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RAN (NM_006325) Human Untagged Clone
CAT＃: SC116166
RAN (untagged)-Human RAN, member RAS oncogene family (RAN)
CNY 3,600.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ARA24; Gsp1; TC4 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_006325 edited
ATGGCTGCGCAGGGAGAGCCCCAGGTCCAGTTCAAACTTGTATTGGTTGGTGATGGTGGT ACTGGAAAAACGACCTTCGTGAAACGTCATTTGACTGGTGAATTTGAGAAGAAGTATGTA GCCACCTTGGGTGTTGAGGTTCATCCCCTAGTGTTCCACACCAACAGAGGACCTATTAAG TTCAATGTATGGGACACAGCCGGCCAGGAGAAATTCGGTGGACTGAGAGATGGCTATTAT ATCCAAGCCCAGTGTGCCATCATAATGTTTGATGTAACATCGAGAGTTACTTACAAGAAT GTGCCTAACTGGCATAGAGATCTGGTACGAGTGTGTGAAAACATCCCCATTGTGTTGTGT GGCAACAAAGTGGATATTAAGGACAGGAAAGTGAAGGCGAAATCCATTGTCTTCCACCGA AAGAAGAATCTTCAGTACTACGACATTTCTGCCAAAAGTAACTACAACTTTGAAAAGCCC TTCCTCTGGCTTGCTAGGAAGCTCATTGGAGACCCTAACTTGGAATTTGTTGCCATGCCT GCTCTCGCCCCACCAGAAGTTGTCATGGACCCAGCTTTGGCAGCACAGTATGAGCACGAC TTAGAGGTTGCTCAGACAACTGCTCTCCCGGATGAGGATGATGACCTGTGA >OriGene 5' read for NM_006325 unedited
AAGTTAGATTTGTATACGACTTATATAGGCGGCCGCGCAATTCGCACGAGGGCTTCCGCC ATCTTTCCAGCCTCAGTCGGACGGGCGCGGAGACGCTTCTGGAAGGAACGCCGCGATGGC TGCGCAGGGAGAGCCCCAGGTCCAGTTCAAACTTGTATTGGTTGGTGATGGTGGTACTGN GAAAAACGACCTTCGTGAAACGTCATTTGACTGGTGAATTTGAGAAGAAGTATGTAGCCA CCTTGGGTGTTGAGGTTCATCCCCTAGTGTTCCACACCAACAGAGGACCTATTAAGTTCA ATGTATGGGACACAGCCGGCCAGGAGAAATTCGGTGGACTGAGAGATGGCTATTATATCC AAGCCCAGTGTGCCATCATAATGTTTGATGTAACATCGAGAGTTACTTACAAGAATGTGC CTAACTGGCATAGAGATCTGGTACGAGTGTGTGAAAACATCCCCATTGTGTTGTGTGGCA ACAAAGTGGATATTAAGGACAGGAAAGTGAAGGCGAAATCCATTGTCTTCCACCGAAAGA AGAATCTTCAGTACTACGACATTTCTGCCAAAAGTAACTACAACTTTGAAAAGCCCTTCC TCTGGCTTGCTAGGAAGCTCATTGGAGACCCTAACTTGGAATTTGTTGCCATGCCTGCTC TCGCCCCACCAGAAGTTGTCATGGACCCAGCTTTGGCAGCACAGTATGAGCACGACTTAG AGGTTGCTCAGACNACTGCTCTCCCGGATGAAGATGATGACCTGTGAGAATGAAGCTGGA GCCCAGCGTCAGAAGTCTAGTTTTATAGGCAGCTGTCCTGTGATGTCAGCGGTGCAGCGT GTGTGCCACCTCATTATTATCTAGCTAAGCGAACATGTGCTTCATCTGTGGGATGCTGAA AGAGATGAGTGGGCA >OriGene 3' read for NM_006325 unedited
ACTTCCAGGGCCGGNATAGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGATCTGTTC AGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGNNNTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTATTGGAAATACAACTTTATTCTGATTCTAAACGAAAAGGA ATGGGAATGACAGTAACAAACAAGATTTCACCACTGAATATTGGGATGTGACTGCAGCAG TCTTTTTTTTGAAACTCAAGGAATCAACTGCGTTCCAAAACAGCTAAATTTGCAGGTCCA AACAATGAAGTTATTTTTTAAACTGCCACATTCACTCCGAAGCCCACTCATTTTCTTTAG CATCCCACAGATGAAGCACATGTTCCGCTTAGCTAAATAATAATGAGGGGGCACACACCC TGNNNCGCTGACATCACAGGACAGCTGCCTATAAAACTAGACTTCTGACGCTGGGCTCCA GCTTCATTCTCACAGGTCATCATCCTCATCCGGGAGAGCAGTTGTCTGAGCAACCTCTAA GTCGTGCTCATACTGTGCTGCCAAAGCTGGGTCCATGACAACTTCTGGTGGGGGCGAGAG CAGGCATGGCAACAAATTCCAAGTTAGGGGTCTCCAATGANGCTTCCTAGCAAGCCAGAG GAAGAGGCTTTNCANNAGTTGTAGTTTACTTTTTGGCAGATATGNNTCGTAGTACTGAAG ATTCTTCTTTTCGGTGGAAGACAATGGATTNTCGCCTTCTNNNNNCCTGTCCTTTATATT CCACTTTTGTTGCCCACAACACATGGNGGAATGTTTTCACCCACTCGTACCAGATCTCTA TGCCAGTATGCACATTCTTGAAGTACTCTNGATGTTCATCAAACTATGATGGCACACTGG CTTGATATATAGCCTCTTTCAGCCACGATTTTTCTGGNCGGCTGTGNCCATCATTGACTT ATTAGGCN |
| Restriction Sites | NotI-NotI |
| ACCN | NM_006325 |
| Insert Size | 1090 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | no |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_006325.2, NP_006316.1 |
| RefSeq Size | 1656 bp |
| RefSeq ORF | 651 bp |
| Locus ID | 5901 |
| UniProt ID | P62826 |
| Domains | ras, RAN, RAS, RHO, RAB |
| Protein Families | Druggable Genome, Transcription Factors |
| Gene Summary | RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC208738 | RAN (Myc-DDK-tagged)-Human RAN, member RAS oncogene family (RAN) |
CNY 2,400.00 |
|
| RC208738L1 | Lenti ORF clone of Human RAN, member RAS oncogene family (RAN), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC208738L2 | Lenti ORF clone of Human RAN, member RAS oncogene family (RAN), mGFP tagged |
CNY 4,800.00 |
|
| RC208738L3 | Lenti ORF clone of Human RAN, member RAS oncogene family (RAN), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC208738L4 | Lenti ORF clone of Human RAN, member RAS oncogene family (RAN), mGFP tagged |
CNY 4,800.00 |
|
| RG208738 | RAN (tGFP-tagged) - Human RAN, member RAS oncogene family (RAN) |
CNY 4,000.00 |
