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Optineurin (OPTN) (NM_021980) Human Untagged Clone
CAT＃: SC112844
OPTN (untagged)-Human optineurin (OPTN), transcript variant 2
CNY 4,304.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA-INTP |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_021980 edited
GAATTCGGCACGAGGCTCCGCCACCGCCGCCGCCCGCCGGCAGGTTCCCTGGTCAGCGTC CCATCCCGGTCGGGAGTTCTCTCCAGGCGGCACGATGCCGAGGAAACAGTGACCCTGAGC GAAGCCAAGCCGGGCGGCAGGTGTGGCTTTGATAGCTGGTGGTGCCACTTCCTGGCCTTG GATGAGCCGTACGCCTCTGTAAACCCAACTTCCTCACCTTTGAAACAGCTGCCTGGTTCA GCATTAATGAAGATTAGTCAGTGACAGGCCTGGTGTGCTGAGTCCGCACATAGAACTTCT GCAATGTCCCATCAACCTCTCAGCTGCCTCACTGAAAAGGAGGACAGCCCCAGTGAAAGC ACAGGAAATGGACCCCCCCACCTGGCCCACCCAAACCTGGACACGTTTACCCCGGAGGAG CTGCTGCAGCAGATGAAAGAGCTCCTGACCGAGAACCACCAGCTGAAAGAAGCCATGAAG CTAAATAATCAAGCCATGAAAGGGAGATTTGAGGAGCTTTCGGCCTGGACAGAGAAACAG AAGGAAGAACGCCAGTTTTTTTGAGATACAGAGCAAAGAAGCAAAAGAGCGTCTAATGGC CTTGAGTCATGAGAATGAGAAATTGAAGGAAGAGCTTGGAAAACTAAAAGGGAAATCAGA AAGGTCATCTGAGGACCCCACTGATGACTCCAGGCTTCCCAGGGCCGAAGCGGAGCAGGA AAAGGACCAGCTCAGGACCCAGGTGGTGAGGCTACAAGCAGAGAAGGCAGACCTGTTGGG CATCGTGTCTGAACTGCAGCTCAAGCTGAACTCCAGCGGCTCCTCAGAAGATTCCTTTGT TGAAATTAGGATGGCTGAAGGAGAAGCAGAAGGGTCAGTAAAAGAAATCAAGCATAGTCC TGGGCCCACGAGAACAGTCTCCACTGGCACGGCATTGTCTAAATATAGGAGCAGATCTGC AGATGGGGCCAAGAATTACTTCGAACATGAGGAGTTAACTGTGAGCCAGCTCCTGCTGTG CCTAAGGGAAGGGAATCAGAAGGTGGAGAGACTTGAAGTTGCACTCAAGGAGGCCAAAGA AAGAGTTTCAGATTTTGAAAAGAAAACAAGTAATCGTTCTGAGATTGAAACCCAGACAGA GGGGAGCACAGAGAAAGAGAATGATGAAGAGAAAGGCCCGGAGACTGTTGGAAGCGAAGT GGAAGCACTGAACCTCCAGGTGACATCTCTGTTTAAGGAGCTTCAAGAGGCTCATACAAA ACTCAGCGAAGCTGAGCTAATGAAGAAGAGACTTCAAGAAAAGTGTCAGGCCCTTGAAAG GAAAAATTCTGCAATTCCATCAGAGTTGAATGAAAAGCAAGAGCTTGTTTATACTAACAA AAAGTTAGAGCTACAAGTGGAAAGCATGCTATCAGAAATCAAAATGGAACAGGCTAAAAC AGAGGATGAAAAGTCCAAATTAACTGTGCTACAGATGACACACAACAAGCTTCTTCAAGA ACATAATAATGCATTGAAAACAATTGAGGAACTAACAAGAAAAGAGTCAGAAAAAGTGGA CAGGGCAGTGCTGAAGGAACTGAGTGAAAAACTGGAACTGGCAGAGAAGGCTCTGGCTTC CAAACAGCTGCAAATGGATGAAATGAAGCAAACCATTGCCAAGCAGGAAGAGGACCTGGA AACCATGACCATCCTCAGGGCTCAGATGGAAGTTTACTGTTCTGATTTTCATGCTGAAAG AGCAGCGAGAGAGAAAATTCATGAGGAAAAGGAGCAACTGGCATTGCAGCTGGCAGTTCT GCTGAAAGAGAATGATGCTTTCGAAGACGGAGGCAGGCAGTCCTTGATGGAGATGCAGAG TCGTCATGGGGCGAGAACAAGTGACTCTGACCAGCAGGCTTACCTTGTTCAAAGAGGAGC TGAGGACAGGGACTGGCGGCAACAGCGGAATATTCCGATTCATTCCTGCCCCAAGTGTGG AGAGGTTCTGCCTGACATAGACACGTTACAGATTCACGTGATGGATTGCATCATTTAAGT GTTGATGTATCACCTCCCCAAAACTGTTGGTAAATGTCAGATTTTTTCCTCCAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_021980 unedited
TTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCTCCGCCACCGCCG CCGCCCGCCGGCAGGTTCCCTGGTCAGCGTCCCATCCCGGTCGGGAGTTCTCTCCAGGCG GCACGATGCCGAGGAAACAGTGACCCTGAGCGAAGCCAAGCCGGGCGGCAGGTGTGGCTT TGATAGCTGGTGGTGCCACTTCCTGGCCTTGGATGAGCCGTACGCCTCTGTAAACCCAAC TTCCTCACCTTTGAAACAGCTGCCTGGTTCAGCATTAATGAAGATTAGTCAGTGACAGGC CTGGTGTGCTGAGTCCGCACATAGAACTTCTGCAATGTCCCATCAACCTCTCAGCTGCCT CACTGAAAAGGAGGACAGCCCCAGTGAAAGCACAGGAAATGGACCCCCCCACCTGGCCCA CCCAAACCTGGACACGTTTACCCCGGAGGAGCTGCTGCAGCAGATGAAAGAGCTCCTGAC CGAGAACCACCAGCTGAAAGAAGCCATGAAGCTAAATAATCAAGCCATGAAAGGGAGATT TGAGGAGCTTTCGGCCTGGACAGAGAAACAGAAGGAAGAACGCCAGTTTTTTTGAGATAC AGAGCAAAGAAGCAAAAGAGCGTCTAATGGCCTTGAGTCATGAGAATGAGAAATTGAAGG AAGAGCTTGGAAAACTAAAAGGGAAATCAGAAAGGTCATCTGAGGACCCCACTGATGACT CCAGNCTTNCCAGGGCCGAAGCGGAGCAGGANAAGGACCCAGCTCAGACCCANNGTGGTG AGGGCTACAGCAGAGAAGGCAGACCTGTTGGGCATCGTGTCTGAACTGCAGCTCAAGCTG AACTTCANCGGGCTCTCAGAAGATTCCTTTGNTGAATTANGATGGCTGAAAGAGAACAC >OriGene 3' read for NM_021980 unedited
TTTGGACGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTGGGAGGAAAAAACTGACATTTACCAACAGTTTTGGGGAGGGGATACCTC AACACTTAAATGATGCCATCCATCACGTGAATCTGTAACGGGTCTATGTCAGGCAAAACC TCTCCACACTTGGGGCAGGAATGAATCGGAATATTCCGCTGTTGCCGCCAGTCCCTGGCC TCAACTCCTTTTTGAACAAGGGAAACCTGCTGGGCAAAATCACTTGTTCTCGCCCCATGA CGACTTTGCATTTCCATCAAGGACTGGCTGCCTCCGTCTTTGAAAGCATCATTTTTTTTT AACAAAACTGCCAACTGCAATGCCAATTGCTCCTTTTCCTCATGAAATTTCTCTCTCGCT GCTCTTTCAGCATGAAAATCAAAACAGTAAACTTCCATTTGAACCCTGAGGAAGGGCATG GGTTCCAAGGCCTCTTCCTGCTTGGCAAAGGGTTGCTTCATTTCATCCATTTGCAGCTGT TTGGAAACCAAAACCTTTTCTGGCAGTTCCAGTTTTTCACTCAGTTCCTTTAACACTGGC CTGGCCACTTTTTCTGACTCTTTTCTTGGTAATTCCTCAATTGGTTTCAAAGCATTATTA TGTTCTTGAAGAAACTTGGTGTGTGTCATCTGTAACCAGTTAATTTGGACTTTTCATCCT CTGGTTTACCCCGTTCCATTTTGAATTCTGATAGCAAGCTTTCCACATTGGAGCTCTAAC TTTTTGTTAATATAAAACAAGCTCTTGCTTTTCATTCAACTCTGAAGGAATTGGGGAAAT TTTCCCTTCAAGGGGCCGACACCTTTNCTTGGAGGCTCTTCCTCATTAACTCAACTTCCC TGAGATTTGATGAGCCTCTTGGACCTCCTTAACAAGATGCACCTGAAGGTAAGGCTTTCA CTTCCTTCACAATTTCCGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_021980 |
| Insert Size | 2140 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_021980.4, NP_068815.2 |
| RefSeq Size | 3376 bp |
| RefSeq ORF | 1734 bp |
| Locus ID | 10133 |
| UniProt ID | Q96CV9 |
| Domains | zf-C2H2 |
| Protein Families | Druggable Genome |
| Gene Summary | This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC221792 | OPTN (Myc-DDK-tagged)-Human optineurin (OPTN), transcript variant 2 |
CNY 4,296.00 |
|
| RC221792L3 | Lenti-ORF clone of OPTN (Myc-DDK-tagged)-Human optineurin (OPTN), transcript variant 2 |
CNY 6,460.00 |
|
| RC221792L4 | Lenti-ORF clone of OPTN (mGFP-tagged)-Human optineurin (OPTN), transcript variant 2 |
CNY 6,460.00 |
|
| RG221792 | OPTN (tGFP-tagged) - Human optineurin (OPTN), transcript variant 2 |
CNY 5,040.00 |
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