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VAV3 (NM_006113) Human Untagged Clone
CAT＃: SC116335
VAV3 (untagged)-Human vav 3 guanine nucleotide exchange factor (VAV3), transcript variant 1
CNY 6,208.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_006113 edited
ATGGAGCCGTGGAAGCAGTGCGCGCAGTGGCTCATCCATTGCAAGGTGCTGCCCACCAAC CACCGGGTGACCTGGGACTCGGCTCAGGTGTTCGACCTTGCGCAGACCCTCCGCGATGGA GTCCTGCTCTGCCAGCTGCTTAACAACCTCCGGGCGCACTCCATCAACCTGAAGGAGATC AACCTGAGGCCGCAGATGTCCCAGTTTCTCTGTTTGAAGAACATAAGGACATTTCTCACG GCCTGTTGTGAGACGTTTGGAATGAGGAAAAGTGAACTTTTCGAGGCATTTGACTTGTTT GATGTTCGTGACTTTGGAAAGGTTATAGAAACATTATCACGACTTTCTCGAACACCTATA GCATTGGCCACAGGAATCAGGCCCTTCCCAACAGAAGAAAGCATTAATGATGAAGACATC TACAAAGGCCTTCCTGATTTAATAGATGAAACCCTTGTGGAAGATGAAGAAGATCTCTAT GACTGTGTTTATGGGGAAGATGAAGGTGGAGAAGTCTATGAGGACTTAATGAAGGCAGAG GAAGCACATCAGCCCAAATGTCCAGAAAATGATATACGAAGTTGTTGTCTAGCAGAAATT AAGCAGACAGAAGAAAAATATACAGAAACTTTGGAGTCAATAGAAAAGTATTTCATGGCA CCACTAAAAAGATTTCTGACAGCAGCAGAATTTGATTCAGTATTCATCAACATTCCTGAA CTTGTAAAACTTCATCGGAACCTAATGCAAGAGATTCATGATTCCATTGTAAATAAAAAT GACCAGAACTTGTACCAAGTTTTTATTAACTACAAGGAAAGATTGGTTATTTACGGGCAG TACTGCAGTGGAGTGGAGTCAGCCATCTCTAGTTTAGACTACATTTCTAAGACAAAAGAA GATGTCAAACTGAAATTAGAGGAATGTTCCAAAAGAGCAAATAATGGGAAATTTACTCTT CGAGACTTGCTTGTGGTTCCTATGCAACGTGTTTTAAAGTACCACCTTCTCCTCCAGGAA CTGGTCAAACATACCACTGATCCGACTGAGAAGGCAAATCTGAAACTGGCTCTTGATGCC ATGAAGGACTTGGCACAATATGTGAATGAAGTGAAAAGAGATAATGAGACCCTTCGTGAA ATTAAACAGTTTCAGCTATCTATAGAGAATTTGAACCAACCAGTTTTGCTTTTTGGACGA CCTCAGGGAGATGGTGAAATTCGAATAACCACTCTAGACAAGCATACCAAACAAGAAAGG CATATCTTCTTATTTGATTTGGCAGTGATCGTATGTAAGAGAAAAGGTGATAACTATGAA ATGAAGGAAATAATAGATCTTCAGCAGTACAAGATAGCCAATAATCCTACAACCGATAAA GAAAACAAAAAGTGGTCTTATGGCTTCTACCTCATCCATACCCAAGGACAAAATGGGTTA GAATTTTATTGCAAAACAAAAGATTTAAAGAAGAAATGGCTAGAACAGTTTGAAATGGCT TTGTCTAACATAAGACCAGACTATGCAGACTCCAATTTCCACGACTTCAAGATGCATACC TTCACTCGAGTCACATCCTGCAAAGTCTGCCAGATGCTCCTGAGGGGAACATTTTATCAA GGCTATTTATGTTTTAAGTGTGGAGCGAGAGCACACAAAGAATGTTTGGGAAGAGTAGAC AATTGTGGCAGAGTTAATTCTGGTGAACAAGGGACACTCAAACTACCAGAGAAACGGACC AATGGACTGCGAAGAACTCCTAAACAGGTGGATCCAGGTTTACCAAAGATGCAGGTCATT AGGAACTATTCTGGAACACCACCCCCAGCTCTGCATGAAGGACCCTCTTTACACCTCCAG GCCGGGGATACCGTTGAACTTCTGAAAGGAGATGCACACAGTCTGTTTTGGCAGGGCAGA AATTTAGCATCTGGAGAGGTTGGATTTTTTCCAAGTGATGCAGTCAAGCCTTGCCCATGT GTGCCCAAACCAGTAGATTATTCTTGCCAACCCTGGTATGCTGGAGCAATGGAAAGATTG CAAGCAGAGACCGAACTTATTAATAGGGTAAATAGTACTTACCTTGTGAGGCACAGGACC AAAGAGTCAGGAGAATATGCAATTAGCATTAAGTACAATAATGAAGCAAAGCACATCAAG ATTTTAACAAGAGATGGCTTTTTTCACATTGCAGAAAATAGAAAATTTAAAAGTTTAATG GAACTTGTGGAGTACTACAAGCATCATTCTCTCAAGGAAGGGTTCAGAACCTTAGATACA ACTCTGCAGTTTCCATACAAGGAGCCAGAACATTCAGCTGGACAGAGGGGTAATAGAGCA GGCAACAGCTTGTTAAGTCCAAAAGTGCTGGGCATTGCCATCGCTCGGTATGACTTCTGT GCAAGAGATATGAGAGAGTTGTCCTTGTTGAAAGGAGATGTGGTGAAGATTTACACAAAG ATGAGTGCAAATGGCTGGTGGAGAGGAGAAGTAAATGGCAGGGTGGGCTGGTTTCCATCC ACATATGTGGAAGAGGATGAATAA >OriGene 5' read for NM_006113 unedited
CACCCATTCCGCACGAGGGCGGCAGCCGCCGCCGAGCCGGCCGGGGCGCACGGAGAGCGC GCGGGACTCGCTGCAGCGGCGGCCGGGTCGCGGCGCACCCGGGCCGGGACCGGAGCCGAG CCTAGCGCGGCGCCCGCGACCCGTCAGCCGCGGCTCCTGCTCCCTCGATCCCGCGCTGTT ATGGGCCGGCGGCTGTTGGCGTCGGCGGGGCGCGGAGGAACCGCGGCGGCGGCGGCGGCG GCCGCATCCTTGCCGCCCGCCCCGGCCCAGCCGCGTCCCGGAGCCGTCGGGCATGGAGCC GTGGAAGCAGTGCGCGCAGTGGCTCATCCATTGCAAGGTGCTGCCCACCAACCACCGGGT GACCTGGGACTCGGCTCAGGTGTTCGACCTTGCGCAGACCCTCCGCGATGGAGTCCTGCT CTGCCAGCTGCTTAACAACCTCCGGGCGCACTCCATCAACCTGAAGGAGATCAACCTGAG GCCGCAGATGTCCCAGTTTCTCTGTTTGAAGAACATAAGGACATTTCTCACGGCCTGTTG TGAGACGTTTGGAATGAGGAAAAGTGAACTTTTCGAGGCATTTGACTTGTTTGATGTTCG TGACTTTGGAAAGGTTATAGAAACATTATCACGACTTTCTCGAACACCTATAGCATTGGC CACAGGAATCAGGCCCTTCCCAACAGAAGAAAGCATTAATGATGAAGACATCTACAAAGG CCTTCCTGATTTAATAGATGAAACCCTTGTGGAAGATGAAGAAGATCTCTATGACTGTGT TTATGGGGAAAGATGAAGTGGAGGAGTCTATGAGGACTTNNATGAGGCAGAGGAAGCACA TCAGCCCANATGTNCCAGAAATGATATACGAAGTT >OriGene 3' read for NM_006113 unedited
CCGCGGCCGCAATCTAGNATCGAGTTTTTTTTTTTTTTTTTTTTTTTCAATTTAGTCACT ATTTATTATATTGACATATTTACAAAATAATACAAAGTGAAATACCACTCTAATTCACCG TATTACACGAGGGCTGCATACAGGCAAGACAAAGTATATGGAAAACATTTACTTCTGTCT TTGGTATTAGAACTCTACACAAATCTGCAGCATTTAAATTTTCCAAAACAAAGTATTAAA CGTGGACAAAGATGTAATTGGTAATGTCACAAAAAGGGGCTCCAATATCCTCTGCTAGGA AACCCCCAGGCCCATGAAATGCAACAGGAAGACTAAACACCATTTATAAGGAGAGGGTCT ATTGACTAAAATAAACAATACATGCTACAATACCATCCACAGGAGTGTTTCTGCTTGTGT GAGGCTGCTCCCTCCATAACAAAGTTCGGCTGACGGCAACAGACAAAACATTCCCGAGAC AGAGTCGCAGATAAGACTTTACAGGAAAGAATCCATTCCAAGAGTACACTTTGAGGTGTA ACTTTATTGTACAGAACATTTTATAAAATACATTNTTGTGATCATTTACACATATACAAA GACTTAAATGGTTTTTAGCAAATATTATTTNTTCTAAACACAATCACAGTTTACATAATT CTGAGGTAAAGGTCTTGATTCTATCCTAGATGAAAAGTCCTACCCCATGAGGGTCTCTAC AGGGGGATGTGTCCACTGACCCTGAGTTCTGCCCCCANACCGATGATGACAGGGCAGCTA CACTGCTCATTTCAGGATGATCAAATTTCAAACTAAAGCTCTGTTCAGTCTACAAGTAAG CTTCTTTTTTCCAACAGAACTTCTAATCTGCAGACAAACTTTGTTTGGAGGAAATTCCAT CAGAAGCCCANTAGGGTTACTGACTGCTGATGGGCTCTGACCCAGAGATGTTTAGCTCTC AAAAAAAGAGGCTGC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_006113 |
| Insert Size | 5000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | no |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_006113.3, NP_006104.3 |
| RefSeq Size | 4768 bp |
| RefSeq ORF | 2544 bp |
| Locus ID | 10451 |
| UniProt ID | Q9UKW4 |
| Domains | RhoGEF, SH2, SH3, CH, PH, DAG_PE-bind |
| Protein Families | Druggable Genome |
| Protein Pathways | B cell receptor signaling pathway, Chemokine signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Regulation of actin cytoskeleton, T cell receptor signaling pathway |
| Gene Summary | This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1, also known as VAV-3alpha) encodes the longer isoform (1). |
Documents
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC220550 | VAV3 (Myc-DDK-tagged)-Human vav 3 guanine nucleotide exchange factor (VAV3), transcript variant 1 |
CNY 6,208.00 |
|
| RC220550L3 | Lenti ORF clone of Human vav 3 guanine nucleotide exchange factor (VAV3), transcript variant 1, Myc-DDK-tagged |
CNY 10,740.00 |
|
| RC220550L4 | Lenti ORF clone of Human vav 3 guanine nucleotide exchange factor (VAV3), transcript variant 1, mGFP tagged |
CNY 10,740.00 |
|
| RG220550 | VAV3 (tGFP-tagged) - Human vav 3 guanine nucleotide exchange factor (VAV3), transcript variant 1 |
CNY 9,690.00 |
