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NPC2 (NM_006432) Human Untagged Clone
CAT＃: SC116115
NPC2 (untagged)-Human Niemann-Pick disease, type C2 (NPC2)
CNY 1,200.00
CNY 2,950.00
| Cited in 2 publications. |
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热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | EDDM1; HE1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC116115 sequence for NM_006432 edited (data generated by NextGen Sequencing)
ATGCGTTTCCTGGCAGCTACATTCCTGCTCCTGGCGCTCAGCACCGCTGCCCAGGCCGAA CCGGTGCAGTTCAAGGACTGCGGTTCTGTGGATGGAGTTATAAAGGAAGTGAATGTGAGC CCATGCCCCACCCAACCCTGCCAGCTGAGCAAAGGACAGTCTTACAGCGTCAATGTCACC TTCACCAGCAATATTCAGTCTAAAAGCAGCAAGGCCGTGGTGCATGGCATCCTGATGGGC GTCCCAGTTCCCTTTCCCATTCCTGAGCCTGATGGTTGTAAGAGTGGAATTAACTGCCCT ATCCAAAAAGACAAGACCTATAGCTACCTGAATAAACTACCAGTGAAAAGCGAATATCCC TCTATAAAACTGGTGGTGGAGTGGCAACTTCAGGATGACAAAAACCAAAGTCTCTTCTGC TGGGAAATCCCAGTACAGATCGTTTCTCATCTCTAA Clone variation with respect to NM_006432.3 >OriGene 5' read for NM_006432 unedited
ATATTTGTATACGACTCACTATAGGGCGGCNCGCGAATTCGCACGAGGCCTGACTGGGCT CCTCCCCGGGCCCGCCCCGACGGTTTGTCTTGTGACCGCGGGCGGCCGCTGCTTCTTTCC CGAGCTTGGAACTTCGTTATCCGCGATGCGTTTCCTGGCAGCTACATTCCTGCTCCTGGC GCTCAGCACCGCTGCCCAGGCCGAACCGGTGCAGTTCAAGGACTGCGGTTCTGTGGATGG AGTTATAAAGGAAGTGAATGTGAGCCCATGCCCCACCCAACCCTGCCAGCTGAGCAAAGG ACAGTCTTACAGCGTCAATGTCACCTTCACCAGCAATATTCAGTCTAAAAGCAGCAAGGC CGTGGTGCATGGCATCCTGATGGGCGTCCCAGTTCCCTTTCCCATTCCTGAGCCTGATGG TTGTAAGAGTGGAATTAACTGCCCTATCCAAAAAGACAAGACCTATAGCTACCTGAATAA ACTACCAGTGAAAAGCGAATATCCCTCTATAAAACTGGTGGTGGAGTGGCAACTTCAGGA TGACAAAAACCAAAGTCTCTTCTGCTGGGAAATCCCAGTACAGATCGTTTCTCATCTCTA AGTGCCTCATTGAGTTCGGTGCATCTGGCCAATGAGTCTGCTGAGACTCTTGACAGCACC TCCAGCTCTGCTGCTTCAACAACAGTGACTTGCTCTCCAATGGTATCCCAGTGATTCGTT GAAGAGGAGGTGCTCTGTAGCAGAAACTGAGCTCCGGGTGGCTGGTTCTCAGTGGTTGNC TCATGTCTCTTTTTCTGTCTTAAGNGGNTTCATTAATGCAGCACTTGGNTAGCAGATGTT TATTTTTTTTTTAACACATAAACTTGTGGCCTCTTCTACACCTGGAATTTACTCTGAATA ATAAAACTCGTTGTCCTGTCTCTGCAAAAAAAAAAAAAACTCGCTCTAGATGCGGCCGCG TCAAGCTGTT >OriGene 3' read for NM_006432 unedited
GCGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTGCAGAAGACAGACAAACGAG TTTTTATTTATTCAAGAGTAAATTTCCAGGTGTAGAAAGAGGCCACAAGTTAATGTTGTT AAAAAAAAAATTAAACATCTGCTAACCAAGTGCTGCATTTAATGAAACCACCTAAGACAG AAAAAGAGACATGAGACAACCACTGAGAACCAGCCACCCGGAGCTCAGTTTCTGCTACAG AGCACCTCCTCTTCAACGAATCACTGGATACCATTGGAGAGCAAGTCACTGTTGTTGAAG CAGCAGAGCTGGAGGTGCTGTCAAGAGTCTCAGCAGACTCATTGGCCAGATGCACCGAAC TCAATGAGGCACTTAGAGATGAGAAACGATCTGTACTGGGATTTCCCAGCAGAAGAGACT TTGGTTTTTGTCATCCTGAAGTTGCCACTCCACCACCAGTTTTATAGAGGGATATTCGCT TTTCACTGGTAGTTTATTCAGGTAGCTATAGGTCTTGTCTTTTTGGATAGGGCAGTTAAT TCCACTCTTACAACCATCAGGCTCAGGAATGGGAAAGGGAACTGGGACGCCCATCAGGAT GCCATGCACCACGGCCTTGCTGCTTTTAGACTGAATATTGCTGGTGAAGGTGACATTGAC GCTGTAAGACTGTCCTTTGCTCANCTGGCANGGGTTGGGTGGGGCATGGGCTCACATTCA CTTCCTTTATACTNCATCCACAGACCGCAGTCCTTTGACTGCACCCGGTTCGCCTGGGNN CACGTGCTGNACGCCAGGACAGGAATGTANCTGCAGGAAACGCATCGCGGATAACGAAAG TCCCAGCTCGGGAAAGAAGCACGGCCGCCCGCGTCACAAGACAAACTGTCGGGGCCGCCC GGGNAGGGACCCAATCAGGCTGGTGCGAAATCCGGNCGCCCTTAGTGGAGTCGATACA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_006432 |
| Insert Size | 850 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_006432.3, NP_006423.1 |
| RefSeq Size | 921 bp |
| RefSeq ORF | 456 bp |
| Locus ID | 10577 |
| UniProt ID | P61916 |
| Domains | ML |
| Protein Families | Druggable Genome, Secreted Protein |
| Gene Summary | This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy. [provided by RefSeq, Jul 2008] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes
,Rodney E. Infante, Michael L. Wang, Arun Radhakrishnan, Hyock Joo Kwon, Michael S. Brown, and Joseph L. Goldstein,
PNAS. published 4 September 2008, 10.1073/pnas.0807328105
[NPC2]
|
|
Purified NPC1 Protein: II. LOCALIZATION OF STEROL BINDING TO A 240-AMINO ACID SOLUBLE LUMINAL LOOP
,Rodney E. Infante, Lina Abi-Mosleh, Arun Radhakrishnan, Jarrod D. Dale, Michael S. Brown, and Joseph L. Goldstein,
J. Biol. Chem. 2008; 283(2): p. 1064-1075
[NPC2]
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