TIM 3 (HAVCR2) (BC020843) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	FLJ14428; hepatitis A virus cellular receptor 2; kidney injury molecule-3; KIM-3; T cell immunoglobulin mucin-3; T cell immunoglobulin mucin 3; Tim-3; TIM3; TIMD3
Vector	pCMV6-XL4
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC020843 edited GAATTCGGCACCAGGTGCTGAGCTAGCACTCAGTGGGGGCGGCTACTGCTCATGTGATTG TGGAGTAGACAGTTGGAAGAAGTACCCAGTCCATTTGGAGAGTTAAAACTGTGCCTAACA GAGGTGTCCTCTGACTTTTCTTCTGCAAGCTCCATGTTTTCACATCTTCCCTTTGACTGT GTCCTGCTGCTGCTGCTGCTACTACTTACAAGGTCCTCAGAAGTGGAATACAGAGCGGAG GTCGGTCAGAATGCCTATCTGCCCTGCTTCTACACCCCAGCCGCCCCAGGGAACCTCGTG CCCGTCTGCTGGGGCAAAGGAGCCTGTCCTGTGTTTGAATGTGGCAACGTGGTGCTCAGG ACTGATGAAAGGGATGTGAATTATTGGACATCCAGATACTGGCTAAATGGGGATTTCCGC AAAGGAGATGTGTCCCTGACCATAGAGAATGTGACTCTAGCAGACAGTGGGATCTACTGC TGCCGGATCCAAATCCCAGGCATAATGAATGATGAAAAATTTAACCTGAAGTTGGTCATC AAACCAGCCAAGGTCACCCCTGCACCGACTCTGCAGAGAGACTTCACTGCAGCCTTTCCA AGGATGCTTACCACCAGGGGACATGGCCCAGCAGAGACACAGACACTGGGGAGCCTCCCT GATATAAATCTAACACAAATATCCACATTGGCCAATGAGTTACGGGACTCTAGATTGGCC AATGACTTACGGGACTCTGGAGCAACCATCAGAATAGGCATCTACATCGGAGCAGGGATC TGTGCTGGGCTGGCTCTGGCTCTTATCTTCGGCGCTTTAATTTTCAAATGGTATTCTCAT AGCAAAGAGAAGATACAGAATTTAAGCCTCATCTCTTTGGCCAACCTCCCTCCCTCAGGA TTGGCAAATGCAGTAGCAGAGGGAATTCGCTCAGAAGAAAACATCTATACCATTGAAGAG AACGTATATGAAGTGGAGGAGCCCAATGAGTATTATTGCTATGTCAGCAGCAGGCAGCAA CCCTCACAACCTTTGGGTTGTCGCTTTGCAATGCCATAGATCCAACCACCTTATTTTTGA GCTTGGTGTTTTGTCTTTTTCAGAAACTATGAGCTGTGTCACCTGACTGGTTTTGGAGGT TCTGTCCACTGCTATGGAGCAGAGTTTTCCCATTTTCAGAAGATAATGACTCACATGGGA ATTGAACTGGGACCTGCACTGAACTTAAACAGGCATGTCATTGCCTCTGTATTTAAGCCA ACAGAGTTACCCAACCCAGAGACTGTTAATCATGGATGTTAGAGCTCAAACGGGCTTTTA TATACACTAGGAATTCTTGACGTGGGGTCTCTGGAGCTCCAGGAAATTCGGGCACATCAT ATGTCCATGAAACTTCAGATAAACTAGGGAAAACTGGGTGCTGAGGTGAAAGCATAACTT TTTTGGCACAGAAAGTCTAAAGGGGCCACTGATTTTCAAAGAGATCTGTGATCCCTTTTT GTTTTTTGTTTTTGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAATGGCACAA TCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCT GAGTGGCTGGGATTACAGGCATGCACCACCATGCCCAGCTAATTTGTTGTATTTTTAGTA GAGACAGGGTTTCACCATGTTGGCCAGTGTGGTCTCAAACTCCTGACCTCATGATTTGCC TGCCTCGGCCTCCCAAAGCACTGGGATTACAGGCGTGAGCCACCACATCCAGCCAGTGAT CCTTAAAAGATTAAGAGATGACTGGACTAGGTCTACCTTGATCTTGAAGATTCCCTTGGA ATGTTGAGATTTAGGCTTATTTGAGCACTACCTGCCCAACTGTCAGTGCCAGTGCATAGC CCTTCTTTTGTCTCCCTTATGAAGACTGCCCTGCAGGGCTGAGATGTGGCAGGAGCTCCC AGGGAAAAAGGAAGTGCATTTGATTGGTGTGTATTGGCCAAGTTTTGCTTGTTGTGTGCT TGAAAGAAAATATCTCTGACCAACTTCTGTATTCGTGGACCAAACTGAAGCTATATTTTT CACAGAAGAAGAAGCAGTGACGGGGACACAAATTCTGTTGCCTGGTGGAAAGAAGGCAAA GGCCTTCAGCAATCTATATTACCAGCGCTGGATCCTTTGACAGAGAGTGGTCCCTAAACT TAAATTTCAAGACGGTATAGGCTTGATCTGTCTTGCTTATTGTTGCCCCCTGCGCCTAGC ACAATTCTGACACACAATTGGAACTTACTAAAAATTTTTTTTTACTGTTAAAAAAAAAAA AAAAAAAAAACTCGAC 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC020843 unedited AATTTGGTATACGACTCACTATAGGGCGGCCGCGAATTCGGCACCAGGTGCTGAGCTAGC ACTCAGTGGGGGCGGCTACTGCTCATGTGATTGTGGAGTAGACAGTTGGAAGAAGTACCC AGTCCATTTGGAGAGTTAAAACTGTGCCTAACAGAGGTGTCCTCTGACTTTTCTTCTGCA AGCTCCATGTTTTCACATCTTCCCTTTGACTGTGTCCTGCTGCTGCTGCTGCTACTACTT ACAAGGTCCTCAGAAGTGGAATACAGAGCGGAGGTCGGTCAGAATGCCTATCTGCCCTGC TTCTACACCCCAGCCGCCCCAGGGAACCTCGTGCCCGTCTGCTGGGGCAAAGGAGCCTGT CCTGTGTTTGAATGTGGCAACGTGGTGCTCAGGACTGATGAAAGGGATGTGAATTATTGG ACATCCAGATACTGGCTAAATGGGGATTTCCGCAAAGGAGATGTGTCCCTGACCATAGAG AATGTGACTCTAGCAGACAGTGGGATCTACTGCTGCCGGATCCAAATCCCAGGCATAATG AATGATGAAAAATTTAACCTGAAGTTGGTCATCAAACCAGCCAAGGTCACCCCTGCACCG ACTCTGCAGAGAGACTTCACTGCAGCCTTTCCAAGGATGCTTACCACCAGNGGACATGGC CCAGCAGAGACACAGACACTGNGGAGCCTCCCTGATATAAATCTAACACANATATCCACA TTGGCCAATGAGTTACGGGACTCTAGATTGGCCAATGACTTACGGGACTCTGGAGCACCA TCAGATATGCATCTACATCGAGCAGGGATCTGTGCTGGGCTGGCTCTGGCTCTTATCTTT CGCAGCTTAATTTCAAATGGGATTCTCATAGCANAGAGATGAACAGAATTAAGCCTCATC TCTTAGCCAACCTCCCTCCCTCAGATTGGCAATGCAGTAGCANAAGGGATTCGCTCAAAT AAAACTCTATACATCGNAGAGACGNTTATGNAATGGAGGACCCATGATACTATTGCTT
Restriction Sites	NotI-NotI
ACCN	BC020843
Insert Size	2500 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC020843.1, AAH20843.1
RefSeq Size	1012 bp
RefSeq ORF	429 bp
Locus ID	84868
Domains	IG
Protein Families	Druggable Genome, Transmembrane
Gene Summary	The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]

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