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CCR5 (NM_000579) Human Untagged Clone
CAT＃: SC110858
CCR5 (untagged)-Human chemokine (C-C motif) receptor 5 (CCR5), transcript variant A
CNY 5,488.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5; CKR5; CMKBR5; IDDM22 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_000579, RT-PCR generated
ATGGATTATCAAGTGTCAAGTCCAATCTATGACATCAATTATTATACATCGGAGCCCTGC CAAAAAATCAATGTGAAGCAAATCGCAGCCCGCCTCCTGCCTCCGCTCTACTCACTGGTG TTCATCTTTGGTTTTGTGGGCAACATGCTGGTCATCCTCATCCTGATAAACTGCAAAAGG CTGAAGAGCATGACTGACATCTACCTGCTCAACCTGGCCATCTCTGACCTGTTTTTCCTT CTTACTGTCCCCTTCTGGGCTCACTATGCTGCCGCCCAGTGGGACTTTGGAAATACAATG TGTCAACTCTTGACAGGGCTCTATTTTATAGGCTTCTTCTCTGGAATCTTCTTCATCATC CTCCTGACAATCGATAGGTACCTGGCTGTCGTCCATGCTGTGTTTGCTTTAAAAGCCAGG ACGGTCACCTTTGGGGTGGTGACAAGTGTGATCACTTGGGTGGTGGCTGTGTTTGCGTCT CTCCCAGGAATCATCTTTACCAGATCTCAAAAAGAAGGTCTTCATTACACCTGCAGCTCT CATTTTCCATACAGTCAGTATCAATTCTGGAAGAATTTCCAGACATTAAAGATAGTCATC TTGGGGCTGGTCCTGCCGCTGCTTGTCATGGTCATCTGCTACTCGGGAATCCTAAAAACT CTGCTTCGGTGTCGAAATGAGAAGAAGAGGCACAGGGCTGTGAGGCTTATCTTCACCATC ATGATTGTTTATTTTCTCTTCTGGGCTCCCTACAACATTGTCCTTCTCCTGAACACCTTC CAGGAATTCTTTGGCCTGAATAATTGCAGTAGCTCTAACAGGTTGGACCAAGCTATGCAG GTGACAGAGACTCTTGGGATGACGCACTGCTGCATCAACCCCATCATCTATGCCTTTGTC GGGGAGAAGTTCAGAAACTACCTCTTAGTCTTCTTCCAAAAGCACATTGCCAAACGCTTC TGCAAATGCTGTTCTATTTTCCAGCAAGAGGCTCCCGAGCGAGCAAGCTCAGTTTACACC CGATCCACTGGGGAGCAGGAAATATCTGTGGGCTTGTGA >OriGene 5' read for NM_000579 unedited
TTGGAACCCAAGTACGGTATTTGTTACACNATACACTATAGGCGGCCGCGCAATCANATC TGGTACCGAGCTCGGCTCCACTAGTAACGGCCGCCAGTGTGCTGGAATTCGGCTTGATCG GAACAAGATGGATTATCAAGTGTCAAGTCCAATCTATGACATCAATTATTATACATCGGA GCCCTGCCAAAAAATAATGTGAAGCANATCGCAGCCCGTCTTTTTCTCCGCTCTACTCAC TGGTGATCATCTTTGGTTTTGAGGGCAACAAGCTGGGCCAACCCCATTCCGAAAAACCGC CAAAGGGTTTAAAAAACAGGGTTTGATTTTAACGGGGTAAACCGGGGAAATTTTTAAGCG GGGTTTTTTTTTTTTAAAAGCCCCCCTTTTGGGGGGAAAAAATATTTTTCCCCCCCCCCC GGGGGGTTTGGTTAAAAAAAAAAAAAAAAGGGTTTTTTTTTGTGGGGGGGGGGGGGGGAN AATAAAAAAGGAAGGGGGGGGGGGGGGGGGGGGAAAAAAAAAAATAATGACCCTTTCCCC TCCCAAAAAAAAAAAAAAAAAAGAAAAAAAAGAATACGCTCGTGGGGGGTGGGGATAGAA TGNGNAGAAAGAAAAAAAAAAAGCACCCCCCCACAACTCTTATACAACTATTGTGTGCGG GTGAAAGAAAAAAAAAAAAATATATTTCGCGGGGGGGGGGGGTTAGGTTNTTTATTTTTT TTANNNTNTNNNCCTTTCTAAAGGCCCCCTCTTCTGTCCAATTATAGAGATAAGAAGTAA GAGGGTGAGGGGAGCGGCGAGGGTCCTGCTCGCCTCCCTACACCTCTGATTTTCCCGCGG GGCGAAAGAAAACAAAACGACAATAAAAAAAAAAAAAAAC |
| Restriction Sites | Please inquire |
| ACCN | NM_000579 |
| Insert Size | 3700 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000579.1, NP_000570.1 |
| RefSeq Size | 3655 bp |
| RefSeq ORF | 1059 bp |
| Locus ID | 1234 |
| UniProt ID | P51681 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane |
| Protein Pathways | Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis |
| Gene Summary | This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015] Transcript Variant: This variant (A) represents the longer transcript. Both variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by published experimental evidence. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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MOLECULAR INTERACTIONS OF CCR5 WITH MAJOR CLASSES OF SMALL-MOLECULE ANTI HIV CCR5 ANTAGONISTS
,Rama Kondru, Jun Zhang, Changhua Ji, Tara Mirzadegan, David Rotstein, Surya Sankuratri, and Marianna Dioszegi,
Mol. Pharmacol., Dec 2007; 10.1124/mol.107.042101.
[CCR5]
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The Second Extracellular Loop of CCR5 Contains the Dominant Epitopes for Highly Potent Anti-HIV Monoclonal Antibodies
,Jun Zhang, Eileen Rao, Marianna Dioszegi, Rama Kondru, Andre Derosier, Eva Chan, Stephan Schwoerer, Nick Cammack, Michael Brandt, Surya Sankuratri, and Changhua Ji,
Antimicrob Agents Chemother. 2007 Apr;51(4):1386-97.
[CCR5]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC223291 | CCR5 (Myc-DDK-tagged)-Human chemokine (C-C motif) receptor 5 (CCR5), transcript variant A |
CNY 5,488.00 |
|
| RC223291L1 | Lenti-ORF clone of CCR5 (Myc-DDK-tagged)-Human chemokine (C-C motif) receptor 5 (CCR5), transcript variant A |
CNY 7,888.00 |
|
| RC223291L2 | Lenti-ORF clone of CCR5 (mGFP-tagged)-Human chemokine (C-C motif) receptor 5 (CCR5), transcript variant A |
CNY 7,888.00 |
|
| RC223291L3 | Lenti-ORF clone of CCR5 (Myc-DDK-tagged)-Human chemokine (C-C motif) receptor 5 (CCR5), transcript variant A |
CNY 7,888.00 |
|
| RC223291L4 | Lenti-ORF clone of CCR5 (mGFP-tagged)-Human chemokine (C-C motif) receptor 5 (CCR5), transcript variant A |
CNY 7,888.00 |
|
| RG223291 | CCR5 (tGFP-tagged) - Human chemokine (C-C motif) receptor 5 (CCR5), transcript variant A |
CNY 7,088.00 |
