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COMP (NM_000095) Human Untagged Clone
CAT＃: SC116330
COMP (untagged)-Human cartilage oligomeric matrix protein (COMP)
CNY 5,552.00
CNY 7,220.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CTS2; EDM1; EPD1; MED; PSACH; THBS5; TSP5 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC116330 sequence for NM_000095 edited (data generated by NextGen Sequencing)
ATGGTCCCCGACACCGCCTGCGTTCTTCTGCTCACCCTGGCTGCCCTCGGCGCGTCCGGA CAGGGCCAGAGCCCGTTGGGCTCAGACCTGGGCCCGCAGATGCTTCGGGAACTGCAGGAA ACCAACGCGGCGCTGCAGGACGTGCGGGAGCTGCTGCGGCAGCAGGTCAGGGAGATCACG TTCCTGAAAAACACGGTGATGGAGTGTGACGCGTGCGGGATGCAGCAGTCAGTACGCACC GGCCTACCCAGCGTGCGGCCCCTGCTCCACTGCGCGCCCGGCTTCTGCTTCCCCGGCGTG GCCTGCATCCAGACGGAGAGCGGCGCGCGCTGCGGCCCCTGCCCCGCGGGCTTCACGGGC AACGGCTCGCACTGCACCGACGTCAACGAGTGCAACGCCCACCCCTGCTTCCCCCGAGTC CGCTGTATCAACACCAGCCCGGGGTTCCGCTGCGAGGCTTGCCCGCCGGGGTACAGCGGC CCCACCCACCAGGGCGTGGGGCTGGCTTTCGCCAAGGCCAACAAGCAGGTTTGCACGGAC ATCAACGAGTGTGAGACCGGGCAACATAACTGCGTCCCCAACTCCGTGTGCATCAACACC CGGGGCTCCTTCCAGTGCGGCCCGTGCCAGCCCGGCTTCGTGGGCGACCAGGCGTCCGGC TGCCAGCGGCGCGCACAGCGCTTCTGCCCCGACGGCTCGCCCAGCGAGTGCCACGAGCAT GCAGACTGCGTCCTAGAGCGCGATGGCTCGCGGTCGTGCGTGTGTGCCGTTGGCTGGGCC GGCAACGGGATCCTCTGTGGTCGCGACACTGACCTAGACGGCTTCCCGGACGAGAAGCTG CGCTGCCCGGAGCGCCAGTGCCGTAAGGACAACTGCGTGACTGTGCCCAACTCAGGGCAG GAGGATGTGGACCGCGATGGCATCGGAGACGCCTGCGATCCGGATGCCGACGGGGACGGG GTCCCCAATGAAAAGGACAACTGCCCGCTGGTGCGGAACCCAGACCAGCGCAACACGGAC GAGGACAAGTGGGGCGATGCGTGCGACAACTGCCGGTCCCAGAAGAACGACGACCAAAAG GACACAGACCAGGACGGCCGGGGCGATGCGTGCGACGACGACATCGACGGCGACCGGATC CGCAACCAGGCCGACAACTGCCCTAGGGTACCCAACTCAGACCAGAAGGACAGTGATGGC GATGGTATAGGGGATGCCTGTGACAACTGTCCCCAGAAGAGCAACCCGGATCAGGCGGAT GTGGACCACGACTTTGTGGGAGATGCTTGTGACAGCGATCAAGACCAGGATGGAGACGGA CATCAGGACTCTCGGGACAACTGTCCCACGGTGCCTAACAGTGCCCAGGAGGACTCAGAC CACGATGGCCAGGGTGATGCCTGCGACGACGACGACGACAATGACGGAGTCCCTGACAGT CGGGACAACTGCCGCCTGGTGCCTAACCCCGGCCAGGAGGACGCGGACAGGGACGGCGTG GGCGACGTGTGCCAGGACGACTTTGATGCAGACAAGGTGGTAGACAAGATCGACGTGTGT CCGGAGAACGCTGAAGTCACGCTCACCGACTTCAGGGCCTTCCAGACAGTCGTGCTGGAC CCGGAGGGTGACGCGCAGATTGACCCCAACTGGGTGGTGCTCAACCAGGGAAGGGAGATC GTGCAGACAATGAACAGCGACCCAGGCCTGGCTGTGGGTTACACTGCCTTCAATGGCGTG GACTTCGAGGGCACGTTCCATGTGAACACGGTCACGGATGACGACTATGCGGGCTTCATC TTTGGCTACCAGGACAGCTCCAGCTTCTACGTGGTCATGTGGAAGCAGATGGAGCAAACG TATTGGCAGGCGAACCCCTTCCGTGCTGTGGCCGAGCCTGGCATCCAACTCAAGGCTGTG AAGTCTTCCACAGGCCCCGGGGAACAGCTGCGGAACGCTCTGTGGCATACAGGAGACACA GAGTCCCAGGTGCGGCTGCTGTGGAAGGACCCGCGAAACGTGGGTTGGAAGGACAAGAAG TCCTATCGTTGGTTCCTGCAGCACCGGCCCCAAGTGGGCTACATCAGGGTGCGATTCTAT GAGGGCCCTGAGCTGGTGGCCGACAGCAACGTGGTCTTGGACACAACCATGCGGGGTGGC CGCCTGGGGGTCTTCTGCTTCTCCCAGGAGAACATCATCTGGGCCAACCTGCGTTACCGC TGCAATGACACCATCCCAGAGGACTATGAGACCCATCAGCTGCGGCAAGCCTAG Clone variation with respect to NM_000095.2 >OriGene 5' read for NM_000095 unedited
NGGGTTCAAATTAGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGCCCAGCT CCCCGCCACCGCCATGGTCCCCGACACCGCCTGCGTTCTTCTGCTCACCCTGGCTGCCCT CGGCGCGTCCGGACAGGGCCAGAGCCCGTTGGGCTCAGACCTGGGCCCGCAGATGCTTCG GGAACTGCAGGAAACCAACGCGGCGCTGCAGGACGTGCGGGAGCTGCTGCGGCAGCAGGT CAGGGAGATCACGTTCCTGAAAAACACGGTGATGGAGTGTGACGCGTGCGGGATGCAGCA GTCAGTACGCACCGGCCTACCCAGCGTGCGGCCCCTGCTCCACTGCGCGCCCGGCTTCTG CTTCCCCGGCGTGGCCTGCATCCAGACGGAGAGCGGCGCGCGCTGCGGCCCCTGCCCCGC GGGCTTCACGGGCAACGGCTCGCACTGCACCGACGTCAACGAGTGCAACGCCCACCCCTG CTTCCCCCGAGTCCGCTGTATCAACACCAGCCCGGGGTTCCGCTGCGAGGCTTGCCCGCC GGGGTACAGCGGCCCCACCCACCAGGGCGTGGGGCTGGCTTTCGCCAAGGCCAACAAGCA GGTTTGCACGGACATCAACGAGTGTGAGACCGGGCAACATAACTGCGTCCCCAACTCCGT GTGCATCAACACCCGGNGCTCCTTCCAGTGCGGCCCGTGCCAGCCCGGCTTCGTGGGCGA CCAGGCGTCCGGCTGCCAGCGGCGCGCACAGCGCTTCTGCCCCGACGGCTCGCCCAGCGA GTGCCACGAGCATGCAGACTGCGTCCTANAGCGCGATGGCTCGCGGTCGTGCGTGTGTGC CGTTGGGCTGGCCGCAACGGGATCCTCTGTGGTCGCGACACTGACCTANACGGCTTCCCG GACGAAAGCTGCGCTGCCCGGAGCGCAG >OriGene 3' read for NM_000095 unedited
GGAACTTCCGCACTTTNATTCTGTCCTCTCTGGACCCTTCTCACTTCCCCCTCAGGCGGC CACCCCTTGGGGCTGGGTGCAGAGCCCCCATCCAGCCGCGGTGAGGGTGGCTGTCATCCG GCGGGTCCTCACCCTGGTCCCTAGGCTTGCCGCAGCTGATGGGTCTCATAGTCCTCTGGG ATGGTGTCATTGCAGCGGTAACGCAGGTTGGCCCAGATGATGTTCTCCTGGGAGAAGCAG AAGACCCCCAGGCGGCCACCCCGCATGGTTGTGTCCAAGACCACGTTGCTGTCGGCCACC AGCTCAGGGCCCTCATAGAATCGCACCCTGATGTAGCCCACTTGGGGCCGGTGCTGCAGG AACCAACGATAGGACTTCTTGTCCTTCCAACCCACGTTTCGCGGGTCCTTCCACAGCAGC CGCACCTGGGACTCTGTGTCTCCTGTATGCCACAGAGCGTTCCGCAGCTGTTCCCCGGGG CCTGTGGAAGACTTCACAGCCTTGAGTTGGATGCCAGGCTCGGCCACAGCACGGAAGGGG TTCGCCTGCCAATACGTTTGCTCCATCTGCTTCCACATGACCACGTAGAAGCTGGAGCTG TCCTGGTAGCCAAAGATGAAGCCCGCATAGTCGTCATCCGTGACCGTGTTCACATGGAAC GTGCCCTCGAAGTCCACGCCATTGAAGGCAGTGTAACCCACAGCCAGCCCTGGGTCGCTG TTCATTGTCTGCACGATCTCCCTTCCCTGGTTGAACACCACCCATTGGGGTCAATCTGCG CGTTACCCTCCGGGTCCAACACCACTGTTTGGGAAGCCCCTGAAGTCGGTGAGCGTGACT TCAGCGTTTCTCCGACACACGTGATCTTGTGTACCACCTTNTCTGCATAAAATCGGCCCG GGACCCGTTGCCCAGCCCGTCCCGGACCGTACTA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000095 |
| Insert Size | 2620 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000095.2, NP_000086.2 |
| RefSeq Size | 2471 bp |
| RefSeq ORF | 2274 bp |
| Locus ID | 1311 |
| UniProt ID | P49747 |
| Domains | EGF_CA, tsp_3, EGF, EGF |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | ECM-receptor interaction, Focal adhesion, TGF-beta signaling pathway |
| Gene Summary | The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Cartilage Oligomeric Matrix Protein Protects Cells against Death by Elevating Members of the IAP Family of Survival Proteins
,Viktoria Gagarina, Alyssa L. Carlberg, Lucilia Pereira-Mouries, and David J. Hall,
J. Biol. Chem., Jan 2008; 283: 648 - 659.
[COMP]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC211080 | COMP (Myc-DDK-tagged)-Human cartilage oligomeric matrix protein (COMP) |
CNY 5,544.00 |
|
| RC211080L1 | Lenti ORF clone of Human cartilage oligomeric matrix protein (COMP), Myc-DDK-tagged |
CNY 7,944.00 |
|
| RC211080L2 | Lenti ORF clone of Human cartilage oligomeric matrix protein (COMP), mGFP tagged |
CNY 5,890.00 |
|
| RC211080L3 | Lenti ORF clone of Human cartilage oligomeric matrix protein (COMP), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC211080L4 | Lenti ORF clone of Human cartilage oligomeric matrix protein (COMP), mGFP tagged |
CNY 7,944.00 |
|
| RG211080 | COMP (tGFP-tagged) - Human cartilage oligomeric matrix protein (COMP) |
CNY 7,144.00 |
|
| SC324350 | COMP (untagged)-Human cartilage oligomeric matrix protein (COMP) |
CNY 5,552.00 |
