTCTACTCTTCTGGACTTCAAACTAAGAAGTTAAAGAGACTTCTC TGTAAATAAACAAATCTCTTCTGCTGTCCTTTTGCATTTGGAGACAGCTTTATTTCACCA TATCCAAGGAGTATAACTAGTGCTGTCATTATGAATGTGACAAGTTTATTTTCCTTTACA AGTCCAGCTGTGAAGAGACTTCTTGGGTGGAAACAGGGCGATGAAGAAGAAAAATGGGCA GAGAAAGCTGTTGATGCTTTGGTGAAAAAACTGAAGAAAAAGAAAGGTGCCATGGAGGAA CTGGAAAAGGCCTTGAGCTGCCCAGGGCAACCGAGTAACTGTGTCACCATTCCCCGCTCT CTGGATGGCAGGCTGCAAGTCTCCCACCGGAAGGGACTGCCTCATGTCATTTACTGCCGT GTGTGGCGCTGGCCCGATCTTCAGAGCCACCATGAACTAAAACCACTGGGATGCTGTGAG TTTCCTTTTGGTTCCAAGCAGAAAGAGGTCTGCATCAATCCCTACCACTATAAGAGAGTA GAAAGCCCTGTACTTCCTCCTGTGCTGGGTCCAAGACACAGCGAATATAATCCTCAGCAC AGCCTCTTAGCTCAGGTTCCGTAACTTAGGACAAAAAGAGCCTCACATGGCACTCCACGC CACTTTTCCAGATTTTTTCAGC >OriGene 3' read for NM_005900 unedited
GCGGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGTTTAAATTTCTGAATCCA ACAGTTGGTCACAGAGGTCAAGTATTATCAAGGCTCCTTTGTCAGTTCTCAATCGTATCT GACTCATCCATCCTTCAAGTACATGCAAGGCTCAATAGTTTTCCAGAGGCAGATGCCTGG GGCCATTTAAGATACAGATGAAATAGGATTATGAGGTGAACCCATTTGAGTAAGAACTTT ATCCAGCCACTGGAGGGGGCCGTGCAGATGTATCTCAATCCAGCAGGGGGTGCTAGTAAC ATCCTGGCGGTGGTATTCTGCTCCCCAGCCCTTCACAAAGCTCATACGTATAGTACACAT TTTTGTAAGCTCATAGACTGTCTCAAATCCATGGTTCACAGACTGTGCCAATAACTGAGC AAATTCTTGGTTGTTAAAAATTTTCAGACTACACCCACTAGGGATCTTGCAAACAGTAGT AGGATGAAATCCATGATGGTAGTTGCAGTTCCGACTTTGCACAAAGATGCTACTGTCACT AAGGCATTCGGCATACACCTCCCCTCCAACATAATAAAGATGAACTCCTTTTCCAATATG CCGNCTGGTGTTTTCATAGTGGAATTCCGGTTAACATTGGAGAGCAGCCCAAGGCAGAAA CGGTTCCTATTGTTGGGAAGGATCAGTGAAACCATTCACCCACACACTTGTGGAGGAAGC ATGAAACGCTTCCCCCCACGATTGTTGACCTCATATAGACATTAAACACCAGTGTTTTGG TTCCTTATTAACAACCGGCTGAACATTTCCTCTGTTGATTTCTGAGGCCAAGGGAGGGCC CATCATGGTTTGGGTCCCTCGGCTGAGACCCTACCTGGGTCATGGGGCTCTTTAGAAGGC AGGAACCAGGGTGGGGGCGTTTCACCCTGCCTTCTGGAAGGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_005900 |
| Insert Size | 2000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_005900.2, NP_005891.1 |
| RefSeq Size | 3056 bp |
| RefSeq ORF | 1398 bp |
| Locus ID | 4086 |
| UniProt ID | Q15797 |
| Domains | DWB, DWA, MH1 |
| Protein Families | Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transcription Factors |
| Protein Pathways | TGF-beta signaling pathway |
| Gene Summary | The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-ß cytostatic program and blocks the antiproliferative effect of TGF-ß
,B Q Trinh, N Barengo, H Naora,
Oncogene (7 February 2011) doi:10.1038/onc.2011.4 Original Article
[SMAD1]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC223918 | SMAD1 (Myc-DDK-tagged)-Human SMAD family member 1 (SMAD1), transcript variant 1 |
CNY 3,656.00 |
|
| RC223918L1 | Lenti ORF clone of Human SMAD family member 1 (SMAD1), transcript variant 1, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC223918L2 | Lenti ORF clone of Human SMAD family member 1 (SMAD1), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC223918L3 | Lenti ORF clone of Human SMAD family member 1 (SMAD1), transcript variant 1, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC223918L4 | Lenti ORF clone of Human SMAD family member 1 (SMAD1), transcript variant 1, mGFP tagged |
CNY 6,056.00 |
|
| RG223918 | SMAD1 (tGFP-tagged) - Human SMAD family member 1 (SMAD1), transcript variant 1 |
CNY 5,256.00 |
