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SELS (SELENOS) (NM_018445) Human Untagged Clone
CAT＃: SC111961
VIMP (untagged)-Human selenoprotein S (SELS), transcript variant 2 (10ug), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below)
CNY 3,432.00
货期*
现货
规格
| Cited in 2 publications. |
Product images
经常一起买 (4)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Synonyms | AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC111961 sequence for NM_018445 edited (data generated by NextGen Sequencing)
ATGGAACGCCAAGAGGAGTCTCTGTCCGCGCGGCCGGCCCTGGAGACCGAGGGGCTGCGC TTCCTGCACACCACGGTGGGCTCCCTGCTGGCCACCTATGGCTGGTACATCGTCTTCAGC TGCATCCTTCTCTACGTGGTCTTTCAGAAGCTTTCCGCCCGGCTAAGAGCCTTGAGGCAG AGGCAGCTGGACCGAGCTGCGGCTGCTGTGGAACCTGATGTTGTTGTTAAACGACAAGAA GCTTTAGCAGCTGCTCGACTGAAAATGCAAGAAGAACTAAATGCGCAAGTTGAAAAGCAT AAGGAAAAACTGAAACAACTTGAAGAAGAAAAAAGGAGACAGAAGATTGAAATGTGGGAC AGCATGCAAGAAGGAAAAAGTTACAAAGGAAATGCAAAGAAGCCCCAGGAGGAAGACAGT CCTGGGCCTTCCACTTCATCTGTCCTGAAACGGAAATCGGACAGAAAGCCTTTGCGGGGA GGAGGTTATAACCCGTTGTCTGGTGAAGGAGGCGGAGCTTGCTCCTGGAGACCTGGACGC AGAGGCCCGTCATCTGGCGGATGAGGCTAA Clone variation with respect to NM_018445.4 >OriGene 5' read for NM_018445 unedited
GGTGCGAATTTTGTAATACGAACTCACTATAGGGCGGCCGCGAATCGGCACGAGGCGGCG GCGGCGGCGGCGGTCATGGAACGCCAAAAGGAGTCTCTGTCCGCGCGGCCGGCCCTGGAG ACCGAGGGGCTGCGCTTCCTGCACACCACGGTGGGCTCCCTGCTGGCCACCTATGGCTGG TACATCGTCTTCAGCTGCATCCTTCTCTACGTGGTCTTTCAGAAGCTTTCCGCCCGGCTA AGAGCCTTGAGGCAGAGGCAGCTGGACCGAGCTGCGGCTGCTGTGGAACCTGATGTTGTT GTTAAACGACAAGAAGCTTTAGCAGCTGCTCGACTGAAAATGCAAGAAGAACTAAATGCG CAAGTTGAAAAGCATAAGGAAAAACTGAAACAACTTGAAGAAGAAAAAAGGAGACAGAAG ATTGAAATGTGGGACAGCATGCAAGAAGGAAAAAGTTACAAAGGAAATGCAAAGAAGCCC CAGGAGGAAGACAGTCCTGGGCCTTCCACTTCATCTGTCCTGAAACGGAAATCGGACAGA AAGCCTTTGCGGGGAGGAGGTTATAACCCGTTGTCTGGTGAAGGAGGCGGAGCTTGCTCC TGGAGACCTGGACGCAGAGGCCCGTCATCTGGCGGATGAGGCTAAGAATCTTGTTAGTGT CACTTTTGACATTAGCAAGATGAACCCTTAACCCTCGATTCAATTGCCTTACGCACGCTN TTCACAGTGACTAGCCAAGGGAGGTGGGGTTGATTTCTGTTCCTAACTACACCTGCATAT GTCAGGGCTCCAGTCAGCAAAGGTATAGATGTTGCCTCTAGCATGAGGTCATGGGTCACA TTCTACTNGNAGACAGTGATTGCATTCATTGGATTCATGGGTAATTGCTAGTTGGGTAGT A >OriGene 3' read for NM_018445 unedited
CCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGGAGGTTGTAATAAAAAG CTATTTAATGTTTGATAGACAAATTGAAGTCCATAAATCTCCTTGAATAAAGATGCTAAA AATGTTATTCTTGTTTTTTAAATAGTTTCGTTTTTACAAAGTTCTGTACATAAAAATAAA TATACAGAAACAAACCCCATCAACTGTCCACATCAGTAATCCTCACTGGTGGGCTCACCA TTGATAAGGAAGACATCATTCAACGCAACCTGTCACAGAGACTGTCCTAGCAGCAAGGAT TTCTAACCTCAAAAGAACATTACTAGGCCTCTTTTATCAAGATTGCTAATCATCTAGAGG CCTTTACCTACCAACTAGCAATTAACCATGAAATCAATGAATGCAATCACTGTCTCCAAG TAGAATGTGACCAATGACCTCATGCCTAGAGGCAACATCTATACCTTTTGCTGACTGGAG CCCTGACATATGCAGGTGTAGTTAGGAACAGAAATCAACCCCACCATCCCTTGGCTAGTC ACTGTGAAAAGCGTGCGTAATGCAATTGAATCGAGGGTTAAGGGTTCATCTTGCTAATGT CAAAAGTGACACTAACAAGATTCTTAGCCTCATCCGCCAGATGACGGGCCTCTGCGTNCA GGTCTCCAGGAGCAAGCTCCGNCTCCTTACCAGACAACGGGTATAACCTCCTNCCCGCAA AGGCTTTCTGTCCGATTTCCGTTTCAGGACAGATGAAGTGGAAAGGGCCCAGACTGTCTT NCTNCTGGGGCCTCCTTTGCATTTNCTTTGTAACTTTTTNCTTCCTGCATGCTNGCCCAC ATTTCAATCTTCTGTCTCCTTTTTTNCTCCTCAAAAGTGGTTCAGNTTTTCCTTATGCTT TNCAACTTGCGCATTTAGGTCTTCTTGCTTTTCAATCNAGCAGCTGCTAAAGCTCCTTGT CGTTAACACAAACTCAGGTTCCAAGAG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_018445 |
| Insert Size | 1240 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). The expression of this clone is not guaranteed due to the nature of selenoproteins. |
| OTI Annotation | This clone encodes a selenoprotein containing the rare amino acid selenocysteine (Sec). Sec is encoded by UGA codon, which normally signals translational termination. Expression of this clone is not guaranteed due to the nature of selenoproteins. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_018445.4, NP_060915.2 |
| RefSeq Size | 1250 bp |
| Locus ID | 55829 |
| UniProt ID | Q9BQE4 |
| Protein Families | Druggable Genome |
| Gene Summary | This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017] Transcript Variant: This variant (1) represents the predominant transcript, and encodes a selenocysteine-containing longer isoform (1). |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Selenoprotein S regulates adipogenesis through IRE1α-XBP1 pathway
,Men, L;Yao, J;Yu, S;Li, Y;Cui, S;Jin, S;Zhang, G;Ren, D;Du, J;,
J. Endocrinol.
,PubMed ID 31846435
[SELENOS]
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|
Selenoprotein S/SEPS1 Modifies Endoplasmic Reticulum Stress in Z Variant 1-Antitrypsin Deficiency
,Emer Kelly, Catherine M. Greene, Tomás P. Carroll, Noel G. McElvaney, and Shane J. O'Neill,
J. Biol. Chem., Jun 2009; 284: 16891 - 16897.
[SELENOS]
|
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC200814 | VIMP (Myc-DDK-tagged)-Human selenoprotein S (SELS), transcript variant 2, (Note, selenocysteine protein, internal stop codon, see reference data summary) |
CNY 998.00 |
|
| RC200814L1 | Lenti-ORF clone of VIMP (Myc-DDK-tagged)-Human selenoprotein S (SELS), transcript variant 2, (Note, selenocysteine protein, internal stop codon, see summary) |
CNY 3,344.00 |
|
| RG200814 | VIMP (GFP-tagged) - Human selenoprotein S (SELS), transcript variant 2, (10ug), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below) |
CNY 2,544.00 |
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