Signal peptide peptidase like 2B (SPPL2B) (AL365405) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	IMP-4; IMP4; PSH4; PSL1
Vector	pCMV6-XL4
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for AL365405, the custom clone sequence may differ by one or more nucleotides CGGGGCGGTTCCTTGCGCTTCAGTCCCCCCCGGGTCCCCTCCTGCTCCCGGGTTTTCTGCCCCGTTCCCC CGGGTGGCTGTGGGCTCCCGAGCCCCGTGTCGGCCAGCCGGCCCCAGGGCCCCACGACCCCATGGTGTCT CCCAAGAAGGTACATGAAGCACAAGCGCGACGATGGGCCCGAGAAGCAGGAGGACGAGGCGGTGGACGTG ACGCCGGTGATGACCTGCGTGTTTGTGGTGATGTGCTGCTCCATGCTGGTGCTGCTCTACTATTTCTACG ACCTCCTCGTGTACGTGGTCATCGGGATCTTCTGCCTGGCCTCCGCCACCGGCCTCTACAGCTGCCTGGC GCCCTGTGTGCGGCGGCTGCCCTTCGGCAAGTGCAGCGCCCGCAGGCCCGTATGCTGCTCCTGGCGCTCT TCTGCGTGGCCGTCAGCGTGGTGTGGGGCGTCTTCCGCAACGAGGACCAGTAAGTGCTGCTTCCCCCGGG CCCCGGCGGGCAGCGGAGTCCTCGGACGCACCAGGGCTCCTGGGGCCCTGACTCCCTGCCCTCCCTGGAG GCCGCCCCAGCCTGGAGCTGCTTCAGCACCGCGTGATGAAGAGCCCTGGCCCCGGGCTGCTCTGACAGGG CTGCGAGGGCGTTTCACCTGGGGTTTGTCCGGGTGTCATGGGAACCCTGACTGGAATCCGGGAGGAGAGG CCGGAGCCCCTGTGGCCAGGAGCCACGTCCTCCAGCCTGGATGGGACTCCTTTGTGGGGCATCGCTGCCC AGGGCCACAGTCTGTCCCCCGCTGTCCCTTTCCTGGCACCCACGTGCACGCCGCAGGTTCGAGGCCCAGG GTGTGGGCACCAGGGCACCCGGTCCTCTTGGTCATGACTGCTGCGGCTTCTGAGCAGTGGTGGAGGTGGG GCAGGCACTGCTCCCCCCACGCTCACCTCCCACGTGGCCTGGACTTGTGGCTGCCTCCCGCTGGCCGGGC CTCCCCCATGAGGCCGAGTGCCTGGTGCCGTGTTGGGAGGACAGAGCTGGCCCGTCCCCGCCCGGTCCCC ACCGCTGTCGCTGATACCATCTGGCACTTCCTCCCAGCCTTCCTGAGGCAGCCAAGTACGCTTGGCTTTG GTGTGTATTGGAGCCACGGCACGTTTAACTGGCAGAAGGAAGATGTGAAAATATTTTGAATCCTTTGTAC ACAAAGAGAAAATGAATCTTTTCAGTTATTTCCAAGCCAGGAAACTCGCTCCGTCACATGAAGTTAGAGC AGGCCTCAGTCAGCTGGGCGCAGGGGCTCACGCCTGGGATCCCAGCATTTGGTAGGCCAAGGCAGGACGA TCACTTTGCCCAGGAGTTCAAGACCAGCCTGGGCAACAAGCGAGACGCCCTATTTAAGAAATAATATAAA ATCAGAAAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for AL365405 unedited NNNGGTTCAAATTTGTAAACGACTCATATAGGCGGCCGCGNAATTCGCACGAGAAGGCAT GGTGCACGTGGTCTCCCAGGCCGGGGGCCCCNGAAGCAAAGACTACTGCATCCTCTACAA CCCGCAGTGGGCCCATCTTCCGCACGACCTCAGCAAGGCATCTTTCCTGCAGCTGCGCAA CTGGACAGCCTCCCTGCTCTGCTCCGCAGCCGACCTCCCCGCCCGTGGCTTCAGCAACCA GATCCCGCTGGTGGCGCGGGGGAACTGCACCTTCTATGAGAAAGTGAGGCTGGCCCAGGG CAGCGGAGCACGCGGGCTGCTCATCGTCAGCAGGGAGAGGCTGGTCCCCCCGGGGGGTAA TAAGACGCAGTATGATGAGATTGGCATTCCCGTGGCCCTGCTCAGCTACAAAGACATGCT GGACATCTTCACGCGTTTCGGCCGCACGGTGAGGGCGGCGCTGTATGCGCCTAAGGAGCC GGTGCTGGACTACAACATGGTCATCATCTTCATCATGGCTGTGGGCACCGTCGCCATCGG CGGCTACTGGGCCGGGAGTCGGGACGTGAAGAAAAGGTACATGAAGCACAAGCGCGACGA TGGGCCCGAGAAGCAGGAGGACGAGGCGGTGGACGTGACGCCGGTGATGACCTGCGTGTT TGTGGTGATGTGCTGCTCCATGCTGGTGCTGCTCTACTATTTCTACGACCTCCTCGTGTA CGTGGTCATCGGGATCTTCTGCCTGGCCTCCGCCACCGGCCTCTACAGCTGCCTGGCGCC CTGTGTGCGGCGGCTGCCCTTCGGCAAGTGCAGGATCCCCAACACAGCCTGCCCTACTTC CACAAGCGCCCCGCAGCCCGTATGCTGCTCCTGGCGCTCTTCTGCGTGGCCGTCAGCGTG GGTGTGGGGGCGTCTTCCGCAACAC
Restriction Sites	NotI-NotI
ACCN	AL365405
Insert Size	3000 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	AL365405.1, CAB96951.1
RefSeq Size	1412 bp
RefSeq ORF	1412 bp
Locus ID	56928
Protein Families	Protease, Transmembrane
Gene Summary	This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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