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PAX6 (NM_001604) Human Untagged Clone
CAT＃: SC109551
PAX6 (untagged)-Human paired box 6 (PAX6), transcript variant 2
CNY 3,656.00
CNY 7,030.00
| Cited in 2 publications. |
Product images
热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AN; AN1; AN2; ASGD5; D11S812E; FVH1; MGDA; WAGR |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC109551 sequence for NM_001604 edited (data generated by NextGen Sequencing)
ATGCAGAACAGTCACAGCGGAGTGAATCAGCTCGGTGGTGTCTTTGTCAACGGGCGGCCA CTGCCGGACTCCACCCGGCAGAAGATTGTAGAGCTAGCTCACAGCGGGGCCCGGCCGTGC GACATTTCCCGAATTCTGCAGACCCATGCAGATGCAAAAGTCCAAGTGCTGGACAATCAA AACGTGTCCAACGGATGTGTGAGTAAAATTCTGGGCAGGTATTACGAGACTGGCTCCATC AGACCCAGGGCAATCGGTGGTAGTAAACCGAGAGTAGCGACTCCAGAAGTTGTAAGCAAA ATAGCCCAGTATAAGCGGGAGTGCCCGTCCATCTTTGCTTGGGAAATCCGAGACAGATTA CTGTCCGAGGGGGTCTGTACCAACGATAACATACCAAGCGTGTCATCAATAAACAGAGTT CTTCGCAACCTGGCTAGCGAAAAGCAACAGATGGGCGCAGACGGCATGTATGATAAACTA AGGATGTTGAACGGGCAGACCGGAAGCTGGGGCACCCGCCCTGGTTGGTATCCGGGGACT TCGGTGCCAGGGCAACCTACGCAAGATGGCTGCCAGCAACAGGAAGGAGGGGGAGAGAAT ACCAACTCCATCAGTTCCAACGGAGAAGATTCAGATGAGGCTCAAATGCGACTTCAGCTG AAGCGGAAGCTGCAAAGAAATAGAACATCCTTTACCCAAGAGCAAATTGAGGCCCTGGAG AAAGAGTTTGAGAGAACCCATTATCCAGATGTGTTTGCCCGAGAAAGACTAGCAGCCAAA ATAGATCTACCTGAAGCAAGAATACAGGTATGGTTTTCTAATCGAAGGGCCAAATGGAGA AGAGAAGAAAAACTGAGGAATCAGAGAAGACAGGCCAGCAACACACCTAGTCATATTCCT ATCAGCAGTAGTTTCAGCACCAGTGTCTACCAACCAATTCCACAACCCACCACACCGGTT TCCTCCTTCACATCTGGCTCCATGTTGGGCCGAACAGACACAGCCCTCACAAACACCTAC AGCGCTCTGCCGCCTATGCCCAGCTTCACCATGGCAAATAACCTGCCTATGCAACCCCCA GTCCCCAGCCAGACCTCCTCATACTCCTGCATGCTGCCCACCAGCCCTTCGGTGAATGGG CGGAGTTATGATACCTACACCCCCCCACATATGCAGACACACATGAACAGTCAGCCAATG GGCACCTCGGGCACCACTTCAACAGGACTCATTTCCCCTGGTGTGTCAGTTCCAGTTCAA GTTCCCGGAAGTGAACCTGATATGTCTCAATACTGGCCAAGATTACAGTAA Clone variation with respect to NM_001604.4 >OriGene 5' read for NM_001604 unedited
GTCACAATTTGTATACGACTCACTATAGGCGGCCGCGAAATTCGCACGAGGCCTCGTGCC GAATTCGGCACGAGGCACACACCAACCCAGCAACATCCGTGGAGAAAACTCTCACCAGCA ACTCCTTTAAAACACCGTCATTTCAAACCATTGTGGTCTTCAAGCAACAACAGCAGCACA AAAAACCCCAACCAAACAAAACTCTTGACAGAAGCTGTGACAACCAGAAAGGATGCCTCA TAAAGGGGGAAGACTTTAACTAGGGGCGCGCAGATGTGTGAGGCCTTTTATTGTGAGAGT GGACAGACATCCGAGATTTCAGAGCCCCATATTCGAGCCCCGTGGAATCCCGCGGCCCCC AGCCAGAGCCAGCATGCAGAACAGTCACAGCGGAGTGAATCAGCTCGGTGGTGTCTTTGT CAACGGGCGGCCACTGCCGGACTCCACCCGGCAGAAGATTGTAGAGCTAGCTCACAGCGG GGCCCGGCCGTGCGACATTTCCCGAATTCTGCAGACCCATGCAGATGCAAAAGTCCAAGT GCTGGACAATCAAAACGTGTCCAACGGATGTGTGAGTAAAATTCTGGGCAGGTATTACGA GACTGGCTCCATCAGACCCAGGGCAATCGGTGGTAGTAAACCGAGAGTAGCGACTCCAGA AGTTGTAAGCAAAATAGCCCAGTATAAGCGGGAGTGCCCGTCCATCTTTGCTTGGGAAAT CCGAGACAGATTACTGTCCCGAGGGGTCTGTACCAACGATAACATACCAAGCGTGTCATC AATAAAACAGAGTCTTCGCACCCTGGCTAGCGAAAAGCACCAGATGGGCCCAGACCGGAT GTATGATTAACTAAAGATGTTGAACGGGCAAACCCGAAGCTGGGGCACCCGCCCTGGTTG GTATCCGGGGGACTTCGGTGCCACGGCAN >OriGene 3' read for NM_001604 unedited
CCGCGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTACTGTAATCTTG GCCAGTATTGAGACATATCAGGTTCACTTCCGGGAACTTGAACTGGAACTGACACACCAG GGGAAAATGAGTCCTGTTGAAGTGGTGCCCGAGGTGCCCATTGGCTGACTGTTCATGTGT GTCTGCATATGTGGGGGGGTGTAGGTATCATAACTCCGCCCATTCACCGAAGGGCTGGTG GGCAGCATGCAGGAGTATGAGGAGGTCTGGCTGGGGACTGGGGGTTGCATAGGCAGGTTA TTTGCCATGGTGAAGCTGGGCATAGGCGGCAGAGCGCTGTAGGTGTTTGTGAGGGCTGTG TCTGTTCGGCCCAACATGGAGCCAGATGTGAAGGAGGAAACCGGTGTGGTGGGTTGTGGA ATTGGTTGGTAGACACTGGTGCTGAAACTACTGCTGATAGGAATATGACTAGGTGTGTTG CTGGCCTGTCTTCTCTGATTCCTCAGTTTTTCTTCTCTTTTCCATTTGGCCCTTCGATTA GAAAACCATACCTGTATTCTTGCTTCAGGTAGATCTATTTTGGCTGCTAGTCTTTCTCGG GCAAACACATCTGGATAATGGGTTCTCTCAAACTCTTTTTCCAGGGCCTTAATTTGCTCT TGGTAAAGGATGTTCTATTTTTTTGCAGCTTCCGCTTCAGCTGAAATCGCATTTGAGCCT AATCTGAATCTTCTCCGCTTGAACTGATGGGATTTGTTATTCTTTCCCCCTTCTTTCTTG TTGCTGGCAGCCTTCTTGCGTAAGGTTCGCCTGGGCACCGAAATCCCCCGTAAACCAACC ACGGGCGGGTTGCCCCAGCTTTCGGGTCTGCCCCGTCAACAATCCTTTATTTTTATAACT GCCGTGTGCGCCCTTTTGTGGTTTTTCCTTACCAGTTGCCAACAATCTTTTTATTGTTTA ACCCT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001604 |
| Insert Size | 1710 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001604.3, NP_001595.2 |
| RefSeq Size | 2781 bp |
| RefSeq ORF | 1311 bp |
| Locus ID | 5080 |
| UniProt ID | P26367 |
| Domains | homeobox, PAX |
| Protein Families | Adult stem cells, Druggable Genome, Embryonic stem cells, Transcription Factors |
| Protein Pathways | Maturity onset diabetes of the young |
| Gene Summary | This gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to a conserved paired box domain, a hallmark feature of this gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of gene transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing results in multiple transcript variants encoding different isoforms. Interestingly, inclusion of a particular alternate coding exon has been shown to increase the length of the paired box domain and alter its DNA binding specificity. Consequently, isoforms that carry the shorter paired box domain regulate a different set of genes compared to the isoforms carrying the longer paired box domain. [provided by RefSeq, Mar 2019] Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, and includes an alternate in-frame exon in the 5' coding region, compared to variant 1. It initiates from the B (P1) promoter. The encoded isoform (b, also known as 5a) is longer than isoform a. Variants 2, 4, 5, 8, and 17-19 all encode the same isoform (b). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Role of miR-223/paired box 6 signaling in temozolomide chemoresistance in glioblastoma multiforme cells
,Cheng, Q;Ma, X;Cao, H;Chen, Z;Wan, X;Chen, R;Peng, R;Huang, J;Jiang, B;,
Mol Med Rep
,PubMed ID 28035389
[PAX6]
|
|
A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells
,null,
BMC Research Notes
,PubMed ID 26921094
[PAX6]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC222644 | PAX6 (Myc-DDK-tagged)-Human paired box 6 (PAX6), transcript variant 2 |
CNY 3,656.00 |
|
| RC222644L1 | Lenti ORF clone of Human paired box 6 (PAX6), transcript variant 2, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC222644L2 | Lenti ORF clone of Human paired box 6 (PAX6), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RC222644L3 | Lenti ORF clone of Human paired box 6 (PAX6), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC222644L4 | Lenti ORF clone of Human paired box 6 (PAX6), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RG222644 | PAX6 (tGFP-tagged) - Human paired box 6 (PAX6), transcript variant 2 |
CNY 5,256.00 |
