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DPP1 (CTSC) (NM_148170) Human Untagged Clone
CAT＃: SC109065
CTSC (untagged)-Human cathepsin C (CTSC), transcript variant 2
CNY 1,200.00
CNY 3,990.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CPPI; DPP-I; DPP1; DPPI; HMS; JP; JPD; PALS; PDON1; PLS |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_148170, the custom clone sequence may differ by one or more nucleotides
ATGGGTGCTGGGCCCTCCTTGCTGCTCGCCGCCCTCCTGCTGCTTCTCTCCGGCGACGGCGCCGTGCGCT GCGACACACCTGCCAACTGCACCTATCTTGACCTGCTGGGCACCTGGGTCTTCCAGGTGGGCTCCAGCGG TTCCCAGCGCGATGTCAACTGCTCGGTTATGGGACCACAAGAAAAAAAAGTAGTGGTGTACCTTCAGAAG CTGGATACAGCATATGATGACCTTGGCAATTCTGGCCATTTCACCATCATTTACAACCAAGGCTTTGAGA TTGTGTTGAATGACTACAAGTGGTTTGCCTTTTTTAAGGATGTCACTGATTTTATCAGTCATTTGTTCAT GCAGCTGGGAACTGTGGGGATATATGATTTGCCACATCTGAGGAACAAACTGGTTATTAAATAG >OriGene 5' read for NM_148170 unedited
CTTAGATTTGTAAACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGTCTTCACCTCT TTTCTCAGCTCCCTGCAGCATGGGTGCTGGGCCCTCCTTGCTGCTCGCCGCCCTCCTGCT GCTTCTCTCCGGCGACGGCGCCGTGCGCTGCGACACACCTGCCAACTGCACCTATCTTGA CCTGCTGGGCACCTGGGTCTTCCAGGTGGGCTCCAGCGGTTCCCAGCGCGATGTCAACTG CTCGGTTATGGGACCACAAGAAAAAAAAGTAGTGGTGTACCTTCAGAAGCTGGATACAGC ATATGATGACCTTGGCAATTCTGGCCATTTCACCATCATTTACAACCAAGGCTTTGAGAT TGTGTTGAATGACTACAAGTGGTTTGCCTTTTTTAAGGATGTCACTGATTTTATCAGTCA TTTGTTCATGCAGCTGGGAACTGTGGGGATATATGATTTGCCACATCTGAGGAACAAACT GGTTATTAAATAGAGCATCTGTTGAGGGACTCTTTTAAAACCACAGCCATGAACAGACGT TGGGGCTAAGAGACAGAGCAGCCTGCGACAGTGTGGACCTACCTGTAGCAGCTAGCAAAG GCCTCTAGCAGCTACAGTCCCTTCTGGAGTCTTTATTTGCATGCAAAATGCAAAGGAGTC CTGGTGACCTACCTCCAAGGCAGCTGCCCTCCTGAACACTCCCTTGGAAAACAGTAAACA TCATTTTGGAATGTGAACAACCAGAGACTACACAGGAGAAAGGAAAAAAAAAATTCTGAA GATGCAAAATCTTGGGTGGCTTCACCGTTCAGTTTTTTAATAAAAGGAACAATNTACANA AAAAAAAANAAAAACTCGACTCTAGATTGCNGCCGCGGTCATAGCTGTTTCCTGAACAGA TCCCGGNTGGCATNCCTGTGNACCCTNNCCATGCCTNTNCTGGCCCTGNAAGTGCCACT >OriGene 3' read for NM_148170 unedited
TAACTATGNAACCGCGGCCGCATNCTAGNGATCGATTTTTTTTTTTTTTTTTTGTATATT GTTCCTTTTATTAAAAAACTGAACGGTGAAGCCACCCAAAATTTTGCATCTTCAGAATTT TTTTTTTCCTTTCTCCTGTGTAGTCTCTGGTTGTTCACATTCCAAAATGATGTTTACTGT TTTCCAAGGGAGTGTTCAGGAGGGCAGCTGCCTTGGAGGTAGGTCACCAGGACTCCTTTG CATTTTGCATGCAAATAAAGACTCCAGAAGGGACTGTAGCTGCTAGAGGCCTTTGCTAGC TGCTACAGGTAGGTCCACACTGTCGCAGGCTGCTCTGTCTCTTAGCCCCAACGTCTGTTC ATGGCTGTGGTTTTAAAAGAGTCCCTCAACAGATGCTCTATTTAATAACCAGTTTGTTCC TCAGATGTGGCAAATCATATATCCCCACAGTTCCCAGCTGCATGAACAAATGACTGATAA AATCAGTGACATCCTTAAAAAAGGCAAACCACTTGTAGTCATTCAACACAATCTCAAAGC CTTGGTTGTAAATGATGGTGAAATGGCCAGAATTGCCAAGGTCATCATATGCTGTATCCA GCTTCTGAAGGTACACCACTACTTTTTTTTCTTGTGGTCCCATAACCGAGCAGTTGACAT CGCGCTGGGAACCGCTGGAGCCCACCTGGAAGACCCCAGTGCCCAGCAAGTCAAGAATAG TGCAGTTGGCAAGTGTGTCGCAACCACGGCGCCGTCGCCGGAAAAAACACCAGGAGGCGG CCAGCACCAAGGAGGGCCCACCACCCTGCTGCAGGGAGCTGAAAAAAAAGTGAAGACCTT CTGCCCAAATTCCGGCCGCCCTATATTGAGTCGTATACCAAAATTTGACGGTTCACTAAC GAGCTCTGCTTATTAGACCTCCAACCTACCACCTACCC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_148170 |
| Insert Size | 800 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_148170.2, NP_680475.1 |
| RefSeq Size | 6131 bp |
| RefSeq ORF | 414 bp |
| Locus ID | 1075 |
| UniProt ID | P53634 |
| Protein Families | Druggable Genome, Protease |
| Protein Pathways | Lysosome |
| Gene Summary | This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015] Transcript Variant: This variant (2) differs in the coding sequence and 3' UTR compared to variant 1. This results in an isoform (b) that is much shorter and contains a different C-terminus than isoform a. Isoform b may act as a negative regulator of a stable mature enzyme. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC215614 | CTSC (Myc-DDK-tagged)-Human cathepsin C (CTSC), transcript variant 2 |
CNY 1,200.00 |
|
| RC215614L3 | Lenti ORF clone of Human cathepsin C (CTSC), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC215614L4 | Lenti ORF clone of Human cathepsin C (CTSC), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RG215614 | CTSC (tGFP-tagged) - Human cathepsin C (CTSC), transcript variant 2 |
CNY 4,370.00 |
