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Cytochrome P450 2C8 (CYP2C8) (NM_000770) Human Untagged Clone
CAT＃: SC107944
CYP2C8 (untagged)-Human cytochrome P450, family 2, subfamily C, polypeptide 8 (CYP2C8), transcript variant 1
CNY 5,488.00
| Cited in 4 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CPC8; CYP2C8DM; CYPIIC8; MP-12/MP-20 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC107944 sequence for NM_000770 edited (data generated by NextGen Sequencing)
ATGGAACCTTTTGTGGTCCTGGTGCTGTGTCTCTCTTTTATGCTTCTCTTTTCACTCTGG AGACAGAGCTGTAGGAGAAGGAAGCTCCCTCCTGGCCCCACTCCTCTTCCTATTATTGGA AATATGCTACAGATAGATGTTAAGGACATCTGCAAATCTTTCACCAATTTCTCAAAAGTC TATGGTCCTGTGTTCACCGTGTATTTTGGCATGAATCCCATAGTGGTGTTTCATGGATAT GAGGCAGTGAAGGAAGCCCTGATTGATAATGGAGAGGAGTTTTCTGGAAGAGGCAATTCC CCAATATCTCAAAGAATTACTAAAGGACTTGGAATCATTTCCAGCAATGGAAAGAGATGG AAGGAGATCCGGCGTTTCTCCCTCACAACCTTGCGGAATTTTGGGATGGGGAAGAGGAGC ATTGAGGACCGTGTTCAAGAGGAAGCTCACTGCCTTGTGGAGGAGTTGAGAAAAACCAAG GCTTCACCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCC GTTGTTTTCCAGAAACGATTTGATTATAAAGATCAGAATTTTCTCACCCTGATGAAAAGA TTCAATGAAAACTTCAGGATTCTGAACTCCCCATGGATCCAGGTCTGCAATAATTTCCCT CTACTCATTGATTGTTTCCCAGGAACTCACAACAAAGTGCTTAAAAATGTTGCTCTTACA CGAAGTTACATTAGGGAGAAAGTAAAAGAACACCAAGCATCACTGGATGTTAACAATCCT CGGGACTTTATCGATTGCTTCCTGATCAAAATGGAGCAGGAAAAGGACAACCAAAAGTCA GAATTCAATATTGAAAACTTGGTTGGCACTGTAGCTGATCTATTTGTTGCTGGAACAGAG ACAACAAGCACCACTCTGAGATATGGACTCCTGCTCCTGCTGAAGCACCCAGAGGTCACA GCTAAAGTCCAGGAAGAGATTGATCATGTAATTGGCAGACACAGGAGCCCCTGCATGCAG GATAGGAGCCACATGCCTTACACTGATGCTGTAGTGCACGAGATCCAGAGATACAGTGAC CTTGTCCCCACCGGTGTGCCCCATGCAGTGACCACTGATACTAAGTTCAGAAACTACCTC ATCCCCAAGGGCACAACCATAATGGCATTACTGACTTCCGTGCTACATGATGACAAAGAA TTTCCTAATCCAAATATCTTTGACCCTGGCCACTTTCTAGATAAGAATGGCAACTTTAAG AAAAGTGACTACTTCATGCCTTTCTCAGCAGGAAAACGAATTTGTGCAGGAGAAGGACTT GCCCGCATGGAGCTATTTTTATTTCTAACCACAATTTTACAGAACTTTAACCTGAAATCT GTTGATGATTTAAAGAACCTCAATACTACTGCAGTTACCAAAGGGATTGTTTCTCTGCCA CCCTCATACCAGATCTGCTTCATCCCTGTCTGA Clone variation with respect to NM_000770.3 >OriGene 5' read for NM_000770 unedited
GTCGGAATTTGTATACGACTCCTATAGGCGGCCGCCTAATTAGCAGGGAGTGTTATAAAA ACTTTGGAGTGCAAGCTCACAGCTGTCTTAATAAGAAGAGAAGGCTTCAATGGAACCTTT TGTGGTCCTGGTGCTGTGTCTCTCTTTTATGCTTCTCTTTTCACTCTGGAGACAGAGCTG TAGGAGAAGGAAGCTCCCTCCTGGCCCCACTCCTCTTCCTATTATTGGAAATATGCTACA GATAGATGTTAAGGACATCTGCAAATCTTTCACCAATTTCTCAAAAGTCTATGGTCCTGT GTTCACCGTGTATTTTGGCATGAATCCCATAGTGGTGTTTCATGGATATGAGGCAGTGAA GGAAGCCCTGATTGATAATGGAGAGGAGTTTTCTGGAAGAGGCAATTCCCCAATATCTCA AAGAATTACTAAAGGACTTGGAATCATTTCCAGCAATGGAAAGAGATGGAAGGAGATCCG GCGTTTCTCCCTCACAACCTTGCGGAATTTTGGGATGGGGAAGAGGAGCATTGAGGACCG TGTTCAAGAGGAAGCTCACTGCCTTGTGGAGGAGTTGAGAAAAACCAAGGCTTCACCCTG TGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGTTCCCGNTGTTTTCC AGAAACGATTTGATTATTAAGATCCAGATTTTCTCACCCTGATGAAAAGATTCAATGAAA ACTTCAGGATTCTGAACTCCCCATGGATCCAGGTCTGNCATAATTTCCCTCTACCATTGG ATTGTTTCCCAGGAACTCACAACANAGTGCTTTAAAAATGTTGCTCTTACACCGAAGNTA CATTAGGNNAGAAAGGTAAAAGAACACCAGGCATCCCTGGATGTTAACAATCCTCGGGAC TTAATCGATTGCTTCTGATCAAATGGAGCAGGGAAAGGAN >OriGene 3' read for NM_000770 unedited
TTTAGCTTGGACCCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTTTCA GCAATTAATAACACTTTTTATTTAGCACATTCACAAAAAAAATGGATCTAAATTATCATT CATTAATCACTTTTCTGTGTTTTACAGGGATAACATATTAAAAAGTCAGCATTAGAAAAG TATTAGCATATGCAGCAATTAATACAAGTGTTACAGAGTATGAATAATTGCAGATATATT TGTGCAGTGACCTGAACAACTCTCCTTAATGGAGTTTGGATGCTTATGGGATATTGAGTG AATGGGAAGATTTGATGAGAGGTCAGAGAAGACATAATAGTGGGAATGTCCTTGATAAAA AAAGAGTTGCAGGTGATAGCAGATCGGCAGCCAGATGGGCTAGCATTCTTCAGACAGGGA TGAAGCAGATCTGGTATGAGGGTGGCAGAGAAACAATCCCTTTGGTAACTGCAGTAGTAT TGAGGTTCTTTAAATCATCAACAGATTTCAGGTTAAAGTTCTGTAAAATTGTGGTTAGAA ATAAAAATAGCTCCATGCGGGCAAGTCCTTCTCCTGCACAAATTCGTTTTCCTGCTGAGA AAGGCATGAAGTAGTCACTTTTCTTAAAGTTGCCATTCTTATCTAGAAAGTGGCCAGGGT CAAAGATATTTGGATTAGGAAATTCTTTGTCATCATGTAGCACGGGAAGTCAGTAATGCC ATTANTGGTTGTGCCCTTGNGGATGANGGTAGTTTCTGAACTTAGTATCAGTGGTCACTG CATGGGGCACACCGGTGGGGACAAGGTCACTGTATCTCTGGATCTCGTGCACTAAGCATC AGTGTAGGCATGTGGGCTCTTCCTGCTGCAGGGCTTCTGTGTCTGCATTACTGATCATCT CTTCTGACTTTACTGGACCTCTGGTGCTCACAGAACAGAGTCTTTCAAAAGGGGCCTTGT GGGCTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000770 |
| Insert Size | 2000 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000770.2, NP_000761.2 |
| RefSeq Size | 1851 bp |
| RefSeq ORF | 1473 bp |
| Locus ID | 1558 |
| UniProt ID | P10632 |
| Domains | p450 |
| Protein Families | Druggable Genome, P450, Transmembrane |
| Protein Pathways | Arachidonic acid metabolism, Drug metabolism - cytochrome P450, Linoleic acid metabolism, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Retinol metabolism |
| Gene Summary | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] Transcript Variant: This variant (1) encodes the longest isoform (a). |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism
,Lazarska, KE;Dekker, SJ;Vermeulen, NPE;Commandeur, JNM;,
Toxicol. Lett.
,PubMed ID 29203276
[CYP2C8]
|
|
Peroxisome proliferator-activated receptor alpha, PPARa, directly regulates transcription of cytochrome P450 CYP2C8
,Thomas, M;Winter, S;Klumpp, B;Turpeinen, M;Klein, K;Schwab, M;Zanger, UM;,
Front Pharmacol
,PubMed ID 26582990
[CYP2C8]
|
|
Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC)
,Tengis S. Pavlov, Daria V. Ilatovskaya, Vladislav Levchenko, David L. Mattson, Richard J. Roman, and Alexander Staruschenko,
Am J Physiol Renal Physiol, Sep 2011; 301: F672 - F681.
[CYP2C8]
|
|
Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC)
,null,
American Journal of Physiology - Renal Physiology
,PubMed ID 21697242
[CYP2C8]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC204605 | CYP2C8 (Myc-DDK-tagged)-Human cytochrome P450, family 2, subfamily C, polypeptide 8 (CYP2C8), transcript variant 1 |
CNY 5,488.00 |
|
| RC204605L1 | Lenti ORF clone of Human cytochrome P450, family 2, subfamily C, polypeptide 8 (CYP2C8), transcript variant 1, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC204605L2 | Lenti ORF clone of Human cytochrome P450, family 2, subfamily C, polypeptide 8 (CYP2C8), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC204605L3 | Lenti ORF clone of Human cytochrome P450, family 2, subfamily C, polypeptide 8 (CYP2C8), transcript variant 1, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC204605L4 | Lenti ORF clone of Human cytochrome P450, family 2, subfamily C, polypeptide 8 (CYP2C8), transcript variant 1, mGFP tagged |
CNY 7,888.00 |
|
| RG204605 | CYP2C8 (tGFP-tagged) - Human cytochrome P450, family 2, subfamily C, polypeptide 8 (CYP2C8), transcript variant 1 |
CNY 7,088.00 |
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