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p38 (MAPK14) (NM_139012) Human Untagged Clone
CAT＃: SC109107
MAPK14 (untagged)-Human mitogen-activated protein kinase 14 (MAPK14), transcript variant 2
CNY 5,488.00
Product images
CNY 1,999.00
CNY 3,490.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38; p38ALPHA; PRKM14; PRKM15; RK; SAPK2A |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_139012 edited
ATGTCTCAGGAGAGGCCCACGTTCTACCGGCAGGAGCTGAACAAGACAATCTGGGAGGTG CCCGAGCGTTACCAGAACCTGTCTCCAGTGGGCTCTGGCGCCTATGGCTCTGTGTGTGCT GCTTTTGACACAAAAACGGGGTTACGTGTGGCAGTGAAGAAGCTCTCCAGACCATTTCAG TCCATCATTCATGCGAAAAGAACCTACAGAGAACTGCGGTTACTTAAACATATGAAACAT GAAAATGTGATTGGTCTGTTGGACGTTTTTACACCTGCAAGGTCTCTGGAGGAATTCAAT GATGTGTATCTGGTGACCCATCTCATGGGGGCAGATCTGAACAACATTGTGAAATGTCAG AAGCTTACAGATGACCATGTTCAGTTCCTTATCTACCAAATTCTCCGAGGTCTAAAGTAT ATACATTCAGCTGACATAATTCACAGGGACCTAAAACCTAGTAATCTAGCTGTGAATGAA GACTGTGAGCTGAAGATTCTGGATTTTGGACTGGCTCGGCACACAGATGATGAAATGACA GGCTACGTGGCCACTAGGTGGTACAGGGCTCCTGAGATCATGCTGAACTGGATGCATTAC AACCAGACAGTTGATATTTGGTCAGTGGGATGCATAATGGCCGAGCTGTTGACTGGAAGA ACATTGTTTCCTGGTACAGACCATATTGATCAGTTGAAGCTCATTTTAAGACTCGTTGGA ACCCCAGGGGCTGAGCTTTTGAAGAAAATCTCCTCAGAGTCTGCAAGAAACTATATTCAG TCTTTGACTCAGATGCCGAAGATGAACTTTGCGAATGTATTTATTGGTGCCAATCCCCTG GCTGTCGACTTGCTGGAGAAGATGCTTGTATTGGACTCAGATAAGAGAATTACAGCGGCC CAAGCCCTTGCACATGCCTACTTTGCTCAGTACCACGATCCTGATGATGAACCAGTGGCC GATCCTTATGATCAGTCCTTTGAAAGCAGGGACCTCCTTATAGATGAGTGGAAAAGCCTG ACCTATGATGAAGTCATCAGCTTTGTGCCACCACCCCTTGACCAAGAAGAGATGGAGTCC TGAGCACCTGGTTTCTGTTCTGTTGATCCCACTTCACTGTGAGGGGAAGGCCTTTTCACG GGAACTCTCCAAATATTATTCAAGTGCCTCTTGTTGCAGAGATTTCCTCCATGGTGGAAG GGGGTGTGCGTGCGTGTGCGTGCGTGTTAGTGTGTGTGCATGTGTGTGTCTGTCTTTGTG GGAGGGTAAGACAATATGAACAAACTATGATCACAGTGACTTTACAGGAGGTTGTGGATG CTCCAGGGCAGCCTCCACCTTGCTCTTCTTTCTGAGAGTTGGCTCAGGCAGAC >OriGene 5' read for NM_139012 unedited
NGGTTCANATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGCAGCAGCT GGAACGGGAGTACTGCGACGCAGCCCGGAGTCGGCCTTGTAGGGGCGAAGGTGCAGGGAG ATCGCGGCGGGCGCAGTCTTGAGCGCCGGAGCGCGTCCCTGCCCTTAGCGGGGCTTGCCC CAGTCGCAGGGGCACATCCAGCCGCTGCGGCTGACAGCAGCCGCGCGCGCGGGAGTCTGC GGGGTCGCGGCAGCCGCACCTGCGCGGGCGACCAGCGCAAGGTCCCCGCCCGGCTGGGCG GGCAGCAAGGGCCGGGGAGAGGGTGCGGGTGCAGGCGGGGGCCCCACAGGGCCACCTTCT TGCCCGGCGGCTGCCGCTGGAAAATGTCTCAGGAGAGGCCCACGTTCTACCGGCAGGAGC TGAACAAGACAATCTGGGAGGTGCCCGAGCGTTACCAGAACCTGTCTCCAGTGGGCTCTG GCGCCTATGGCTCTGTGTGTGCTGCTTTTGACACAAAAACGGGGTTACGTGTGGCAGTGA AGAAGCTCTCCAGACCATTTCAGTCCATCATTCATGCGAAAAGAACCTACAGAGAACTGC GGTTACTTAAACATATGAAACATGAAAATGTGATTGGTCTGTTGGACGTTTTTACACCTG CAAGGTCTCTGGAGGAATTCAATGATGTGTATCTGGTGACCCATCTCATGGGGGCAGATC TGAACAACATTGTGAAATGTCAGAAGCTTACAGATGACCATGTTCAGTTCCTTATCTACC ANATCTNCGAGGTCTAAAGTATATACATTCAGCTGACATAATTCACAGGNACCCCTAAAC CTAGTATCTANCTGTGAATGAAGACTGTGAGCTGAAGATTCTGGNATTTGGACTGGNCTC GCCACAGAT >OriGene 3' read for NM_139012 unedited
TTGGCCGCGGCCGCATCTANATCGAGTTTTTTTTTTTTTTTTTTAAATTTGAAAAAAGGC TTTATTTTAACCAGTGGTATTGTCTGACATCCTATACGGCATAACTGATTACAGCCAAGT TCATGAATACAAATAAAATAGCAATTTCCCTCATTCTCTCTTTTGTTTTCTGTTCAGAGA AATCAGGAGATGGGAGCATTATGCTCAGAAACCGAAGAGCTCTTCCAAGAGCTCCAGCTT AGAGTCCAGGCTTCCAGAGCATGCAGCCTCCTAACACGTATGTGGTCACATGTGCAAAGA CCTTTATTACAAAATATTCAGAGCAGTATTTCTGTAGGAAATCACACGAGCATTTACAAC CAAACATGGCTGATAAAATTCATCTTGCTGTGGATGGTAAGGATTTGAACTGCAATAAAG GAGATGAGGCCTTTACTTTAAAGGTTCACTTTCCTTGAAAGGGGGAGAGTCCCGGGTGAG AGGGAATCGCCATCAGTCTGCCTCCTTCCTTCTTGCTCCAGTTGACTCAGGGGGTCCACC CTGTCCCTCTGGAGTACATGTATCACTGCACTGATTGAGAAATGGAAACACCTTGGCCCA AATACAAGATTCTGTCACACAGCCAACACTGGAAGTGACTTTATACTTTCTTATTACACA AAAGGCTTAAATATATGAGTCCTCATGTAGAACAAAATGCCTGAAATTCAGCAAGTTATG AAAACGACACTTCTCCACCCCTGAGGATATTTTATCTTTATAAAGTTGAAATACAAAATA TTAAATTATTTGCCCTTTCTCCCATCAAAGGAATACATTCTCAAAGGATCCTACAATTAC AAAATCTGAACCAATTTATTCTCCCAACCAAGAGTCATGTTAACCTGCAAGAGACCTTTT CATAGAGTGAAAAGACCCTGTTACTTTTATTTAAGAATCCTTTAGAAAGACACAAAGGAG TTCTGGCCTATGGCTAATT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_139012 |
| Insert Size | 3990 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_139012.1, NP_620581.1 |
| RefSeq Size | 3757 bp |
| RefSeq ORF | 1083 bp |
| Locus ID | 1432 |
| UniProt ID | Q16539 |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | Amyotrophic lateral sclerosis (ALS), Epithelial cell signaling in Helicobacter pylori infection, Fc epsilon RI signaling pathway, GnRH signaling pathway, Leukocyte transendothelial migration, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Progesterone-mediated oocyte maturation, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway, VEGF signaling pathway |
| Gene Summary | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (2) contains a different segment within the coding region when compared to variant 1. The translation frame remains the same, and the resulting isoform 2 has an internal segment different from that of isoform 1. |
Documents
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| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC206605 | MAPK14 (Myc-DDK-tagged)-Human mitogen-activated protein kinase 14 (MAPK14), transcript variant 2 |
CNY 5,488.00 |
|
| RC206605L1 | Lenti ORF clone of Human mitogen-activated protein kinase 14 (MAPK14), transcript variant 2, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC206605L2 | Lenti ORF clone of Human mitogen-activated protein kinase 14 (MAPK14), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RC206605L3 | Lenti ORF clone of Human mitogen-activated protein kinase 14 (MAPK14), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC206605L4 | Lenti ORF clone of Human mitogen-activated protein kinase 14 (MAPK14), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RG206605 | MAPK14 (tGFP-tagged) - Human mitogen-activated protein kinase 14 (MAPK14), transcript variant 2 |
CNY 7,088.00 |
