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DCTN1 (NM_004082) Human Untagged Clone
CAT＃: SC110869
DCTN1 (untagged)-Human dynactin 1 (DCTN1), transcript variant 1
CNY 8,904.00
货期*
现货
规格
| Cited in 1 publication. |
Product images
经常一起买 (4)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | DAP-150; DP-150; P135 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC110869 sequence for NM_004082 edited (data generated by NextGen Sequencing)
ATGGCACAGAGCAAGAGGCACGTGTACAGCCGGACGCCCAGCGGCAGCAGGATGAGTGCG GAGGCAAGCGCCCGGCCTCTGCGGGTGGGCTCCCGTGTAGAGGTGATTGGAAAAGGCCAC CGAGGCACTGTGGCCTATGTTGGAGCCACACTGTTTGCCACTGGCAAATGGGTAGGCGTG ATTCTGGATGAAGCAAAGGGCAAAAATGATGGAACTGTTCAAGGCAGGAAGTACTTCACT TGTGATGAAGGGCATGGCATCTTTGTGCGCCAGTCCCAGATCCAGGTATTTGAAGATGGA GCAGATACTACTTCCCCAGAGACACCTGATTCTTCTGCTTCAAAAGTCCTCAAAAGAGAG GGAACTGATACAACTGCAAAGACTAGCAAACTGCGGGGACTGAAGCCTAAGAAGGCACCG ACAGCCCGAAAGACCACAACTCGGCGACCCAAGCCCACGCGCCCAGCCAGTACTGGGGTG GCTGGGGCCAGTAGCTCCCTGGGCCCCTCTGGCTCAGCGTCAGCAGGTGAGCTGAGCAGC AGTGAGCCCAGCACCCCGGCTCAGACTCCGCTGGCAGCACCCATCATCCCCACGCCGGTC CTCACCTCTCCTGGAGCAGTCCCCCCGCTTCCTTCCCCATCCAAGGAGGAGGAGGGACTA AGGGCTCAGGTGCGGGACCTGGAGGAGAAACTAGAGACCCTGAGACTGAAACGGGCAGAA GACAAAGCAAAGCTAAAAGAGCTGGAGAAACACAAAATCCAGCTGGAGCAGGTGCAGGAA TGGAAGAGCAAAATGCAGGAGCAGCAGGCCGACCTGCAGCGGCGCCTCAAGGAGGCGAGA AAGGAAGCCAAGGAGGCGCTGGAGGCAAAGGAACGCTATATGGAGGAGATGGCTGATACT GCTGATGCCATTGAGATGGCCACTTTGGACAAGGAGATGGCTGAAGAGCGGGCTGAGTCC CTGCAGCAGGAGGTGGAGGCACTGAAGGAGCGGGTGGACGAGCTCACTACTGACTTAGAG ATCCTCAAGGCTGAGATTGAAGAGAAGGGCTCAGATGGCGCTGCATCCAGTTATCAGCTC AAGCAGCTTGAGGAGCAGAATGCCCGCCTGAAGGATGCCCTGGTGAGGATGCGGGATCTT TCTTCCTCAGAGAAGCAGGAGCATGTGAAGCTCCAGAAGCTCATGGAAAAGAAGAACCAA GAGCTGGAAGTTGTGAGGCAACAGCGGGAGCGTCTGCAGGAGGAGCTAAGCCAGGCAGAG AGCACCATTGATGAGCTCAAGGAGCAGGTGGATGCTGCTCTGGGTGCTGAGGAGATGGTG GAGATGCTGACAGATCGGAACCTGAATCTGGAAGAGAAAGTGCGCGAGTTGAGGGAGACT GTGGGAGACTTGGAAGCGATGAATGAGATGAACGATGAGCTGCAGGAGAATGCACGTGAG ACAGAACTGGAGCTGCGGGAGCAGCTGGACATGGCAGGCGCGCGGGTTCGTGAGGCCCAG AAGCGTGTGGAGGCAGCCCAGGAGACGGTTGCAGACTACCAGCAGACCATCAAGAAGTAC CGCCAGCTGACCGCCCATCTACAGGATGTGAATCGGGAACTGACAAACCAGCAGGAAGCA TCTGTGGAGAGGCAACAGCAGCCACCTCCAGAGACCTTTGACTTCAAAATCAAGTTTGCT GAGACTAAGGCCCATGCCAAGGCAATTGAGATGGAATTGAGGCAGATGGAGGTGGCCCAG GCCAATCGACACATGTCCCTGCTGACAGCCTTCATGCCTGACAGCTTCCTTCGGCCAGGT GGGGACCATGACTGCGTTCTGGTGCTGTTGCTCATGCCTCGTCTCATTTGCAAGGCAGAG CTGATCCGGAAGCAGGCCCAGGAGAAGTTTGAACTAAGTGAGAACTGTTCAGAGCGGCCT GGGCTGCGAGGAGCTGCTGGGGAGCAACTCAGCTTTGCTGCTGGACTGGTGTACTCGCTG AGCCTGCTGCAGGCCACGCTACACCGCTATGAGCATGCCCTCTCTCAGTGCAGTGTGGAT GTGTATAAGAAAGTGGGCAGCCTGTACCCTGAGATGAGTGCCCATGAGCGCTCCTTGGAT TTCCTCATTGAACTGCTGCACAAGGATCAGCTGGATGAGACTGTCAATGTGGAGCCTCTC ACCAAGGCCATCAAGTACTATCAGCATCTGTACAGCATCCACCTTGCCGAACAGCCTGAG GACTGTACTATGCAGCTGGCTGACCACATTAAGTTCACGCAGAGTGCTCTGGACTGCATG AGTGTGGAGGTAGGACGGCTGCGTGCCTTCTTGCAGGGTGGGCAGGAGGCTACAGATATT GCCCTCCTGCTCCGGGATCTGGAAACTTCATGCAGTGACATCCGCCAGTTCTGCAAGAAG ATCCGAAGGCGAATGCCAGGGACAGATGCTCCTGGGATCCCAGCTGCACTGGCCTTTGGA CCACAGGTATCTGACACGCTCCTAGACTGCAGGAAACACTTGACGTGGGTCGTGGCTGTG CTGCAGGAGGTGGCAGCTGCTGCTGCCCAGCTCATTGCCCCACTGGCAGAGAATGAGGGG CTACTTGTGGCTGCTCTGGAGGAACTGGCTTTCAAAGCAAGCGAGCAGATCTATGGGACC CCCTCCAGCAGCCCCTATGAGTGTCTGCGCCAGTCATGCAACATCCTCATCAGTACCATG AACAAGCTGGCCACAGCCATGCAGGAGGGGGAGTATGATGCAGAGCGGCCCCCCAGCAAG CCTCCACCGGTTGAACTGCGGGCTGCTGCCCTTCGTGCAGAGATCACAGATGCTGAAGGC CTGGGTTTGAAGCTCGAAGATCGAGAGACAGTTATTAAGGAGTTGAAGAAGTCACTCAAG ATTAAGGGAGAGGAGCTAAGTGAGGCCAATGTGCGGCTGAGCCTCCTGGAGAAGAAGTTG GACAGTGCTGCCAAGGATGCAGATGAGCGCATCGAGAAAGTCCAGACTCGGCTGGAGGAG ACCCAGGCACTGCTGCGAAAGAAGGAGAAAGAGTTTGAGGAGACAATGGATGCACTCCAG GCTGACATCGACCAGCTGGAGGCAGAGAAGGCAGAACTAAAGCAGCGTCTGAACAGCCAG TCCAAACGCACGATTGAGGGACTCCGGGGCCCTCCTCCTTCAGGCATTGCTACTCTGGTC TCTGGCATTGCTGGTGAAGAACAGCAGCGAGGAGCCATCCCTGGGCAGGCTCCAGGGTCT GTGCCAGGCCCAGGGCTGGTGAAGGACTCACCACTGCTGCTTCAGCAGATCTCTGCCATG AGGCTGCACATCTCCCAGCTCCAGCATGAGAACAGCATCCTCAAGGGAGCCCAGATGAAG GCATCCTTGGCATCCCTGCCCCCTCTGCATGTTGCAAAGCTATCCCATGAGGGCCCTGGC AGTGAGTTACCAGCTGGAGCGCTGTATCGTAAGACCAGCCAGCTGCTGGAGACATTGAAT CAATTGAGCACACACACGCACGTAGTAGACATCACTCGCACCAGCCCTGCTGCCAAGAGC CCGTCGGCCCAACTTATGGAGCAAGTGGCTCAGCTTAAGTCCCTGAGTGACACCGTCGAG AAGCTCAAGGATGAGGTCCTCAAGGAGACAGTATCTCAGCGCCCTGGAGCCACAGTACCC ACTGACTTTGCCACCTTCCCTTCATCAGCCTTCCTCAGGGCCAAGGAGGAGCAGCAGGAT GACACAGTCTACATGGGCAAAGTGACCTTCTCATGTGCGGCTGGTTTTGGACAGCGACAC CGGCTGGTGCTGACCCAGGAGCAGCTGCACCAGCTTCACAGTCGCCTCATCTCCTAA Clone variation with respect to NM_004082.4 >OriGene 5' read for NM_004082 unedited
GGTAAAGGTTCAATACTTTGTNAATACGAACTCACTATNAGGGCAGGCCGCGTAATTCGG CACGAGGCTGGGTTCAGGAATCCTCAGGCAGCAGAGGGGACTTGCTCCTCAGCCCCCATC ACTGCCCCCACCCCTACCCGTGTAGGCCACCGAGTGAGGCCCATGGACTGGGGAGGGCTG TGCCTGACGACTCCTGTGTCCCTCTATGAGGGCCCAGCGCCCTGACCCTCCTGCCTAGGT TTCTACCTTTTCTCTCTGTCTTTGGCCAGCTGGGGGAGGGGGTAGAGGCCGGGTGAGCAA CATGGCACAGAGCAAGAGGCACGTGTACAGCCGGACGCCCAGCGGCAGCAGGATGAGTGC GGAGGCAAGCGCCCGGCCTCTGCGGGTGGGCTCCCGTGTAGAGGTGATTGGAAAAGGCCA CCGAGGCACTGTGGCCTATGTTGGAGCCACACTGTTTGCCACTGGCAAATGGGTAGGCGT GATTCTGGATGAAGCAAAGGGCAAAAATGATGGAACTGTTCAAGGCAGGAAGTACTTCAC TTGTGATGAAGGGCATGGCATCTTTGTGCGCCAGTCCCAGATCCAGGTATTTGAAGATGG AGCAGATACTACTTCCCCAGAGACACCTGATTCTTCTGCTTCAAAAGTCCTCAAAAGAGA GGGAACTGATACAACTGCAAAGACTAGCAAACTGCGGGGACTGAAGCCTAAGAAGGCACC GACAGCCCGAAAGACCACAACTCGGCGACCCAAGCCCACGCGCCCAGCCAGTACTGGGGG TAGGCTGGGAGCCAGTAGCCTCCCTGGGGCCCCTCTAGGCTCANCGTCAGCAGGTGAGCT GAGCAGCAGTGAGCCCAGCACCCCGGCTCATACTNCGCTGGCAGCACCCATCATCCCCAC GCCAGTCCTCANCTCTCTGG >OriGene 3' read for NM_004082 unedited
NCCTTCTCTGGNACCGCGGCCGCAATCTAGNATCGAGTTTTTTTTTTTTTTTTTTTGAAG CAGAAGTTGCTTTAATCAAGGGGTGAAGTCCTCAATCAAGGGGACCTCACTTAACCTTTG GTGGTGGGGTCTCAGCCTACCCCCCACAAGCCCTGAGGCCCCTCAGGAAGGAGGGAGCAG TTGAACAACAAATTATGGCAGAGGCCAGGGAATGGGAGTGGGGGAACCCGGGTCAAGGTG AAGGGGCAGGACGCTGAAAGGGTGGGAGTGAAGCTGAACGGGGCAGGAAGAGCTTAACCC ACGTTTCTACCTGGGGGCTGGCTGAGGTGGCTGTGCATCGGGCAGAGCGGCACCAGAGGG CTGAGGGTCGAAGGGGACAGCAGGGGAAAGGAGTGCTTAGGAGATGAGGCGACTGTGAAG CTGGTGCAGCTGCTCCTGGGTCAGCACCAGCCGGTGTCGCTGTCCAAAACCAGCCGCACA TGAGAAGGTCACTTTGCCCATGTAGACTGTGTCATCCTGCTGCTCCTCCTTGGCCCTGAG GAAGGCTGATGAAGGGAAGGTGGCAAAGTCAGTGGGTACTGTGGCTCCAGGGCGCTGAGA TACTGTCTCCTTGAGGACCTCATCCTTGAGCTTCTCGACGGTGTCACTCAGGGACTTAAG CTGAGCCACTTGCTCCATAAGTTGGGCCGACGGGCTCTTGGCAGCANGGCTGTTGCGAGT GATGTCTACTACGTGCGTGTGTGTGCTCAATTGATTCAATGTCTCCAGCAGCTGGCTGGT CTTACGATACAGCGCTCCAGCTTGTAACTCACTGGCAGGGCCCTCATGGGATACCTTTGC ACATGCAAAGGGGGCAGGNATGCCAAGGATGCCCTTCTTGGGGCTCCTTGAAGATGGCTG TTTCAGCTGGACCTGGGAAAGTGCACCCTATGTCAGAAATCGCTGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004082 |
| Insert Size | 4280 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_004082.2, NP_004073.2 |
| RefSeq Size | 4992 bp |
| RefSeq ORF | 3837 bp |
| Locus ID | 1639 |
| UniProt ID | Q14203 |
| Domains | CAP_GLY, M |
| Protein Families | Druggable Genome |
| Protein Pathways | Huntington's disease |
| Gene Summary | This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008] Transcript Variant: This variant (1) has multiple differences in the 5' UTR, 5' coding region and 3' coding region, compared to variant 4. These differences cause translation initiation from an upstream AUG and a protein (isoform 1) with a longer N-terminus containing a CAP-Gly domain and a longer C-terminus, compared to isoform 4. Isoform 1 is also called p150. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
,Deshimaru, M;Kinoshita-Kawada, M;Kubota, K;Watanabe, T;Tanaka, Y;Hirano, S;Ishidate, F;Hiramoto, M;Ishikawa, M;Uehara, Y;Okano, H;Hirose, S;Fujioka, S;Iwasaki, K;Yuasa-Kawada, J;Mishima, T;Tsuboi, Y;,
International Journal of Molecular Sciences
,PubMed ID 33924373
[DCTN1]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC211975 | DCTN1 (Myc-DDK-tagged)-Human dynactin 1 (DCTN1), transcript variant 1 |
CNY 8,896.00 |
|
| RC211975L3 | Lenti ORF clone of Human dynactin 1 (DCTN1), transcript variant 1, Myc-DDK-tagged |
CNY 11,500.00 |
|
| RC211975L4 | Lenti ORF clone of Human dynactin 1 (DCTN1), transcript variant 1, mGFP tagged |
CNY 11,296.00 |
|
| RG211975 | DCTN1 (tGFP-tagged) - Human dynactin 1 (DCTN1), transcript variant 1 |
CNY 10,496.00 |
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