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Caspase 4 (CASP4) (NM_001225) Human Untagged Clone
CAT＃: SC111600
CASP4 (untagged)-Human caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant alpha
CNY 3,656.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ICE(rel)II; ICEREL-II; ICH-2; Mih1; Mih1/TX; TX |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC111600 sequence for NM_001225 edited (data generated by NextGen Sequencing)
ATGGCAGAAGGCAACCACAGAAAAAAGCCACTTAAGGTGTTGGAATCCCTGGGCAAAGAT TTCCTCACTGGTGTTTTGGATAACTTGGTGGAACAAAATGTACTGAACTGGAAGGAAGAG GAAAAAAAGAAATATTACGATGCTAAAACTGAAGACAAAGTTCGGGTCATGGCAGACTCT ATGCAAGAGAAGCAACGTATGGCAGGACAAATGCTTCTTCAAACCTTTTTTAACATAGAC CAAATATCCCCCAATAAAAAAGCTCATCCGAATATGGAGGCTGGACCACCTGAGTCAGGA GAATCTACAGATGCCCTCAAGCTTTGTCCTCATGAAGAATTCCTGAGACTATGTAAAGAA AGAGCTGAAGAGATCTATCCAATAAAGGAGAGAAACAACCGCACACGCCTGGCTCTCATC ATATGCAATACAGAGTTTGACCATCTGCCTCCGAGGAATGGAGCTGACTTTGACATCACA GGGATGAAGGAGCTACTTGAGGGTCTGGACTATAGTGTAGATGTAGAAGAGAATCTGACA GCCAGGGATATGGAGTCAGCGCTGAGGGCATTTGCTACCAGACCAGAGCACAAGTCCTCT GACAGCACATTCTTGGTACTCATGTCTCATGGCATCCTGGAGGGAATCTGCGGAACTGTG CATGATGAGAAAAAACCAGATGTGCTGCTTTATGACACCATCTTCCAGATATTCAACAAC CGCAACTGCCTCAGTCTGAAGGACAAACCCAAGGTCATCATTGTCCAGGCCTGCAGAGGT GCAAACCGTGGGGAACTGTGGGTCAGAGACTCTCCAGCATCCTTGGAAGTGGCCTCTTCA CAGTCATCTGAGAACCTAGAGGAAGATGCTGTTTACAAGACCCACGTGGAGAAGGACTTC ATTGCTTTCTGCTCTTCAACGCCACACAACGTGTCCTGGAGAGACAGCACAATGGGCTCT ATCTTCATCACACAACTCATCACATGCTTCCAGAAATATTCTTGGTGCTGCCACCTAGAG GAAGTATTTCGGAAGGTACAGCAATCATTTGAAACTCCAAGGGCCAAAGCTCAAATGCCC ACCATAGAACGACTGTCCATGACAAGATATTTCTACCTCTTTCCTGGCAATTGA Clone variation with respect to NM_001225.3 >OriGene 5' read for NM_001225 unedited
NGGGTGCACATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGAACGCTG TAAAAAAGACAGAGGCTGTTCCCTATGGCAGAAGGCAACCACAGNAAAAAAGCCACTTAA GGTGTTGGAATCCCTGGGCAAAGATTTCCTCACTGGTGTTTTGGATAACTTGGTGGAACA AAATGTACTGAACTGGAAGGAAGAGGAAAAAAAGAAATATTACGATGCTAAAACTGAAGA CAAAGTTCGGGTCATGGCAGACTCTATGCAAGAGAAGCAACGTATGGCAGGACAAATGCT TCTTCAAACCTTTTTTAACATAGACCAAATATCCCCCAATAAAAAAGCTCATCCGAATAT GGAGGCTGGACCACCTGAGTCAGGAGAATCTACAGATGCCCTCAAGCTTTGTCCTCATGA AGAATTCCTGAGACTATGTAAAGAAAGAGCTGAAGAGATCTATCCAATAAAGGAGAGAAA CAACCGCACACGCCTGGCTCTCATCATATGCAATACAGAGTTTGACCATCTGCCTCCGAG GAATGGAGCTGACTTTGACATCACAGGGATGAAGGAGCTACTTGAGGGTCTGGACTATAG TGTAGATGTAGAAGAGAATCTGACAGCCAGGGATATGGAGTCAGCGCTGAGGGCATTTGC TACCAGACCAGAGCACAAGTCCTCTGACAGCACATTCTTGGTACTCATGTCTCATGGCAT CCTGGAGGGAATCTGCGGAACTGTGCATGATGAGAAAAAACCAGATGTGCTGCTTTATGA CACCATCTTCCAGATATTCAACAAACCGCACTGCCTCAGTCTGAAGGACAAACCCAAGTC ATCATTGTCCAGGCCTGCAGAAGTGCANACCGTGGGGAACNNTGTGGTCAGAGACTCTTC AGCATCCTTGA >OriGene 3' read for NM_001225 unedited
NCCTCTGTGNACCGCGCCGCATTCTANGATCGGTTTTTTTTTTTTTTTTTTGTCTTCACT TTTATTGAAATACAAAATGTTAAATATGCAAGCTGTACTAATGAAGGTGCTCCTTGAAGT TGATTAAGGAGGGCTGGGCTGCTTGTGGCTTCCATTTTCAATTGCCAGGAAAGAGGTAGA AATATCTTGTCATGGACAGTCGTTCTATGGTGGGCATTTGAGCTTTGGCCCTTGGAGTTT CAAATGATTGCTGTACCTTCCGAAATACTTCCTCTAGGTGGCAGCACCAAGAATATTTCT GGAAGCATGTGATGAGTTGTGTGATGAAGATAGAGCCCATTGTGCTGTCTCTCCAGGACA CGTTGTGTGGCGTTGAAGAGCAGAAAGCAATGAAGTCCTTCTCCACGTGGGTCTTGTAAA CAGCATCTTCCTCCAGGTTCTCAGATGACTGTGAAGAGGCCACTTCCAAGGATGCTGGAG AGTCTCTGACCCACAGTTCCCCACGGTTTGCACCTCTGCAGGCCTGGACAATGATGACCT TGGGTTTGTCCTTCAGACTGAGGCAGTTGCGGTTGTTGAATATCTGGAAGATGGTGTCAT AAAGCAGCACATCTGGTTTTTTCTCATCATGCACAGTTCCGCAGATTCCCTCCAGGATGC CATGAGACATGAGTACCAAGAATGTGCTGTCAGAAGACTTGTGCTCTGGTCTGGTAGCAN ATGCCCTCAGCGCTGACTCCATATCCCTGGCTGTCAGATTCTCTTCTACATCTACACTAT AGTCCAGACCCCTCAGTAGCTCCTTCATCCCTGTGATGTCAAAGTCAGCTCCATTCCTCG NAGGCAGATGGTCAAACTCTGTATTGCATATGATGAGAAGCCAGNCGTGTGCCGGGTGGT TCTCTCCTTTATGGATAAGACTCTTCAGCTCTTTCTTTACATANNCTN |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001225 |
| Insert Size | 1290 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001225.3, NP_001216.1 |
| RefSeq Size | 1319 bp |
| RefSeq ORF | 1134 bp |
| Locus ID | 837 |
| UniProt ID | P49662 |
| Domains | CARD, CASc, ICE_p10, ICE_p20 |
| Protein Families | Druggable Genome, Protease |
| Gene Summary | This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (alpha) encodes the longest isoform (alpha). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens
,Knodler, LA;Crowley, SM;Sham, HP;Yang, H;Wrande, M;Ma, C;Ernst, RK;Steele-Mortimer, O;Celli, J;Vallance, BA;,
Cell Host Microbe
,PubMed ID 25121752
[CASP4]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC217703 | CASP4 (Myc-DDK-tagged)-Human caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant alpha |
CNY 3,656.00 |
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| RC217703L1 | Lenti ORF clone of Human caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant alpha, Myc-DDK-tagged |
CNY 6,056.00 |
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| RC217703L2 | Lenti ORF clone of Human caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant alpha, mGFP tagged |
CNY 5,890.00 |
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| RC217703L3 | Lenti ORF clone of Human caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant alpha, Myc-DDK-tagged |
CNY 6,056.00 |
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| RC217703L4 | Lenti ORF clone of Human caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant alpha, mGFP tagged |
CNY 6,056.00 |
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| RG217703 | CASP4 (tGFP-tagged) - Human caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant alpha |
CNY 5,256.00 |
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